Neurology
M-A | eHealth-based psychosocial interventions for adults with insomnia
23 Mar, 2023 | 12:31h | UTC
M-A | Risk factors of hemorrhagic transformation in acute ischaemic stroke
22 Mar, 2023 | 13:21h | UTC
Cohort study | Professional soccer players are at increased risk of Alzheimer’s disease and other dementias
21 Mar, 2023 | 13:46h | UTCSummary: The article reports on a cohort study conducted in Sweden to investigate whether male soccer players in the top division are at increased risk of neurodegenerative disease compared to matched controls from the general population. This is a topic of concern as there is a hypothesis that the repetitive mild head trauma sustained through heading the ball and concussions might cause neurodegenerative disease.
The study included 6007 football players and 56,168 controls and used nationwide registers to identify diagnoses of neurodegenerative disease. The study revealed that male professional soccer players in Sweden had a higher risk of neurodegenerative disease, particularly Alzheimer’s disease and other dementias, and outfield players had a higher risk than goalkeepers.
News Release: Elite football players are more likely to develop dementia, suggests Swedish study – Lancet
Commentaries:
Dementia risk higher for outfield players than goalkeepers – study – BBC
Neurodegenerative Diseases Are the Cost of Sports – Health Policy Watch
Related:
Dementia risk in former professional footballers is related to player position and career length.
Study: Neurodegenerative Disease Mortality Increased Among Former Professional Soccer Players
Review | Neuromonitoring in critically ill patients
20 Mar, 2023 | 13:18h | UTCNeuromonitoring in Critically Ill Patients – Critical Care Medicine (free for a limited period)
Related: The importance of neuromonitoring in non-brain injured patients – Critical Care
RCT | Impact of two ketogenic diet types in refractory childhood epilepsy
16 Mar, 2023 | 13:13h | UTCImpact of two ketogenic diet types in refractory childhood epilepsy – Pediatric Research
Related:
Efficacy and Safety of Dietary Therapies for Childhood Drug-Resistant Epilepsy: A Systematic Review and Network Meta-analysis – JAMA Pediatrics (link to abstract – $ for full-text)
Safety, Efficacy, and Tolerability of Modified Atkins Diet in Persons With Drug-Resistant Epilepsy: A Randomized Controlled Trial – Neurology (link to abstract – $ for full-text)
ACCP Guidelines | Respiratory management of patients with neuromuscular weakness
15 Mar, 2023 | 15:16h | UTC
Review | Prehospital stroke management and mobile stroke units
15 Mar, 2023 | 14:54h | UTCPrehospital stroke management and mobile stroke units – Current Opinion in Neurology
Podcast and Brief Review | TIA/Stroke pearls for the hospitalist
14 Mar, 2023 | 13:36h | UTC#385 TIA/Stroke for the Hospitalist featuring Dr. Karima Benameur – The Curbsiders
M-A | The influence of seated exercises on disability after a stroke
10 Mar, 2023 | 14:25h | UTC
Evidence Analysis | Menière’s disease: experience, evidence gaps & treatment choices
9 Mar, 2023 | 14:21h | UTCMenière’s disease: experience, evidence gaps & treatment choices – Evidently Cochrane
New Cochrane Reviews:
Systemic pharmacological interventions for Ménière’s disease – Cochrane Library
Intratympanic gentamicin for Ménière’s disease – Cochrane Library
Intratympanic corticosteroids for Ménière’s disease – Cochrane Library
Positive pressure therapy for Ménière’s disease – Cochrane Library
Lifestyle and dietary interventions for Ménière’s disease – Cochrane Library
Surgical interventions for Ménière’s disease – Cochrane Library
SR | There is insufficient evidence to recommend pharmacological treatments for central sleep apnea in adults
9 Mar, 2023 | 14:01h | UTCPharmacological treatment for central sleep apnoea in adults – Cochrane Library
Summary: Medicines for central sleep apnoea in adults – Cochrane Library
RCT | Antipsychotic association seems better than antidepressant switch in treatment-resistant geriatric depression
6 Mar, 2023 | 14:23h | UTCSummary:
This open-label randomized trial compared the benefits and risks of augmenting therapy vs. switching antidepressants in older adults with treatment-resistant depression. In the first step, 619 patients were randomly assigned to augmentation of existing antidepressant medication with aripiprazole (an antipsychotic), augmentation with bupropion, or a switch from existing antidepressant medication to bupropion. In step 2, 248 patients who did not benefit from or were ineligible for step 1 were randomly assigned to augmentation with lithium or a switch to nortriptyline.
