Pharmacology/Pharmaceutical Industry
[Abstract Only] Study: Exposure to Antidepressant Medication and the Risk of Incident Dementia
8 Jul, 2019 | 09:53h | UTCExposure to Antidepressant Medication and the Risk of Incident Dementia – The American Journal of Geriatric Psychiatry (link to abstract – $ for full-text)
Commentaries: Antidepressants in old age may increase risk of dementia, Israeli study finds – The Times of Israel (free) AND Antidepressant use in older age is linked to increased dementia risk – Univadis (free registration required)
[Abstract Only] Randomized Trial: Treatments for Membranous Nephropathy Compared
4 Jul, 2019 | 11:09h | UTCRituximab or Cyclosporine in the Treatment of Membranous Nephropathy – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Study Finds Rituximab Noninferior to Cyclosporine for Membranous Nephropathy – Center for Biosimilars (free)
Review: Immune Checkpoint Inhibitor Toxicities
3 Jul, 2019 | 06:14h | UTCImmune Checkpoint Inhibitor Toxicities – Mayo Clinic Proceedings (free)
Related Guidelines: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Management of Immunotherapy-Related Toxicities, Version 1.2019, NCCN Clinical Practice Guidelines in Oncology (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)
Related Reviews: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free) AND Severe toxicity from checkpoint protein inhibitors: What intensive care physicians need to know? – Annals of Intensive Care (free) AND Checkpoint Inhibitors: The diagnosis and treatment of side effects – Deutsches Ärzteblatt international (free)
Systematic Review: Immune Checkpoint Inhibitor Therapy and Myocarditis
2 Jul, 2019 | 01:10h | UTC
Estimation of Kidney Function in Oncology
30 Jun, 2019 | 17:47h | UTC“In one retrospective study, approximately one half of kidney function–impaired patients with solid tumors who were receiving a drug that necessitated dose adjustments for kidney function received almost 50% of their prescriptions at standard doses”.
Review: The Use of Activated Charcoal to Treat Intoxications
30 Jun, 2019 | 17:46h | UTCThe Use of Activated Charcoal to Treat Intoxications – Deutsches Arzteblatt International (free)
Mass Drug Administration for Scabies
28 Jun, 2019 | 07:43h | UTCMass Drug Administration for Scabies — 2 Years of Follow-up – New England Journal of Medicine (free)
Commentaries: New Australian-Pacific scabies treatment has lasting results, study finds – Murdoch Childrens Research Institute (free) AND Scabies Means Misery. This Pill Can End It. – The New York Times (10 articles per month are free)
Related Study: Mass Drug Administration Reduces Scabies Cases by 90% in Solomon Islands’ Communities (free)
Study Review: Antiretroviral Treatment can Reduce the Risk of HIV Transmission Between Male Partners to ‘Zero’
28 Jun, 2019 | 07:40h | UTCOriginal Study: Undetectable = Untransmittable: Risk of HIV Transmission in Serodifferent Gay Couples (free study and commentaries)
Related: Systematic Review: Negligible Risk of Transmitting HIV During Sex When Viral Load is Suppressed (free study and commentaries) AND UNAIDS Explainer: UNDETECTABLE = UNTRANSMITTABLE (free)
[Abstract Only] Study: Triclosan Exposure Linked to Osteoporosis in Women
28 Jun, 2019 | 07:35h | UTCCommentaries: Triclosan Exposure May Lower Bone Mineral Density in Women – MPR (free) AND Osteoporosis: Investigating the role of a common antibacterial chemical – Medical News Today (free) AND Chemical in soaps, hand sanitizers tied to osteoporosis – Reuters (free)
Randomized Trial: Amisulpride for the Rescue Treatment of Postoperative Nausea or Vomiting
27 Jun, 2019 | 09:25h | UTCRelated Study: Randomized, Double-Blind, Placebo-Controlled Study of Intravenous Amisulpride as Treatment of Established Postoperative Nausea and Vomiting in Patients Who Have Had No Prior Prophylaxis (link to abstract)
