Pharmacology/Pharmaceutical Industry | Page 122 of 166 | Links Medicus Content Curation & Alerts in Medicine

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Penicillin V four times daily for five days versus three times daily for 10 days in patients with pharyngotonsillitis caused by group A streptococci: ?? randomised controlled, open label, non-inferiority study. #IDTwitter #IDuptodate https://t.co/djhOIvAbPc

— Antibiotic Steward (@ABsteward) October 5, 2019

[Abstract Only] Randomized Trial: Monoclonal Anti-IgE Antibody for Chronic Spontaneous Urticaria

7 Oct, 2019 | 00:47h | UTC

Ligelizumab for Chronic Spontaneous Urticaria – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Ligelizumab safely, effectively treats hives – MedicalXpress (free) AND Ligelizumab May Improve Response in Chronic Urticaria – Medscape (free registration required)

Study: Antidepressant use During Pregnancy Linked to Increased Risk of Gestational Diabetes

3 Oct, 2019 | 01:08h | UTC

Antidepressant use during pregnancy and the risk of gestational diabetes mellitus: a nested case–control study – BMJ Open (free)

Commentaries: Antidepressants linked to heightened pregnancy related diabetes risk – BMJ (free) AND Antidepressants linked to risk of gestational diabetes – OnMedica (free) AND Antidepressants are linked to a higher gestational diabetes risk in a new study – CNN (free)

Systematic Review: Association of Antidepressant Use with Adverse Health Outcomes

3 Oct, 2019 | 01:03h | UTC

Association of Antidepressant Use With Adverse Health Outcomes: A Systematic Umbrella Review – JAMA Psychiatry (free for a limited period)

Editorial: Selective Serotonin Reuptake Inhibitor Use During Pregnancy—Associated With but Not Causative of Autism in Offspring (free for a limited period)

Commentaries: Antidepressant medications appear to be generally safe,study suggests – Linköping University (free) AND Expert reaction to study on association of antidepressant use with adverse health outcomes – Science Media Centre (free)

[Abstract Only] Randomized Trial: Triple Therapy Inhaler for Uncontrolled Asthma

2 Oct, 2019 | 01:45h | UTC

Single inhaler extrafine triple therapy in uncontrolled asthma (TRIMARAN and TRIGGER): two double-blind, parallel-group, randomised, controlled phase 3 trials – The Lancet (link to abstract – $ for full-text)

Commentaries: Asthma 3-in-1 Therapy May Improve Lung Function, Study Shows – The New York Times (10 articles per month are free) AND Triple-Therapy Inhaler Tied to Better Lung Function in Asthma – NEJM Journal Watch (free)

FDA Warns About Rare Occurrence of Serious Liver Injury with Use of Hepatitis C Medicines in Some Patients with Advanced Liver Disease

2 Oct, 2019 | 01:41h | UTC

FDA warns about rare occurrence of serious liver injury with use of hepatitis C medicines Mavyret, Zepatier, and Vosevi in some patients with advanced liver disease – U.S. Food & Drug Administration (free)

Commentary: Hepatitis C medicines have led to liver decompensation in some patients – ACP Gastroenterology (free)

Population-Based Observational Study Suggests Statins at Higher Doses May Increase the Incidence of Osteoporosis

1 Oct, 2019 | 00:45h | UTC

Diagnosis of osteoporosis in statin-treated patients is dose-dependent – Annals of Rheumatic Diseases (free)

Commentary: Statins could increase or decrease osteoporosis risk — the dosage makes the difference – Complexity Science Hub Vienna (free)

FDA Issues Drug Safety Alert on Severe Lung Inflammation Due to Treatment with CDK4/6 Inhibitors for Breast Cancer

1 Oct, 2019 | 00:36h | UTC

FDA warns about rare but severe lung inflammation with Ibrance, Kisqali, and Verzenio for breast cancer – U.S. Food & Drug Administration (free)

Commentary: FDA Issues Drug Safety Communication on Lung Inflammation Due to Treatment With CDK4/6 Inhibitors – The ASCO Post (free)

