Internal Medicine | Page 8 of 475 | Links Medicus Content Curation & Alerts in Medicine

RCT | Swallowing and oral-care program enhances oral-feeding resumption and reduces pneumonia post-extubation

14 Jul, 2023 | 12:44h | UTC

Effects of a swallowing and oral-care program on resuming oral feeding and reducing pneumonia in patients following endotracheal extubation: a randomized, open-label, controlled trial – Critical Care

Cohort Study | Long-term cancer survivors face higher risk of noncancer death

14 Jul, 2023 | 12:38h | UTC

Relative Burden of Cancer and Noncancer Mortality Among Long-Term Survivors of Breast, Prostate, and Colorectal Cancer in the US – JAMA Network Open

Commentary on Twitter

Patients surviving ≥5 years from initial diagnosis of early breast, prostate, or colorectal cancer, the risk of dying from the cancer varied widely vs noncancer causes of death. Patients at low risk at diagnosis had a 3x higher risk of noncancer death. https://t.co/z2ffG9LqPv pic.twitter.com/HcqFkWAzZf

— JAMA Network Open (@JAMANetworkOpen) July 12, 2023

M-A | Adjunctive corticosteroids improve survival, clinical outcomes in severe community-acquired pneumonia

13 Jul, 2023 | 13:09h | UTC

Efficacy and safety of adjunctive corticosteroids in the treatment of severe community-acquired pneumonia: a systematic review and meta-analysis of randomized controlled trials – Critical Care

RCT | Hydrocortisone reduces mortality in severe community-acquired pneumonia

Effect of corticosteroids on mortality and clinical cure in community-acquired pneumonia: A systematic review, meta-analysis, and meta-regression of randomized control trials – CHEST

Corticosteroids for CAP, influenza and COVID-19: when, how and benefits or harm? – European Respiratory Review

ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia

Review | Cushing Syndrome

13 Jul, 2023 | 13:08h | UTC

Cushing Syndrome: A Review – JAMA (free for a limited period)

Audio clinical review: Diagnosis and Treatment of Cushing Syndrome – JAMA

RCT | Metformin boosts effectiveness of lifestyle interventions for diabetes prevention in individuals with impaired glucose regulation

13 Jul, 2023 | 13:07h | UTC

Safety and effectiveness of metformin plus lifestyle intervention compared with lifestyle intervention alone in preventing progression to diabetes in a Chinese population with impaired glucose regulation: a multicentre, open-label, randomised controlled trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Related Study: Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin – New England Journal of Medicine (link to abstract – $ for full-text)

Single Arm Trial | Low-carbohydrate diet improves glycemic control in type 1 diabetes

13 Jul, 2023 | 13:04h | UTC

Effects of a low-carbohydrate diet in adults with type 1 diabetes management: A single arm non-randomised clinical trial – PLOS One

Related:

Management of Type 1 Diabetes With a Very Low–Carbohydrate Diet – Pediatrics (link to abstract – $ for full-text)

Meta-analysis of randomized trials: patients adhering to a low carbohydrate diet for six months may experience remission of diabetes without adverse consequences

RCT | A calorie-unrestricted low-carbohydrate, high-fat diet resulted in short-term weight loss and better glycemic control.

Comparison of the Effectiveness of Low Carbohydrate Versus Low Fat Diets, in Type 2 Diabetes: Systematic Review and Meta-Analysis of Randomized Controlled Trials – Nutrients

Consensus Statement: Effect of carbohydrate-restricted diets and intermittent fasting on obesity, type 2 diabetes mellitus, and hypertension management.