Study: Antidepressants May Increase Suicide Risk
27 Jun, 2019 | 09:14h | UTCCommentary: New study: antidepressants significantly raise the risk of suicide in the treatment of depression for adults (free)
Observational Study Points to an Increased Risk of Diabetes Among Patients Using Statins
27 Jun, 2019 | 08:54h | UTCCommentaries: Statins may double the risk of type 2 diabetes – Medical News Today (free) AND Cholesterol Medication Could Invite Diabetes, Study Suggests – Ohio State University (free)
Related Studies: Another Observational Study Showing Association of Statin Use with Risk of New‐Onset Diabetes Mellitus (free study and commentaries) AND Cohort Study: Statin Use Associated with a 38% Higher Risk of Incident Type 2 Diabetes (link to abstract and commentaries)
Randomized Trials: Shorter Duration of Dual Antiplatelet Therapy May be an Option for Patients Undergoing Percutaneous Coronary Intervention
26 Jun, 2019 | 02:14h | UTCEffect of 1-Month Dual Antiplatelet Therapy Followed by Clopidogrel vs 12-Month Dual Antiplatelet Therapy on Cardiovascular and Bleeding Events in Patients Receiving PCI: The STOPDAPT-2 Randomized Clinical Trial – JAMA (free for a limited period)
Related Study: Effect of P2Y12 Inhibitor Monotherapy vs Dual Antiplatelet Therapy on Cardiovascular Events in Patients Undergoing Percutaneous Coronary Intervention: The SMART-CHOICE Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Dual Antiplatelet Therapy: Is It Time to Cut the Cord With Aspirin? (free for a limited period)
Audio Summary: Reducing the Intensity of Antithrombotic Therapy Following Coronary Stent Procedures (free)
Commentaries: Shorter Dual Antiplatelet Therapy May Be an Option for Patients Undergoing PCI – NEJM Journal Watch (free) AND Short and Optimal Duration of Dual Antiplatelet Therapy After Everolimus-Eluting Cobalt-Chromium Stent-2 – STOPDAPT-2 – American College of Cardiology (free)
Related Commentary on Twitter
Among patients undergoing PCI, aspirin and clopidogrel therapy (DAPT) for 1 vs 12 months resulted in a lower rate of CV and bleeding events, meeting criteria for both noninferiority and superiority https://t.co/OJ76qrEGiq
— JAMA (@JAMA_current) June 25, 2019
Study: Anticholinergic Drug Exposure and the Risk of Dementia
25 Jun, 2019 | 07:03h | UTCCommentaries: Preventing Alzheimer Disease by Deprescribing Anticholinergic Medications – JAMA Internal Medicine (free for a limited period) AND Commonly prescribed anticholinergic drugs linked to dementia risk – UPI (free) AND Expert reaction to anticholinergic drug exposure and risk of dementia – Science Media Centre (free) Commonly prescribed drugs are tied to nearly 50% higher dementia risk in older adults, study says – CNN (free)
Teachable Moment: Avoid Routine Testing for PT and/or INR, as Well as aPTT, in Patients Taking DOACs
25 Jun, 2019 | 06:54h | UTCCoagulation Testing in Patients Taking Direct Oral Anticoagulants: A Teachable Moment – JAMA Internal Medicine (free for a limited period)
Meta-Analysis: Vitamin D Not Effective for Cardiovascular Disease Prevention
20 Jun, 2019 | 06:17h | UTCVitamin D Supplementation and Cardiovascular Disease Risks in More Than 83 000 Individuals in 21 Randomized Clinical Trials: A Meta-analysis – JAMA Cardiology (free for a limited period)
Commentaries: The Demise of Vitamin D for Cardiovascular Prevention – JAMA Cardiology (free for a limited period) AND Does Vitamin D Supplementation Provide Cardiovascular Protection? – MPR (free)
Related Commentary on Twitter
#VitaminD supplementation does not confer cardio-protection and is not indicated for this purpose. https://t.co/pkAZByVrRG
— JAMA Cardiology (@JAMACardio) June 19, 2019
[Abstract Only] Randomized Trial: Oral GLP-1 Receptor Agonist and Cardiovascular Outcomes in Patients with Type 2 Diabetes
