Pediatrics – Critical Care & Emergencies | Page 8 of 12 | Links Medicus Content Curation & Alerts in Medicine

RCT: Among premature infants with a gestational age of less than 30 weeks and intubated for at least 7 days at 14 to 28 days, hydrocortisone did not improve survival without bronchopulmonary dysplasia.

24 Mar, 2022 | 09:58h | UTC

Hydrocortisone to Improve Survival without Bronchopulmonary Dysplasia – New England Journal of Medicine (link to abstract – $ for full-text)

Rapid point-of-care genotyping to avoid aminoglycoside-induced ototoxicity in neonatal intensive care.

22 Mar, 2022 | 08:01h | UTC

Rapid Point-of-Care Genotyping to Avoid Aminoglycoside-Induced Ototoxicity in Neonatal Intensive Care – JAMA Pediatrics

Editorial: Genetic Testing in Newborns Moves From Rare to Routine Application

Commentary on Twitter

The MT-RNR1 m.1555A>G variant predisposes to profound aminoglycoside-induced ototoxicity
The MT-RNR1 POCT was able to genotype the m.1555A>G variant in 26 minutes. #IDTwitter #medtwitter #TwitteRx #MedEd #PIDTwitter https://t.co/BbkpNMiNHN

— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) March 21, 2022

RCT: Nebulized Poractant Alfa in premature babies with respiratory distress syndrome.

21 Mar, 2022 | 08:25h | UTC

A Randomized, Controlled Trial to Investigate the Efficacy of Nebulized Poractant Alfa in Premature Babies with Respiratory Distress Syndrome – The Journal of Pediatrics

Commentary: Should we give up on nebulised surfactant? – Neonatal Research

Commentary on Twitter

The CURONEB RCT by Dani et al. in @JPediatr stopped early, but showed that nebulised poractant alfa is safe but does not reduce respiratory failure within 72 hours in 28-33 weekers https://t.co/gW57rPTd4f #FOAMneo #EBNEOalerts #neoEBM #neotwitter pic.twitter.com/G5Cii33fRD

— Evidence-Based Neo (@EBNEO) March 8, 2022

How to: Clostridioides difficile infection in children.

16 Mar, 2022 | 08:39h | UTC

How to: Clostridioides difficile infection in children – Clinical Microbiology and Infection

Observational Study: Comparison of intracranial pressure measurements before and after hypertonic saline or mannitol treatment in children with severe traumatic brain injury.

14 Mar, 2022 | 00:51h | UTC

Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury – JAMA Network Open

Invited Commentary: ADAPTing to a New Era of Comparative Effectiveness Research in Traumatic Brain Injury—Generating Evidence From Observational Data – JAMA Network Open

Commentary on Twitter

For children with severe TBI, hypertonic saline is recommended in published guidelines. However, mannitol is in wide-spread clinical use. In this comparative effectiveness, hypertonic saline was associated with improved ICP compared to mannitol. https://t.co/7JW224Dbio

— JAMA Network Open (@JAMANetworkOpen) March 10, 2022

RCT: In pediatric ICUs, a bundled intervention that emphasized a physiologically focused cardiopulmonary resuscitation training did not improve outcomes in cardiac arrest.

11 Mar, 2022 | 09:37h | UTC

Effect of Physiologic Point-of-Care Cardiopulmonary Resuscitation Training on Survival With Favorable Neurologic Outcome in Cardiac Arrest in Pediatric ICUs: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentary: CPR Intervention Failed to Improve Survival in Kids With Cardiac Arrest — Physiologically focused CPR training did not lead to difference in survival to discharge – MedPage Today (free registration required)

Commentary on Twitter

Among patients in pediatric ICUs, a bundled intervention that emphasized physiologically focused CPR training and structured clinical event debriefing did not significantly improve patient survival to hospital discharge with favorable neurologic outcome. https://t.co/MbmmSM0Xrt

— JAMA (@JAMA_current) March 8, 2022

Extending the reach of antimicrobial stewardship to pediatric patients.

10 Mar, 2022 | 10:12h | UTC

Extending the Reach of Antimicrobial Stewardship to Pediatric Patients – Infectious Diseases and Therapy

Association of acute respiratory failure in early childhood with long-term neurocognitive outcomes.

9 Mar, 2022 | 08:41h | UTC

Association of Acute Respiratory Failure in Early Childhood With Long-term Neurocognitive Outcomes – JAMA (link to abstract – $ for full-text)

Commentaries:

IQ Lower for Survivors of PICU Respiratory Failure Hospitalization – HealthDay

Investigating The Effects of Critical Illness in Early Childhood On Neurocognitive Outcomes – University of Pennsylvania School of Nursing

FDA issues warning after 2 children strangled by enteral feeding set tubing.

