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Pediatrics – Infectious Diseases

Commentary on the Latest AAP Guidelines for the Febrile Neonate.

5 Aug, 2021 | 08:36h | UTC

Small Talk – Hot Off The Presses: The Latest AAP Guidelines for the Febrile Neonate – emDocs

Original guideline:

AAP Guideline: Evaluation and management of well-appearing febrile infants 8 to 60 days old.

Related:

M-A: Low prevalence of bacterial meningitis among well-appearing febrile infants aged 29-60 days with positive urinalysis results – “These results suggest that for these infants, the decision to use lumbar puncture should not be guided by urinalysis results alone”.

Things We Do for No Reason: Lumbar Punctures in Low-Risk Febrile Infants with Bronchiolitis

[Abstract Only] Observational Study Suggests Testing for Meningitis May Not be Necessary for Febrile Well-Appearing Young Infants with Positive Urinalysis

Study: Clinical Prediction Rule to Identify Febrile Infants at Low Risk for Serious Bacterial Infections

Cohort Study: Accuracy of Complete Blood Cell Counts to Identify Febrile Infants 60 Days or Younger With Invasive Bacterial Infections

 


Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

4 Aug, 2021 | 10:06h | UTC

Illness duration and symptom profile in symptomatic UK school-aged children tested for SARS-CoV-2 – The Lancet Child & Adolescent Health

Invited commentary: Citizen science and biomedical research (free registration required)

Commentaries:

Expert reaction to study looking at long-lasting symptoms from COVID-19 in children – Science Media Centre

Long Covid uncommon in children, analysis finds – King’s College London

Study finds long-term Covid symptoms rare in school-age children – The Guardian

Most children with Covid-19 recover within a week, but a small percentage have long-term symptoms, a study says. – The New York Times

Related:

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Cohort study: Risk factors for long covid in previously hospitalized children.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

 

Commentary on Twitter

 


AAP Interim guidance on supporting the emotional and behavioral health needs of children, adolescents, and families during the COVID-19 pandemic.

4 Aug, 2021 | 10:03h | UTC

Interim Guidance on Supporting the Emotional and Behavioral Health Needs of Children, Adolescents, and Families During the COVID-19 Pandemic – American Academy of Pediatrics

 


AAP Guidance: Post-COVID-19 conditions in children and adolescents.

4 Aug, 2021 | 10:01h | UTC

Post-COVID-19 Conditions in Children and Adolescents – American Academy of Pediatrics

 


Cohort study: Six month follow-up of Multisystem Inflammatory Syndrome in Children.

3 Aug, 2021 | 09:05h | UTC

Six Month Follow-up of Patients With Multisystem Inflammatory Syndrome in Children – Pediatrics (PDF)

 


Cohort study: Risk factors for long covid in previously hospitalized children.

3 Aug, 2021 | 09:06h | UTC

Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study – European Respiratory Review

Commentaries:

Study investigates long-term sequelae of COVID-19 in hospitalized children – News Medical

 

Commentary on Twitter

 


Opinion | Should pregnant women have a COVID vaccine? The evidence says it’s safe and effective.

2 Aug, 2021 | 00:28h | UTC

Should pregnant women have a COVID vaccine? The evidence says it’s safe and effective – The Conversation

 


ACOG and SMFM Recommend COVID-19 Vaccination for Pregnant Individuals – “ACOG encourages its members to enthusiastically recommend vaccination to their patients.”

2 Aug, 2021 | 00:31h | UTC

ACOG and SMFM Recommend COVID-19 Vaccination for Pregnant Individuals – American College of Obstetricians and Gynecologists (ACOG) and the Society for Maternal-Fetal Medicine (SMFM)

Additional reading:

Practice Advisory: COVID-19 Vaccination Considerations for Obstetric-Gynecologic Care

COVID-19 Vaccines and Pregnancy: Conversation Guide for Clinicians

Commentaries:

Obstetrician groups recommend COVID vaccine during pregnancy – Associated Press

Statements By Obstetrics Societies Strongly Advise Covid-19 Vaccinations For Pregnant Women – Forbes

 

Commentary on Twitter

 


RCT: Among pregnant women with primary CMV infection diagnosed before 24 weeks’ gestation, monthly infusion of CMV hyperimmune globulin did not prevent congenital cytomegalovirus infection.

30 Jul, 2021 | 11:42h | UTC

A Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus Infection – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Hyperimmune Globulin Fails to Prevent Congenital CMV – Physician’s Weekly

 


Household transmission of SARS-CoV-2 from children and adolescents.

28 Jul, 2021 | 10:08h | UTC

Household Transmission of SARS-CoV-2 from Children and Adolescents – New England Journal of Medicine

Related:

Effect of Vaccination on Household Transmission of SARS-CoV-2 in England – “the likelihood of household transmission was approximately 40 to 50% lower in households of index patients who had been vaccinated 21 days or more before testing positive than in households of unvaccinated index patients”.

Covid-19 vaccination prevents transmission from vaccinated to unvaccinated household members.

Study in England showed one dose of COVID-19 vaccine can cut household transmission by up to half – This protection is on top of the reduced risk of a vaccinated person developing symptomatic infection, which is around 60 to 65% after the first dose

Study: Household transmission of SARS-CoV-2 and risk factors for susceptibility and infectivity

A meta-analysis on the role of children in SARS-CoV-2 in household transmission clusters

Report: SARS-CoV-2 setting-specific transmission rates. Households showed the highest transmission rates (21.1%). Asymptomatic infections do occur but much less efficiently than symptomatic infection.

