Neurosurgery
Randomized trial: Dexamethasone for chronic subdural hematoma resulted in fewer favorable outcomes and more adverse events than placebo at 6 months
17 Dec, 2020 | 09:02h | UTCTrial of Dexamethasone for Chronic Subdural Hematoma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Dexamethasone should be avoided in patients with chronic subdural haematoma – University of Cambridge AND Dexamethasone for Chronic Subdural Hematoma? – NEJM Journal Watch
Commentary on Twitter
In a trial that compared a 2-week course of dexamethasone with placebo in patients with a chronic subdural hematoma, a favorable outcome on the modified Rankin scale at 6 months was more common in the placebo group than in the dexamethasone group.
— NEJM (@NEJM) December 17, 2020
Review: Perioperative venous thromboembolism prophylaxis
3 Dec, 2020 | 08:28h | UTCPerioperative Venous Thromboembolism Prophylaxis – Mayo Clinic Proceedings
Tranexamic acid after traumatic brain injury: Exploratory analysis combining data from CRASH-2 and CRASH-3 trials suggests reduced mortality
13 Nov, 2020 | 09:21h | UTC
Commentary on Twitter
📊🔍 IPD meta-analysis of #CRASH2 and #CRASH3 trials show rapid #TXA (<3 hrs) reduces early deaths by >20% in both studies
Highly consistent results that #TXA reduces trauma deaths regardless of the location of the #bleeding 🩸
READ @Crit_Care 👉https://t.co/s3vkm6c6Tf pic.twitter.com/og9jYi5tqo
— Clinical Trials Unit – Global Health Trials Group (@CTU_LSHTM) November 11, 2020
Mechanical ventilation in patients with acute brain injury: recommendations of the European Society of Intensive Care Medicine consensus
13 Nov, 2020 | 09:19h | UTC
Review: Management of common postoperative complications
4 Nov, 2020 | 09:26h | UTCManagement of Common Postoperative Complications – Mayo Clinic Proceedings
Meta-analysis: Efficacy and safety of tranexamic acid in acute traumatic brain injury
22 Oct, 2020 | 09:31h | UTC
Commentary on Twitter
Tranexamic acid in acute TBI
➡️ 9 RCTs/14,747 pts
➡️ probably NO effect on mortality or disability
➡️ may decrease hematoma expansion on subsequent imaging (likely of minor importance to pts)
➡️ probably NO increased risk of adverse events#FOAMcc @yourICM https://t.co/sqn80NfNv4 pic.twitter.com/dMf8rYowC2— Intensive Care Medicine (@yourICM) October 21, 2020
Case report: Cerebrospinal fluid leak after nasal swab testing for Covid-19
2 Oct, 2020 | 09:22h | UTC
C0mmentary on Twitter
There’s been a lot of joking about getting a nasopharyngeal swab can be like a brain biopsy. Well, that actually happened https://t.co/kczvr9lIFb @JAMAOto pic.twitter.com/Lio0yV0GkS
— Eric Topol (@EricTopol) October 1, 2020
NICE Guideline: Low back pain and sciatica in over 16s
23 Sep, 2020 | 14:41h | UTC
Randomized trial: Out-of-hospital tranexamic acid does not improve neurologic outcomes in patients with traumatic brain injury
9 Sep, 2020 | 09:20h | UTCEditorial: Out-of-Hospital Tranexamic Acid for Traumatic Brain Injury
Commentary on Twitter
In this phase II RCT prehospital tranexamic acid, which inhibits breakdown of fibrin clot, did not improve neurologic outcomes at 6 months vs placebo in patients with moderate to severe TBI https://t.co/PHK91YYxK3 @SusanRowellMD
— JAMA (@JAMA_current) September 8, 2020
Consensus recommendations on the prehospital care of the injured athlete with a suspected catastrophic cervical spine injury
21 Aug, 2020 | 02:16h | UTC
Guidelines for the management of severe traumatic brain injury: 2020 update of the decompressive craniectomy recommendations
10 Aug, 2020 | 01:46h | UTC
Cerebral Cavernous Malformation: What a Practicing Clinician Should Know
29 Jun, 2020 | 08:53h | UTCCerebral Cavernous Malformation: What a Practicing Clinician Should Know – Mayo Clinic Proceedings
Guidelines for the Acute Treatment of Cerebral Edema in Neurocritical Care Patients
11 Jun, 2020 | 09:21h | UTCSource: Critical Care Reviews
Framingham Heart Study: Assessment of Incidence and Risk Factors of Intracerebral Hemorrhage
10 Jun, 2020 | 04:42h | UTCAssessment of Incidence and Risk Factors of Intracerebral Hemorrhage Among Participants in the Framingham Heart Study Between 1948 and 2016 – JAMA Neurology (free for a limited period)
Review: Minimizing SARS-CoV-2 Exposure When Performing Surgical Interventions
28 May, 2020 | 09:42h | UTC
Analysis of Traumatic Brain Injury Lesions on Head CT Using Deep Learning