8 Mar, 2022 | 08:33h | UTC

FDA issues warning after 2 children strangled by enteral feeding set tubing – AAP News

Original Report: Potential Risk of Strangulation in Children who Use Enteral Feeding Delivery Sets – U.S. Food & Drug Administration

Risk factors for PICU admission and death among children and young people hospitalized with COVID-19 and PIMS-TS in England during the first pandemic year.

17 Feb, 2022 | 09:58h | UTC

Risk factors for PICU admission and death among children and young people hospitalized with COVID-19 and PIMS-TS in England during the first pandemic year – Nature Medicine

Commentary: Studies detail risk of severe COVID-19, GI problems in kids – CIDRAP

Commentary on Twitter

The risk of intensive care unit admission among children with COVID-19 is affected by age, ethnicity and comorbidities, according to a @NatureMedicine paper. Understanding these modifiers might help identify at-risk children and guide interventions. https://t.co/MIkLecyNI6 pic.twitter.com/JtN3Ab4Lu7

— Nature Portfolio (@NaturePortfolio) December 20, 2021

ACR Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS–CoV-2 and Hyperinflammation in Pediatric COVID-19.

15 Feb, 2022 | 10:17h | UTC

American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS–CoV-2 and Hyperinflammation in Pediatric COVID-19: Version 3 – Arthritis & Rheumatism

Commentary and summary: ACR Updates Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With COVID – RheumNow

Study identifies risk factors for severe CoviD-19 in children.

15 Feb, 2022 | 10:01h | UTC

Risk Factors for Severe COVID-19 in Children – Pediatrics

2022 SCCM Guidelines on prevention and management of pain, agitation, neuromuscular blockade, and delirium in critically ill pediatric patients with consideration of the ICU environment and early mobility.

13 Feb, 2022 | 22:19h | UTC

2022 Society of Critical Care Medicine Clinical Practice Guidelines on Prevention and Management of Pain, Agitation, Neuromuscular Blockade, and Delirium in Critically Ill Pediatric Patients With Consideration of the ICU Environment and Early Mobility – Pediatric Critical Care Medicine

Commentary on Twitter

New in #PANDEM guidelines for infants & children: guidance on nonpharmacological interventions that can lead to better outcomes:
✅ Music
✅ Physical
✅ Occupational
✅ Child life
What interventions have worked well for you?
Guidelines: https://t.co/lMfFsiEPeV #SCCMSoMe #PedsICU pic.twitter.com/BLksVV0pNo

— SCCM (@SCCM) February 4, 2022

Criteria for Pediatric Sepsis—A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce.

8 Feb, 2022 | 08:40h | UTC

Criteria for Pediatric Sepsis—A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce – Critical Care Medicine

Commentary on Twitter

#OpenAccess #FreeArticle

Menon et al: Peds sepsis criteria
👨🏾‍💻data validation
👨‍👩‍👧‍👦 #PedsICU #Sepsis Definition Taskforce

📚Sys Rev & MA
🔖106 studies, 81 in MA

Link: https://t.co/0CdRgwMPcA #CritCareMed @SCCM

Fig: Pooled Mortality rates pic.twitter.com/QcfwmFUylS

— Critical Care Medicine (@CritCareMed) January 1, 2022

In mechanically ventilated pediatric patients, an observational study showed hospitals varied widely in their use of endotracheal aspirates cultures, and higher rates were correlated with increased antibiotic use.

3 Feb, 2022 | 08:19h | UTC

Association of Endotracheal Aspirate Culture Variability and Antibiotic Use in Mechanically Ventilated Pediatric Patients – JAMA Network Open

Commentary from the author on Twitter (thread – click for more)

https://twitter.com/andreaprinzi/status/1476627285490864128

Systematic Review: Short intravenous antibiotic courses for urinary infections in young infants.

26 Jan, 2022 | 01:24h | UTC

Short Intravenous Antibiotic Courses for Urinary Infections in Young Infants: A Systematic Review – Pediatrics (link to abstract – $ for full-text)

RCT: Lidocaine spray may reduce pain during radial arterial puncture.

21 Jan, 2022 | 09:19h | UTC

Effectiveness of lidocaine spray on radial arterial puncture pain: A randomized double-blind placebo controlled trial – The American Journal of Emergency Medicine (link to abstract – $ for full-text)

Expert consensus for plasma and platelet transfusion practice in critically ill children.

20 Jan, 2022 | 08:44h | UTC

Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative—Control/Avoidance of Bleeding (TAXI-CAB) – Pediatric Critical Care Medicine

RCT: In children with community-acquired pneumonia, outpatient antibiotic therapy for 5 days resulted in similar clinical response rates compared to a standard 10-day strategy.

