Pharmacology/Pharmaceutical Industry
[Abstract Only] Small Study Suggests a Benefit of Using Single-syringe Administration of Diluted Adenosine for SVT
3 Dec, 2019 | 08:08h | UTCSingle Syringe Adenosine for SVT – JournalFeed (free)
See also: Trick of the Trade: Combine Adenosine with the Flush – AliEM (free)
Original Research Letter: Single-syringe Administration of Diluted Adenosine – Academic Emergency Medicine ($)
Antiretroviral Therapy Has Saved Millions of Lives From AIDS and Could Save More
3 Dec, 2019 | 01:05h | UTCAntiretroviral therapy has saved millions of lives from AIDS and could save more – Our World in Data (free)
A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics
29 Nov, 2019 | 10:16h | UTCA Randomized, Controlled Trial of Ebola Virus Disease Therapeutics – New England Journal of Medicine (free)
Commentaries: Investigational Drugs Reduce Risk of Death from Ebola Virus Disease – NIH News Releases (free) AND New data highlight promise of 2 Ebola treatments – CIDRAP (free) AND Two Ebola treatments yield ‘substantial decrease’ in mortality, landmark trial shows – STAT (free)
Meta-Analysis: The Clinical Efficacy and Safety of Vancomycin Loading Dose
29 Nov, 2019 | 08:09h | UTCRelated: Vancomycin Therapeutic Guidelines: A Summary of Consensus Recommendations from the Infectious Diseases Society of America, the American Society of Health-System Pharmacists, and the Society of Infectious Diseases Pharmacists – Clinical Infectious Diseases (free) AND Therapeutic drug monitoring of vancomycin: a guideline of the Division of Therapeutic Drug Monitoring, Chinese Pharmacological Society – Journal of Antimicrobial Therapy (free) AND Practice Guidelines for Therapeutic Drug Monitoring of Vancomycin: A Consensus Review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring – Journal of Infection and Chemotherapy (free PDF)
Bridging Anticoagulation Therapy: A Teachable Moment
29 Nov, 2019 | 07:37h | UTCBridging Anticoagulation Therapy: A Teachable Moment – JAMA Internal Medicine (free for a limited period)
Related: 2017 ACC Expert Consensus Decision Pathway for Periprocedural Management of Anticoagulation in Patients With Nonvalvular Atrial Fibrillation (free) AND Bridging Anticoagulation: Primum Non Nocere – Journal of the American College of Cardiology (free) AND Periprocedural heparin bridging in patients receiving oral anticoagulation: a systematic review and meta-analysis – BMC Cardiovascular Disorders (free) AND Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation – New England Journal of Medicine (free)
[Abstract Only] Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus
28 Nov, 2019 | 10:36h | UTCRandomized Trial of Three Anticonvulsant Medications for Status Epilepticus – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Head-to-head comparison finds three anti-seizure drugs equally effective for severe form of epilepsy – NIH News Release (free)
Related Commentary on Twitter
Intravenous valproate, levetiracetam, and fosphenytoin stopped status epilepticus that was resistant to initial treatment with lorazepam in approximately half the patients and did not differ significantly in effectiveness. https://t.co/RfO7YKEoue
— NEJM (@NEJM) November 28, 2019
Study: Proton Pump Inhibitors May be Associated with Increased the Risk of Viral Gastroenteritis
29 Nov, 2019 | 07:46h | UTCCommentaries: Further Evidence to Monitor Long-term Proton Pump Inhibitor Use – JAMA Network Open (free) AND Prescription antacids may increase risk for stomach infections – UPI (free)
FDA Issues Safety Warning on Cannabidiol Products
28 Nov, 2019 | 10:29h | UTCCommentaries: FDA’s Warning On CBD: Cannabis Stocks Drop, Companies Object – Forbes (free) AND ‘CBD has the potential to harm you,’ FDA warns consumers – MarketWatch (free)
Related: Cannabidiol Products Are Everywhere, but Should People Be Using Them? – JAMA (free for a limited period) AND NICE Guideline: Cannabis-Based Medicinal Products (free Guideline and other resources)
Perspective: What Are the Benefits of Probiotics?
