Pharmacology/Pharmaceutical Industry
Study: Patients with Type 2 Diabetes Safely Switched from Analog to Less Costly Human Insulin
30 Jan, 2019 | 01:13h | UTCImplementation of a Health Plan Program for Switching From Analogue to Human Insulin and Glycemic Control Among Medicare Beneficiaries With Type 2 Diabetes – JAMA (link to abstract – $ for full-text)
Commentary: Medicare Patients with Type 2 Diabetes Safely Switched From Analog to Human Insulin, JAMA Study Finds – AJMC (free)
Related: Meta-Analysis: Comparative Benefits and Harms of Basal Insulin Analogues for Type 2 Diabetes (link to abstract and commentaries) AND Retrospective Observational Study: Basal Insulin Analogs vs NPH Insulin for Type 2 Diabetes (link to abstract and commentaries)
“Patients with type 2 diabetes (T2D) enrolled in a CareMore Health Medicare Part D plan switched from analog to human insulin without significant loss of glycemic control while saving millions for themselves and for the health plan.: (from AJMC)
FSRH Clinical Guidance: Combined Hormonal Contraception
30 Jan, 2019 | 00:47h | UTCCommentaries: No benefit to contraception pill intervals — according to guidance – OnMedica (free) AND Is it OK to take the pill every day without a break? – BBC News (free)
Study: Human Papillomavirus Vaccine Effectiveness and Herd Protection in Young Women
29 Jan, 2019 | 00:00h | UTCHuman Papillomavirus Vaccine Effectiveness and Herd Protection in Young Women – Pediatrics (free)
Commentaries: Three Important Findings From a Study on HPV “Real World” Effectiveness – Pediatrics (free) AND HPV vaccine effective against infection and for herd immunity – 2 Minute Medicine (free)
Related Perspective on Herd Immunity: The Herd to the Rescue: How an Invisible Shield Can Keep us Healthy (free)
ASCO Standards: Safe Handling of Hazardous Drugs
28 Jan, 2019 | 23:29h | UTCSafe Handling of Hazardous Drugs: ASCO Standards – Journal of Clinical Oncology (free)
Summary: Safe Handling of Hazardous Drugs (free)
Editorial: ASCO Standards for Safe Handling of Hazardous Drugs (free)
News Release: New Standards for Safe Handling of Hazardous Drugs Focus on Developing Evidence-Based Measures (free)
How to Save Billions on Cancer Care Costs: The Potential of Value-Based Prescribing in Oncology
27 Jan, 2019 | 20:39h | UTCRelated: Research: Low-Dose Abiraterone With Food vs Standard Dose Abiraterone In Prostate Cancer (link to abstract and commentaries) AND Tackling the High Cost of Cancer Care (free commentaries)
Observational Study Suggests Potential Mental Health Benefits with the Use of Common Drugs
24 Jan, 2019 | 16:28h | UTCCommentaries: Can Some Common Drugs Also Benefit Mental Health? – PsychCentral (free) AND 3 common drugs associated with reduced risk of hospitalization and harm in serious mental illness – ACP Internist (free)
Study: Medication Review to Optimize and Potentially Reduce Psychotropic Drug Prescription in Institutionalized Dementia Patients
24 Jan, 2019 | 00:04h | UTCRelated: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject)
Study: Hospital Observation Upon Reversal (HOUR) With Naloxone
24 Jan, 2019 | 00:01h | UTCCommentary: Study confirms 1-hour discharge rule for patients given naloxone after opiate overdose – Society for Academic Emergency Medicine (free)
Meta-Analysis: Association of Aspirin Use for Primary Prevention with Cardiovascular Events and Bleeding Events
22 Jan, 2019 | 22:18h | UTCAssociation of Aspirin Use for Primary Prevention With Cardiovascular Events and Bleeding Events: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)
Commentaries: Expert reaction to study looking at aspirin use in healthy people, and cardiovascular events and bleeding – Science Media Centre (free) AND Aspirin Modest at Best in Primary CV Prevention – MedPage Today (free registration required) AND When to take (or not take) aspirin to prevent heart trouble – CNN (free)
Related: Meta-Analysis: Efficacy and Safety of Aspirin for Primary Prevention of Cardiovascular Events (link to abstract and commentaries) AND Aspirin Did Not Prevent Deaths or Disability in Healthy Older Adults (free study and commentaries)
Study: Patient Organizations and Conflicts of Interest
22 Jan, 2019 | 00:28h | UTCEditorial: Patient organizations and conflict of interest (free)
Commentaries: Jeremy Taylor: Financial interests of patient organisations – The BMJ Opinion (free) AND Financial interests common in patient reps on NICE appraisal – OnMedica (free)
Related Opinion: Why Big Pharma Must Disclose Payments to Patient Groups (free)
“Opioids Don’t Work for Most People with Chronic Pain. So Why do We Still Prescribe Them?”