CDC Report: Transmission of SARS-COV-2 infections in households

The household secondary attack rate of SARS-CoV-2: A rapid review

 

Commentary on Twitter

 


Cohort study: Neurological manifestations of SARS-CoV-2 infection in hospitalized children and adolescents in the UK – “around 1 in 20 of children hospitalized with COVID-19 develop brain or nerve complications linked to the viral infection”.

26 Jul, 2021 | 02:58h | UTC

Neurological manifestations of SARS-CoV-2 infection in hospitalised children and adolescents in the UK: a prospective national cohort study – The Lancet Child & Adolescent Health

Commentaries:

Neuroinflammation triggered by SARS-CoV-2 infection: syndromes and therapies – The Lancet Child & Adolescent Health

New UK study reveals extent of brain complications in children hospitalized with COVID-19 – University of Liverpool

 

Commentary on Twitter

 


Should children get COVID vaccines? What the science says.

22 Jul, 2021 | 11:06h | UTC

Should children get COVID vaccines? What the science says – Nature

 


Opinion | The benefits of a COVID vaccine far outweigh the small risk of treatable heart inflammation.

22 Jul, 2021 | 10:57h | UTC

The benefits of a COVID vaccine far outweigh the small risk of treatable heart inflammation – The Conversation

 


Analysis finds benefits of COVID-19 vaccination outweigh risks of rare cases of myocarditis.

22 Jul, 2021 | 11:05h | UTC

News release: Study finds benefits of COVID-19 vaccination outweigh risks of rare cases of myocarditis – American Heart Association

Original study: Myocarditis with COVID-19 mRNA Vaccines – Circulation

Commentary: Myocarditis and COVID-19 Vaccines: New Review Tackles Knowns, Unknowns – TCTMD

 

Commentary on Twitter

 


WHO Guidelines for the management of symptomatic sexually transmitted infections.

22 Jul, 2021 | 10:54h | UTC

Guidelines for the management of symptomatic sexually transmitted infections – World Health Organization

News release: Launch WHO guidelines for the management of symptomatic sexually transmitted infection – World Health Organization

 

Commentary on Twitter

 


Opinion | Kids aren’t just littler adults – here’s why they need their own clinical trials for a COVID-19 vaccine.

22 Jul, 2021 | 10:55h | UTC

Kids aren’t just littler adults – here’s why they need their own clinical trials for a COVID-19 vaccine – The Conversation

 


WHO and UNICEF warn of a decline in vaccinations during COVID-19.

20 Jul, 2021 | 10:27h | UTC

WHO and UNICEF warn of a decline in vaccinations during COVID-19 – World Health Organization

See also: COVID-19 pandemic leads to major backsliding on childhood vaccinations, new WHO, UNICEF data shows – World Health Organization

Related: Millions of children worldwide missed routine vaccinations during the pandemic, study suggests.

 


Experts recommend Covid jabs for some under-18s in UK – “advice is that 16 to 18-year-olds can be offered a Pfizer jab if they are in a priority group or live with someone who has a weakened immune system”.

20 Jul, 2021 | 10:15h | UTC

Commentaries: Experts recommend Covid jabs for some under-18s in UK – BBC

See report: JCVI statement on COVID-19 vaccination of children and young people aged 12 to 17 years: 15 July 2021 – Joint Committee on Vaccination and Immunisation

 


AAP Guideline: Evaluation and management of well-appearing febrile infants 8 to 60 days old.

20 Jul, 2021 | 10:14h | UTC

Evaluation and Management of Well-Appearing Febrile Infants 8 to 60 Days Old – Pediatrics

News Release: AAP releases clinical practice guideline on well-appearing febrile infants – AAP News

 


Measuring routine childhood vaccination coverage in 204 countries and territories, 1980–2019: a systematic analysis for the Global Burden of Disease Study 2020.

20 Jul, 2021 | 10:04h | UTC

Measuring routine childhood vaccination coverage in 204 countries and territories, 1980–2019: a systematic analysis for the Global Burden of Disease Study 2020, Release 1 – The Lancet

Related: Millions of children worldwide missed routine vaccinations during the pandemic, study suggests.

 


Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

16 Jul, 2021 | 11:06h | UTC

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – JAMA

 


Deaths from COVID ‘incredibly rare’ among children.

16 Jul, 2021 | 10:58h | UTC

Deaths from COVID ‘incredibly rare’ among children – Nature

Related: [Preprint] Study confirms children’s extremely low risk of death from Covid-19 – “99·995% of children and young people with a positive SARS-CoV-2 test survived”.

 


Long COVID and kids: scientists race to find answers – “Children get long COVID too, but researchers are still working to determine how frequently and how severely”.

15 Jul, 2021 | 09:23h | UTC

Long COVID and kids: scientists race to find answers – Nature

 


Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.

14 Jul, 2021 | 11:20h | UTC

Between BNT162b2 Vaccination and Incidence of SARS-CoV-2 Infection in Pregnant Women – JAMA

Commentary: Pfizer COVID vaccine shows 78% efficacy in pregnancy – CIDRAP

 


New Zealand children falling ill in high numbers due to Covid ‘immunity debt’.

14 Jul, 2021 | 11:16h | UTC

New Zealand children falling ill in high numbers due to Covid ‘immunity debt’ – The Guardian

Related: New Zealand, where Covid-19 is dormant, fights another respiratory virus – The New York Times


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