Pediatrics – Infectious Diseases
CDC: mRNA vaccines are likely linked to cases of myocarditis and pericarditis – 1,226 cases of myocarditis or pericarditis have been reported mostly in people under 30.
24 Jun, 2021 | 09:51h | UTCSee also: Experts: mRNA COVID-19 vaccines likely tied to heart inflammation – CIDRAP
Related: Case series: 7 cases of myocarditis following mRNA-based COVID-19 vaccination. AND Case series: clinical and cardiac magnetic resonance imaging findings of 4 cases of myocarditis following mRNA-based COVID-19 vaccination. AND Case series: symptomatic acute myocarditis in 7 adolescents following mRNA COVID-19 vaccination. AND CDC says heart inflammation cases were higher than expected in 16- to 24-year-olds after second Covid vaccine shot, but still rare. AND Israel reports link between rare cases of heart inflammation and COVID-19 vaccination in young men. AND CDC is investigating several reports that teenagers and young adults may have developed myocarditis after receiving mRNA vaccines. Most cases were mild, more often in males than females, more often following dose 2 than dose 1, and typically, within 4 days after vaccination.
Audio Interview: potential treatments for children with Multisystem Inflammatory Syndrome (MIS-C) associated with Covid-19.
18 Jun, 2021 | 08:33h | UTCAudio Interview: Covid-19 in Children – New England Journal of Medicine
Symptomatic fever management in children: A systematic review of national and international guidelines.
21 Jun, 2021 | 08:28h | UTC
Cohort study: Among children with Multisystem Inflammatory Syndrome (MIS-C) associated with Covid-19, initial treatment with intravenous immune globulin (IVIG) plus glucocorticoids was associated with a lower risk of new or persistent cardiovascular dysfunction than IVIG alone.
18 Jun, 2021 | 08:35h | UTCEditorial: Immunotherapy for MIS-C — IVIG, Glucocorticoids, and Biologics
Cohort study: Among children with Multisystem Inflammatory Syndrome (MIS-C) associated with Covid-19, there was no evidence that recovery differed after primary treatment with intravenous immune globulin (IVIG) alone, IVIG plus glucocorticoids, or glucocorticoids alone.
18 Jun, 2021 | 08:36h | UTCTreatment of Multisystem Inflammatory Syndrome in Children – New England Journal of Medicine
Editorial: Immunotherapy for MIS-C — IVIG, Glucocorticoids, and Biologics
Commentaries: Steroids may be effective treatment for COVID-19 complications in children – Imperial College London AND Expert reaction to study looking at treatments for COVID-19 complications in children – Science Media Centre
Case series: clinical and cardiac magnetic resonance imaging findings of 4 cases of myocarditis following mRNA-based COVID-19 vaccination.
17 Jun, 2021 | 09:43h | UTCCommentary: Possible Association Between COVID-19 Vaccine and Myocarditis – American College of Cardiology
Related: CDC says heart inflammation cases were higher than expected in 16- to 24-year-olds after second Covid vaccine shot, but still rare. AND Israel reports link between rare cases of heart inflammation and COVID-19 vaccination in young men. AND CDC is investigating several reports that teenagers and young adults may have developed myocarditis after receiving mRNA vaccines. Most cases were mild, more often in males than females, more often following dose 2 than dose 1, and typically, within 4 days after vaccination.
Case series: 7 cases of myocarditis following mRNA-based COVID-19 vaccination.
17 Jun, 2021 | 09:45h | UTCMyocarditis after BNT162b2 and mRNA-1273 Vaccination – Circulation
Related: CDC says heart inflammation cases were higher than expected in 16- to 24-year-olds after second Covid vaccine shot, but still rare. AND Israel reports link between rare cases of heart inflammation and COVID-19 vaccination in young men. AND CDC is investigating several reports that teenagers and young adults may have developed myocarditis after receiving mRNA vaccines. Most cases were mild, more often in males than females, more often following dose 2 than dose 1, and typically, within 4 days after vaccination.
Case series: symptomatic acute myocarditis in 7 adolescents following mRNA COVID-19 vaccination.
17 Jun, 2021 | 09:41h | UTCRelated: CDC says heart inflammation cases were higher than expected in 16- to 24-year-olds after second Covid vaccine shot, but still rare. AND Israel reports link between rare cases of heart inflammation and COVID-19 vaccination in young men. AND CDC is investigating several reports that teenagers and young adults may have developed myocarditis after receiving mRNA vaccines. Most cases were mild, more often in males than females, more often following dose 2 than dose 1, and typically, within 4 days after vaccination.
Cohort study showed that the incidence of Multisystem Inflammatory Syndrome in Children (MIS-C) was 316 persons per 1 000 000 SARS-CoV-2 infections in persons younger than 21 years. The incidence was higher among Black, Hispanic or Latino, and Asian or Pacific Islander persons.
