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Pharmacology/Pharmaceutical Industry

#KidneyWk – Randomized Trial: Vitamin D and Omega-3 Fatty Acids Do Not Preserve Kidney Function in Patients with Type 2 Diabetes

10 Nov, 2019 | 14:36h | UTC

Effect of Vitamin D and Omega-3 Fatty Acid Supplementation on Kidney Function in Patients With Type 2 Diabetes: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Vitamin D and Health Outcomes: Then Came the Randomized Clinical Trials – JAMA (free for a limited period)

Commentary: Supplements don’t preserve kidney health in Type 2 diabetes – University of Washington School of Medicine (free)

#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019

 

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#KidneyWk – [Abstract Only] Randomized Trial: New Drug May Reduce Itch Intensity in Hemodialysis Patients

10 Nov, 2019 | 14:34h | UTC

A Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Novel Drug Eases Uremic Pruritus – Renal & Urology News (free)

#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019

 

#KidneyWk – Study: Baclofen Associated with Increased Risk of Encephalopathy in Patients with Chronic Kidney Disease

10 Nov, 2019 | 14:35h | UTC

Association of Baclofen with Encephalopathy in Patients With Chronic Kidney Disease – JAMA (free for a limited period)

Commentary: Common muscle relaxant causes severe confusion in patients with kidney disease – University of Western Ontario (free)

#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019

 

#KidneyWk – [Not Published Yet] Randomized Trial: Less Expensive Azathioprine as Good as Mycophenolate Mofetil in Kidney Transplant Recipients on Steroid-Free Low-Dose Cyclosporine Immunosuppression

10 Nov, 2019 | 14:33h | UTC

Mycophenolate Mofetil versus Azathioprine in Kidney Transplant Recipients on Steroid-Free Low-Dose Cyclosporine Immunosuppression: The ATHENA Trial – 2019 American Transplant Congress (free)

#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019

 

FDA Safety Communication: Biotin Supplements May Result in Falsely Low Troponin Results

10 Nov, 2019 | 13:43h | UTC

UPDATE: The FDA Warns that Biotin May Interfere with Lab Tests: FDA Safety Communication – U.S Food and Drug Administration (free)

Commentary: FDA Updates Warning on Biotin Interfering with Lab Results – NEJM Journal Watch (free)

“…the FDA is particularly concerned about biotin interference causing a falsely low result for troponin, a clinically important biomarker to aid in the diagnosis of heart attacks, which may lead to a missed diagnosis and potentially serious clinical implications. The FDA continues to receive adverse events reports indicating biotin interference caused falsely low troponin results.”

 

[Abstract Only] Randomized Trial: Treatments for Relapsed or Refractory FLT3-mutated Acute Myeloid Leukemia Compared

10 Nov, 2019 | 12:57h | UTC

Gilteritinib or Chemotherapy for Relapsed or Refractory FLT3-Mutated AML – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: ADMIRAL: Gilteritinib vs Chemotherapy in Relapsed or Refractory FLT3-Mutated AML – The ASCO Post (free)

 

[Abstract Only] Randomized Trial Suggests Possible Harm from Perioperative Probiotics Among Patients Undergoing Major Abdominal Operation

8 Nov, 2019 | 07:49h | UTC

Randomized Trial of Perioperative Probiotics Among Patients Undergoing Major Abdominal Operation – Journal of the American College of Surgeons (link to abstract – $ for full-text)

Source: EvidenceAlerts

“A significantly higher readmission rate was observed among those exposed to probiotics. Additional studies remain warranted.”

 

[Abstract Only] Study: Evidence of Bacterial Transmission from Probiotic Capsule to Blood in ICU Patients

8 Nov, 2019 | 07:36h | UTC

Genomic and epidemiological evidence of bacterial transmission from probiotic capsule to blood in ICU patients – Nature Medicine (link to abstract – $ for full-text)

Related: Systematic Review: Harms Reporting in Trials with Probiotics (link to abstract and commentaries) AND The Problem With Probiotics – The New York Times (free)

 

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[Abstract Only] Randomized Trial: Efficacy of a Tetravalent Dengue Vaccine in Healthy Children and Adolescents

