Neurology

This large cohort confirms an increased stroke risk with oral hormone therapies, but suggests no increased risk of stroke with transdermal or vaginal estrogen application.

Exenatide for Parkinson’s disease?

11 Aug, 2017 | 16:48h | UTC

Exenatide once weekly versus placebo in Parkinson’s disease: a randomised, double-blind, placebo-controlled trial – The Lancet (link to abstract – $ to full-text)

Commentaries: Diabetes drug may be helpful for Parkinson’s disease – NHS Choices (free) AND Diabetes drug could help those living with Parkinson’s disease, research reveals – The Guardian (free) AND First hints Parkinson’s can be stopped – BBC (free) AND Diabetes drug shows potential as disease-modifying therapy for Parkinson’s disease – University College London, via EurekAlert (free)

Small trial suggests exenatide is beneficial for motor symptoms in Parkinson disease. Larger trials showing improvements in quality of life are warranted. (see NHS Choices commentary)

Lifestyle Risk Factors Increase the Risk of Hospitalization for Sciatica

11 Aug, 2017 | 16:04h | UTC

Lifestyle Risk Factors Increase the Risk of Hospitalization for Sciatica: Findings of Four Prospective Cohort Studies – The American Journal of Medicine (link to abstract – $ for full-text)

Commentary: Walking and biking tied to lower risk of hospitalization with sciatica – Reuters (free)

Related guideline: Low back pain and sciatica in over 16s: assessment and management – NICE (free)

Mechanical Thrombectomy Outcomes With and Without Intravenous Thrombolysis in Stroke Patients

11 Aug, 2017 | 13:41h | UTC

Mechanical Thrombectomy Outcomes With and Without Intravenous Thrombolysis in Stroke Patients: A Meta-Analysis – Stroke (link to abstract – $ for full-text)

Commentary: Better outcomes seen in patients who received IV thrombolysis before thrombectomy – ACP Hospitalist (free)

“The results support current guideline recommendations to give intravenous thrombolysis to eligible patients even if they are being considered for mechanical thrombectomy, according to the meta-analysis authors” (from ACP)

Source: Hospital Medicine Virtual Journal Club

“A best estimate is that U.S. costs of hypnotic harms to healthcare systems are on the order of $55 billion, but conceivably might be as low as $10 billion or as high as $100 billion”.

Effect of marijuana use on cardiovascular and cerebrovascular mortality

10 Aug, 2017 | 17:13h | UTC

Effect of marijuana use on cardiovascular and cerebrovascular mortality: A study using the National Health and Nutrition Examination Survey linked mortality file – European Journal of Preventive Cardiology (free)

Commentaries: Marijuana associated with three-fold risk of death from hypertension – European Society of Cardiology, via Science Daily (free) AND Marijuana use holds three-fold blood pressure death risk: study – Reuters (free) AND Marijuana Use Tied to Death from Hypertension, Study Suggests – Physician’s First Watch (free) AND Marijuana ‘may be worse than cigarettes for cardiovascular health’ – Medical News Today (free)

Gadolinium deposition in the brain: summary of evidence and recommendations

9 Aug, 2017 | 15:37h | UTC

Gadolinium deposition in the brain: summary of evidence and recommendations – The Lancet Neurology (free registration required)

Commentaries: Gadolinium deposition: practical guidelines in the face of uncertainty – The Lancet Neurology (free registration required) AND MRI Contrast Agents Accumulate in the Brain – Case Western Reserve University, via NewsWise (free)

Systematic Review: Preventing Complications and Treating Symptoms of Diabetic Peripheral Neuropathy

Review: Coma After Acute Head Injury

Study: Association of Lithium in Drinking Water With the Incidence of Dementia

Review: Evaluation and management of sport-related concussions in adolescent athletes

Study: Uric acid and incident dementia

Free Online Course: Advanced Neurobiology I

Coma After Acute Head Injury

Benefits and safety of gabapentinoids in chronic low back pain

Epilepsy ‘Not a Rare Condition’

Guidelines for diagnosis, treatment and follow-up of patients with leptomeningeal metastasis from solid tumours

Risk traumatic brain injuries associated with antidepressant use among patients with Alzheimer’s disease

Risk Factors for Post-stroke Depression

Management of urinary tract infections in patients with neurogenic bladder

Car crashes in older adult drivers using Zolpidem

Neurologic Complications Associated With the Zika Virus

Day-to-Day Blood Pressure Variability and Risk of Dementia

Risk of Stroke With Various Types of Menopausal Hormone Therapies

Exenatide for Parkinson’s disease?

Lifestyle Risk Factors Increase the Risk of Hospitalization for Sciatica

Mechanical Thrombectomy Outcomes With and Without Intravenous Thrombolysis in Stroke Patients

Intracranial Arterial Dolichoectasia

Left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation

What do hypnotics cost hospitals and healthcare?

Effect of marijuana use on cardiovascular and cerebrovascular mortality

Gadolinium deposition in the brain: summary of evidence and recommendations

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