14 Jun, 2021 | 08:48h | UTCCommentary: MIS-C Incidence 316 Persons Per 1 Million SARS-CoV-2 Infections – HealthDay
Commentary on Twitter
About 1 in every 3,000 children who got COVID ended up with MIS-C. MIS-C incidence among Black persons and Hispanic or Latino persons was approximately 9x higher, and incidence among Asian or Pacific Islander persons was approximately 3x higher https://t.co/JTEsvgvFcz
— Daniel Griffin MD PhD (@DanielGriffinMD) June 12, 2021
Children with symptomatic SARS-CoV-2 infection have similar viral loads and may be as contagious as symptomatic adults.
14 Jun, 2021 | 08:49h | UTCEditorial: Implications of SARS-CoV-2 Viral Load in Children: Getting Back to School and Normal
Commentary on Twitter (thread – click for more)
In a new study in @JAMAPediatrics, we compared symptoms and viral load in children and adults with SARS-CoV-2. Those with symptoms had higher virus loads than those without. Importantly, within these groups – viral load was the same in children and adults. https://t.co/UgaFzvMNlg pic.twitter.com/cjpt2yqQ3R
— Helen Chu (@HelenChuMD) June 11, 2021
CDC says heart inflammation cases were higher than expected in 16- to 24-year-olds after second Covid vaccine shot, but still rare.
11 Jun, 2021 | 08:28h | UTCSee also: CDC plans “emergency meeting” on rare heart inflammation following COVID-19 vaccines – CBC News
Related: Israel reports link between rare cases of heart inflammation and COVID-19 vaccination in young men.
China to offer COVID-19 vaccine to children as young as three.
9 Jun, 2021 | 08:26h | UTCChina to offer COVID-19 vaccine to children as young as three – MedicalXpress
See also: Sinovac says its vaccine is safe for children as young as 3 – Associated Press
In youth, COVID-19 causes more complications than flu; fatality is rare.
9 Jun, 2021 | 08:23h | UTCOriginal study: 30-Day Outcomes of Children and Adolescents With COVID-19: An International Experience – Pediatrics
Underlying medical conditions associated with severe COVID-19 illness among children – the strongest risk factors for hospitalization were chronic and complex chronic diseases, type 1 diabetes, and obesity.
8 Jun, 2021 | 09:37h | UTCCommentaries: Underlying illness, respiratory infection raise risk for severe COVID in kids – CIDRAP AND COVID-19 in Children—Not Just Little Adults – JAMA Network Open
Commentary on Twitter
This cross-sectional study found a higher risk of severe #COVID19 illness among children with medical complexity and certain underlying conditions, such as type 1 diabetes, cardiac and circulatory congenital anomalies, and obesity. https://t.co/ifq1Ao0HKS
— JAMA Network Open (@JAMANetworkOpen) June 7, 2021
WHO: Vaccinating kids ‘not a high priority’ amid shortage
4 Jun, 2021 | 10:31h | UTCWHO: Vaccinating kids ‘not a high priority’ amid shortage – Associated Press
Related: WHO: Wealthy nations urged to delay youth Covid vaccines, donate to solidarity scheme AND Editorial: Vaccinating children against SARS-CoV-2 – “Hard to justify right now for most children in most countries”. AND Opinion | American Kids Can Wait – “The U.S. should delay shots for children until global vaccine-manufacturing capacity significantly expands and the crisis in India subsides”. AND Vaccinating children before poor morally wrong, Oxford scientist says – BBC
Cohort study showed good recovery for most children 6 months after Pediatric Inflammatory Multisystem Syndrome (PIMS-TS) associated with SARS-CoV-2.
3 Jun, 2021 | 11:06h | UTCCommentary: Most severe effects of MIS-C in children typically resolve within six months, new research suggests – CNN AND Children who developed a rare inflammation disease after COVID-19 are mostly better after 6 months, but some still suffer fatigue and anxiety, a small UK study found – Insider AND Most severe effects of PIMS-TS resolved at six months – HealthDay
Commentary on Twitter
New Research—A study of 46 patients with #PIMSTS found that most symptoms were resolved after 6 months, but fatigue, difficulty exercising, and emotional difficulties persisted in some childrenhttps://t.co/mHz3D8a11d #COVID19 @GreatOrmondSt @KarynMoshal pic.twitter.com/PJCxGGmJNo
— The Lancet Child & Adolescent Health (@LancetChildAdol) May 24, 2021
Israel reports link between rare cases of heart inflammation and COVID-19 vaccination in young men.
2 Jun, 2021 | 08:37h | UTCIsrael reports link between rare cases of heart inflammation and COVID-19 vaccination in young men – Science (a few articles per month are free)
Commentary on Twitter
?Paging @CDCgov and @US_FDA
“In a report submitted today to the Israeli Ministry of Health, they conclude that between one in 3000 and one in 6000 men ages 16 to 24 who received the vaccine developed the rare condition.” https://t.co/aoz2rkgdwO
— Ramin Farzaneh-Far MD (@rfsquared) June 1, 2021
RCT: Among children with protracted bacterial bronchitis, a 4-week course of amoxicillin–clavulanate is not better than a 2-week course in achieving clinical cure by 28 days.
