Pharmacology/Pharmaceutical Industry
[Abstract Only] Large Observational Study Suggests No Benefit from Adult Booster Vaccinations Against Tetanus or Diphtheria
26 Feb, 2020 | 06:59h | UTCIncidence of Tetanus and Diphtheria in Relation to Adult Vaccination Schedules – Clinical Infectious Diseases (link to abstract – $ for full-text)
Commentaries: Adults don’t need tetanus, diphtheria boosters if fully vaccinated as children – Oregon Health & Science University (free) AND Most adults don’t need booster vaccinations for tetanus and diphtheria, new study concludes – STAT (free)
Study: Evaluation of a Common Prescribing Cascade of Calcium Channel Blockers and Diuretics in Older Adults with Hypertension
25 Feb, 2020 | 06:42h | UTCEvaluation of a Common Prescribing Cascade of Calcium Channel Blockers and Diuretics in Older Adults With Hypertension – JAMA Internal Medicine (free for a limited period)
Commentary: Antihypertensive Prescribing Cascades as High-Priority Targets for Deprescribing – JAMA Internal Medicine (free for a limited period)
Related Commentary on Twitter
Prescribing cascades occur when a second medicine is prescribed to counteract the effects of the first medicine. This @JAMAInternalMed article is the strongest empiric evidence I have seen that these cascades are very real #geriatrics https://t.co/KmJ2nhLlXM
— Ken Covinsky (@geri_doc) February 24, 2020
Meta-Analysis: Evaluation of the Association Between Gastric Acid Suppression and Risk of Intestinal Colonization with Multidrug-Resistant Microorganisms
25 Feb, 2020 | 06:39h | UTCAuthor Interview: Evaluation of Association Between Gastric Acid Suppression and Risk of Intestinal Colonization With MDROs – JAMA (free)
Commentary: Deprescribing Proton Pump Inhibitors: Overcoming Resistance – JAMA Internal Medicine (free for a limited period)
Related: Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Deprescribing Proton Pump Inhibitors – Therapeutics Initiative (free)
Related Commentary on Twitter
NEW 🔥⚡systematic review& meta-analysis @JAMAInternalMed
The use of acid suppressants (mainly PPIs or H2RAs) associated w 75% ⬆️ odds of intestinal MDRO colonization,chiefly resistant Enterobacterales&VRE in the community&health care setting #IDTwitterhttps://t.co/ZKFtIYztqX pic.twitter.com/mLIuzM8V3p— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) February 24, 2020
JAMA Patient Page: Aspirin for Prevention of Cardiovascular Disease
25 Feb, 2020 | 06:07h | UTCAspirin for Prevention of Cardiovascular Disease – JAMA (free)
Related: Aspirin for primary prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups – BMC Medicine (free) AND Acetylsalicylic acid for primary prevention of cardiovascular events – Canadian Family Physician (free) AND Evidence evolving on aspirin as prevention – ACP Internist (free) AND Benefits and Harms of Aspirin for Primary Prevention of Cardiovascular Disease – Annals of Internal Medicine (link to abstract and commentaries) AND Aspirin for Primary Prevention: Is This the End of the Road? (selection of resources on the subject)
[Abstract Only] Meta-Analysis: Lower vs. Standard INR Targets in Atrial Fibrillation
25 Feb, 2020 | 06:04h | UTCLower versus Standard INR Targets in Atrial Fibrillation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials – Thrombosis and Haemostasis (link to abstract – $ for full-text)
Source: EvidenceAlerts
Cohort Study: Maternal and Fetal Outcomes Following Exposure to Duloxetine in Pregnancy
25 Feb, 2020 | 05:59h | UTCMaternal and fetal outcomes following exposure to duloxetine in pregnancy: cohort study – The BMJ (free)
Meta-Analysis: Comparison of Cardiovascular Events Among Users of Different Classes of Antihypertension Medications
23 Feb, 2020 | 22:10h | UTC
Cohort Study: Aromatase Inhibitors and the Risk of Cardiovascular Outcomes in Women with Breast Cancer
