Review: New aspects in the management of hypertension in patients with chronic kidney disease not on renal replacement therapy. 11 Jan, 2022 | 02:22h | UTC New Aspects in the Management of Hypertension in Patients with Chronic Kidney Disease not on Renal Replacement Therapy – High Blood Pressure & Cardiovascular Prevention Related: RCT: In patients with advanced chronic kidney disease and poorly controlled hypertension, Chlortalidone had a significant impact in blood-pressure control (−11.0 mm Hg vs. −0.5 mm Hg in the placebo group).