Pharmacology/Pharmaceutical Industry
[Abstract Only] Meta-Analysis: Epinephrine Improves Overall Survival but not Neurologic Outcomes for Out-of-Hospital Cardiac Arrest
9 Feb, 2020 | 20:12h | UTCEpinephrine for Out-of-Hospital Cardiac Arrest: An Updated Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text)
Related: A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest – New England Journal of Medicine (free)
Meta-Analysis Confirms Increased Cardiovascular Risk with Rosiglitazone
7 Feb, 2020 | 08:13h | UTCCommentaries: The power of shared data to better understand drug safety – The BMJ Opinion (free) AND New study adds to evidence of diabetes drug link to heart problems – BMJ (free) AND Largest ever evaluation of the cardiovascular risk of rosiglitazone published – OnMedica (free) AND Individual patient data analysis firms up rosiglitazone safety verdict – medwire News (free)
Recommended Adult Immunization Schedule, United States, 2020
4 Feb, 2020 | 08:02h | UTCRecommended Adult Immunization Schedule, United States, 2020 – Annals of Internal Medicine (free)
Commentary: ACIP releases updated vaccination schedule with several changes – ACP Hospitalist (free)
Related Commentary on Twitter
Just out in @AnnalsofIM
New Advisory Committee on Immunization Practices (#ACIP) Adult #Immunization Schedule recommends changes to several vaccineshttps://t.co/wa31QMpWct
Nice simplified tables, too. 👇#vaccines pic.twitter.com/u2EoD1gNbe
— Chris Hendel (@chrishendel) February 3, 2020
Meta-Analysis: Aspirin for Venous Thromboembolism Prophylaxis After Total Hip and Knee Replacement
4 Feb, 2020 | 07:55h | UTC
[Abstract Only] Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain
31 Jan, 2020 | 01:26h | UTCCannabinoids for adult cancer-related pain: systematic review and meta-analysis – BMJ Supportive & Palliative Care (link to abstract – $ for full-text)
Commentary: Cannabinoids No Help for Cancer Pain, Concludes Meta-Analysis – Medscape (free registration required)
Related: NICE Guideline: Cannabis-Based Medicinal Products (free guideline and resources on the subject)
Antimicrobial-associated Harm in Critical Care: A Narrative Review
31 Jan, 2020 | 01:30h | UTCAntimicrobial-associated harm in critical care: a narrative review – Intensive Care Medicine (free for a limited period)
FDA Safety Communication: Untreated Constipation caused by Clozapine Can Lead to Serious Bowel Problems
31 Jan, 2020 | 01:09h | UTCSource: FDA Strengthens Constipation Warning on Clozapine – NEJM Journal Watch (free)
Systematic Review: Oral Janus Kinase Inhibitors for Maintenance of Remission in Ulcerative Colitis
31 Jan, 2020 | 00:44h | UTCOral Janus kinase inhibitors for maintenance of remission in ulcerative colitis – Cochrane Library (free)
Summary: Oral Janus kinase inhibitors (tofacitinib) for maintenance of remission in ulcerative colitis – Cochrane Library (free)
Systematic Review: Intravenous Immunoglobulin for Preventing Infection in Preterm and/or Low Birth Weight Infants
31 Jan, 2020 | 00:46h | UTCIntravenous immunoglobulin for preventing infection in preterm and/or low birth weight infants – Cochrane Library (free)
Summary: Intravenous immunoglobulin for preventing infection in preterm and/or low birth weight infants – Cochrane Library (free)
BSH Guideline: Laboratory Diagnosis of G6PD Deficiency
30 Jan, 2020 | 07:36h | UTC
ASCO Guideline: Bone Health and Bone-Targeted Therapies for Prostate Cancer
30 Jan, 2020 | 07:26h | UTC
Eliminating Medication Overload: A National Action Plan
29 Jan, 2020 | 08:28h | UTCEliminating Medication Overload: A National Action Plan – Lown Institute (free PDF)
Press Release: Millions of Older Americans Harmed by Too Many Medications – Lown Institute (free)
Commentary: ‘Small’ tactics to counter Big Pharma’s influence on medication overload – STAT (free)
Related: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject)
Related Commentary on Twitter
After a year of collaboration and hard work, our comprehensive action plan to eliminate medication overload is published! Find out how you can help reduce harm from multiple #medication use here: https://t.co/pHjKbpVsIY
— Lown Institute (@lowninstitute) January 28, 2020
Study: First-Trimester Pregnancy Exposure to Modafinil and Risk of Congenital Malformations
29 Jan, 2020 | 08:16h | UTCFirst-Trimester Pregnancy Exposure to Modafinil and Risk of Congenital Malformations – JAMA (free for a limited period)
Commentary: Modafinil in First Trimester Associated with Birth Defects – NEJM Journal Watch (free)
EULAR Recommendations for the Management of Rheumatoid Arthritis with Synthetic and Biological Disease-modifying Antirheumatic Drugs
28 Jan, 2020 | 09:09h | UTC
[Abstract Only] Practice Changing? Randomized Trial of Low-dose Aspirin for the Prevention of Preterm Delivery in Nulliparous Women with a Singleton Pregnancy
26 Jan, 2020 | 23:02h | UTCLow-dose aspirin for the prevention of preterm delivery in nulliparous women with a singleton pregnancy (ASPIRIN): a randomised, double-blind, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)