The aripiprazole-augmentation group showed significant improvement in well-being compared to the switch-to-bupropion group. Remission occurred in 28.9% of patients in the aripiprazole-augmentation group, 28.2% in the bupropion-augmentation group, and 19.3% in the switch-to-bupropion group. In step 2, similar remission rates occurred in the lithium-augmentation group (18.9%) and the switch-to-nortriptyline group (21.5%).
Article: Antidepressant Augmentation versus Switch in Treatment-Resistant Geriatric Depression – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
#AAGPAM23: In a pragmatic trial involving older persons with treatment-resistant depression, augmentation of existing antidepressants with aripiprazole was better than augmentation with bupropion or a switch to bupropion. Full results of the OPTIMUM trial: https://t.co/2OPOxH67Qx pic.twitter.com/g0AtrYGhKV
— NEJM (@NEJM) March 3, 2023
Perspective | Why functional neurological disorder is not feigning or malingering
6 Mar, 2023 | 14:17h | UTCWhy functional neurological disorder is not feigning or malingering – Nature Reviews Neurology (free for a limited period)
Nitrous oxide-induced subacute combined degeneration of the cord: diagnosis and treatment
3 Mar, 2023 | 14:01h | UTC
Cohort Study | Long-term changes in the size of pituitary microadenomas
3 Mar, 2023 | 13:49h | UTCSummary: The prevalence of pituitary lesions in radiologic studies is estimated to be 10% to 38.5%. However, it is unclear how frequently incidental lesions should be monitored by serial pituitary MRI. A retrospective longitudinal cohort study was conducted to evaluate changes in pituitary microadenomas over time. During the study period (from 2003 to 2021), 414 patients with pituitary microadenomas were identified, and 177 patients had more than 1 MRI. Approximately two-thirds of the microadenomas demonstrated no change or a decrease in size, while the rest exhibited a slow growth rate, indicating that less frequent monitoring could be considered safe.
Article: Long-Term Changes in the Size of Pituitary Microadenomas – Annals of Internal Medicine (link to abstract – $ for full-text)
News Release: Fewer surveillance MRIs may be appropriate for patients with incidental pituitary lesions – American College of Physicians
Commentary on Twitter
New from @harvardmed: new study suggests that less frequent pituitary #MRI surveillance for patients with incidental pituitary #microadenomas may be safe: https://t.co/w4hzk8ISQq pic.twitter.com/2MeK14SRph
— Annals of Int Med (@AnnalsofIM) February 28, 2023
Cohort Study | Association between a healthy lifestyle and memory decline in older adults
3 Mar, 2023 | 13:44h | UTCSummary: This study examined the association between a healthy lifestyle and memory decline in older adults over a 10-year period. The study included 29,072 participants aged 60 or older with normal cognition and apolipoprotein E (APOE) genotyping at baseline. Six healthy lifestyle factors were assessed: a healthy diet, regular physical exercise, active social contact, active cognitive activity, never or former smoker, and never drinking alcohol. Participants were categorized into three groups based on their lifestyle factors: favorable, average, and unfavorable. The results showed that participants in the favorable group had slower memory decline than those in the unfavorable group, even in the presence of the APOE ε4 allele. These findings have important implications for public health initiatives to protect older adults against memory decline.
Editorial: Healthy lifestyles for dementia prevention – The BMJ
News Release: Healthy lifestyle linked to slower memory decline in older adults – BMJ Newsroom
Commentary: Healthful Lifestyle May Slow Memory Loss, Even for APOE Gene Carriers – JAMA
Commentary on Twitter
A healthy lifestyle is associated with slower memory decline, even in the presence of the [high risk] APOE ε4 allele.