7 Nov, 2019 | 08:28h | UTC

Efficacy of a Tetravalent Dengue Vaccine in Healthy Children and Adolescents – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: A Takeda vaccine for dengue appears effective, but the story is nuanced – STAT (free) AND A new dengue vaccine shows promise — at least for now – ScienceNews (free) AND New dengue vaccine performs well in large trial, but safety remains key concern – Science (a few articles per month are free) AND Takeda’s dengue vaccine effective overall in study but with major limitation – Reuters (free)

 

State of the Art Review: Vasopressor Therapy in Critically Ill Patients with Shock

7 Nov, 2019 | 08:09h | UTC

Vasopressor therapy in critically ill patients with shock – Intensive Care Medicine (free)

Related: Editorial: Focus on Blood Pressure Targets and Vasopressors in Critically Ill Patients (free editorial and reviews)

 

[Abstract Only] Another Study Questions the Association of Contrast Use and Acute Kidney Injury

7 Nov, 2019 | 08:03h | UTC

Association of contrast and acute kidney injury in the critically ill: A propensity matched study – CHEST (link to abstract – $ for full-text)

Commentary: No association between contrast use and AKI seen in critically ill patients with normal kidney function – ACP Hospitalist (free)

Related: Does contrast cause kidney injury? The evidence – First10EM (free) AND Are the Risks Of Drugs That Enhance Imaging Tests Overblown? – NPR (free) AND Acute Kidney Injury After Computed Tomography: A Meta-analysis – Annals of Emergency Medicine (link to abstract – $ for full-text) AND Risk of Acute Kidney Injury After Intravenous Contrast Media Administration – Annals of Emergency Medicine (link to abstract – $ for full-text) AND

 

Study: Association Between Gifts from Pharmaceutical Companies to Doctors and Their Drug Prescribing Patterns

7 Nov, 2019 | 08:07h | UTC

Association between gifts from pharmaceutical companies to French general practitioners and their drug prescribing patterns in 2016: retrospective study using the French Transparency in Healthcare and National Health Data System databases – The BMJ (free)

 

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Viewpoint: Ranking Antipsychotics for Efficacy and Safety in Schizophrenia

7 Nov, 2019 | 07:41h | UTC

Ranking Antipsychotics for Efficacy and Safety in Schizophrenia – JAMA Psychiatry (free for a limited period)

Original Study: Meta-Analysis: Comparative Efficacy and Tolerability of 32 Antipsychotics for the Acute Treatment of Schizophrenia (free study and commentaries)

 

Cohort Study: Metformin Use Linked to Lower Risk of Hospitalization for Heart Failure in Patients with Type 2 Diabetes

7 Nov, 2019 | 07:40h | UTC

Metformin Use Is Associated With a Lower Risk of Hospitalization for Heart Failure in Patients With Type 2 Diabetes Mellitus: a Retrospective Cohort Analysis – Journal of the American Heart Association (free)

Commentary: Metformin lowers risk of HF hospitalization in those with T2D – Cardiovascular Business (free)

Related Study: Metformin Use Linked to Reduced Risk for Cardiovascular Death and All-cause Mortality (link to abstract and commentaries)

 

[Abstract Only] Meta-Analysis: Fish Oil Supplements Have no Effect on Anxiety and Depression

5 Nov, 2019 | 08:13h | UTC

Omega-3 and polyunsaturated fat for prevention of depression and anxiety symptoms: systematic review and meta-analysis of randomised trials – British Journal of Psychiatry (link to abstract – $ for full-text)

News Release: Fish oil supplements have no effect on anxiety and depression – University of East Anglia (free)

 

Randomized Trial: Naproxen vs. Colchicine for the Treatment of Gout Flares in Primary Care

4 Nov, 2019 | 01:13h | UTC

Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care – Annals of Rheumatic Diseases (free)

 

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Podcast: Emerging Applications for Ketamine

4 Nov, 2019 | 00:50h | UTC

Emerging Applications for Ketamine – JAMA (free audio)

Related Resources:

Ketamine for Pain: Consensus Guidelines on the Use of Intravenous Ketamine Infusions for Acute Pain Management From the American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, and the American Society of Anesthesiologists (free)

Ketamine for Depression: Ketamine and depression: a narrative review – Drug Design, Development and Therapy (free)

 

Cohort Study: Incidence of Acute Kidney Injury in Patients Receiving Immune Checkpoint Inhibitors

4 Nov, 2019 | 00:24h | UTC

The Incidence, Causes, and Risk Factors of Acute Kidney Injury in Patients Receiving Immune Checkpoint Inhibitors – Clinical Journal of the American Society of Nephrology (free for a limited period)

