Pharmacology/Pharmaceutical Industry
ASCO Guideline: Use of Endocrine Therapy for Breast Cancer Risk Reduction
5 Sep, 2019 | 08:15h | UTCRelated: USPSTF Recommendation Statement: Medication Use to Reduce Risk of Breast Cancer (free)
USPSTF Recommendation Statement: Medication Use to Reduce Risk of Breast Cancer
4 Sep, 2019 | 09:11h | UTCRecommendation Summary: Medication Use to Reduce Risk of Breast Cancer (free)
Editorials: Medications to Reduce Breast Cancer Risk: Promise and Limitations (free for a limited period) AND Breast Cancer Chemoprevention—Can We Make a Case for Precision Medicine? (free for a limited period)
Evidence Report and Systematic Review: Medication Use for the Risk Reduction of Primary Breast Cancer in Women – US Preventive Services Task Force (free)
Author Interview: USPSTF Recommendation: Medication Use to Reduce Risk of Breast Cancer (free audio)
Commentaries: Medication can lower some women’s risk of breast cancer – Reuters (free) AND USPSTF: Aromatase Inhibitors Recommended to Help Prevent Breast Cancer – NEJM Journal Watch (free)
Guidelines on the Management of Patients Developing QT Prolongation on Antipsychotic Medication
4 Sep, 2019 | 09:00h | UTC
#ESCCongress – [Not Published Yet] Randomized Trial: SGLT2 inhibitors Seems Beneficial for Heart Failure Even in Nondiabetics
2 Sep, 2019 | 01:09h | UTCCommentaries: Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction – DAPA-HF – American College of Cardiology (free) Dapagliflozin reduces death and hospitalisation in patients with heart failure – European Society of Cardiology (free)
Related Commentary on Twitter
DAPA-HF trial at #ESCCongress: significant reduction of events in HFrEF patients by dapagliflozine. Half of the 5744 pts had diabetes, the others did not: same effect in both groups.
SGLT2 inhibitors just better diuretics or the "statins of HF"?@escardio #cardiotwitter pic.twitter.com/nzTv58d0cd— Stephan Achenbach (@Steph_Achenbach) September 1, 2019
Meta-Analysis: Menopausal Hormone Therapy Increases Breast Cancer Risk
30 Aug, 2019 | 08:55h | UTCCommentaries: Menopausal hormones: definitive evidence for breast cancer – The Lancet (free) AND Menopausal hormone therapy and 20-year breast cancer mortality – The Lancet (free) AND Hormone therapy during menopause raises breast cancer risk for years, study finds – STAT (free) AND Expert reaction to study looking at HRT use and risk of breast cancer – Science Media Centre (free)
Study: Sodium Polystyrene Sulphonate is Associated with Increased Risk of GI Adverse Events in Patients with CKD
30 Aug, 2019 | 08:28h | UTCCommentary: Hyperkalemia Drug Again Linked to Adverse GI Events – Renal & Urology News (free)
Related Study: Risk of Hospitalization for Serious Adverse Gastrointestinal Events Associated with Sodium Polystyrene Sulfonate (link to abstract and commentary)
Cohort Study: SGLT2 Inhibitors Associated with Reduced Risk of Heart Failure
30 Aug, 2019 | 08:24h | UTCCommentaries: SGLT2 inhibitors cut heart failure risk for T2D patients – Cardiovascular Business (free) AND Newer diabetes drug drops heart failure risk by 34 percent, study says – UPI (free)
Related observational studies: SGLT2 agents may reduce cardiovascular risk in diabetics (link to abstract and commentaries)
Randomized Trial: Effect of Low-Dose Vasopressin on Need for Transfusions in Patients With Trauma and Hemorrhagic Shock
29 Aug, 2019 | 06:45h | UTCEffect of Low-Dose Supplementation of Arginine Vasopressin on Need for Blood Product Transfusions in Patients With Trauma and Hemorrhagic Shock: A Randomized Clinical Trial – JAMA Surgery (free for a limited period)
Commentaries: Vasopressin as an Early Adjunct to Resuscitation in Hemorrhagic Shock: Crisis AVERTed? – JAMA Surgery (free) AND Giving trauma patients blood pressure stabilizing hormone cuts transfusions by half – University of Pennsylvania School of Medicine (free)
Author Interview: Arginine Vasopressin Supplementation in Early Traumatic Shock (free)
“Additional research is necessary to determine whether including AVP improves morbidity or mortality.”
