Neurology
Podcast | Parkinson’s Disease for primary care.
6 Dec, 2022 | 13:43h | UTC#370 Parkinson’s Disease for Primary Care with Dr. Albert Hung – The Curbsiders
RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns.
2 Dec, 2022 | 14:40h | UTCLecanemab in Early Alzheimer’s Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
Heralded Alzheimer’s drug works — but safety concerns loom – Nature
Lecanemab and Alzheimer’s: More Data – Science
Alzheimer’s Drug is Hailed Amid Safety Concerns – Health Policy Watch
Related: Second death linked to potential antibody treatment for Alzheimer’s disease – Science
Commentary on Twitter
In a phase 3 trial, participants with early Alzheimer’s disease who received the monoclonal antibody lecanemab had less decline on measures of cognitive function at 18 months than those who received placebo. https://t.co/NjEloWVk1V pic.twitter.com/n33yjV9117
— NEJM (@NEJM) November 30, 2022
Cross-sectional study | Overweight women may be at increased risk of long Covid.
2 Dec, 2022 | 14:33h | UTCCommentaries:
Overweight women may be at highest risk of long COVID – new research – The Conversation
RCT | Effect of irrigation fluid temperature on recurrence in the evacuation of chronic subdural hematoma.
30 Nov, 2022 | 13:45h | UTCNews Release: Warmer brain-irrigation fluid in surgery more efficacious – University of Gothenburg
Commentary on Twitter
Study explored how a physical property, such as irrigation fluid temperature, can affect outcomes of neurosurgery for chronic subdural hematoma evacuation. https://t.co/ZHciO3VaTP #Research
— JAMA Neurology (@JAMANeuro) November 22, 2022
Review | Safety and management of implanted epilepsy devices for imaging and surgery.
27 Nov, 2022 | 22:03h | UTC
Brief Review | Ischemic stroke in patients with malignancy.
27 Nov, 2022 | 22:01h | UTCIschemic Stroke in Patients With Malignancy – Mayo Clinic Proceedings
Brief Review | Extubation in neurocritical care patients: lesson learned.
25 Nov, 2022 | 12:31h | UTCExtubation in neurocritical care patients: lesson learned – Intensive Care Medicine
Commentary on Twitter
Extubation in neuro #ICU
🧠 assess neuro function stability
🧠 perform if minimal level of consciousness, upper airway secure, negative fluid balance
📃 elaborate multi-disciplinary local protocols, selecting criteria according to resources/expertise
🖇️ https://t.co/5tvpdkHcar pic.twitter.com/DAdCKwkHng— Intensive Care Medicine (@yourICM) October 17, 2022
Cohort Study | Association of obesity with disease outcomes in multiple sclerosis.
25 Nov, 2022 | 12:24h | UTCNews Release: Obesity at MS diagnosis linked to higher levels of disability – BMJ Newsroom
SR | Surgical decompression for malignant cerebral edema after ischemic stroke.
24 Nov, 2022 | 13:25h | UTCSurgical decompression for malignant cerebral oedema after ischaemic stroke – Cochrane Library
Summary: Surgical decompression for people with severe brain swelling after stroke – Cochrane Library
RCT | Simvastatin is ineffective as a disease-modifying treatment for patients with Parkinson’s Disease.
23 Nov, 2022 | 13:42h | UTCCommentary: Simvastatin Ineffective as Disease-Modifying Therapy for Intermediate Parkinson Disease – AJMC
Commentary on Twitter
In a randomized clinical trial, #simvastatin was futile as a disease-modifying therapy in UK patients with moderate #ParkinsonDisease. https://t.co/etNsG7b3fI @Pen_CTU @NIHRSW @CureParkinsonsT @UHP_NHS @PlymUni
— JAMA Neurology (@JAMANeuro) November 1, 2022
M-A | Use of CT of the head in patients with acute atraumatic altered mental status.
22 Nov, 2022 | 13:38h | UTC
Commentary on Twitter
Meta-analysis: 94% of patients with atraumatic altered mental status received a noncontrast CT head, with an average yield of 11% which varied by setting: 18% in ED patients, 12% of ICU patients, and 3% of general inpatients had positive findings on CT. https://t.co/yHWj6uSwTM
— JAMA Network Open (@JAMANetworkOpen) November 18, 2022
Cohort Study | Delayed intracranial hemorrhage after head injury among elderly patients on anticoagulation seen in the ED.