Most to least impactful: diet, cognitive activity, physical exercise, active social contact, never/former smoking, & never drinking.https://t.co/j21cH2wyo6 pic.twitter.com/6qgd9bJ2Gr
— Joseph C. Watso, PhD (@Joseph_Watso) January 27, 2023
Under a http://creativecommons.org/licenses/by-nc/4.0/ license
SR | Endovascular therapy vs. medical treatment for symptomatic intracranial artery stenosis
3 Mar, 2023 | 13:35h | UTC
Cohort Study | Female hormone therapy and risk of intracranial hemorrhage from cerebral cavernous malformations
2 Mar, 2023 | 13:03h | UTCSummary: The study aimed to investigate the association between female hormone therapy (oral contraception or menopausal hormone therapy) and intracranial hemorrhage in female patients with cerebral cavernous malformations (CCM) using data from 2 large prospective cohort studies. The researchers analyzed data from 722 female patients with CCM and found that female hormone therapy use was associated with an increased risk of subsequent intracranial hemorrhage. The risk was more significant among female patients aged 10-44 years using oral contraceptives (adjusted hazard ratio 2·00, 95% CI 1·26-3·17; p=0·003). These findings raise questions about the safety of female hormone therapy in patients with cerebral cavernous malformation.
Article: Female Hormone Therapy and Risk of Intracranial Hemorrhage From Cerebral Cavernous Malformations: A Multicenter Observational Cohort Study – Neurology (link to abstract – $ for full-text – you can try this link for full-text)
Cohort Study | Lifetime traumatic brain injury and cognitive domain deficits in late life
2 Mar, 2023 | 12:45h | UTCLifetime Traumatic Brain Injury and Cognitive Domain Deficits in Late Life: The PROTECT-TBI Cohort Study – Journal of Neurotrauma (link to abstract – you can try this link for full-text)
News Release: Three or more concussions linked with worse brain function in later life – University of Exeter
M-A | Efficacy of brief behavioral therapy for insomnia in older adults with chronic insomnia
1 Mar, 2023 | 13:55h | UTC
RCT | Effects of globus pallidus focused ultrasound ablation in Parkinson’s disease
27 Feb, 2023 | 13:02h | UTCSummary: The study evaluated the efficacy and safety of unilateral focused ultrasound ablation of the internal segment of globus pallidus in patients with Parkinson’s disease and dyskinesias or motor fluctuations. The randomized controlled trial involved 94 patients who were either assigned to undergo ultrasound ablation or a sham procedure. The study found that unilateral pallidal ultrasound ablation resulted in a higher percentage of patients who improved motor function or reduced dyskinesia than a sham procedure over a period of 3 months but was associated with adverse events. The study suggests the need for longer and larger trials to determine the effect and safety of this technique in persons with Parkinson’s disease.
Article: Trial of Globus Pallidus Focused Ultrasound Ablation in Parkinson’s Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Focused ultrasound reduces physical symptoms of Parkinson’s disease – Health Imaging
Video Summary: Focused Ultrasound Ablation for Parkinson’s Disease | NEJM
Parkinson disease primer for the general practitioner
27 Feb, 2023 | 13:00h | UTCPart 1: Diagnosis – Canadian Family Physician
Part 2: Management of motor and nonmotor symptoms – Canadian Family Physician
Related:
Management of psychiatric and cognitive complications in Parkinson’s disease – The BMJ
Podcast | Parkinson’s Disease for primary care.
Cohort Study | Could regular laxative use be associated with an increased risk of dementia?
27 Feb, 2023 | 12:59h | UTCAssociation Between Regular Laxative Use and Incident Dementia in UK Biobank Participants – Neurology (link to abstract – $ for full-text)
News Release: Study: People Who Regularly Use Laxatives May Have an Increased Risk of Dementia – American Academy of Neurology
Commentary: Regular Use of Laxatives Linked to Risk for All-Cause Dementia – HealthDay
Review | Glioblastoma and other primary brain malignancies in adults
24 Feb, 2023 | 13:54h | UTCArticle: Glioblastoma and Other Primary Brain Malignancies in Adults: A Review – JAMA (free for a limited period)
Audio clinical review: Glioblastoma and Other Primary Brain Malignancies in Adults – JAMA
Commentary on Twitter
Review summarizes current evidence regarding diagnosis and treatment of primary malignant brain tumors in adults. https://t.co/pNKio61bN5
— JAMA (@JAMA_current) February 21, 2023
Review | Young-onset dementia diagnosis, management and care
24 Feb, 2023 | 13:37h | UTC