Randomized Trial: High-Dose Vitamin D Supplementation Does Not Improve Bone Health and May Result in Lower Bone Mineral Density
28 Aug, 2019 | 02:33h | UTCEffect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentary: High-Dose Vitamin D Might Reduce Bone Mineral Density – NEJM Journal Watch (free)
Related Commentary on Twitter
Vitamin D study: "Among healthy adults, supplementation with higher doses of vitamin D did not improve bone health." https://t.co/pugZ4Ilxke via @JAMA_current @SMCCanada cc @DietitiansCAN @medmyths @joansalgeblake @picardonhealth @CBCHealth pic.twitter.com/4BocJC1EeT
— Timothy Caulfield (@CaulfieldTim) August 27, 2019
Cohort Study: How Many Older Adults Receive Drugs of Questionable Clinical Benefit Near the End of Life?
28 Aug, 2019 | 02:26h | UTCRelated Studies: Use of Medications of Questionable Benefit at the End of Life (link to abstract and commentaries) AND Preventive Drugs in the Last Year of Life of Older Adults with Cancer: Is There Room for Deprescribing? (link to abstract and commentary)
Cardiovascular Toxicity of Immune Checkpoint Inhibitors in Cancer Patients
28 Aug, 2019 | 02:11h | UTCRelated: Immune Checkpoint Inhibitor Toxicities (free guidelines and reviews on the subject)
Meta-Analysis: Cardiovascular Adverse Events Associated With BRAF and MEK Inhibitors for the Treatment of Melanoma
28 Aug, 2019 | 02:11h | UTCCommentary: Risk of Cardiovascular Adverse Events in Patients With Melanoma Treated With Combined BRAF and MEK Inhibition vs BRAF Inhibition Alone – The ASCO Post (free)
Study: Acute Gallbladder or Biliary Disease More Common in Patients Using Liraglutide
27 Aug, 2019 | 00:31h | UTCEffects of Liraglutide Compared With Placebo on Events of Acute Gallbladder or Biliary Disease in Patients With Type 2 Diabetes at High Risk for Cardiovascular Events in the LEADER Randomized Trial – Diabetes Care (free PDF for a limited period)
Commentary: Gallbladder, Biliary Tract Events Increased With Liraglutide – Medscape (free registration required)
[Abstract Only] Observational Study Suggests Women with Heart Failure May Need Lower Doses of ACE Inhibitors or ARBs and β blockers than Men
25 Aug, 2019 | 21:31h | UTCIdentifying optimal doses of heart failure medications in men compared with women: a prospective, observational, cohort study – The Lancet (link to abstract – $ for full-text)
Related Commentary on Twitter
BIOSTAT-CHF trial (n=1,710) lowest mortality rates occurred at 100% of the recommended dose of ACEIs & β blockers for men, but women showed significant lower risk at 50% of the recommended doses with no further improvement at higher dose levels.https://t.co/OL2PIPl1aF
— Dr Rani Khatib (@DrRaniKhatib) August 23, 2019
[Abstract Only] Randomized Trial: Effectiveness of Polypill for Primary and Secondary Prevention of Cardiovascular Diseases
23 Aug, 2019 | 08:48h | UTCEffectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial – The Lancet (link to abstract – $ for full-text)
Commentaries: 4-Drug Polypill Cuts CV Risk – NEJM Journal Watch (free) AND Four-in-one pill prevents third of heart problems – BBC (free)
Related: Clinical Impact of the Polypill for Cardiovascular Prevention in Latin America: A Consensus Statement of the Inter-American Society of Cardiology – Global Heart (free) AND Perspective: The Polypill and the Long Journey to Major Impact (opinion and reviews on the subject) AND Research: Low-Dose ‘Triple Pill’ Lowers Blood Pressure More Than Usual Care (free commentaries)
Related Commentary on Twitter
NEW Research—Large five-year randomised trial supports use of #polypill to prevent #CVD: finding from PolyIran, a pragmatic, cluster-randomised trial #LancetCardiology #ESCCongress https://t.co/YtU4MBPWom pic.twitter.com/GocADDE7Kv
— The Lancet (@TheLancet) August 23, 2019
Clinicians’ Guide to Cannabidiol and Hemp Oils
23 Aug, 2019 | 08:40h | UTCClinicians’ Guide to Cannabidiol and Hemp Oils – Mayo Clinic Proceedings (free)
Related: Guideline for Prescribing Medical Cannabinoids in Primary Care (free)
Redefining Medication Management in Dialysis: A Kidney Pharmacy Quality Pyramid