[Abstracts Only] Biologics Found to be Effective for Ulcerative Colitis in Industry-funded Trials

30 Sep, 2019 | 00:11h | UTC

Biologics found to be effective for ulcerative colitis in industry-funded trials – ACP Gastroenterology (free)

Original Studies: Vedolizumab versus Adalimumab for Moderate-to-Severe Ulcerative Colitis – New England Journal of Medicine (link to abstract – $ for full-text) AND Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis – New England Journal of Medicine (link to abstract – $ for full-text)

Randomized Trial: New Antibiotic Seems Effective for Community-Acquired Bacterial Pneumonia

30 Sep, 2019 | 00:07h | UTC

Oral Lefamulin vs Moxifloxacin for Early Clinical Response Among Adults With Community-Acquired Bacterial Pneumonia: The LEAP 2 Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Lefamulin—A New Antibiotic for Community-Acquired Pneumonia (free for a limited period)

Related Commentary on Twitter

Among patients with CABP, 5-day oral lefamulin was noninferior to 7-day oral moxifloxacin with respect to early clinical response at 96 hours after first dose https://t.co/wwQrx79kFq

— JAMA (@JAMA_current) September 28, 2019

Evidence Synthesis: Should Antidepressants be Used for Major Depressive Disorder?

27 Sep, 2019 | 08:33h | UTC

Should antidepressants be used for major depressive disorder? – BMJ Evidence-Based Medicine (free)

Related Commentary: Do Antidepressants Work? – The New York Times (10 articles per month are free)

“Generally, all the previous reviews show that antidepressants seem to have statistically significant effects on depressive symptoms, but the size of the effect has questionable importance to most patients.”

ACOG Committee Opinion: Over-the-Counter Access to Hormonal Contraception

27 Sep, 2019 | 08:28h | UTC

Over-the-Counter Access to Hormonal Contraception – American College of Obstetricians and Gynecologists (free)

Summary: Over-the-Counter Access to Hormonal Contraception (free)

News Release: ACOG Updates Guidance on Over-the-Counter Access to Hormonal Contraception (free)

Commentaries: Hormonal Contraceptives Should Be Available OTC, ACOG Recommends – NEJM Journal Watch (free) AND All hormonal birth control should be available over the counter, OB-GYN group says – NBC News (free)

Perspective: A Simple Regimen Can Prevent TB. Why Aren’t More People on It?

25 Sep, 2019 | 08:26h | UTC

A Simple Regimen Can Prevent TB. Why Aren’t More People on It? – The New York Times (10 articles per month are free)

ATS Research Statement: Knowledge Gaps and Research Priorities in Immune Checkpoint Inhibitor–related Pneumonitis

19 Sep, 2019 | 07:59h | UTC

Knowledge Gaps and Research Priorities in Immune Checkpoint Inhibitor–related Pneumonitis. An Official American Thoracic Society Research Statement – American Journal of Respiratory and Critical Care Medicine (free)

Related: Immune Checkpoint Inhibitor Toxicities (guidelines and reviews on the subject)

Randomized Trial: Sertraline is Unlikely to Reduce Depressive Symptoms

23 Sep, 2019 | 01:06h | UTC

The clinical effectiveness of sertraline in primary care and the role of depression severity and duration (PANDA): a pragmatic, double-blind, placebo-controlled randomised trial – The Lancet Psychiatry (free)

Commentaries: Examining the antidepressant scattergun approach – The Lancet Psychiatry (free) AND Expert reaction to study on the clinical effectiveness of the antidepressant sertraline – Science Media Centre (free) AND Common antidepressant more effective for anxiety than depression – UPI (free) AND Antidepressants work, but just not how scientists thought they worked – The Conversation (free) AND Antidepressants may reduce anxiety more than depressive symptoms – University College London (free)

Related Commentary on Twitter (Thread – click for more)

Important new trial on the real-world effectiveness of antidepressants (sertraline) in primary care patients. Main finding: There is no evidence that antidepressants effectively treat depression symptoms in real-world patients (effect size: d<0.2) https://t.co/bq9atTwrdo

— Michael P. Hengartner, PhD (@HengartnerMP) September 20, 2019