28 Nov, 2019 | 10:28h | UTCWhat Are the Benefits of Probiotics? – The New York Times (free)
Related: Systematic Review: Harms Reporting in Trials with Probiotics (link to abstract and commentaries) AND The Problem With Probiotics – The New York Times (free)
Viewpoint: Implementation Strategies for Cardiovascular Polypills
27 Nov, 2019 | 08:09h | UTCImplementation Strategies for Cardiovascular Polypills – JAMA (free for a limited period)
See also: Cardiovascular Disease Prevention at a Crossroads: Precision Medicine or Polypill? – JAMA (free)
Author Interview: Implementation Strategies for Cardiovascular Polypills (free)
Related: The Polypill Revisited: Why We Still Need Population-Based Approaches in the Precision Medicine Era (free for a limited period) AND Randomized Trial: Polypill for Cardiovascular Disease Prevention in an Underserved Population (randomized trials, commentaries and guideline on the subject)
Observational Study: Proton-pump Inhibitor Use is Associated with a Broad Spectrum of Neurological Adverse Events Including Impaired Hearing, Vision, and Memory
27 Nov, 2019 | 08:06h | UTCCommentary: PPIs linked to adverse neurological effects – Univadis (free registration required)
CDC Updates Guidance on Pneumococcal Vaccination
27 Nov, 2019 | 07:42h | UTCCommentary: PCV13 No Longer Recommended for All Seniors – NEJM Journal Watch (free)
Randomized Trial: FLAURA Trial – Treatments for EGFR-Mutated Advanced Non–small-cell Lung Cancer Compared
26 Nov, 2019 | 08:16h | UTCOverall Survival with Osimertinib in Untreated, EGFR-Mutated Advanced NSCLC – New England Journal of Medicine (free for a limited period)
Commentary: FLAURA Trial: First-Line Osimertinib Improves Overall Survival in EGFR-Mutated Advanced Lung Cancer – The ASCO Post (free)
Review: Immune Checkpoint Inhibitor-associated Gastrointestinal and Hepatic Adverse Events and Their Management
26 Nov, 2019 | 07:34h | UTCRelated: Management of Gastrointestinal Toxicity from Immune Checkpoint Inhibitor – Portuguese Journal of Gastroenterology (free) AND Immune Checkpoint Inhibitor Toxicities (free guidelines and reviews on the subject)
Systematic Review: Comparisons of Exacerbations and Mortality Among Regular Inhaled Therapies for Patients with Stable COPD
24 Nov, 2019 | 20:55h | UTCRelated Guidelines: 2020 Global Strategy for Prevention, Diagnosis and Management of COPD – GOLD Reports 2020 (free PDF) AND Chronic obstructive pulmonary disease in over 16s: diagnosis and management – National Institute for Health and Care Excellence (free)
Randomized Trial: Injectable 17-α-hydroxyprogesterone Not Effective for the Prevention of Recurrent Preterm Birth
24 Nov, 2019 | 20:59h | UTCCommentary: Advice to pull a drug used to prevent premature birth sparks controversy – News Medical (free) AND Unexpected Findings in Confirmatory Trial of Preterm Birth Drug – MedPage Today (free registration required)
Related Study: A Randomized Trial of Progesterone in Women with Recurrent Miscarriages – New England Journal of Medicine (free)
Perspective: Toward Increased Understanding of the Steroid Controversy in Septic Shock
22 Nov, 2019 | 08:35h | UTCToward Increased Understanding of the Steroid Controversy in Septic Shock – Critical Care Medicine (free)
See also: Why Understanding Sepsis Endotypes Is Important for Steroid Trials in Septic Shock (free) AND Why the Adjunctive Corticosteroid Treatment in Critically Ill Patients With Septic Shock (ADRENAL) Trial Did Not Show a Difference in Mortality (free) AND Why My Steroid Trials in Septic Shock Were “Positive” (free)
Related: Review: Adjunctive Corticosteroid Treatment in Septic Shock (free review, guideline, and meta-analysis on the subject)
Related Commentary on Twitter
Caught up in steroid controversy in septic shock? Read 3 viewpoints in #CritCareMed from investigators of ADRENAL, APROCCHSS & VANISH trials.
Russell et al: Toward Increased Understanding of Steroid Controversy in Septic Shock
Link: https://t.co/Is5laK5DXR@SCCM #Sepsis pic.twitter.com/v8TbxuAi93— Critical Care Medicine (@CritCareMed) November 21, 2019
CDC 2019 Core Elements of Hospital Antibiotic Stewardship
21 Nov, 2019 | 10:34h | UTCCDC Page: Core Elements of Hospital Antibiotic Stewardship Programs (free resources)
Commentary: CDC updates ‘core’ antibiotic stewardship elements for hospitals – CIDRAP (free)
Perspective: Cannabidiol Products Are Everywhere, but Should People Be Using Them?
