Pediatrics – Infectious Diseases
RCT: The effect of azithromycin on structural lung disease in infants with cystic fibrosis.
7 Jun, 2022 | 11:29h | UTCThe effect of azithromycin on structural lung disease in infants with cystic fibrosis (COMBAT CF): a phase 3, randomised, double-blind, placebo-controlled clinical trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)
Cohort Study: Association of SARS-CoV-2 infection during pregnancy with maternal and perinatal outcomes.
3 Jun, 2022 | 11:55h | UTCAssociation of SARS-CoV-2 Infection During Pregnancy With Maternal and Perinatal Outcomes – JAMA
Maternal vaccination: a review of current evidence and recommendations.
3 Jun, 2022 | 11:40h | UTC
Commentary on Twitter
AJOG Expert Review: Maternal vaccination: a review of current evidence and recommendations – Placental transfer of IgG antibodies from maternal to fetal circulation https://t.co/yd3DQpwSoD pic.twitter.com/obicClLhzC
— AJOG (@AJOG_thegray) April 1, 2022
M-A: Use of benznidazole to treat chronic Chagas disease.
3 Jun, 2022 | 11:19h | UTC
State of the Art Review | Dengue: A growing problem with new interventions.
2 Jun, 2022 | 10:54h | UTCDengue: A Growing Problem With New Interventions – Pediatrics
M-A: Prevalence of respiratory viruses in community-acquired pneumonia in children.
1 Jun, 2022 | 10:57h | UTCPrevalence of respiratory viruses in community-acquired pneumonia in children: a systematic review and meta-analysis – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)
Commentary on Twitter
#Respiratory viruses are frequently detected in community-acquired #pneumonia among #children of all ages and geographical regions. Most common viruses were #RSV (23%) and #rhinovirus (22%) in the pre-COVID years
New Research by @MejbahBhuiyan & team: https://t.co/4ph2Isotcu
— The Lancet Child & Adolescent Health (@LancetChildAdol) May 31, 2022
Recommendation document on rapid intravenous rehydration in acute gastroenteritis.
31 May, 2022 | 11:27h | UTC
Investigating acute hepatitis of unknown origin in children.
30 May, 2022 | 11:39h | UTCInvestigating Acute Hepatitis of Unknown Origin in Children – American Society for Microbiology
Related:
What’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both? – Science
Puzzling pediatric hepatitis cases echo an earlier mysterious illness – STAT
Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC
Hepatitis outbreak in children: What do we know so far? – Imperial College London
Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Commentary on Twitter
Unexplained, severe acute hepatitis has been increasingly reported in children. Adenovirus has been detected in some (but not all) cases & is being investigated as 1 of many potential causes. @andreaprinzi discusses the ongoing epidemiologic investigation: https://t.co/P6EPdT8sOA
— ASM (@ASMicrobiology) May 27, 2022
Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019.
27 May, 2022 | 12:15h | UTCCommentaries:
Need for improved global measurement of early childhood respiratory syncytial virus disease – The Lancet (free registration required)
RSV kills 100,000 kids under age 5 a year worldwide – CHEST Physician
Modeling Study: 20% of multi-drug resistant tuberculosis cases in children could be averted by household testing and treatment.
25 May, 2022 | 10:44h | UTCInvited Commentary: Investing in drug-resistant tuberculosis household contact management and preventive treatment – The Lancet Global Health
What’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both?
23 May, 2022 | 01:48h | UTCWhat’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both? – Science
Related:
Puzzling pediatric hepatitis cases echo an earlier mysterious illness – STAT
Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC
Hepatitis outbreak in children: What do we know so far? – Imperial College London
Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Review: Tympanostomy tubes for children with acute otitis media.
23 May, 2022 | 00:46h | UTCTympanostomy tubes for children with acute otitis media – Canadian Family Physician
Study Commentary | Antibiotics for pediatric pneumonia: might less be enough?
17 May, 2022 | 10:39h | UTCAntibiotics for Pediatric Pneumonia: Might Less Be Enough? – Annals of Emergency Medicine
Related:
Treatment of UTIs in Infants <2 Months: A Living Systematic Review – Hospital Pediatrics
Test-negative, case-control study: Association of prior BNT162b2 COVID-19 vaccination with symptomatic SARS-CoV-2 infection in children and adolescents during Omicron predominance.
16 May, 2022 | 02:25h | UTCEditorial: Protecting Children Against Omicron – JAMA
Commentary on Twitter (thread – click for more)
This new JAMA study is worth discussing. It found that, this winter, vax effectiveness in 12-15 yos dropped to 0% after 3-5 months & vaccinated were MORE likely to test+ at month 7. May be confounded (see?)