Commentaries: Low-dose aspirin may reduce preterm birth risk among first-time mothers – NIH News Releases (free) AND Daily aspirin may reduce preterm birth risk among first-time mothers – OnMedica (free)
CDC Updated Recommendations: Use of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccines
26 Jan, 2020 | 22:47h | UTCCommentaries: CDC: Tdap Acceptable Alternative to Td Vaccine – NEJM Journal Watch (free) AND ACIP: Updated Recommendations for Tdap Vaccination – MPR (free)
Related Commentary on Twitter
Vaccine providers: New ACIP recommendations allow more flexibility for use of either #Tdap or #Td for decennial #tetanus boosters, tetanus prophylaxis during wound management, and catch-up immunizations. Learn more: https://t.co/TMQhK5F4aq pic.twitter.com/3CTJpYxEwM
— Mandy K. Cohen, MD, MPH (@CDCDirector) January 24, 2020
[Abstract Only] Observational Study: Morphine may Interact with Clopidogrel and is Linked to Higher Rates of Ischemic Events Among Patients with Non-ST-Segment Elevation Acute Coronary Syndromes Undergoing Coronary Angiography
26 Jan, 2020 | 22:48h | UTCMorphine and Cardiovascular Outcomes Among Patients With Non-ST-Segment Elevation Acute Coronary Syndromes Undergoing Coronary Angiography – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentary: Clopidogrel Interaction With Morphine in ACS Linked to More Ischemic Events – TCTMD (free)
Meta-Analysis: Optimal Doses of Antidepressants in Dependence on Age
26 Jan, 2020 | 22:29h | UTCRelated Meta-analysis: Optimal Dose of Antidepressants in Major Depression – The Lancet Psychiatry (free study and commentaries)
Study: Textbooks Used to Train Physicians Lack of Conflict of Interest Transparency
24 Jan, 2020 | 08:13h | UTCTextbooks Used to Train Physicians Lack of Conflict of Interest Transparency – MedicalResearch.com (free)
Original Study: A Quantitative and Narrative Evaluation of Goodman and Gilman’s Pharmacological Basis of Therapeutics – Pharmacy (free)
Related: Authors of premier medical textbook didn’t disclose $11 million in industry payments (free commentary) AND Study: Undisclosed Financial Ties Between Guideline Writers and Pharmaceutical Companies (several resources on the subject)
Meta-Analysis: Industry Funding of Patient and Health Consumer Organizations
24 Jan, 2020 | 08:11h | UTCEditorials: Corporate sponsorship of patient groups: It’s time for mandatory disclosure (free for a limited period) AND The prevalence of industry funding of patient groups – BMJ Opinion (free)
[Abstract Only] Randomized Trial: Teprotumumab for the Treatment of Active Thyroid Eye Disease
24 Jan, 2020 | 08:07h | UTCTeprotumumab for the Treatment of Active Thyroid Eye Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Teprotumumab bests placebo for active thyroid eye disease – MedicalXpress (free)
[Abstract Only] Randomized Trial: Elagolix for Heavy Menstrual Bleeding in Women with Uterine Fibroids
24 Jan, 2020 | 08:06h | UTCElagolix for Heavy Menstrual Bleeding in Women with Uterine Fibroids – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Endometriosis drug reduces bleeding in women with fibroids – Reuters (free) AND Oral hormone-blocking drug may help with heavy menstrual bleeding – Thomas Jefferson University (free)
Randomized Trial: Seven-day Vonoprazan and Low-dose Amoxicillin Dual Therapy as First-line Helicobacter Pylori Treatment
24 Jan, 2020 | 07:58h | UTCCommentary: Dual Therapy for 7 Days Effective for H. Pylori Eradication – Medscape (free registration required)
[Abstract Only] Observational Study on the Effects of Vaccination of Infants with Meningococcal Group B Vaccine in England
23 Jan, 2020 | 09:47h | UTCVaccination of Infants with Meningococcal Group B Vaccine (4CMenB) in England – New England Journal of Medicine (link to abstract – $ for full-text)
Related Study: Meningococcal B Vaccine and Meningococcal Carriage in Adolescents in Australia – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Vaccine prevents deadly meningitis B in infants – Reuters (free)
Related Commentary on Twitter
A meningococcal group B vaccine was introduced in the U.K. as part of the infant vaccination program. Investigators from Public Health England assessed the effect of this vaccination on the incidence of meningococcal group B disease. https://t.co/n1ZkU53Fny
— NEJM (@NEJM) January 22, 2020
Randomized Trial: Effect of Sunscreen Application on Plasma Concentration of Sunscreen Active Ingredients
23 Jan, 2020 | 09:45h | UTCEffect of Sunscreen Application on Plasma Concentration of Sunscreen Active Ingredients: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Systemic Absorption of Sunscreen: Balancing Benefits With Unknown Harms (free for a limited period)
Commentaries: Expert reaction to study looking at sunscreen ingredients and absorption into the blood – Science Media Centre (free) AND All Major Sunscreen Ingredients Absorbed Through the Skin – MedicalResearch.com (free) AND Sunscreen ingredients really do seep into the blood. Is that bad? – Reuters (free)