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Nephrology

RCT: In critically ill adults, using a balanced multielectrolyte solution did not lower the risk of death or acute kidney injury compared to standard saline.

19 Jan, 2022 | 08:41h | UTC

Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Australian study set to guide the treatment of critically ill patients worldwide – George Institute for Global Health

Related:

BaSICS RCT: Among critically ill patients requiring fluid therapy, treatment with a balanced solution did not lead to reduced mortality compared to a 0.9% saline solution.

BaSICS RCT: Among critically ill patients requiring fluid therapy, there was no difference in mortality with slower (333 mL/h) vs. faster (999 mL/h) intravenous fluid bolus rates.

Cochrane Review: Buffered Solutions Do Not Improve Mortality in Critically Ill Adults and Children Compared to 0,9% Saline

 

Commentary on Twitter

https://twitter.com/NEJM/status/1483540959518281730

 

Systematic Review: Exercise training for adults undergoing maintenance dialysis.

19 Jan, 2022 | 08:32h | UTC

Exercise training for adults undergoing maintenance dialysis – Cochrane Library

Summary: Exercise training for adults receiving dialysis treatments – Cochrane Library

 

Commentary on Twitter

 

Multi-Disciplinary Guideline: Management of nephrolithiasis in pregnancy.

16 Jan, 2022 | 23:17h | UTC

Management of Nephrolithiasis in Pregnancy: Multi-Disciplinary Guidelines From an Academic Medical Center – Frontiers in Surgery

 

Commentary from the author on Twitter

 

Review: New aspects in the management of hypertension in patients with chronic kidney disease not on renal replacement therapy.

11 Jan, 2022 | 02:22h | UTC

New Aspects in the Management of Hypertension in Patients with Chronic Kidney Disease not on Renal Replacement Therapy – High Blood Pressure & Cardiovascular Prevention

Related: RCT: In patients with advanced chronic kidney disease and poorly controlled hypertension, Chlortalidone had a significant impact in blood-pressure control (−11.0 mm Hg vs. −0.5 mm Hg in the placebo group).

 

Perspective: Introducing nephrocardiology.

16 Dec, 2021 | 08:31h | UTC

Introducing Nephrocardiology – Clinical Journal of the American Society of Nephrology

 

Global strategy for the diagnosis and management of acute kidney injury in patients with liver cirrhosis.

10 Dec, 2021 | 09:58h | UTC

Global strategy for the diagnosis and management of acute kidney injury in patients with liver cirrhosis – United European Gastroenterology Journal

 

Prevention and management of hyperkalemia in patients treated with renin–angiotensin–aldosterone system inhibitors.

8 Dec, 2021 | 09:58h | UTC

Prevention and management of hyperkalemia in patients treated with renin–angiotensin–aldosterone system inhibitors – Canadian Medical Association Journal

 

Guideline: Management of ureteral calculi.

2 Dec, 2021 | 09:54h | UTC

Canadian Urological Association guideline: Management of ureteral calculi – Abridged version – Canadian Urological Association Journal

Related Guidelines:

Renal and ureteric stones: assessment and management – National Institute for Health and Care Excellence

Dietary and Pharmacologic Management to Prevent Recurrent Nephrolithiasis in Adults: A Clinical Practice Guideline From the American College of Physicians

Metabolic diagnosis and medical prevention of calcium nephrolithiasis and its systemic manifestations: a consensus statement – Journal of Nephrology

The Urological Association of Asia clinical guideline for urinary stone disease – International Journal of Urology

 

Cohort Study: Timing of dialysis initiation to reduce mortality and cardiovascular events in advanced chronic kidney disease.

2 Dec, 2021 | 09:47h | UTC

Timing of dialysis initiation to reduce mortality and cardiovascular events in advanced chronic kidney disease: nationwide cohort study – The BMJ

 

Commentary from the author on Twitter (thread – click for more)

 

Podcast: Metabolic Alkalosis and Hypokalemia.

30 Nov, 2021 | 09:57h | UTC

#308 Metabolic Alkalosis and Hypokalemia: Kidney Boy Returns! – The Curbsiders

 

Systematic Review: Renal denervation may have a modest effect in improving 24h ambulatory blood pressure monitoring (reduction in SBP by 5.29 mmHg and DBP by 3.75 mmHg) but does not improve major cardiovascular outcomes and renal function.

24 Nov, 2021 | 08:33h | UTC

Summary: Renal denervation for improving outcomes in individuals with resistant hypertension – Cochrane Library

Original Review: Renal denervation for resistant hypertension – Cochrane Library

Related: M-A: Renal denervation for hypertension is associated with a modest reduction in ambulatory blood pressure control (3.61 mm Hg reduction in ambulatory systolic BP and 1.85 mm Hg reduction in ambulatory diastolic BP).

 

Commentary on Twitter

https://twitter.com/CochraneHTN/status/1462979551558995971

 

In a survey of about 27,600 U.S. individuals, 18.5% of adults with hypertension used medications that may raise blood pressure; the most commonly reported classes were antidepressants, nonsteroidal anti-inflammatory drugs, steroids, and estrogens.

23 Nov, 2021 | 08:33h | UTC

Prevalence of Medications That May Raise Blood Pressure Among Adults With Hypertension in the United States – JAMA Internal Medicine (free for a limited period)

 

Commentary from the author on Twitter (thread – click for more)

What Is the best maintenance therapy for ANCA vasculitis?