News Release: Study Examines Kidney Injury in Patients Taking Immunotherapy Cancer Medications – American Society of Nephrology (free)

Related: Immune Checkpoint Inhibitor Toxicities (free guidelines and reviews on the subject)

 

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https://twitter.com/CJASN/status/1190342954830966785

 

[Abstract Only] Randomized Trial: Triple Therapy Effective for the Treatment of Cystic Fibrosis

1 Nov, 2019 | 10:22h | UTC

Elexacaftor–Tezacaftor–Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele – New England Journal of Medicine (link to abstract – $ for full-text)

Editorial: Realizing the Dream of Molecularly Targeted Therapies for Cystic Fibrosis (free)

Related Research: Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Commentary: Three-drug combo improves lung function in most common genetic form of cystic fibrosis – UT Southwestern Medical Center (free)

 

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[Abstract Only] Randomized Trial: Experimental Vaccine Partially Effective at Preventing Latent Tuberculosis from Turning into Active Disease

30 Oct, 2019 | 08:20h | UTC

Final Analysis of a Trial of M72/AS01E Vaccine to Prevent Tuberculosis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Vaccine shows promise for preventing active TB disease – Associated Press (free) AND Researchers move closer to new vaccine for killer TB – MedicalXpress (free)

 

Study: In Utero Acetaminophen Exposure Linked to Increased Risk of ADHD and Autism Spectrum Disorder in Childhood

31 Oct, 2019 | 08:12h | UTC

Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood – JAMA Psychiatry (free for a limited period)

Commentaries: NIH-funded study suggests acetaminophen exposure in pregnancy linked to higher risk of ADHD, autism – NIH News Releases (free) AND Babies at higher risk for ADHD, autism if pregnant moms took acetaminophen – Reuters (free) AND Expert reaction to study looking at paracetamol in pregnancy and autism, ADHD and other developmental disabilities in children – Science Media Centre (free)

Related Studies: Cohort Study: Associations Between Paracetamol Intake Between 18 and 32 Weeks Gestation and Neurocognitive Outcomes in the Child (free) AND Meta-Analysis: Prenatal Exposure to Acetaminophen and Risk for ADHD and Autistic Spectrum Disorder (free) AND Prenatal Exposure to Acetaminophen and Risk of ADHD (free)

 

Meta-Analysis: Medications with Anti-inflammatory Properties Show Promising Effects in the Treatment of Depression

30 Oct, 2019 | 08:18h | UTC

Efficacy and safety of anti-inflammatory agents for the treatment of major depressive disorder: a systematic review and meta-analysis of randomised controlled trials – Journal of Neurology, Neurosurgery & Psychiatry (free)

Commentaries: Expert reaction to systematic review and meta-analysis of RCTs on anti-inflammatory drugs for depression – Science Media Centre (free) AND Anti-inflammatories can curb major depressive symptoms – OnMedica (free) AND Anti-inflammatory agents can effectively and safely curb major depressive symptoms, study suggests – BMJ (free)

 

Viewpoint: Real-Time Benefit Tools for Drug Prices

29 Oct, 2019 | 08:46h | UTC

Real-Time Benefit Tools for Drug Prices – JAMA (free for a limited period)

 

[Abstract Only] Meta-Analysis: Insufficient Evidence for The Use of Cannabinoids for Treating Mental Disorders

29 Oct, 2019 | 10:24h | UTC

Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analysis – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentaries: Marijuana Cannabinoids Don’t Help With Depression, Anxiety, ADHS, Tourettes, Psychosis, Or PTSD – Scientific Blogging (free) AND There is little evidence that cannabis helps mental health problems – NewScientist (free) AND There’s ‘Scarce Evidence’ to Suggest Cannabis Improves Mental Health Symptoms, a New Research Review Says – TIME (free) AND Medicinal cannabis not proven in mental health, study finds – Reuters (free) AND Risks of cannabis use for mental health treatment outweigh benefits – The Guardian (free)

 

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Interest in Cannabidiol Products Keeps Soaring Despite Limited Evidence in Humans

27 Oct, 2019 | 19:29h | UTC

Trends in Internet Searches for Cannabidiol (CBD) in the United States – JAMA Network Open (free)

Commentaries: Interest in CBD products keeps soaring, but health experts wary – HealthDay (free) AND Online Searches For CBD Skyrocket – MedicalResearch.com (free)

 

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