21 Feb, 2020 | 10:35h | UTCAromatase Inhibitors and the Risk of Cardiovascular Outcomes in Women With Breast Cancer: A Population-Based Cohort Study – Circulation (free for a limited period)
Meta-Analysis: Individual Differences in Response to Antidepressants
21 Feb, 2020 | 07:33h | UTCIndividual Differences in Response to Antidepressants: A Meta-analysis of Placebo-Controlled Randomized Clinical Trials – JAMA Psychiatry (free for a limited period)
Editorial: Is This Where We Stand After Decades of Research to Develop More Personalized Treatments for Depression? (free for a limited period)
Commentary: How Variable are Patient Responses to Antidepressants? – MedPage Today (free registration required)
Randomized Trial: No Evidence That Daily Emollient During the First Year of Life Prevents Eczema
21 Feb, 2020 | 07:28h | UTCRelated Study: Skin emollient and early complementary feeding to prevent infant atopic dermatitis (PreventADALL): a factorial, multicentre, cluster-randomised trial – The Lancet (link to abstract – $ for full-text)
Commentaries: Emollients for prevention of atopic dermatitis in infancy – The Lancet (free) AND Daily moisturizer does not prevent eczema according to new research – News Medical (free)
Related Commentary on Twitter
NEW—No evidence that daily emollient during the first year of life prevents eczema in high-risk children and some evidence to suggest an increased risk of skin infections: finding from the BEEP randomised controlled trial https://t.co/nN4hr4TLdo pic.twitter.com/5QATGdRmWx
— The Lancet (@TheLancet) February 20, 2020
Study: A Deep Learning Approach to Antibiotic Discovery
21 Feb, 2020 | 07:23h | UTCA Deep Learning Approach to Antibiotic Discovery – Cell (free for a limited period)
Commentaries: Powerful antibiotics discovered using AI – Nature (free) AND Aided by machine learning, scientists find a novel antibiotic able to kill superbugs in mice – STAT (free)
Cohort Study: Macrolide Antibiotics in Early Pregnancy Linked to Increased Risk of Birth Defects
20 Feb, 2020 | 10:51h | UTCCommentaries: Warning over prescribing antibiotics during pregnancy – OnMedica (free) AND Some antibiotics prescribed during pregnancy linked with birth defects – BMJ (free) AND Expert reaction to study looking at macrolide antibiotics in pregnancy and birth defects – Science Media Centre (free) AND Macrolide Antibiotics Early in Pregnancy Tied to Birth Defects – The New York Times (10 articles per month are free)
Meta-Analysis: Insufficient Evidence that Herbal Medicines are Effective for Weight Loss
19 Feb, 2020 | 10:16h | UTCCommentary: Insufficient evidence backing herbal medicines for weight loss – University of Sidney (free)
Opinion: “Without Oversight, Electronic Prescribing Can Harm Patients”
19 Feb, 2020 | 08:25h | UTCWithout oversight, electronic prescribing can harm patients – STAT (free)
Large Observational Study Suggests Hydrochlorothiazide may be as Effective as Chlortalidone with Less Adverse Effects
18 Feb, 2020 | 08:17h | UTCComparison of Cardiovascular and Safety Outcomes of Chlorthalidone vs Hydrochlorothiazide to Treat Hypertension – JAMA Internal Medicine (free for a limited period)
Commentary: Hypertension Treatments with Chlorthalidone vs HCTZ: Cardiac and Safety Outcomes – MedicalResearch.com (free)
[Abstract Only] Randomized Trial: Adverse Effects of Low-Dose Methotrexate
18 Feb, 2020 | 08:08h | UTCAdverse Effects of Low-Dose Methotrexate: A Randomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Study investigates rates of adverse events for common rheumatoid arthritis drug – Brigham and Women’s Hospital (free) AND Low-dose methotrexate use ‘has inherent risks’ – Medicine Matters (free)
Opinion Article – Use of Methylphenidate Analogues as Cognitive Enhancers: The Prelude to Cosmetic Neurology and an Ethical Issue
18 Feb, 2020 | 08:03h | UTCRelated: Perspective: Use of ‘Smart Drugs’ on the Rise (several texts on the subject)
