Pharmacology/Pharmaceutical Industry
Cohort Study: Association of Treatment With 5α-Reductase Inhibitors and Prostate Cancer Mortality
27 Oct, 2019 | 19:27h | UTCCommentary: Association between 5α-reductase inhibitors, prostate cancer mortality replicated – Medicine Matters (free)
Related Study: Use of 5α-reductase Inhibitors is Associated with Delayed Prostate Cancer Diagnosis and Increased Mortality in Men Undergoing PSA Screening (link to abstract and commentary)
Buying Birth Control Pills Online May Be Safe, Efficient
27 Oct, 2019 | 19:21h | UTCBuying birth control pills online may be safe, efficient – Reuters (free)
Original Research: A Study of Telecontraception – New England Journal of Medicine ($)
[Abstract Only] Large Observational Analysis Suggests Thiazide Diuretics are Superior as First-Line Drugs for the Treatment of Hypertension
25 Oct, 2019 | 08:48h | UTCComprehensive comparative effectiveness and safety of first-line antihypertensive drug classes: a systematic, multinational, large-scale analysis – The Lancet (link to abstract – $ for full-text)
Commentaries: Most Prescribed Blood Pressure Drugs May Be Less Effective than Others – Columbia University Irving Medical Center (free) AND Diuretics Better Than ACE Inhibitors as Initial Hypertension Treatment, Analysis Suggests – NEJM Journal Watch (free)
Related Cochrane Review: Thiazides best first choice for hypertension (free)
Review: Potassium Binders for Hyperkalemia in Chronic Kidney Disease, Renin-Angiotensin-Aldosterone System Inhibitor Therapy, and Hemodialysis
24 Oct, 2019 | 07:48h | UTC
[Abstract Only] Practice Changing? – Bedtime Hypertension Treatment Improves Cardiovascular Risk Reduction in Randomized Trial
23 Oct, 2019 | 08:23h | UTCBedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial – European Heart Journal (link to abstract – $ for full-text)
Commentaries: Blood pressure pills ‘work better at bedtime’ – BBC (free) AND You might want to change the time of day you take your blood pressure medicine – CNN (free) AND Expert reaction to study looking at the time of day when blood pressure medication is taken and cardiovascular disease risk – Science Media Centre (free)
Meta-Analysis: Calcium and Vitamin D Not Helpful to Reduce the Risk of Fractures
23 Oct, 2019 | 08:18h | UTCCommentary: Network meta-analysis nixes bone benefit from vitamin D, calcium – Univadis (free registration required)
Related Meta-Analysis: Calcium or Vitamin D Supplementation and Fracture Incidence in Older Adults – JAMA (free study and commentaries)
[Abstract Only] Meta-Analysis: Lithium Exposure During Pregnancy and the Postpartum Period
23 Oct, 2019 | 07:51h | UTCLithium Exposure During Pregnancy and the Postpartum Period: A Systematic Review and Meta-Analysis of Safety and Efficacy Outcomes – The American Journal of Psychiatry (link to abstract – $ for full-text)
Commentary: Prescribing Lithium During Pregnancy Requires Careful Balancing of Benefits, Risks – Psychiatric News Alert (free)
Review: Emerging Drug Classes and Their Potential Use in Hypertension
23 Oct, 2019 | 07:23h | UTCEmerging Drug Classes and Their Potential Use in Hypertension – Hypertension (free for a limited period)
[Abstract Only] Study: Hydroxychloroquine Blood Levels Predict Hydroxychloroquine Retinopathy
23 Oct, 2019 | 07:22h | UTCHydroxychloroquine Blood Levels Predict Hydroxychloroquine Retinopathy – Arthritis & Rheumatology (link to abstract – $ for full-text)
Commentaries: Hydroxychloroquine Blood Levels Predict Retinopathy Risk in Lupus – Physician’s Weekly (free) AND Monitoring blood hydroxychloroquine levels beneficial in SLE – Medwire News (free)
Review: Pulmonary Complications of Immune Checkpoint Inhibitors in Patients with Nonsmall Cell Lung Cancer
23 Oct, 2019 | 07:18h | UTCRelated: Immune Checkpoint Inhibitor Toxicities (free guidelines and reviews on the subject)
Meta-Analysis: Interleukin Inhibitors Increase the Risk of Infections and Cancer in Patients with Rheumatologic Diseases
22 Oct, 2019 | 07:38h | UTCCommentary: Interleukin Targeted Biologics Increase Risks of Infection – RheumNow (free)
Randomized Trial: Fibrinogen Concentrate vs. Cryoprecipitate for the Treatment of Bleeding in Cardiac Surgery