But I don't see this as good reason for boostershttps://t.co/zpkIDdZhnn pic.twitter.com/bxAIDmiR8s— Tracy Høeg, MD, PhD (@TracyBethHoeg) May 14, 2022
Hypotheses | Severe acute hepatitis in children: investigate SARS-CoV-2 superantigens.
16 May, 2022 | 02:22h | UTCRelated:
Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC
Hepatitis outbreak in children: What do we know so far? – Imperial College London
Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Commentary on Twitter
A solid hypothesis for the basis of the mysterious, severe acute hepatitis in children: superantigen formation from prior Covid viral reservoir in the GI tract with superimposed adenovirus infection https://t.co/1eehyQmlhi @LancetGastroHep pic.twitter.com/UqCAh3igMH
— Eric Topol (@EricTopol) May 14, 2022
Explaining the unexplained hepatitis in children.
13 May, 2022 | 11:39h | UTCExplaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Related:
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
RCT: Evaluation of mRNA-1273 Covid-19 vaccine in children 6 to 11 years of age.
12 May, 2022 | 10:22h | UTC
Commentary on Twitter
Two 50-μg doses of mRNA-1273 vaccine were found to be safe and effective in inducing immune responses and preventing Covid-19 in children 6 to 11 years of age. https://t.co/A5SBK4zK6E pic.twitter.com/7x4JgOwK57
— NEJM (@NEJM) May 11, 2022
Epidemiological update: Hepatitis of unknown etiology in children.
12 May, 2022 | 10:12h | UTCRelated:
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Commentary on Twitter (thread – click for more)
Update: #Hepatitis of unknown aetiology in children – 11 May 2022
Approximately 106 cases have been identified in 14 EU/EEA countries and 450 cases are reported worldwide.
The cause of the disease is still under investigation.
Read more: https://t.co/B0lLm7I0dV— ECDC Outbreaks (@ECDC_Outbreaks) May 11, 2022
Group B streptococcus infection during pregnancy and infancy: estimates of regional and global burden.
12 May, 2022 | 10:03h | UTCInvited Commentary: Variation of invasive neonatal GBS disease across the regions – The Lancet Global Health
Commentary on Twitter
Group B #streptococcus (GBS) colonisation during #pregnancy can lead to invasive GBS disease (iGBS) in #infants, including #meningitis or sepsis with a high mortality risk. There is a higher burden of iGBS than previously estimatedhttps://t.co/jr8zNS7Lak@LancetGH pic.twitter.com/XBsImwD13H
— The Lancet Reg Health-Southeast Asia (@LancetRH_SEAsia) May 5, 2022
M-A: Interventions for neglected tropical diseases among children and adolescents.
11 May, 2022 | 10:44h | UTC
M-A: Interventions to improve immunization coverage among children and adolescents.
11 May, 2022 | 10:45h | UTC
Technical briefing 2: Investigation into acute hepatitis of unknown etiology in children in England.
9 May, 2022 | 02:18h | UTCRelated: With usual suspects ruled out, disease detectives try to crack mystery of viral hepatitis cases in kids (several updates on the subject)
Summary on Twitter (thread – click for more)
NEW: @UKHSA Technical Briefing 2 on Paediatric acute hepatitis in England
A ? ⤵️https://t.co/E9MvVTK505 pic.twitter.com/YZCHdCdt4U
— ?? Meaghan Kall (@kallmemeg) May 6, 2022
Diagnostic stewardship tied to fewer blood cultures, antibiotics in sick kids.
9 May, 2022 | 01:23h | UTCCommentary: Diagnostic stewardship tied to fewer blood cultures, antibiotics in sick kids – CIDRAP
Commentary on Twitter
Results from the Bright STAR collaborative: Multi-center diagnostic stewardship found blood cultures in the PICU safely reduced overtesting and broad-spectrum antibiotic use. https://t.co/523QlbOLL2 @BrightSTAR_QI @HopkinsKids @ChildrensPhila #PICUtwitter
— JAMA Pediatrics (@JAMAPediatrics) May 2, 2022
Podcast: Appendicitis Pearls.
9 May, 2022 | 01:15h | UTC#49: Appendicitis – Tips and Tricks For When It’s the Appendix – The Cribsiders
M-A: Interventions for high-burden infectious diseases in children and adolescents.
9 May, 2022 | 01:12h | UTC