Internal Medicine
RCT: Low-dose methylprednisolone does not improve outcomes in critically ill patients with severe community-acquired pneumonia.
21 Jun, 2022 | 11:04h | UTC
M-A: Opioid versus opioid-free analgesia after surgical discharge.
21 Jun, 2022 | 11:08h | UTCOpioid versus opioid-free analgesia after surgical discharge: a systematic review and meta-analysis of randomised trials – The Lancet (link to abstract – $ for full-text)
News Release: Taking opioids at home after surgery: More harms than benefits – McGill University Health Center
Cohort Study: Cardiometabolic multimorbidity, genetic risk, and dementia.
21 Jun, 2022 | 11:01h | UTCNews Release: Multiple heart-related conditions linked to triple dementia risk regardless of genetics – University of Oxford
Related:
Genetic Risk, Midlife Life’s Simple 7, and Incident Dementia in the Atherosclerosis Risk in Communities Study – Neurology (link to abstract – $ for full-text) AND Commentary: Seven healthy habits linked to lower risk of dementia in those with genetic risk – American Academy of Neurology
Preventing dementia: what’s the evidence? – Evidently Cochrane
How common is long COVID? Why studies give different answers.
21 Jun, 2022 | 11:03h | UTCHow common is long COVID? Why studies give different answers – Nature
Cohort Study: Association of cardiovascular risk trajectory with cognitive decline and incident dementia.
21 Jun, 2022 | 10:58h | UTCCommentary: Heart Risk Factors Can Be Recipe for Dementia – HealthDay
Related:
Genetic Risk, Midlife Life’s Simple 7, and Incident Dementia in the Atherosclerosis Risk in Communities Study – Neurology (link to abstract – $ for full-text) AND Commentary: Seven healthy habits linked to lower risk of dementia in those with genetic risk – American Academy of Neurology
Preventing dementia: what’s the evidence? – Evidently Cochrane
Commentary on Twitter
Study findings show that the longitudinal, cumulative trajectory of #cardiovascular risk is predictive of #dementia risk and associated with the emergence of memory decline. Read the article: https://t.co/CT1NQ63sXO #NeuroTwitter pic.twitter.com/KMGAPLQFe7
— Neurology Journal (@GreenJournal) May 17, 2022
Cohort Study: Cardiometabolic multimorbidity linked to accelerated cognitive decline and dementia progression.
21 Jun, 2022 | 10:59h | UTCNews Release: Diabetes and cardiovascular disease increase dementia risk – Karolinska Institutet
Related:
Genetic Risk, Midlife Life’s Simple 7, and Incident Dementia in the Atherosclerosis Risk in Communities Study – Neurology (link to abstract – $ for full-text) AND Commentary: Seven healthy habits linked to lower risk of dementia in those with genetic risk – American Academy of Neurology
Preventing dementia: what’s the evidence? – Evidently Cochrane
Guidelines for the management of patients with severe acute pancreatitis.
21 Jun, 2022 | 10:57h | UTCRelated:
Evidence-Based Disposition of Acute Pancreatitis – emDocs
Pancreatitis – National Institute for Health and Care Excellence
Summary of the new 2022 AHA/ASA Guideline on intracerebral hemorrhage.
21 Jun, 2022 | 10:54h | UTCIntracerebral Hemorrhage 2022 Guideline Update – emDocs
Original Guideline: 2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage: A Guideline From the American Heart Association/American Stroke Association – Stroke
Top Things to Know: 2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage – American Heart Association
News Release: New guideline refines care for brain bleeds: compression socks, some meds not effective – American Heart Association
Safety of bariatric surgery in patients with previous acute coronary events or heart failure: nationwide cohort study.
21 Jun, 2022 | 10:44h | UTC
Commentary on Twitter
#Bariatric surgery improves metabolic health of patients, but what are the risks if they have had MI before surgery?
National dataset matched 16000 pts🇸🇪
Heart dis assoc w/🔼 cardiac events post op, plus 🔼risk of SBO and stricture.#SoMe4Surgery https://t.co/iHsZiHIgdG pic.twitter.com/v2SXMpcZd3— BJS Open (@BjsOpen) June 17, 2022
Onconephrology: Update in anticancer drug-related nephrotoxicity.