23 Aug, 2019 | 08:38h | UTCRedefining Medication Management in Dialysis: A Kidney Pharmacy Quality Pyramid – Kidney Medicine (free)
Related: Drug Management in the Elderly Adult With Chronic Kidney Disease: A Review for the Primary Care Physician – Mayo Clinic Proceedings (free) AND Medication Reconciliation and Therapy Management in Dialysis-Dependent Patients: Need for a Systematic Approach – Clinical Journal of the American Society of Nephrology (free)
Study: Billions Could be Saved if Older Generics Were Prescribed
21 Aug, 2019 | 08:32h | UTCCommentary: Prescribing older generics could’ve saved Medicare $17.7B, study finds – Becker’s Hospital Review (free)
Related Study: Potential Savings from Generic Substitution and Therapeutic Interchange of ACE Inhibitors and Angiotensin-II-Receptor Blockers (no abstract – $ for full-text)
AHA Scientific Advisory: Omega-3 Fatty Acids for the Management of Hypertriglyceridemia
20 Aug, 2019 | 08:57h | UTCNews Release: Prescription omega-3 fatty acid medications effectively lower high triglycerides – American Heart Association (free)
Related: Omega-3 Supplements Do Not Reduce the Risk of Cancer or Cardiovascular Disease (randomized trial and systematic reviews on the subject)
Cohort Study: Intensifying Antihypertensive Medication Regimens Among Older Adults at Hospital Discharge Linked to Worse Outcomes
20 Aug, 2019 | 08:35h | UTCClinical Outcomes After Intensifying Antihypertensive Medication Regimens Among Older Adults at Hospital Discharge – JAMA Internal Medicine (free for a limited period)
Commentary: Intensifying Antihypertensives at Discharge Tied to Adverse Events – NEJM Journal Watch (free)
Related Study: Overtreatment of Blood Pressure Common at Hospital Discharge (free)
Promising new Tuberculosis Drug Approved, But Will it be Affordable?
18 Aug, 2019 | 22:00h | UTCOriginal News Release: FDA approves new drug for treatment-resistant forms of tuberculosis that affects the lungs – U.S. Food & Drug Administration (free)
See also: New Drug Could Be Game Changer For Drug-Resistant TB. But A Question Looms – NPR (free) AND Treatment for extreme drug-resistant tuberculosis wins US government approval – Nature (free) AND Scientists Discover New Cure for the Deadliest Strain of Tuberculosis – The New York Times (10 articles per month are free) AND U.S. FDA approves TB Alliance’s treatment for drug-resistant tuberculosis – Reuters (free)
Randomized Trial: Bismuth Subsalicylate Reduces Antibiotic Use Among Adult Outpatients With Diarrhea
18 Aug, 2019 | 21:59h | UTC
Meta-Analysis: Association Between Vitamin D Supplementation and Mortality
16 Aug, 2019 | 07:59h | UTCRelated: Meta-Analysis: Vitamin D Not Effective for Cardiovascular Disease Prevention (link to abstract and commentary) AND NICE Guideline: Vitamin D Supplementation (free)
Vitamin D supplementation was not associated with all-cause mortality, cardiovascular mortality, or non-cancer, non-cardiovascular mortality. However, Vitamin D supplementation statistically significantly reduced the risk of cancer death by 16%.
Related Commentary on Twitter
Vitamin D supplementation alone was not associated with all cause mortality in adults compared with placebo or no treatment. However, it was associated with a reduced risk of cancer mortality by 16%, finds #BMJResearch https://t.co/jc4Tdxl6Bb
— The BMJ (@bmj_latest) August 12, 2019
Update on the Contraceptive Contraindications
14 Aug, 2019 | 08:32h | UTCRelated Guidelines: WHO Medical eligibility criteria for contraceptive use (free PDF) AND US Medical Eligibility Criteria for Contraceptive Use (free) AND UK Medical Eligibility Criteria for Contraceptive Use (free)
Study: Androgen-deprivation Therapies May Increase the Risk of QT Prolongation and Arrhythmias
13 Aug, 2019 | 01:26h | UTCAndrogenic Effects on Ventricular Repolarization: A Translational Study From the International Pharmacovigilance Database to iPSC-Cardiomyocytes – Circulation (free PDF for a limited period)
Commentaries: Androgen-Deprivation Therapy May Increase Risk for QT Prolongation and Torsades de Pointes – The ASCO Post (free) AND ADT Linked to Arrhythmias, QT Prolongation – MedPage Today (free registration required)