FDA Requests the Withdrawal of the Weight-loss Drug Lorcaserin from the Market – Potential Risk of Cancer Outweighs the Benefits
16 Feb, 2020 | 21:33h | UTCSource: Lorcaserin (Belviq ) Withdrawn From US Market Due to Cancer Risk – Medscape (free registration required)
Related: FDA Safety Communication: Possible Increased Risk of Cancer with Weight-loss Medicine Lorcaserin (free)
[Abstract Only] Study: An Electroencephalographic Signature Predicts Antidepressant Response in Major Depression
16 Feb, 2020 | 21:27h | UTCAn electroencephalographic signature predicts antidepressant response in major depression – Nature Biotechnology (link to abstract – $ for full-text)
Commentaries: Neural signature identifies people likely to respond to antidepressant medication – NIH News Releases (free) AND Brain-wave pattern can identify people likely to respond to antidepressant, study finds – Stanford Medicine (free) AND AI, brain scans may alter how doctors treat depression – UT Southwestern Medical Center (free) AND Brain scans could be used to identify who will benefit from antidepressants – Business Insider (free) AND Resting-State EEG Can Predict Sertraline Treatment Outcomes – MPR (free) AND Will That Antidepressant Work For You? The Answer May Lie In Your Brain Waves – NPR (free)
Principles of Vaccine Licensure, Approval, and Recommendations for Use
16 Feb, 2020 | 20:41h | UTCPrinciples of Vaccine Licensure, Approval, and Recommendations for Use – Mayo Clinic Proceedings (free)
Recommended Childhood and Adolescent Immunization Schedule: United States, 2020
13 Feb, 2020 | 08:09h | UTCRecommended Childhood and Adolescent Immunization Schedule: United States, 2020 – Pediatrics (free)
Table 3. Recommended Child and Adolescent Immunization Schedule by Medical Indication, United States, 2020 – Centers for Disease Control and Prevention (free)
NICE Guideline: Antimicrobial Prescribing for Leg Ulcer Infection
12 Feb, 2020 | 07:35h | UTCLeg ulcer infection: antimicrobial prescribing – National Institute for Health and Care Excellence (free)
Related: NICE Antimicrobial prescribing guidelines (resource covering many common conditions) AND NICE Summary of antimicrobial prescribing guidance – managing common infections (free PDF)
Related Commentary on Twitter
Using antibiotics when they're not needed means they may not work as well in the future.
Today, we've published final guidance that sets out an antimicrobial prescribing strategy for adults with leg ulcer infection.https://t.co/4UIa6VcHr8 pic.twitter.com/Wk3V93Ycp7
— NICE (@NICEComms) February 11, 2020
[Abstract Only] Another Study Suggesting One Dose of HPV Vaccine may be Effective for Prevention of Cervical Cancer
11 Feb, 2020 | 01:52h | UTCComparison of the long‐term impact and clinical outcomes of fewer doses and standard doses of human papillomavirus vaccine in the United States: A database study – Cancer (link to abstract – $ for full-text)
Commentaries: Single HPV vaccine dose may be effective against cervical cancer – Wiley (free) AND Expert reaction to study on single dose of HPV vaccine – Science Media Centre (free)
Related: Another Observational Study Suggests One Dose of HPV Vaccine may be Enough (free studies)
Psychopharmacological Treatment in Older People: Avoiding Drug Interactions and Polypharmacy
9 Feb, 2020 | 20:21h | UTC
Review: Drugs for Some Common Eye Disorders
9 Feb, 2020 | 20:15h | UTCDrugs for Some Common Eye Disorders – JAMA (free for a limited period)
If the link above does not work, try this one
Related Commentary on Twitter
Many artificial tear preparations are available OTC. There is no data that they are any worse at relieving symptoms than the much more expensive prescription cyclosporine emulsion (Restatis) or lifitegrast solution (Xiidra) https://t.co/qEL4IyDfrn
— JAMA (@JAMA_current) February 7, 2020