21 Jun, 2022 | 10:47h | UTCOnconephrology: Update in Anticancer Drug-Related Nephrotoxicity – Nephron
Related:
Commentary from the author on Twitter
Just published! Our review about anticancer drugs related kidney injury with @PepaSolerR and @julianadraibe @SENefrologia @onconephsociety @onconefrologia @senjoven @ERAkidney @womeninnephro https://t.co/jFStKwym5z @KargerPublisher pic.twitter.com/zvbl7wxAbD
— Clara García Carro (@ClaraGCarro) June 20, 2022
Cohort Study: Association of obsessive-compulsive disorder and obsessive-compulsive symptoms with substance misuse.
21 Jun, 2022 | 10:42h | UTC
Commentary on Twitter
In this Swedish cohort study, individuals with OCD diagnosis had a nearly 4-fold risk of substance use disorders, substance-related criminal convictions or deaths. The association was partially accounted for by shared genetics. https://t.co/BDwKw227FG
— JAMA Network Open (@JAMANetworkOpen) June 6, 2022
M-A: Benefits and risks of rapid initiation of antiretroviral therapy in patients with HIV.
21 Jun, 2022 | 10:41h | UTC
M-A: Accuracy of Fluorodeoxyglucose Positron Emission Tomography/ Computerized Tomography for diagnosing periprosthetic joint infections.
21 Jun, 2022 | 10:38h | UTC
Cluster RCT: Evaluation of a multicomponent intervention consisting of education and feedback to reduce benzodiazepine prescriptions by general practitioners.
21 Jun, 2022 | 10:29h | UTC
Associations of bilateral vestibulopathy with cognition in older adults matched with healthy controls for hearing status.
21 Jun, 2022 | 10:24h | UTC
Commentary on Twitter
In this study, older adults with #bilateralvestibulopathy had worse #cognition than their matched control. These results support an association between vestibular loss and cognitive impairment, in particular #Alzheimerdisease. https://t.co/atHR8QlWD9
— JAMA Otolaryngology – Head & Neck Surgery (@JAMAOto) June 17, 2022
WHO Situation Update: Multi-country monkeypox outbreak.
20 Jun, 2022 | 10:45h | UTCMulti-country monkeypox outbreak: situation update – World Health Organization
Related:
Monkeypox Genital Lesions – New England Journal of Medicine
Monkeypox vaccination begins — can the global outbreaks be contained? – Nature
Incubation period for monkeypox: Estimates from the Netherlands.
‘Discriminatory and stigmatizing’: Scientists push to rename monkeypox viruses – STAT
Rename monkeypox strains to remove geographic stigma, researchers say – Science
2022 Monkeypox and Orthopoxvirus Outbreak Global Map – Centers for Disease Control and Prevention
As monkeypox threat grows, scientists debate best vaccine strategy – Science
Monkeypox is a new global threat. African scientists know what the world is up against – Science
Experts highlight sexual aspect of monkeypox spread – CIDRAP
What to Know About Monkeypox – JAMA
Multi-country monkeypox outbreak in non-endemic countries: Update – World Health Organization
Monkeypox outbreaks: 4 key questions researchers have – Nature
Study reports first use of antivirals in monkeypox patients – Lancet
Surveillance, case investigation and contact tracing for Monkeypox – World Health Organization
Laboratory testing for the monkeypox virus: Interim guidance – World Health Organization
A Novel International Monkeypox Outbreak – Annals of Internal Medicine
EU health agency warns monkeypox could become endemic in Europe if outbreak continues – STAT
Monkeypox cases increase across Europe, North America – CIDRAP
Multi-country monkeypox outbreak in non-endemic countries – World Health Organization
Monkeypox goes global: why scientists are on alert – Nature
Monkeypox: What do we know about the outbreaks in Europe and North America? – The BMJ
Seven Confirmed Monkeypox Cases in UK Includes Sexually Transmitted Cluster – STAT
Monkeypox: Time to worry or one to ignore? – BBC
UK, Spain, Portugal report more monkeypox cases – CIDRAP
U.S. monkeypox case reported, as Spain, Portugal report infections in growing outbreak – STAT
Monkeypox – United Kingdom of Great Britain and Northern Ireland – World Health Organization
Monkeypox cases confirmed in England – latest updates – UK Health Security Agency
Seven Confirmed Monkeypox Cases in UK Includes Sexually Transmitted Cluster – Health Policy Watch
European outbreak of monkeypox: what you need to know – The Conversation
Rare monkeypox outbreak in U.K., Europe and U.S.: What is it and should we worry – NPR
Monkeypox cases under investigation in Canada as outbreak spreads in Europe, U.S. – CBC News
WHO report highlights urgent need to transform mental health and mental health care.
