Pharmacology/Pharmaceutical Industry
Review: The Use of Medication in Pregnancy
14 Jan, 2020 | 00:09h | UTCThe Use of Medication in Pregnancy – Deutsches Ärzteblatt international (free)
[Abstract Only] Randomized Trial: Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes
14 Jan, 2020 | 00:03h | UTCLuspatercept in Patients with Lower-Risk Myelodysplastic Syndromes – New England Journal of Medicine (link to abstract – $ for full-text)
Randomized Trial: A Head-to-head Comparison of the Efficacy and Safety of Ixekizumab and Adalimumab in Biological-naïve Patients with Active Psoriatic Arthritis
14 Jan, 2020 | 00:02h | UTCCommentary: We Have a Winner: Head-to-Head Study Compares Biologics for PsA – MedPage Today (free registration required)
Study: Rifampicin is Likely to be the Safest Latent Tuberculosis Infection Treatment Option
12 Jan, 2020 | 21:26h | UTCAdverse events in adults with latent tuberculosis infection receiving daily rifampicin or isoniazid: post-hoc safety analysis of two randomised controlled trials – The Lancet Infectious Diseases (free registration required)
Commentaries: What is the best regimen to treat latent tuberculosis infection? – The Lancet Infectious Diseases (free) AND Four Months of Rifampicin May Be Best Option for Latent TB – Medscape / Reuters (free registration required)
Related Commentary on Twitter
New study @McGill_TB: “In patients without a contraindication, rifampicin is likely to be the safest latent tuberculosis infection treatment option.” https://t.co/rg2wmcLcqo
— Madhu Pai, MD, PhD (@paimadhu) January 9, 2020
Systematic Review and Economic Evaluation: Different Strategies for Pharmacological Thromboprophylaxis for Lower-limb Immobilization after Injury
12 Jan, 2020 | 21:14h | UTCSource: EvidenceAlerts
Meta-analysis: Systemic Pharmacological Treatments for Chronic Plaque Psoriasis
12 Jan, 2020 | 20:52h | UTCSystemic pharmacological treatments for chronic plaque psoriasis: a network meta‐analysis – Cochrane Library (free)
Summary: Systemic (oral or injected) medicines for psoriasis – Cochrane Library (free)
Author Interview: Living Systematic Review: Pharmacological treatments for psoriasis, network meta analysis – Cochrane Library (free)
Study Commentary: Herpes Zoster Vaccine Reduces Chances of Shingles after Stem Cell Transplants
9 Jan, 2020 | 23:22h | UTCHerpes zoster vaccine reduces chances of shingles after stem cell transplants – NIHR Signal (free)
Original Study: Effect of Recombinant Zoster Vaccine on Incidence of Herpes Zoster After Autologous Stem Cell Transplantation: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Study Commentary: Continuing an Anticoagulant at Home After Abdominal Surgery Cuts Thrombosis Risk
9 Jan, 2020 | 23:21h | UTCContinuing an anticoagulant at home after abdominal surgery cuts thrombosis risk – NIHR Signal (free)
Original Study: Systematic Review: Prolonged Thromboprophylaxis with Low Molecular Weight Heparin for Abdominal or Pelvic Surgery – Cochrane Library (link to study and summary)
Study Commentary: Taking Blood Pressure Medications at Night Seems Best
9 Jan, 2020 | 23:24h | UTCTaking blood pressure medications at night seems best – NIHR Signal (free)
Original Study: Practice Changing? – Bedtime Hypertension Treatment Improves Cardiovascular Risk Reduction in Randomized Trial – European Heart Journal (free study and commentaries)
Study Commentary: ‘As-needed’ Combination Asthma Inhalers Can be More Effective than Regular Inhaled Steroids
9 Jan, 2020 | 23:12h | UTCOriginal Study: Randomized Trial: In Adults with Mild to Moderate Asthma, As-Needed Long-acting Beta-agonist Plus an Inhaled Corticosteroid is as Effective as Maintenance Inhaled Corticosteroid Therapy Plus As-needed Short-acting Beta-agonist – The Lancet (link to abstract and commentary)
Review – Beyond Depression: Other Uses for Tricyclic Antidepressants
9 Jan, 2020 | 01:21h | UTCBeyond depression: Other uses for tricyclic antidepressants – Cleveland Clinic Journal of Medicine (free)
Consensus Report: Framing Opioid Prescribing Guidelines for Acute Pain
8 Jan, 2020 | 22:22h | UTCCommentaries: Statement on National Academies of Sciences, Engineering, and Medicine report on framing opioid prescribing guidelines for acute pain – U.S Food & Drug Administration (free) AND National Academies outlines opioid guidelines, aiming to make approach to prescribing more consistent – STAT (free)
[Abstract Only] Randomized Trial: Olanzapine Plus Standard Antiemetic Therapy for the Prevention of Chemotherapy-induced Nausea and Vomiting
8 Jan, 2020 | 22:12h | UTCOlanzapine 5 mg plus standard antiemetic therapy for the prevention of chemotherapy-induced nausea and vomiting (J-FORCE): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)
Related Commentary on Twitter
in phase III trial, patients received anti-emetic combination plus placebo or 5 mg olanzapine (dose lower than standard to avoid somnolence); 5 mg dose was deemed effective https://t.co/urEz3AKFdA