21 Nov, 2019 | 08:16h | UTCCannabidiol Products Are Everywhere, but Should People Be Using Them? – JAMA (free for a limited period)
Related: NICE Guideline: Cannabis-Based Medicinal Products (free Guideline and other resources)
Systematic Review: Safety of Peripheral Administration of Vasopressor Medications
21 Nov, 2019 | 08:08h | UTC
#AHA19 – [Abstract Only] Randomized Trial: After an Ischemic Stroke or TIE a Lower LDL Treatment Target Reduces Cardiovascular Events
19 Nov, 2019 | 09:51h | UTCA Comparison of Two LDL Cholesterol Targets after Ischemic Stroke – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Treat Stroke to Target Finds Lower Risk of CV Events With Lower LDL-C Levels – American College of Cardiology (free) AND Treat Stroke to Target – Treat Stroke to Target – American College of Cardiology (free) AND Lower Cholesterol Cuts CV Events: Treat Stroke to Target Trial – TCTMD (free)
#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting
Related Commentary on Twitter
In patients with stroke and atherosclerosis randomly assigned to LDL targets of 70 mg/dl or 100 mg/dL, a composite CV endpoint was 12% lower over a median of 3.5 years in the lower LDL target group. #AHA19 https://t.co/l8vZ1M7XF6
— NEJM (@NEJM) November 18, 2019
Review: HIV Preexposure Prophylaxis—The Role of Primary Care Clinicians in Ending the HIV Epidemic
19 Nov, 2019 | 07:38h | UTCHIV Preexposure Prophylaxis—The Role of Primary Care Clinicians in Ending the HIV Epidemic – JAMA Internal Medicine (free for a limited period)
Related: USPSTF Statement: Preexposure Prophylaxis for the Prevention of HIV Infection (free) AND British Guidelines on the Use of HIV Pre–exposure Prophylaxis (PrEP) (several guidelines on the subject)
NICE Guideline: Cannabis-Based Medicinal Products
12 Nov, 2019 | 11:27h | UTCCannabis-based medicinal products – National Institute for Health and Care Excellence (free)
Commentaries: Drug experts on the new guidance for medicinal cannabis – The Conversation (free) AND Ian Hamilton: New guidelines for prescribing medicinal cannabis—another dashed hope for patients – The BMJ Opinion (free)
Related: Guideline for Prescribing Medical Cannabinoids in Primary Care – Canadian Family Physician (free) AND Cannabinoids for Chronic Pain – Therapeutics Initiative AND (free) Meta-Analysis: Insufficient Evidence for The Use of Cannabinoids for Treating Mental Disorders – The Lancet Psychiatry (link to abstract and commentaries) AND The Effects of Cannabis Among Adults With Chronic Pain – Annals of Internal Medicine (link to abstract and commentaries)
“In short, NICE has concluded that more research is needed before it can recommend the use of cannabis-based products for medicinal use.” (from The Conversation)
Study: Testosterone Therapy Linked to Increased Risk of Venous Thromboembolism Among Men with and Without Hypogonadism
12 Nov, 2019 | 11:22h | UTCAssociation of Testosterone Therapy With Risk of Venous Thromboembolism Among Men With and Without Hypogonadism – JAMA Internal Medicine (free for a limited period)
Related Commentary on Twitter
Using testosterone therapy in 6-month case period associated with doubling of VTE risk for men both with and without clinical hypogonadism. https://t.co/rosKWgWgBS
— JAMA Internal Medicine (@JAMAInternalMed) November 11, 2019
Meta-Analysis: Aspirin for Primary Prevention of Cardiovascular Disease with a Particular Focus on Subgroups
12 Nov, 2019 | 11:19h | UTCRelated: Acetylsalicylic acid for primary prevention of cardiovascular events – Canadian Family Physician (free) AND Evidence evolving on aspirin as prevention – ACP Internist (free) AND Benefits and Harms of Aspirin for Primary Prevention of Cardiovascular Disease – Annals of Internal Medicine (link to abstract and commentaries) AND Aspirin for Primary Prevention: Is This the End of the Road? (selection of resources on the subject)