20 Jun, 2022 | 10:47h | UTCNews Release: WHO highlights urgent need to transform mental health and mental health care – World Health Organization
Report: World mental health report: Transforming mental health for all – World Health Organization
Commentary: Urgent Need to Transform Mental Health Care – WHO Says In Largest Review Ever – Health Policy Watch
Commentary on Twitter (thread – click for more)
WHO calls on all stakeholders to work together to deepen the value and commitment given to #MentalHealth, reshape the environments that influence mental health and strengthen the systems that care for people’s mental health: WHO #WorldMentalHealthReport https://t.co/J856BrylBB
— World Health Organization (WHO) (@WHO) June 17, 2022
RCT: A restrictive intravenous fluid strategy does not improve outcomes in ICU patients with septic shock.
20 Jun, 2022 | 10:51h | UTCRestriction of Intravenous Fluid in ICU Patients with Septic Shock – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: No Fewer Deaths Seen With Restricted IV Fluid for Septic Shock – HealthDay
Related:
Fluid administration and monitoring in ARDS: which management? – Intensive Care Medicine
Commentary on Twitter
In this trial, a restrictive approach to intravenous fluid administration in critically ill patients with septic shock did not reduce mortality. #CCR22 https://t.co/UfY1936Qwb pic.twitter.com/FtSaDIIroj
— NEJM (@NEJM) June 17, 2022
Opinion | Normalizing menopause – “Martha Hickey and colleagues argue that social and cultural attitudes contribute to the varied experience of menopause and that medicalization fuels negative perceptions”.
20 Jun, 2022 | 10:38h | UTCNormalizing menopause – The BMJ (free for a limited period)
News Release: Medicalizing menopause may be unhelpful for some women – British Medical Journal
Commentary: Menopause is not a disease. Experts call for new narrative for this natural stage of a woman’s life – CNN
Cohort Study: Association of gamma-glutamyltransferase levels with total mortality, liver-related and cardiovascular outcomes.
20 Jun, 2022 | 10:36h | UTC
Commentary on Twitter
Still remember working on this in 2019 but it's out today!
Gamma-GT level has a strong association with mortality outcomes and could add to the prediction of CV mortality
https://t.co/0lzqGfgiGc pic.twitter.com/C8tSZLWlI2— Fred Ho (@fredho42) May 13, 2022
Under a CC BY-NC-ND 4.0 license
Consensus Study: A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research.
20 Jun, 2022 | 10:31h | UTCNews Release: Key outcomes of Long COVID identified in international consensus study – King’s College London
Invited Commentary: Post-COVID-19 condition in children: a COS is urgently needed – The Lancet Respiratory Medicine
Commentary on Twitter
NEW POSITION PAPER—A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research
From Daniel Munblit & co https://t.co/zAxQ1ww6bT pic.twitter.com/WIitohP3Xo
— The Lancet Respiratory Medicine (@LancetRespirMed) June 15, 2022
Clues to long Covid: Scientists strive to unravel what is driving disabling symptoms.
20 Jun, 2022 | 10:30h | UTC
Case-control study: Risk of long COVID associated with delta vs. omicron variants of SARS-CoV-2.
20 Jun, 2022 | 10:34h | UTCRisk of long COVID associated with delta versus omicron variants of SARS-CoV-2 – The Lancet
News Release: Long COVID risk less during Omicron compared to Delta, study finds – King’s College London
Commentaries:
Omicron less likely to lead to long COVID, study finds – CIDRAP
Covid-19: Long covid risk is lower with omicron than delta, researchers find – The BMJ
Commentary on Twitter
Substantial (~50-75%) reduction of #LongCovid with Omicron compared with Delta variant, magnitude influenced by age and time since vaccination @TheLancet https://t.co/shAzJn8WSj pic.twitter.com/bXoct0sXd1
— Eric Topol (@EricTopol) June 17, 2022
Review, Statements, and Recommendations: Cuffless blood pressure measuring devices.
20 Jun, 2022 | 01:26h | UTCRelated:
[Preprint] Open-label RCT: Baricitinib noninferior to Tocilizumab in hospitalized patients with severe COVID-19.
20 Jun, 2022 | 10:28h | UTCRelated:
WHO recommends two new drugs to treat COVID-19 – World Health Organization
Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19 – New England Journal of Medicine
Commentary on Twitter
Preprint⚡⚡
Baricitinib Vs Tocilizumab open label RCT
Baricitinib was non-inferior to tocilizumab with regards to the composite outcome of mechanical ventilation or death by day 28 and the time to discharge by day 28 in patients with severe #COVID19 https://t.co/sQkhATkjEd— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) June 16, 2022