— NatureRevClinOncol (@NatRevClinOncol) December 19, 2019
[Abstract Only] Randomized Trial: Four Cycles of R-CHOP Non-inferior to Six Cycles of R-CHOP in Patients with Aggressive B-cell non-Hodgkin Lymphoma and Favorable Prognosis
8 Jan, 2020 | 21:49h | UTCFour versus six cycles of CHOP chemotherapy in combination with six applications of rituximab in patients with aggressive B-cell lymphoma with favourable prognosis (FLYER): a randomised, phase 3, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Related Commentary on Twitter
Four cycles of CHOP chemotherapy in combination with six applications of rituximab in patients with aggressive B-cell lymphoma with favourable prognosis (FLYER): The new standard of care for limited DLBCL with favorable prognosis https://t.co/oAH9dJJGZA
— Georgios Pongas, MD (@pongasg) December 24, 2019
[Abstract Only] Dose-Response Meta-Analysis of Antipsychotic Drugs for Acute Schizophrenia
8 Jan, 2020 | 21:51h | UTCDose-Response Meta-Analysis of Antipsychotic Drugs for Acute Schizophrenia – American Journal of Psychiatry (link to abstract – $ for full-text)
Randomized Trial: Long-term Aromatase Inhibitor Prevents Breast Cancer in High-risk Postmenopausal Women
8 Jan, 2020 | 21:48h | UTCCommentaries: IBIS-II study finds anastrozole reduces breast cancer rates for high risk postmenopausal women – Queen Mary, University of London (free) AND Drug that prevents half of breast cancers carries on working – BBC (free) AND Long-Term Results of IBIS-II: Anastrozole for Breast Cancer Prevention – The ASCO Post (free)
[Abstract Only] Randomized Trial: Overall Survival with Daratumumab, Bortezomib, Melphalan, and Prednisone in Newly Diagnosed Multiple Myeloma
8 Jan, 2020 | 21:47h | UTCOverall survival with daratumumab, bortezomib, melphalan, and prednisone in newly diagnosed multiple myeloma (ALCYONE): a randomised, open-label, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Commentary: Overall Survival With the Addition of Daratumumab to VMP in Newly Diagnosed, Transplant-Ineligible Multiple Myeloma -The ASCO Post (free)
ACP Guideline: Testosterone Treatment in Adult Men With Age-Related Low Testosterone
8 Jan, 2020 | 08:51h | UTCCommentaries: ACP issues guideline on testosterone treatment for age-related low testosterone levels – ACP Internist (free) AND Most older men don’t need testosterone replacement, new guidelines say – Reuters (free)
Randomized Trial: Switching to Dolutegravir/Lamivudine Two-Drug Regimen Noninferior to Continuing a Tenofovir Alafenamide–Based Three- or Four-Drug Regimen for Maintenance of Virologic Suppression in Adults With HIV-1
8 Jan, 2020 | 08:37h | UTC
FDA Safety Communication: Gabapentinoids may Cause Serious Respiratory Problems in Predisposed Patients
8 Jan, 2020 | 01:10h | UTCCommentaries: Gabapentinoids Linked to Respiratory Problems in Certain Patients – NEJM Journal Watch (free) AND FDA warns gabapentin, pregabalin may cause serious breathing problems – The Hospitalist (free)
[Abstract Only] Randomized Trial: Direct Oral Anticoagulant Similarly Effective as Standard Anticoagulants for the Treatment of Acute Venous Thromboembolism in Children
8 Jan, 2020 | 01:02h | UTCRivaroxaban compared with standard anticoagulants for the treatment of acute venous thromboembolism in children: a randomised, controlled, phase 3 trial – The Lancet Haematology (link to abstract – $ for full-text)
Commentary: Thrombosis: Anticoagulant Rivaroxaban soon also available for children – Medical University of Vienna (free)
Consensus Statement: Insufficient Evidence to Recommend Brain Health Supplements
8 Jan, 2020 | 00:57h | UTCCommentary: AARP report: Insufficient evidence that dietary supplements benefit brain health – Science-Based Medicine (free)
Meta-Analysis: Comparative Effects of 18 Antipsychotics on Metabolic Function in Patients with Schizophrenia
8 Jan, 2020 | 00:56h | UTCCommentaries: Insights into metabolic dysregulations associated with antipsychotics – The Lancet Psychiatry (free) AND Not all antipsychotics increase the risk of diabetes and raise cholesterol – some may be protective – The Conversation (free)
[Abstract Only] Study: Long-term Follow Up of Gene Therapy for Hemophilia A
8 Jan, 2020 | 00:52h | UTCMultiyear Follow-up of AAV5-hFVIII-SQ Gene Therapy for Hemophilia A – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Study shows safety, long-term beneficial impact of gene therapy for patients with Hemophilia A – Queen Mary University of London (free)
[Abstract Only] Randomized Trial: Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive Metastatic Breast Cancer
8 Jan, 2020 | 00:51h | UTCCommentaries: SABCS 2019: Adding Tucatinib to Capecitabine/Trastuzumab Improved Survival for Patients With Advanced HER2-Positive Breast Cancer – The ASCO Post (free) AND HER2CLIMB and DESTINY-Breast01 Findings in Heavily Pretreated HER2-positive MBC – ESMO (free)