Pharmacology/Pharmaceutical Industry
[Abstract Only] Randomized Trial: Overall Survival with Ribociclib plus Fulvestrant in Advanced Breast Cancer
8 Jan, 2020 | 00:51h | UTCOverall Survival with Ribociclib plus Fulvestrant in Advanced Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Targeted therapy drug helps women with aggressive breast cancer live longer – University of California (free) AND Overall Survival With the Addition of Ribociclib to Fulvestrant in Hormone Receptor–Positive, HER2-Negative Advanced Breast Cancer: MONALEESA-3 – The ASCO Post (free)
Meta-analysis of Observational Studies: Use of Antibiotics Linked to Poor Outcomes in Patients Receiving Immune-checkpoint Blockade
6 Jan, 2020 | 23:24h | UTCRelated: Observational Study Suggests Antibiotics Can Greatly Impair the Response to Immune Checkpoint Inhibitors in Patients with Cancer – JAMA Oncology (link to abstract and commentaries)
[Abstract Only] Open-Label Randomized Trial: Oseltamivir vs. Usual Care for Influenza-like Illness in Primary Care
6 Jan, 2020 | 23:21h | UTCOseltamivir plus usual care versus usual care for influenza-like illness in primary care: an open-label, pragmatic, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Commentaries (with conflicting opinions): Tamiflu, Cure-All – Emergency Literature of Note (free) AND Flu antiviral has bigger benefits for sicker, older patients – University of Oxford (free)
Related Systematic Reviews: Neuraminidase inhibitors for preventing and treating influenza in adults and children – Cochrane Library (free) AND Oseltamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comments – The BMJ (free) AND Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials – The Lancet (free registration required) AND Effectiveness of oseltamivir in adults: a meta-analysis of published and unpublished clinical trials – Family Practice (free)
Related Commentary on Twitter
New paper published in the Lancet found a moderate improvement in symptoms in pts treated with open label oseltamivir compared to usual care. Any one else find it curious it worked equally well in pts with and without confirmed influenza? https://t.co/KpBM1xMOTu pic.twitter.com/GcGi4yFBVO
— Rory Spiegel (@EMNerd_) January 3, 2020
Opinion: An Update on Peripheral Vasopressors
6 Jan, 2020 | 23:17h | UTCAn update on peripheral vasopressors – First10EM (free)
Related: Safety of peripheral administration of vasopressor medications: A systematic review – Emergency Medicine Australasia (free)
Guideline: ADA 2020 Standards of Medical Care in Diabetes
25 Dec, 2019 | 21:43h | UTCJust published! New ADA 2021 Guideline for the Management of Diabetes
Guideline Homepage: ADA 2020 Standards of Medical Care in Diabetes – American Diabetes Association (free supplement)
Commentaries: ADA 2020 Standards of Care Incorporate CVD Risk Stratification, New Medications – Endocrinology Advisor (free) AND ADA releases 2020 standards of medical care in diabetes – University of North Carolina at Chapel Hill School of Medicine (free)
See also: Standards of Medical Care in Diabetes—2020 Abridged for Primary Care Providers – American Diabetes Association (free PDF) AND 2019 update to: Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) – Diabetologia (free)
See ADA 2020 Guideline topics below:
Introduction: Standards of Medical Care in Diabetes—2020
Summary of Revisions: Standards of Medical Care in Diabetes—2020
- Improving Care and Promoting Health in Populations: Standards of Medical Care in Diabetes—2020
- Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2020
- Prevention or Delay of Type 2 Diabetes: Standards of Medical Care in Diabetes—2020
- Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Medical Care in Diabetes—2020
- Facilitating Behavior Change and Well-being to Improve Health Outcomes: Standards of Medical Care in Diabetes—2020
- Glycemic Targets: Standards of Medical Care in Diabetes—2020
- Diabetes Technology: Standards of Medical Care in Diabetes—2020
- Obesity Management for the Treatment of Type 2 Diabetes: Standards of Medical Care in Diabetes—2020
- Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes—2020
- Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes—2020
- Microvascular Complications and Foot Care: Standards of Medical Care in Diabetes−2020
- Older Adults: Standards of Medical Care in Diabetes—2020
- Children and Adolescents: Standards of Medical Care in Diabetes−2020
- Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes—2020
- Diabetes Care in the Hospital: Standards of Medical Care in Diabetes—2020
Related Commentary on Twitter
ADA's "Standards of Medical Care in Diabetes—2020" is finally here! Featuring American Diabetes Association's latest clinical practice recommendations, the global standard for diabetes care. #ADASOC2020
READ NOW (OPEN ACCESS): https://t.co/CCArNKXi9D pic.twitter.com/Yj9gExpVdG
— ADA Professional Publications (@ADA_Pubs) December 20, 2019
Analysis: Doctors Prescribe More of a Drug If They Receive Money from a Pharma Company Tied to It
5 Jan, 2020 | 14:17h | UTCDoctors Prescribe More of a Drug If They Receive Money from a Pharma Company Tied to It – ProPublica (free)