19 Jun, 2019 | 07:49h | UTCOral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Peptide Innovation for Early Diabetes Treatment 6 – PIONEER 6 – American College of Cardiology (free) AND Oral semaglutide falls just short of cardioprotection in event-driven PIONEER 6 – Medicine Matters (free) AND Oral Semaglutide Meets CV Safety Mark, Reduces Events in High-Risk T2D Patients – AJMC (free)
Randomized Trial: Trastuzumab for 6 Months as Good as Treatment for 12 Months in Patients with HER2-positive Early Breast Cancer
17 Jun, 2019 | 01:30h | UTCCommentaries: Is the duration of adjuvant trastuzumab debate still clinically relevant? – The Lancet (free) AND 6 months treatment with Herceptin is as good as 12 months for preventing breast cancer return – University of Warwick (free)
[Abstract Only] Randomized Trial: SGLT2 Inhibitor Reduces Adverse Renal Events in Patients with Type 2 Diabetes and Nephropathy
14 Jun, 2019 | 06:49h | UTCCanagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation – CREDENCE – American College of Cardiology (free)
Higher Doses of Antidepressants “Not Optimal”, According to New Review
14 Jun, 2019 | 02:32h | UTCHigher doses of antidepressants “not optimal”, according to new review – The Mental Elf (free)
Original Article: Meta-analysis: Optimal Dose of Antidepressants in Major Depression (free study and commentaries)
[Abstract Only] Risks of 23 Specific Malformations Associated with Prenatal Exposure to 10 Antiepileptic Drugs
14 Jun, 2019 | 02:33h | UTCRisks of 23 specific malformations associated with prenatal exposure to 10 antiepileptic drugs – Neurology (link to abstract – $ for full-text)
Commentaries: Epilepsy drugs linked to higher risk of birth defects, study says – CNN (free) AND Study Confirms Teratogenicity of Valproic Acid, Topiramate – MPR (free)
Related: Guideline: Valproate Use in Women and Girls Of Childbearing Years (free) AND Research: Topiramate Use Early in Pregnancy and the Risk of Oral Clefts (free)
Cohort Study: Gabapentinoids linked to Increased Risk of Suicidal Behavior
14 Jun, 2019 | 02:26h | UTCEditorial: Gabapentinoids linked to new risks, including suicidal behavior (free)
Commentaries: Epilepsy drugs linked to increased risk of suicidal behavior, particularly in young people – The BMJ (free) AND Expert reaction to study on gabapentinoids and risk of suicidal behavior – Science Media Centre (free)
[Abstract Only] Early Acid Suppression Therapy Exposure and Fracture Risk in Young Children
12 Jun, 2019 | 05:18h | UTCEarly Acid Suppression Therapy Exposure and Fracture in Young Children – Pediatrics (link to abstract – $ for full-text)
Commentary: Early exposure to antacids could put infants at risk for bone fractures during childhood – News Medical (free)
[Abstract Only] Randomized Trial: GLP-1 Receptor Agonist and Cardiovascular Outcomes in Type 2 Diabetes
11 Jun, 2019 | 03:01h | UTCDulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial – The Lancet (link to abstract – $ for full-text)
Commentary: Dulaglutide Cuts Cardiovascular Risk in Type 2 Diabetes – NEJM Journal Watch (free)
During a median follow-up of 5.4 years, the primary outcome (a composite endpoint of non-fatal myocardial infarction, non-fatal stroke, or death from cardiovascular causes) occurred in 12.0% of participants in the dulaglutide group and in 13.4% of participants in the placebo group (incidence rate of 2.4 per 100 person-years vs 2.7 per 100 person-years in the placebo group).
Risk of Hospitalization for Serious Adverse Gastrointestinal Events Associated with Sodium Polystyrene Sulfonate
11 Jun, 2019 | 02:36h | UTCRisk of Hospitalization for Serious Adverse Gastrointestinal Events Associated With Sodium Polystyrene Sulfonate Use in Patients of Advanced Age – JAMA Internal Medicine (free for a limited period)
Editorial: Sodium Polystyrene Sulfonate for Hyperkalemia (free)
Commentary: Sodium Polystyrene Sulfonate Tied to Increased Risk for Serious GI Events in Seniors – NEJM Journal Watch (free)