18 Nov, 2021 | 08:34h | UTC

What Is the Best Maintenance Therapy for ANCA Vasculitis? – Clinical Journal of the American Society of Nephrology

 

Systematic Review: Immunosuppressive treatment for primary membranous nephropathy in adults with nephrotic syndrome.

16 Nov, 2021 | 08:25h | UTC

Summary: Immunosuppressive treatment for adults with idiopathic membranous nephropathy – Cochrane Library

Original Study: Immunosuppressive treatment for primary membranous nephropathy in adults with nephrotic syndrome – Cochrane Library

 

White-Coat Hypertension: Pathophysiological and Clinical Aspects.

12 Nov, 2021 | 09:48h | UTC

White-Coat Hypertension: Pathophysiological and Clinical Aspects: Excellence Award for Hypertension Research 2020 – Hypertension (free for a limited period)

 

Review: Uremic Encephalopathy.

10 Nov, 2021 | 06:49h | UTC

Uremic Encephalopathy – Kidney International

 

RCT: In patients with chronic kidney diseases and anemia undergoing dialysis, Daprodustat (oral drug) was noninferior to darbepoetin alfa to increase hemoglobin levels and regarding cardiovascular outcomes.

7 Nov, 2021 | 20:18h | UTC

Daprodustat for the Treatment of Anemia in Patients Undergoing Dialysis – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Oral pill as safe, efficacious as conventional treatment for anemia in patients with kidney disease – Brigham and Women’s Hospital

 

Commentary on Twitter

 

RCT: In patients with chronic kidney diseases and anemia not undergoing dialysis, Daprodustat (oral drug) was noninferior to darbepoetin alfa in increasing hemoglobin levels and regarding cardiovascular outcomes.

7 Nov, 2021 | 20:17h | UTC

Daprodustat for the Treatment of Anemia in Patients Not Undergoing Dialysis – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Oral pill as safe, efficacious as conventional treatment for anemia in patients with kidney disease – Brigham and Women’s Hospital

 

Commentary on Twitter

 

RCT: In patients with advanced chronic kidney disease and poorly controlled hypertension, Chlortalidone had a significant impact in blood-pressure control (−11.0 mm Hg vs. −0.5 mm Hg in the placebo group).

7 Nov, 2021 | 20:20h | UTC

Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Cheap Diuretic, Chlorthalidone, Drops BP in Advanced Kidney Disease – Medscape (free registration required)

 

Commentary on Twitter

 

NICE draft guideline recommends SGLT2 inhibitor dapagliflozin for some patients with chronic kidney disease.

7 Nov, 2021 | 20:14h | UTC

NICE recommend dapagliflozin for people with chronic kidney disease – National Institute for Health and Care Excellence

See draft guideline:

Appraisal consultation document (online commenting)

Appraisal consultation document (PDF version)

Related:

NICE Guideline: Assessment and management of chronic kidney disease.

Secondary analysis of RCT finds Dapagliflozin is safe for patients with stage 4 chronic kidney disease.

Randomized trial: Dapagliflozin in patients with chronic kidney disease

 

M-A: Renal denervation for hypertension is associated with a modest reduction in ambulatory blood pressure control (3.61 mm Hg reduction in ambulatory systolic BP and 1.85 mm Hg reduction in ambulatory diastolic BP).

5 Nov, 2021 | 09:46h | UTC

Renal Denervation for Hypertension: A Systematic Review and Meta-Analysis of Randomized, Blinded, Placebo-Controlled Trials – JACC: Cardiovascular Interventions

Commentaries:

Meta-Analysis of Renal Denervation for Hypertension – American College of Cardiology

Is Renal Denervation a Useful Strategy in BP Management? – American College of Cardiology

Related:

#ACC21 – RCT: Among patients with resistant hypertension, ultrasound renal denervation resulted in a modest improvement in systolic BP (–4.5 mm Hg) vs. sham procedure.

Meta-Analysis: Sham-Controlled Randomized Trials of Catheter-Based Renal Denervation in Patients with Hypertension

 

Increased temperatures contributed to more than 200,000 cases of kidney disease in 15 years in Brazil alone.

2 Nov, 2021 | 02:46h | UTC

News release: Increased temperatures contributed to more than 200,000 cases of kidney disease in 15 years in Brazil alone, world’s largest study finds – Monash University

Original Study: Association between Ambient Temperature and Hospitalization for Renal Diseases in Brazil during 2000–2015: A Nationwide Case-Crossover Study – The Lancet Regional Health Americas

 

Recurrent Glomerular Disease after Kidney Transplantation: Diagnostic and Management Dilemmas.

28 Oct, 2021 | 09:43h | UTC

Recurrent Glomerular Disease after Kidney Transplantation: Diagnostic and Management Dilemmas – Clinical Journal of the American Society of Nephrology

 

Commentary on Twitter

 

In a major scientific advance, a pig kidney is successfully transplanted into a human.

21 Oct, 2021 | 09:52h | UTC

In a major scientific advance, a pig kidney is successfully transplanted into a human – NPR

 

Things We Do for No Reason: fluid restriction for the management of acute decompensated heart failure in patients with reduced ejection fraction.

20 Oct, 2021 | 10:00h | UTC

Things We Do for No Reason™: Fluid Restriction for the Management of Acute Decompensated Heart Failure in Patients With Reduced Ejection Fraction – Journal of Hospital Medicine (free for a limited period)

 

Commentary on Twitter

 

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