22 Nov, 2022 | 13:31h | UTCRelated:
Research: Incidence of Delayed Intracranial Hemorrhage in Older Patients After Blunt Head Trauma
2ry analysis of a RCT | Effect of Atogepant for preventive migraine treatment on patient-reported outcomes.
22 Nov, 2022 | 13:32h | UTCOriginal Study: Atogepant for the Preventive Treatment of Migraine – New England Journal of Medicine
SR | Pharmaceutical interventions for emotionalism after stroke.
22 Nov, 2022 | 13:24h | UTCPharmaceutical interventions for emotionalism after stroke – Cochrane Library
M-A | Effects of Tai Chi and Qigong on the mobility of stroke survivors.
22 Nov, 2022 | 13:10h | UTC
RCT | New drug can improve constipation in patients with Parkinson Disease.
22 Nov, 2022 | 13:00h | UTCOral ENT-01 Targets Enteric Neurons to Treat Constipation in Parkinson Disease: A Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries:
New Drug Could Ease Parkinson’s-Related Constipation – HealthDay
Commentary on Twitter
A #RTC of 150 persons with #ParkinsonDisease has found that ENT-01 is safe for up to 25 days of treatment and significantly improves constipation and possibly neurological symptoms: https://t.co/JdDhaHiFOA @MayoClinic pic.twitter.com/IWWCBzvrWV
— Annals of Int Med (@AnnalsofIM) November 8, 2022
Cohort Study | Association of antidepressant use during pregnancy with risk of neurodevelopmental disorders in children.
21 Nov, 2022 | 14:33h | UTCAssociation of Antidepressant Use During Pregnancy With Risk of Neurodevelopmental Disorders in Children – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries:
Antidepressants in Pregnancy Do Not Affect Child Neurodevelopment – HealthDay
Commentary on Twitter
https://twitter.com/JAMAInternalMed/status/1593046260440776704
M-A | Comparative benefits and harms of individual opioids for chronic non-cancer pain.
21 Nov, 2022 | 13:34h | UTC
Commentary on Twitter
https://twitter.com/BJAJournals/status/1552579835217821698
SR | There is insufficient evidence to recommend Ginkgo biloba for tinnitus.
18 Nov, 2022 | 13:19h | UTCGinkgo biloba for tinnitus – Cochrane Library
Summary: Ginkgo biloba herbal supplement for tinnitus – Cochrane Library
M-A | Mechanical thrombectomy in acute basilar artery stroke.
17 Nov, 2022 | 12:13h | UTCRelated:
Commentary on Twitter
https://twitter.com/drjkwan/status/1590403041840467969
Review | POCUS for aortic dissection in the clinical presentation of ischemic stroke.
17 Nov, 2022 | 12:08h | UTCPOCUS for aortic dissection in the clinical presentation of ischemic stroke – emDocs
USPSTF Statement | There is insufficient evidence to recommend routine screening for obstructive sleep apnea.
16 Nov, 2022 | 13:46h | UTCEvidence Report: Screening for Obstructive Sleep Apnea in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA
JAMA Patient Page: Screening for Obstructive Sleep Apnea
Author Interview: USPSTF Recommendation: Screening for Obstructive Sleep Apnea in Adults
Commentary: USPSTF: Evidence Inadequate for Recommending OSA Screening – HealthDay
RCT | Efficacy of Safinamide as add-on therapy to Levodopa in patients with Parkinson’s disease with motor fluctuations.
11 Nov, 2022 | 13:53h | UTC
SR | Not enough evidence for routine use of antifibrinolytic therapy (e.g., tranexamic acid) in aneurysmal subarachnoid hemorrhage.
11 Nov, 2022 | 13:50h | UTCAntifibrinolytic therapy for aneurysmal subarachnoid haemorrhage – Cochrane Library
Cohort Study | Association between dietary habits in midlife with dementia incidence over a 20-year period.
11 Nov, 2022 | 13:40h | UTCNews Release: Does the Mediterranean diet really decrease your risk of dementia? – American Academy of Neurology
Commentary: Study Casts Doubt on Mediterranean Diet’s Benefit to Brain – HealthDay