Neurology | Page 8 of 81 | Links Medicus Content Curation & Alerts in Medicine

Postoperative delirium’s linked to long-term cognitive decline in elderly patients

3 Apr, 2023 | 13:20h | UTC

Postoperative Delirium’s linked to Long-term Cognitive Decline in Elderly Patients – JAMA Internal Medicine (link to abstract – $ for full-text)

News Release: Developing postoperative delirium associated with a faster rate of cognitive decline, says study – EurekAlert

Commentary: Postoperative Delirium Associated With Accelerated Cognitive Decline, Study Finds – Psychiatric News Alert

Commentary on Twitter

Delirium associated with accelerated cognitive decline that continued for 72 months following the index delirium episode; it's uncertain if delirium causes cognitive decline or if pts with preclinical brain disease are more likely to develop delirium. https://t.co/ADz7yxEZiP

— JAMA Internal Medicine (@JAMAInternalMed) March 20, 2023

SR | Etiologies of vertigo in the elderly

31 Mar, 2023 | 13:38h | UTC

Vertigo in the Elderly: A Systematic Literature Review – Journal of Clinical Medicine

RCT | Zavegepant 10 mg nasal spray vs. placebo for the acute treatment of migraine

31 Mar, 2023 | 13:24h | UTC

Safety, tolerability, and efficacy of zavegepant 10 mg nasal spray for the acute treatment of migraine in the USA: a phase 3, double-blind, randomised, placebo-controlled multicentre trial – The Lancet Neurology (link to abstract – $ for full-text)

2ry analysis of a RCT | Vitamin D supplementation does not affect cognitive function in older adults

30 Mar, 2023 | 14:14h | UTC

Vitamin D supplementation and cognition—Results from analyses of the D-Health trial – Journal of the American Geriatrics Society (link to abstract – $ for full-text)

Original Study: RCT: Oral Vitamin D supplementation (60.000 IU per month) did not reduce mortality in patients 60 years or older (unscreened individuals in Australia, many without insufficiency, average 30ng/mL). Exploratory analyses pointed towards an increased risk of death from cancer.

Meta-Analysis: Vitamin D Not Effective for Cardiovascular Disease Prevention

Association between vitamin D supplementation and mortality: systematic review and meta-analysis – The BMJ

USPSTF Draft Statement: Insufficient evidence to recommend multivitamin supplements for the prevention of CVD or cancer. The statement also recommends against the use of beta-carotene (increases risk of CVD mortality and lung cancer) or vitamin E (clear evidence of no benefit)

Vitamin D, calcium, other vitamins, and supplements do not prevent cardiovascular diseases

Research: Circulating vitamin D concentration and risk of seven cancers

Research: Vitamin D and risk of total and site specific cancers

Review | Insomnia diagnosis and treatment across the lifespan

30 Mar, 2023 | 13:36h | UTC

Insomnia diagnosis and treatment across the lifespan – Journal of Family Practice

Review | Cerebrovascular manifestations of SARS-CoV-2

29 Mar, 2023 | 13:29h | UTC

Cerebrovascular Manifestations of SARS-CoV-2: A Comprehensive Review – Current Treatment Options in Neurology

Brief Review | Long-term outcomes of intensive care unit delirium

27 Mar, 2023 | 13:09h | UTC

Long-term outcomes of intensive care unit delirium – Intensive Care Medicine

Commentary on Twitter

#ICU delirium
🏥 well described short-term effects: ⬆️ hospital mortality, MV duration, ICU/hospital LoS
📚 more recent findings related to long-term outcomes (≥ 6 months post-ICU)
How to mitigate this serious acute BI & its long-term burden? #FOAMcc
🖇️ https://t.co/kg5TIOmVHm pic.twitter.com/Hnbc1ISKnI

— Intensive Care Medicine (@yourICM) March 25, 2023

Guidelines for neuroprognostication in comatose adult survivors of cardiac arrest

27 Mar, 2023 | 12:54h | UTC

Guidelines for Neuroprognostication in Comatose Adult Survivors of Cardiac Arrest – Neurocritical Care

Guidelines for neuroprognostication in adults with Guillain-Barré Syndrome

27 Mar, 2023 | 12:52h | UTC

Guidelines for Neuroprognostication in Adults with Guillain–Barré Syndrome – Neurocritical Care

Cohort Study | Functional recovery, symptoms, and quality of life 1 to 5 years after traumatic brain injury

24 Mar, 2023 | 12:52h | UTC

Functional Recovery, Symptoms, and Quality of Life 1 to 5 Years After Traumatic Brain Injury – JAMA Network Open

RCT | Safety and efficacy of pitolisant in children aged 6 years or older with narcolepsy with or without cataplexy

23 Mar, 2023 | 12:44h | UTC

Safety and efficacy of pitolisant in children aged 6 years or older with narcolepsy with or without cataplexy: a double-blind, randomised, placebo-controlled trial – The Lancet Neurology (link to abstract – $ for full-text)

M-A | eHealth-based psychosocial interventions for adults with insomnia

23 Mar, 2023 | 12:31h | UTC

eHealth-Based Psychosocial Interventions for Adults With Insomnia: Systematic Review and Meta-analysis of Randomized Controlled Trials – Journal of Medical Internet Research

M-A | Risk factors of hemorrhagic transformation in acute ischaemic stroke

22 Mar, 2023 | 13:21h | UTC

Risk factors of hemorrhagic transformation in acute ischaemic stroke: A systematic review and meta-analysis – Frontiers in Neurology

Cohort study | Professional soccer players are at increased risk of Alzheimer’s disease and other dementias

21 Mar, 2023 | 13:46h | UTC

Summary: The article reports on a cohort study conducted in Sweden to investigate whether male soccer players in the top division are at increased risk of neurodegenerative disease compared to matched controls from the general population. This is a topic of concern as there is a hypothesis that the repetitive mild head trauma sustained through heading the ball and concussions might cause neurodegenerative disease.