19 Jan, 2022 | 08:39h | UTC

Short- vs Standard-Course Outpatient Antibiotic Therapy for Community-Acquired Pneumonia in Children: The SCOUT-CAP Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)

Commentaries:

Trial finds 5 days of antibiotics superior to 10 for kids with pneumonia – CIDRAP

Shorter antibiotics treatment is better for young children with outpatient pneumonia – Vanderbilt University Medical Center

ACP Guidance: Appropriate Use of Short-Course Antibiotics in Common Infections

RCT: 5 days of high-dose amoxicillin therapy noninferior to 10 days for the treatment of pediatric community-acquired pneumonia

RCT: Among children with community-acquired pneumonia discharged within 48 hours from the ED or hospital, lower-dose outpatient oral amoxicillin was noninferior to a higher dose, and a 3-day duration course was noninferior to 7 days.

Treatment of urinary tract infections in infants <2 Months: A Living Systematic Review – short and long duration of parenteral antibiotics were associated with a similar risk of UTI recurrence.

RCT: 7 days of antibiotic therapy as good as 14 days for afebrile men with urinary tract infection.

Randomized Trial: Seven vs. Fourteen Days of Antibiotic Therapy for Uncomplicated Gram-negative Bacteremia

Meta-Analysis: Efficacy of Short-Course Antibiotic Treatments for Community-Acquired Pneumonia

Review: Treatment of multisystem inflammatory syndrome (MIS-C) in children and adolescents.

18 Jan, 2022 | 09:46h | UTC

Treatment of MIS-C in Children and Adolescents – Current Pediatrics Reports

Review of 4,470 cases of Multisystem Inflammatory Syndrome in Children in the US.

WHO issues guidelines on the treatment of children with multisystem inflammatory syndrome associated with COVID-19.

An Update on Multisystem Inflammatory Syndrome in Children Related to SARS-CoV-2.

Ten Things to Know About Multisystem Inflammatory Syndrome in Children (MIS-C).

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: An Overview and Comparison.

Cohort study: Six month follow-up of Multisystem Inflammatory Syndrome in Children.

Cohort study: Among children with Multisystem Inflammatory Syndrome (MIS-C) associated with Covid-19, there was no evidence that recovery differed after primary treatment with intravenous immune globulin (IVIG) alone, IVIG plus glucocorticoids, or glucocorticoids alone.

Cohort study: Among children with Multisystem Inflammatory Syndrome (MIS-C) associated with Covid-19, initial treatment with intravenous immune globulin (IVIG) plus glucocorticoids was associated with a lower risk of new or persistent cardiovascular dysfunction than IVIG alone.

Cohort study showed that the incidence of Multisystem Inflammatory Syndrome in Children (MIS-C) was 316 persons per 1 000 000 SARS-CoV-2 infections in persons younger than 21 years. The incidence was higher among Black, Hispanic or Latino, and Asian or Pacific Islander persons.

Cohort study showed good recovery for most children 6 months after Pediatric Inflammatory Multisystem Syndrome (PIMS-TS) associated with SARS-CoV-2.

Epidemiology of Multisystem Inflammatory Syndrome in Children: A Step Closer to Understanding Who, Where, and When

Neurologic involvement in children and adolescents with COVID-19 or Multisystem Inflammatory Syndrome

Clinical Update: Acute covid-19 and multisystem inflammatory syndrome in children

Differences in characteristics and outcomes of children and adolescents with Multisystem Inflammatory Syndrome in Children (MIS-C) vs. severe acute COVID-19

Cutaneous findings in SARS-CoV-2-associated Multisystem Inflammatory Disease in Children (MIS-C)

SR: Multisystem inflammatory syndrome in children related to COVID-19

Observational study: The combination of Immunoglobulins + Methylprednisolone was associated with a better course of fever compared to Immunoglobulins alone in Multisystem Inflammatory Syndrome in children

ACR Guidance for pediatric patients with multisystem inflammatory syndrome in children associated with SARS‐CoV‐2

New systematic review of Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 infection summarizes the clinical features, management, and outcomes of the disease, showing favorable outcomes for the majority of children

RCT: In full-term and near-term neonates, drug treatment of all clinically and electrographically detected seizures was not associated with reduced death rates or disability at 2 years compared with the treatment of only the clinically detected seizures.

13 Jan, 2022 | 08:24h | UTC

Effect of Treatment of Clinical Seizures vs Electrographic Seizures in Full-Term and Near-Term Neonates: A Randomized Clinical Trial – JAMA Network Open

Commentaries:

Should we treat electrographic seizures? – Neonatal Research

Subclinical Electrographic Seizures in the Newborn—Is More Treatment Better? – JAMA Network Open

Neonatal Seizures: Little Difference Between EEG/Clinical Treatment – Physician’s Weekly

Commentary on Twitter

NEST trial in @JAMANetworkOpen by @rodwhunt explores if treatment of EEG + clinical seizures compared with only treating clinical seizures in encephalopathic infants decreased odds of severe disability at 2 years of age. https://t.co/s3yYi6R3fV #EBNEOalerts #neoEBM #neotwitter pic.twitter.com/xoxVKC2a5z

— Evidence-Based Neo (@EBNEO) December 29, 2021