22 Jan, 2019 | 00:26h | UTCRelated study: Meta-Analysis: Opioids for Chronic Noncancer Pain (link to abstract and commentaries)
See also: Opioid Wisely – Choosing Wisely Canada (free) AND Guideline for opioid therapy and chronic noncancer pain – Canadian Medical Association Journal (free)
New Single-Dose Drug to Prevent Relapse of Plasmodium vivax Malaria
21 Jan, 2019 | 14:18h | UTCSingle-Dose Tafenoquine to Prevent Relapse of Plasmodium vivax Malaria – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: New one-dose drug prevents malaria relapse, studies show – CIDRAP (free)
New Treatment for Acquired Thrombotic Thrombocytopenic Purpura
21 Jan, 2019 | 10:12h | UTCCaplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: A New Drug for Patients with Thrombotic Thrombocytopenic Purpura – Transfusion News (free)
Systematic Review: Adrenaline and Vasopressin for Cardiac Arrest
20 Jan, 2019 | 17:52h | UTCAdrenaline and vasopressin for cardiac arrest – Cochrane Library (free)
Summary: Adrenaline and vasopressin for cardiac arrest – Cochrane Library (free)
Related: Randomized Trial: Epinephrine in Out-of-Hospital Cardiac Arrest (link to abstract and commentaries) AND Opinion: Epinephrine Harms/Helps in Out of Hospital Cardiac Arrest (free commentaries) AND Review: The Role of Adrenaline in Cardiopulmonary Resuscitation (free)
Study: Marketing of Opioids Linked to More Overdose Deaths
20 Jan, 2019 | 16:58h | UTCEditorial: A Perspective Regarding the Current State of the Opioid Epidemic (free)
Author Interview: Marketing of Opioid Products and Mortality From Opioid-Related Overdoses; Comparison of Wait Times for New Patients Between the Private Sector and VA Medical Centers (free)
Commentaries: Study Links More Marketing Of Opioids To More Overdose Deaths – CommonHealth (free) AND Heavy marketing of opioid drugs linked to overdose deaths – UPI (free) AND Study Links Drug Maker Gifts for Doctors to More Overdose Deaths – The New York Times (10 articles per month are free)
Systematic Review: Antidepressants do not Help Treat Depression in People Living with Dementia
20 Jan, 2019 | 13:47h | UTCAntidepressants do not help treat depression in people living with dementia – NIHR Signal (free)
Original Article: Antidepressants for treating depression in dementia – Cochrane Library (free)
Randomized Trial: Enteral vs. Intravenous Approach for the Sedation of Critically Ill Patients
20 Jan, 2019 | 13:51h | UTC
Study: Appropriateness of Outpatient Antibiotic Prescribing
18 Jan, 2019 | 01:01h | UTCCommentaries: Nearly a fourth of outpatient antibiotics unneeded, study finds – CIDRAP (free) AND Nearly a quarter of antibiotic prescriptions for children and adults may be unnecessary – University of Michigan (free)
USPSTF Draft Statement: Medication Use to Reduce Risk of Breast Cancer
16 Jan, 2019 | 00:48h | UTCCommentary: USPSTF Reaffirms Drugs for Women at High Risk for Breast Cancer – Medscape (free registration required)
Immunotherapy 2.0: Improving the Response to Checkpoint Inhibitors
16 Jan, 2019 | 00:39h | UTCImmunotherapy 2.0: Improving the Response to Checkpoint Inhibitors – JAMA (free for a limited period)
Meta-analysis: Benzodiazepines or Related Drugs and Risk of Pneumonia
16 Jan, 2019 | 00:32h | UTCCommentary: Benzodiazepines May Boost Pneumonia Risk, Especially in Seniors – Medscape (free registration required)
Cohort Study: Maternal Ondansetron Use and Risk of Cardiac Malformations and Oral Clefts in Offspring
15 Jan, 2019 | 00:20h | UTCAssociation of Maternal First-Trimester Ondansetron Use With Cardiac Malformations and Oral Clefts in Offspring – JAMA (link to abstract – $ for full-text)
Commentaries: Does Zofran (ondansetron) for Nausea & Vomiting Cause Birth Defects? – MedicalResearch.com (free) AND Risk of malformations in offspring likely minimal with use of ondansetron (Zofran) in first trimester – MedicalResearch.com (free) AND Morning sickness pill study finds small link to increased risk of clefts but ‘not a cause for alarm’ – CNN (free)
Use of Hormone Replacement Therapy and Risk of Venous Thromboembolism
13 Jan, 2019 | 23:19h | UTCCommentaries: HRT patches and gels ‘may be safer’ than tablets for older women – NHS News (free) AND HRT tablets associated with increased risk of blood clots – MedicalXpress (free) AND Expert reaction to HRT and blood clots – Science Media Centre (free)
Cohort Study: Acute Kidney Injury in Patients Receiving Systemic Treatment for Cancer
13 Jan, 2019 | 21:08h | UTCCommentaries: Incidence of Acute Kidney Injury in Patients Receiving Systemic Therapy for Cancer – The ASCO Post (free) AND AKI Risk High in Cancer Patients Receiving Systemic Therapy – Renal & Urology News (free) AND Serious kidney injury common during cancer chemotherapy – Reuters (free)
Review: Neurological Complications of Immune Checkpoint Inhibitors
13 Jan, 2019 | 19:49h | UTC