Commentary: We’ve Been Tracking Pharma Payments to Doctors For Nearly A Decade. We Just Made A Big Breakthrough – ProPublica (free)
[Abstract Only] Observational Study: Taking Supplements During Chemotherapy Linked to Increased Risk of Disease Recurrence and Death
5 Jan, 2020 | 13:34h | UTCDietary Supplement Use During Chemotherapy and Survival Outcomes of Patients With Breast Cancer Enrolled in a Cooperative Group Clinical Trial (SWOG S0221) – Journal of Clinical Oncology (link to abstract – $ for full-text)
Commentaries: Antioxidant use during chemotherapy risky for breast cancer patients- SWOG (free) AND Taking certain vitamins during breast cancer chemo tied to recurrence, death – Reuters (free) AND Dietary supplement use during chemotherapy and survival outcomes of patients with breast cancer enrolled in a cooperative group clinical trial – 2 Minute Medicine (free)
Another Observational Study Suggests One Dose of HPV Vaccine may be Enough
5 Jan, 2020 | 13:25h | UTCCommentaries: One dose of HPV vaccine may prevent infection from cancer-causing virus, study reveals – News Medical (free) AND Just 1 dose of the HPV vaccine may protect against infection, new study suggests – CNN (free)
Related: Systematic Review: Comparison of Different HPV Vaccine Types and Dose Schedules for Prevention of HPV‐related Disease in Females and Males – Cochrane Library (free) AND Large Observational Study Suggests One Dose of HPV Vaccine May Be as Effective as Three (free)
Randomized Trial: Lemborexant vs. Placebo vs. Zolpidem Tartrate Extended Release for the Treatment of Older Adults with Insomnia Disorder
5 Jan, 2020 | 13:27h | UTCCommentary: Insomnia: Lemborexant With Placebo Vs Zolpidem Tartrate Extended Release – MedicalResearch.com (free)
[Abstract Only] Randomized Trial: Rocuronium NOT Non-inferior to Succinylcholine for Endotracheal Intubation Success Rate Among Patients Undergoing Out-of-Hospital Rapid Sequence Intubation
5 Jan, 2020 | 12:57h | UTCEffect of Rocuronium vs Succinylcholine on Endotracheal Intubation Success Rate Among Patients Undergoing Out-of-Hospital Rapid Sequence Intubation: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentary: Newer Drug Falls Short for Quick Prehospital Intubation – MedPage Today (free registration required)
Related Commentary on Twitter
In this RCT, #rocuronium did not demonstrate noninferiority vs #succinylcholine in first-attempt intubation success rate in patients undergoing endotracheal intubation in out-of-hospital emergency settings. #rapidsequenceintubation https://t.co/rgw7oVVp3v
— JAMA (@JAMA_current) December 18, 2019
European Guidelines for the Treatment of HIV-positive Adults
12 Dec, 2019 | 08:29h | UTCEuropean Guidelines for the treatment of HIV-positive adults – European AIDS Clinical Society (free PDF)
Source: HIV Infection Clinical Practice Guidelines (2019): European AIDS Clinical Society (EACS) – Medscape (free summary – registration required)
[Abstract Only] Randomized Trial: Vitamin D Not Beneficial for Critically Ill Patients
12 Dec, 2019 | 08:25h | UTCCommentaryy High doses of vitamin D for critically ill patients yield minimal benefit – CU Anschutz Medical Campus (free)
Study: Up to 43% of Antibiotic Prescriptions in the US Could be Inappropriate or are Improperly Documented
12 Dec, 2019 | 08:11h | UTCEditorial: Coding infections in primary care (free)
Commentaries: Up to two-fifths of antibiotic prescriptions in the US could be inappropriate – University of Bristol (free) AND Up to 43% of Antibiotic Prescriptions in the U.S. Are Unnecessary or Improperly Written, Analysis Finds – TIME (free) AND Over 40% of Antibiotic Prescriptions Potentially Inappropriate – NEJM Journal Watch (free)
Randomized Trial: Angiotensin-II Receptor Blockade Reduces the Rate of Aortic Dilatation in Patients with Marfan Syndrome
12 Dec, 2019 | 08:24h | UTCInvited Commentary: Angiotensin-II receptor blockade in Marfan syndrome – The Lancet (free)
Related Commentary on Twitter
NEW—Irbesartan is associated with a reduction in the rate of aortic dilatation in children and young adults with #Marfansyndrome and could reduce the incidence of aortic complications: finding from AIMS, double-blind, placebo-controlled randomised trial https://t.co/uVUWOC062A pic.twitter.com/FPiph5RcJu
— The Lancet (@TheLancet) December 11, 2019
ESC Position Paper: Role and Safety of New Glucose‐lowering Drugs in Patients with Heart Failure
11 Dec, 2019 | 08:25h | UTC
Meta-Analysis Suggests Low Risk of Nephrogenic Systemic Fibrosis in Patients with Chronic Kidney Disease Receiving a Gadolinium-Based Contrast Agent
11 Dec, 2019 | 08:23h | UTCRisk of Nephrogenic Systemic Fibrosis in Patients With Stage 4 or 5 Chronic Kidney Disease Receiving a Group II Gadolinium-Based Contrast Agent: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)
Invited Commentary: Risk of Gadolinium-Based Contrast Agents in Chronic Kidney Disease—Is Zero Good Enough? – JAMA Internal Medicine (free for a limited period)
State of the Art Review: Does General Anesthesia Affect Neurodevelopment in Infants and Children?