31 May, 2021 | 08:02h | UTCCommentary: Four weeks of antibiotics for kids’ chronic cough no better than 2, study finds – CIDRAP
Commentary on Twitter
NEW Research—4 weeks of amoxicillin–clavulanate for children with chronic wet cough and suspected PBB confers little advantage vs 2 weeks in achieving clinical cure by 28 days
RCT from Tom Ruffles & colleagues https://t.co/77w08dZ20z pic.twitter.com/LYgOeJbDX8
— The Lancet Respiratory Medicine (@LancetRespirMed) May 26, 2021
RCT: Pfizer-BioNTech Covid-19 vaccine shows 100% efficacy in adolescents – mainly transient mild-to-moderate reactogenicity was frequently observed, such as injection-site pain (in 79 to 86% of participants), fatigue (in 60 to 66%), and headache (in 55 to 65%).
28 May, 2021 | 08:24h | UTC
Commentary on Twitter
The 12-15 year-olds mRNA vaccine randomized, placebo-controlled clinical trial is published @NEJM today [@BioNTech_Group/@Pfizer]https://t.co/7GlgC9xdd0
—100% efficacy (95% CI 75,100)
—1.8 X higher levels of neutralizing antibodies than 16-25 yr olds
—very good safety profile pic.twitter.com/hQzkpuA5Nu— Eric Topol (@EricTopol) May 27, 2021
Moderna says its Covid vaccine is 100% effective in teens, plans to seek FDA OK in early June.
27 May, 2021 | 08:25h | UTCModerna says its Covid vaccine is 100% effective in teens, plans to seek FDA OK in early June – CNBC
Commentary on Twitter
BREAKING: Moderna study of more than 3,700 12- to 17-year olds found 100% effficacy in those who received 2-dose #covid19 #vaccine, no significant safety problems. Will apply for FDA authorization.https://t.co/l0MHiLjCcA
— Leana Wen, M.D. (@DrLeanaWen) May 25, 2021
CDC is investigating several reports that teenagers and young adults may have developed myocarditis after receiving mRNA vaccines. Most cases were mild, more often in males than females, more often following dose 2 than dose 1, and typically, within 4 days after vaccination.
24 May, 2021 | 08:41h | UTCCommentaries: C.D.C. Is Investigating a Heart Problem in a Few Young Vaccine Recipients – The New York Times AND U.S. CDC looking into heart inflammation in some young vaccine recipients – Reuters
Related: Israel said probing link between Pfizer shot and heart problem in men under 30 – The Times of Israel
M-A: Low prevalence of bacterial meningitis among well-appearing febrile infants aged 29-60 days with positive urinalysis results – “These results suggest that for these infants, the decision to use lumbar puncture should not be guided by urinalysis results alone”.
21 May, 2021 | 08:24h | UTC
Commentary on Twitter
This metanalysis found positive urinalysis alone is not an indication for LP in well looking febrile infants >28 days old. Prevalence among UA-positive infants: 0.4% vs UA-negative infants: 0.5%. https://t.co/dTzCiLHrSg
— JAMA Network Open (@JAMANetworkOpen) May 12, 2021
Cohort study: Babies surviving Group B strep more likely to require special educational support.
21 May, 2021 | 08:27h | UTC
Opinion | Vaccinating children before poor morally wrong, Oxford scientist says.
19 May, 2021 | 08:44h | UTCVaccinating children before poor morally wrong, Oxford scientist says – BBC
Related: WHO: Wealthy nations urged to delay youth Covid vaccines, donate to solidarity scheme AND Editorial: Vaccinating children against SARS-CoV-2 – “Hard to justify right now for most children in most countries”. AND Opinion | American Kids Can Wait – “The U.S. should delay shots for children until global vaccine-manufacturing capacity significantly expands and the crisis in India subsides”.
Cohort study of 12,306 pediatric COVID-19 patients finds only 16.5% presented with typical respiratory symptoms (cough, dyspnea). 13.9% had GI symptoms, 8.1% had dermatological symptoms (rash), 4.8% had neurological (headache), and 18.8% had other non-specific symptoms (fever, malaise, myalgia, arthralgia and disturbances of smell or taste).
14 May, 2021 | 08:48h | UTCCommentary: COVID-19: Majority of infected children may not show typical symptoms – Nature Publishing Group
Commentary on Twitter
A retrospective cohort study of 12,306 pediatric COVID-19 patients
?5% require hospitalization
?18% of these require critical care
?4% of these require ventilation
https://t.co/X6MTdS8D1i— Rick MaskDonald MD ?♂️??? (@Kidsdoc1Rick) May 13, 2021