Neurology

Observational analysis of over 300.000 patients suggests a J-shaped, or U-shaped relationships between BP and outcomes (both lower and higher BP levels detrimental). Among patients submitted to thrombolytic therapy, there were fewer complications with lower blood pressure.

Antidepressant Switching vs Augmentation in Resistent Depression?

12 Jul, 2017 | 15:24h | UTC

Effect of Antidepressant Switching vs Augmentation on Remission Among Patients With Major Depressive Disorder Unresponsive to Antidepressant Treatment: The VAST-D Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Study Compares Switching Meds vs an Additional Med for Patients Unresponsive to an Antidepressant – The Jama Network (free) AND For Treatment-Resistant Depression, Add an Antipsychotic or Switch Antidepressants? – Physician’s First Watch (free)

Augmentation with aripiprazole led to a modestly increased likelihood of remission, but with more adverse effects. “Given the small effect size and adverse effects associated with aripiprazole, further analysis including cost-effectiveness is needed to understand the net utility of this approach”.

Positive airway pressure doesn’t reduce cardiovascular events and death in adults with sleep apnea

12 Jul, 2017 | 15:01h | UTC

Association of Positive Airway Pressure With Cardiovascular Events and Death in Adults With Sleep Apnea: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)

Commentaries: More Doubt Cast on CPAP for Reducing CVD Risk in Sleep Apnea Patients – MedPage Today (free registration required) AND Positive airway pressure doesn’t reduce heart risk with sleep apnea – Reuters (free)

“PAP for obstructive sleep apnea improves quality of life but not CV events or BP with up to 5 years of follow up” (RT @AnilMakam see Tweet)

Effect of Depth and Duration of Cooling on Death or Disability at Age 18 Months Among Neonates With Hypoxic-Ischemic Encephalopathy

11 Jul, 2017 | 21:35h | UTC

Effect of Depth and Duration of Cooling on Death or Disability at Age 18 Months Among Neonates With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Interview with the author: Effect of Depth and Duration of Cooling on Death or Disability at Age 18 Months Among Neonates With Hypoxic-Ischemic Encephalopathy – MedicalResearch.com (free)

Source: EvidenceAlerts (free resource to find articles of interest)

Deutetrabenazine for treatment of involuntary movements in patients with tardive dyskinesia

11 Jul, 2017 | 16:44h | UTC

Deutetrabenazine for treatment of involuntary movements in patients with tardive dyskinesia (AIM-TD): a double-blind, randomised, placebo-controlled, phase 3 trial – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentaries: Drug Eases Tardive Dyskinesia Linked to Antipsychotic Use – Medscape (free registration required) AND Second Tardive Dyskinesia Drug Works – MedPage Today (free registration required)

Gabapentin for chronic neuropathic pain in adults

9 Jul, 2017 | 00:26h | UTC

Cochrane Review: Gabapentin for chronic neuropathic pain in adults – Cochrane Library (link to abstract – $ for full-text)

Commentary: Analgesic Effects of Gabapentin Assessed in Chronic Neuropathic Pain – MPR (free)

“Gabapentin at doses of 1800 mg to 3600 mg daily (1200 mg to 3600 mg gabapentin encarbil) can provide good levels of pain relief to some people with postherpetic neuralgia and peripheral diabetic neuropathy”.

Association of Playing High School Football With Cognition and Mental Health Later in Life

8 Jul, 2017 | 20:22h | UTC

Association of Playing High School Football With Cognition and Mental Health Later in Life – JAMA Neurology (free)

Editorial: Reassuring News About Football and Cognitive Decline? Not So Fast

Commentaries: What Are Outcomes Later in Life for High School Football Players? – The JAMA Network (free) AND High School Football: No Link to Later Cognitive Decline – Medscape (free registration required)

Rivastigmine reviewed: doubts about dementia drug

7 Jul, 2017 | 13:56h | UTC

Rivastigmine reviewed: doubts about dementia drug – Evidently Cochrane (free)

Related review: Rivastigmine for people with Alzheimer’s disease – Cochrane Library (link to abstract – $ for full-text)

“”Sadly, “small” and “of uncertain clinical importance” are the words chosen by the Cochrane reviewers to describe…” (RT @CochraneUK see Tweet)

Commentaries: Does Shingles Increase the Risk of Heart Attack, Stroke? – American College of Cardiology, Latest in Cardiology (free) AND Shingles may up risk of heart attack, stroke – Reuters Health (free) AND Heart attack and stroke risk higher with shingles – OnMedica (free)

Quality of Life in Dementia

4 Jul, 2017 | 21:20h | UTC

Quality of Life in Dementia – The AMA Journal of Ethics (free)

“What can clinicians do to normalize the experience of dementia? Our new issue explores the ethics of dementia care” (RT @JournalofEthics see Tweet)

Rest tremor revisited: Parkinson’s disease and other disorders

3 Jul, 2017 | 18:00h | UTC

Rest tremor revisited: Parkinson’s disease and other disorders – Translational Neurodegeneration (free)

Toxins in Brain! Magnetic Resonance (MR) Imaging of Toxic Leukoencephalopathy

3 Jul, 2017 | 17:34h | UTC

Toxins in Brain! Magnetic Resonance (MR) Imaging of Toxic Leukoencephalopathy – A Pictorial Essay – Polish Journal of Radiology (free)

Concise review: Amyotrophic Lateral Sclerosis

Emergency Management of Pediatric Seizures

Inborn Errors of Metabolism and Epilepsy: Current Understanding, Diagnosis, and Treatment Approaches

Multiple Sclerosis: Immunopathology and Treatment Update

Systematic review: Antiepileptic drug monotherapy

Differential diagnosis of neuromyelitis optica spectrum disorders

Study: No effect of commercial cognitive training on cognitive function

Blood pressure and in-hospital outcomes in patients presenting with ischaemic stroke

Antidepressant Switching vs Augmentation in Resistent Depression?

Positive airway pressure doesn’t reduce cardiovascular events and death in adults with sleep apnea

Effect of Depth and Duration of Cooling on Death or Disability at Age 18 Months Among Neonates With Hypoxic-Ischemic Encephalopathy

Deutetrabenazine for treatment of involuntary movements in patients with tardive dyskinesia

Gabapentin for chronic neuropathic pain in adults

Association of Playing High School Football With Cognition and Mental Health Later in Life

Rivastigmine reviewed: doubts about dementia drug

Sarcopenia: Neurological Point of View

Revised diagnostic criteria for neurocysticercosis

Autism spectrum disorder and epileptic encephalopathy: common causes, many questions

Medication-Induced Tardive Dyskinesia

Functional neuroimaging and chorea

Surgical clipping or endovascular coiling for unruptured intracranial aneurysms

Herpes Zoster Increases the Risk of Stroke and Myocardial Infarction

Quality of Life in Dementia

Rest tremor revisited: Parkinson’s disease and other disorders

Toxins in Brain! Magnetic Resonance (MR) Imaging of Toxic Leukoencephalopathy

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