The study included 6007 football players and 56,168 controls and used nationwide registers to identify diagnoses of neurodegenerative disease. The study revealed that male professional soccer players in Sweden had a higher risk of neurodegenerative disease, particularly Alzheimer’s disease and other dementias, and outfield players had a higher risk than goalkeepers.

Article: Neurodegenerative disease among male elite football (soccer) players in Sweden: a cohort study – The Lancet Public Health

News Release: Elite football players are more likely to develop dementia, suggests Swedish study – Lancet

Commentaries:

Dementia risk higher for outfield players than goalkeepers – study – BBC

Neurodegenerative Diseases Are the Cost of Sports – Health Policy Watch

Study: Neurodegenerative Disease Mortality Increased Among Former Professional Soccer Players

Review | Neuromonitoring in critically ill patients

20 Mar, 2023 | 13:18h | UTC

Neuromonitoring in Critically Ill Patients – Critical Care Medicine (free for a limited period)

RCT | Impact of two ketogenic diet types in refractory childhood epilepsy

16 Mar, 2023 | 13:13h | UTC

Impact of two ketogenic diet types in refractory childhood epilepsy – Pediatric Research

Safety, Efficacy, and Tolerability of Modified Atkins Diet in Persons With Drug-Resistant Epilepsy: A Randomized Controlled Trial – Neurology (link to abstract – $ for full-text)

Efficacy of Ketogenic Diet, Modified Atkins Diet, and Low Glycemic Index Therapy Diet Among Children With Drug-Resistant Epilepsy: A Randomized Clinical Trial – JAMA Pediatrics

ACCP Guidelines | Respiratory management of patients with neuromuscular weakness

15 Mar, 2023 | 15:16h | UTC

Respiratory Management of Patients with Neuromuscular Weakness: An American College of Chest Physicians Clinical Practice Guideline and Expert Panel Report – CHEST

News Release: Clinical practice guideline on respiratory management of patients with neuromuscular weakness – American College of Chest Physicians

Review | Prehospital stroke management and mobile stroke units

15 Mar, 2023 | 14:54h | UTC

Prehospital stroke management and mobile stroke units – Current Opinion in Neurology

Podcast and Brief Review | TIA/Stroke pearls for the hospitalist

14 Mar, 2023 | 13:36h | UTC

#385 TIA/Stroke for the Hospitalist featuring Dr. Karima Benameur – The Curbsiders

M-A | The influence of seated exercises on disability after a stroke

10 Mar, 2023 | 14:25h | UTC

The influence of seated exercises on balance, mobility, and cardiometabolic health outcomes in individuals living with a stroke: A systematic review and meta-analysis – Clinical Rehabilitation

Evidence Analysis | Menière’s disease: experience, evidence gaps & treatment choices

9 Mar, 2023 | 14:21h | UTC

Menière’s disease: experience, evidence gaps & treatment choices – Evidently Cochrane

New Cochrane Reviews:

Systemic pharmacological interventions for Ménière’s disease – Cochrane Library

Intratympanic gentamicin for Ménière’s disease – Cochrane Library

Intratympanic corticosteroids for Ménière’s disease – Cochrane Library

Positive pressure therapy for Ménière’s disease – Cochrane Library

Lifestyle and dietary interventions for Ménière’s disease – Cochrane Library

Surgical interventions for Ménière’s disease – Cochrane Library

SR | There is insufficient evidence to recommend pharmacological treatments for central sleep apnea in adults

9 Mar, 2023 | 14:01h | UTC

Pharmacological treatment for central sleep apnoea in adults – Cochrane Library

Summary: Medicines for central sleep apnoea in adults – Cochrane Library

RCT | Antipsychotic association seems better than antidepressant switch in treatment-resistant geriatric depression

6 Mar, 2023 | 14:23h | UTC

Summary:

This open-label randomized trial compared the benefits and risks of augmenting therapy vs. switching antidepressants in older adults with treatment-resistant depression. In the first step, 619 patients were randomly assigned to augmentation of existing antidepressant medication with aripiprazole (an antipsychotic), augmentation with bupropion, or a switch from existing antidepressant medication to bupropion. In step 2, 248 patients who did not benefit from or were ineligible for step 1 were randomly assigned to augmentation with lithium or a switch to nortriptyline.

The aripiprazole-augmentation group showed significant improvement in well-being compared to the switch-to-bupropion group. Remission occurred in 28.9% of patients in the aripiprazole-augmentation group, 28.2% in the bupropion-augmentation group, and 19.3% in the switch-to-bupropion group. In step 2, similar remission rates occurred in the lithium-augmentation group (18.9%) and the switch-to-nortriptyline group (21.5%).

Article: Antidepressant Augmentation versus Switch in Treatment-Resistant Geriatric Depression – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Adding antipsychotic med to antidepressant may help older adults with treatment-resistant depression – Washington University School of Medicine in St. Louis

Commentary on Twitter

#AAGPAM23: In a pragmatic trial involving older persons with treatment-resistant depression, augmentation of existing antidepressants with aripiprazole was better than augmentation with bupropion or a switch to bupropion. Full results of the OPTIMUM trial: https://t.co/2OPOxH67Qx pic.twitter.com/g0AtrYGhKV

— NEJM (@NEJM) March 3, 2023