22 Oct, 2019 | 07:36h | UTCEffect of Fibrinogen Concentrate vs Cryoprecipitate on Blood Component Transfusion After Cardiac Surgery: The FIBRES Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Should Fibrinogen Concentrate Replace Cryoprecipitate in Cardiac Surgery? (free for a limited period)
Meta-Analysis: Mental Health Outcomes Associated with the Use of Amphetamines
20 Oct, 2019 | 22:42h | UTC
“Dollars for Doctors: We Found Over 700 Doctors Who Were Paid More Than a Million Dollars by Drug and Medical Device Companies”
20 Oct, 2019 | 22:27h | UTC
Randomized Trial: Increasing Testosterone Enhances Physical Performance in Young Women
20 Oct, 2019 | 22:26h | UTCCommentaries: Rise in testosterone level boosts young women’s running capacity – BMJ (free) AND Study: Testosterone may help women run faster, longer – UPI (free) AND Higher testosterone levels enable women to run for longer – UPI (free) AND Boosting women’s testosterone can increase muscle mass and endurance – Reuters (free)
Short Review: Bisphosphonates for Postmenopausal Osteoporosis
20 Oct, 2019 | 22:23h | UTCBisphosphonates for Postmenopausal Osteoporosis – JAMA (free for a limited period)
Observational Study Suggests Angiotensin Receptor Blockers May Increase the Risk of Suicide
20 Oct, 2019 | 22:21h | UTCCommentaries: Concerns Raised by a Study of Suicide as an Adverse Drug Effect—Replicating Findings From Real-World Data – JAMA Network Open (free) AND Expert reaction to study looking at ACE inhibitor blood pressure drugs, angiotensin receptor blockers (ARBs) blood pressure drugs, and risk of suicide – Science Media Centre (free) AND Certain Blood Pressure Meds Tied to Suicide Risk in Study – HealthDay News (free)
[Abstract Only] Randomized Trial: Evaluation of a Closed-loop System that Automates Insulin Delivery in Patients with Type 1 Diabetes
17 Oct, 2019 | 08:30h | UTCSix-Month Randomized, Multicenter Trial of Closed-Loop Control in Type 1 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Artificial pancreas system better controls blood glucose levels than current technology – NIH News Releases (free)
Related: Artificial pancreas treatment for outpatients with type 1 diabetes: systematic review and meta-analysis – The BMJ (free)
Analysis Suggests Statins for Primary Prevention has Marginal Benefits for Most People
17 Oct, 2019 | 08:26h | UTCStatins for primary prevention of cardiovascular disease – The BMJ (free)
Commentaries: For most healthy people, benefits of statins ‘may be marginal at best’ – The BMJ (free) AND Expert reaction to benefits of statins for low risk patients – Science Media Centre (free) AND Statin Guidelines Continue to Perplex – NEJM Journal Watch (free)
Sodium-glucose Cotransporter Inhibitors in Type 2 Diabetes: Thinking Beyond Glucose Lowering
17 Oct, 2019 | 08:23h | UTC
CSACI Position Statement: Newer Generation H1-Antihistamines are Safer than First-generation H1-Antihistamines
16 Oct, 2019 | 10:32h | UTC
[Abstract Only] Meta-Analysis: Comparative Efficacy of Interventions for Aggressive and Agitated Behaviors in Dementia
15 Oct, 2019 | 10:35h | UTCComparative Efficacy of Interventions for Aggressive and Agitated Behaviors in Dementia: A Systematic Review and Network Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Non-pharmacologic treatments may be more effective for psychiatric symptoms of dementia – St. Michael’s Hospital (free) AND To ease dementia agitation, drugs may not be best option – Reuters (free)
Study: Youth Suicide Attempts Often Involve Over-the-counter Painkillers
15 Oct, 2019 | 10:16h | UTCYouth suicide attempts often involve over-the-counter painkillers – Reuters (free)
Original Study: Suicide attempts by self-poisoning in the United States among 10–25 year olds from 2000 to 2018: substances used, temporal changes and demographics – Journal of Clinical Toxicology (free)
Randomized Trial: Wirelessly Observed Therapy vs. Directly Observed Therapy to Confirm Tuberculosis Treatment Adherence
15 Oct, 2019 | 10:31h | UTCCommentary: Ingestible sensor allows patients to be independent but still supported during TB treatment – Specialists in Global Health (free)
Meta-Analysis: Comparison of Treatments for Advanced EGFR Mutated Non-small Cell Lung Cancer
14 Oct, 2019 | 08:03h | UTC