26 May, 2020 | 09:23h | UTCCommentaries: Deep learning: a turning point in acute neurology – The Lancet Digital Health
AI successfully used to identify different types of brain injuries – University of Cambridge AND Deep learning automatically measures key features of TBI – Health Imaging
Randomized Trial: Beta-Blocker Therapy Promising in Severe Traumatic Brain Injury
29 Apr, 2020 | 04:47h | UTCRelated Meta-Analysis: Beta-Blockers and Traumatic Brain Injury: A Systematic Review and Meta-Analysis – Annals of Surgery
“We recommend further high-quality trials to answer questions about the mechanisms of action, effectiveness on subgroups, dose-response, length of therapy, functional outcome, and quality of life after β-blocker use for TBI” (from the 2017 meta-analysis above)
Review: Surgery for Spontaneous Intracerebral Hemorrhage
10 Mar, 2020 | 10:21h | UTCSurgery for spontaneous intracerebral hemorrhage – Critical Care (free)
[Abstract Only] Randomized Trial: Hippocampal Avoidance During Whole-Brain Radiotherapy for Patients with Brain Metastases
10 Mar, 2020 | 10:17h | UTCHippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001 – Journal of Clinical Oncology (link to abstract – $ for full-text)
Commentaries: Hippocampal avoidance during WBRT reduces risks on NRG Oncology trial – NRG Oncology (free) AND ‘Practice-Changing’ Study on WBRT for Patients With Brain Mets – Medscape (free registration required)
Clinical Update – Preventing Surgical Site Infections: Looking Beyond the Current Guidelines
23 Feb, 2020 | 22:21h | UTCPreventing Surgical Site Infections: Looking Beyond the Current Guidelines – JAMA (free for a limited period)
Related Guidelines: Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017 – JAMA Surgery (free) AND Global guidelines on the prevention of surgical site infection – World Health Organization (free) AND Surgical site infections: prevention and treatment – National Institute for Health and Care Excellence (free) AND APSIC guidelines for the prevention of surgical site infections – Antimicrobial Resistance & Infection Control (free) AND Intraoperative surgical site infection control and prevention: a position paper and future addendum to WSES intra-abdominal infections guidelines – World Journal of Emergency Surgery (free)
Cohort Study: Maximal Extent of Resection of Contrast-Enhanced and Non–Contrast-Enhanced Tumor and Survival in Patients with Glioblastoma
7 Feb, 2020 | 08:09h | UTCAssociation of Maximal Extent of Resection of Contrast-Enhanced and Non–Contrast-Enhanced Tumor With Survival Within Molecular Subgroups of Patients With Newly Diagnosed Glioblastoma – JAMA Oncology (free for a limited period)
Commentaries: A Common Rule for Resection of Glioblastoma in the Molecular Era – JAMA Oncology (free) AND Brain tumor surgery that pushes boundaries boosts patients survival – University of California (free) AND More aggressive surgery may improve brain cancer survival – UPI (free)
What is New in Decompressive Craniectomy in Neurological Emergencies: The Good, the Bad and the Ugly
31 Jan, 2020 | 01:28h | UTCWhat is new in decompressive craniectomy in neurological emergencies: the good, the bad and the ugly – Intensive Care Medicine (free for a limited period)
Related Systematic Review: Decompressive Craniectomy for the Treatment of High Intracranial Pressure in Closed Traumatic Brain Injury – Cochrane Library (free article, guideline and randomized trial)
Consensus Statement: A Management Algorithm for Adult Patients with Both Brain Oxygen and Intracranial Pressure Monitoring
26 Jan, 2020 | 22:50h | UTC
[Abstract Only] Long-term Results of Prenatal Repair of Myelomeningocele and School-age Functional Outcomes
26 Jan, 2020 | 22:30h | UTCPrenatal Repair of Myelomeningocele and School-age Functional Outcomes – Pediatrics (link to abstract – $ for full-text)
Original Study: A Randomized Trial of Prenatal versus Postnatal Repair of Myelomeningocele – New England Journal of Medicine (free)
Commentaries: Fetal surgery for spina bifida makes a huge difference 10 years later – News Medical (free) AND Benefits of fetal surgery to repair spina bifida persist through school age – NIH News Releases (free)
Related: Guidelines For Pediatric Myelomeningocele – Congress of Neurological Surgeons (free)
Expert Consensus on the Management of Brain Arteriovenous Malformations
14 Jan, 2020 | 00:24h | UTC