11 Dec, 2019 | 08:12h | UTCDoes general anesthesia affect neurodevelopment in infants and children? – The BMJ (free for a limited period)
Related Study: Randomized Trial: General Anesthesia in Infancy Does Not Seem to Impair Neurodevelopmental Outcomes (link to abstract and commentary)
Review: Cannabis-based Medicines and the Perioperative Physician
10 Dec, 2019 | 08:30h | UTCCannabis-based medicines and the perioperative physician – Perioperative Medicine (free)
Related: Perioperative care of cannabis users: A comprehensive review of pharmacological and anesthetic considerations – Journal of Clinical Anesthesia (free)
Randomized Trial: Efficacy Analysis of a Typhoid Conjugate Vaccine
9 Dec, 2019 | 01:41h | UTCCommentaries: Typhoid vaccine over 81% effective in tackling disease in Nepal – University of Oxford (free) AND Typhoid vaccine shows protection in phase 3 trial – CIDRAP (free)
[Abstract Only] Randomized Trial: Histologic Improvement with Obeticholic Acid in Non-alcoholic Steatohepatitis
9 Dec, 2019 | 01:16h | UTCObeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial – The Lancet (link to abstract – $ for full-text)
“This study is ongoing to assess clinical outcomes.”
ASH Guideline: Prevention of Venous Thromboembolism in Surgical Hospitalized Patients
5 Dec, 2019 | 11:29h | UTCRelated: European guidelines on perioperative venous thromboembolism prophylaxis – European Journal of Anaesthesiology (comprehensive resource on the subject) AND American Society of Hematology 2018 Guidelines for Management of Venous Thromboembolism: Prophylaxis for Hospitalized and Nonhospitalized Medical Patients (free)
Systematic Review: Metformin for Prevention or Delay of Type 2 Diabetes Mellitus and Its Associated Complications
4 Dec, 2019 | 08:24h | UTCMetformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased risk for the development of type 2 diabetes mellitus – Cochrane Library (free)
The BMJ Manifesto for Producing Evidence That is Free of Commercial Influences
4 Dec, 2019 | 08:22h | UTCPathways to independence: towards producing and using trustworthy evidence – The BMJ (free)
See Complete Series: Commercial Influence in Health: from Transparency to Independence (free articles)
Commentary: Time to end drug company distortion of medical evidence – The Conversation (free)
Related Commentary on Twitter
It’s time to stop the endemic financial entanglement with industry that's distorting the production and use of healthcare evidence, causing harm to individuals and waste for health systems, argue an influential group of international experts in @bmj_latest https://t.co/4mkdYGNRrB pic.twitter.com/YXdrJS4c56
— BMJ Group (@bmj_company) December 3, 2019
Randomized Trial: Fidaxomicin vs. Vancomycin in Children and Adolescents with Clostridioides (Clostridium) Difficile Infection
3 Dec, 2019 | 08:09h | UTCCommentary: Phase 3 trial shows good results for fidaxomicin against C difficile in kids – CIDRAP in Stewardship / Resistance Scan for Nov 27, 2019 (free)
Guidelines for the Management of Paracetamol Poisoning
3 Dec, 2019 | 08:11h | UTCUpdated guidelines for the management of paracetamol poisoning in Australia and New Zealand – The Medical Journal of Australia (free for a limited period)