Effects of a 6-month, low-carbohydrate diet on glycaemic control, body composition, and cardiovascular risk factors in patients with type 2 diabetes: An open-label randomized controlled trial – Diabetes, Obesity and Metabolism

Lower carbohydrate diets for adults with type 2 diabetes – British Journal of Nutrition

Low carbohydrate diet: Insights from a general practice service in patients with type 2 diabetes

Diabetes Canada Position Statement on Low-Carbohydrate Diets for Adults With Diabetes: A Rapid Review – Canadian Journal of Diabetes

Low Carbohydrate Diets for Diabetes: A Review of the Clinical Effectiveness and Guidelines – Canadian Agency for Drugs and Technologies in Health

Adapting diabetes medication for low carbohydrate management of type 2 diabetes: a practical guide – British Journal of General Practice

RCT| Exercise during hemodialysis improves physical function in chronic kidney failure patients

13 Jul, 2023 | 13:01h | UTC

Exercise during Hemodialysis in Patients with Chronic Kidney Failure – NEJM Evidence

RCT | Cytisinicline shows significant efficacy in smoking cessation over placebo

13 Jul, 2023 | 12:58h | UTC

Cytisinicline for Smoking Cessation: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

See also: Visual Abstract

News Release: First large US clinical trial of cytisinicline finds the smoking cessation medication effective and well tolerated – Massachusetts General Hospital

Practice Guidance | Six steps to better care for older people in acute hospitals

12 Jul, 2023 | 14:00h | UTC

Six steps to better care for older people in acute hospitals – British Geriatrics Society

News Release: New guidance outlines ‘Six steps to better care for older people in hospital’ – British Geriatrics Society

Clinical practice guideline for deprescribing opioid analgesics

12 Jul, 2023 | 13:58h | UTC

Clinical practice guideline for deprescribing opioid analgesics: summary of recommendations – Medical Journal of Australia

RCT | Opioids not more effective than placebo for acute low back and neck pain

Deprescribing considerations for older people in general practice – Australian Journal of General Practice

Deprescribing Strategies for Opioids and Benzodiazepines with Emphasis on Concurrent Use: A Scoping Review – Journal of Clinical Medicine

An Overview of Systematic Reviews and Meta-Analyses on the Effect of Medication Interventions Targeting Polypharmacy for Frail Older Adults – Journal of Clinical Medicine

Physician-led medication reviews in polypharmacy patients treated with at least 12 medications in a type 2 diabetes outpatient clinic: a randomised trial – Diabetic Medicine

RCT | A deprescribing intervention reduced medication burden among older adults in post-acute care

Achieving sustainable healthcare through deprescribing of unnecessary medications: making sense of the evidence – Cochrane Library

Deprescribing medicines in older people living with multimorbidity and polypharmacy: the TAILOR evidence synthesis – Health Technology Assessment

Barriers and facilitators to deprescribing of cardiovascular medications: a systematic review – BMJ Open

A National Modified Delphi Consensus Process to Prioritize Experiences and Interventions for Antipsychotic Medication Deprescribing Among Adult Patients With Critical Illness – Critical Care Explorations

Deprescribing proton pump inhibitors – Australian Journal of General Practice

Medication reviews and deprescribing as a single intervention in falls prevention: a systematic review and meta-analysis – Age and Ageing

Optimizing Medication Use in Older Adults With Rheumatic Musculoskeletal Diseases: Deprescribing as an Approach When Less May Be More – ACP Open Rheumatology

Facing the challenge of polypharmacy when prescribing for older people with cardiovascular disease. A review by the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy – European Heart Journal – Cardiovascular Pharmacotherapy

Deprescribing in Older Adults with Cardiovascular Disease – Journal of the American College of Cardiology

Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology

Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports

How-to guide for medication reviews in older adults with cancer: A Young International Society of Geriatric Oncology and Nursing & Allied Health Interest Group initiative – Journal of Geriatric Oncology

Deprescribing in Palliative Cancer Care – Life

Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360

Process evaluation of implementation strategies to reduce potentially inappropriate medication prescribing in older population: A scoping review – Research in Social and Administrative Pharmacy

AGA Clinical Practice Update on De-Prescribing of Proton Pump Inhibitors: Expert Review – Gastroenterology

Development of a Metric to Detect and Decrease Low-Value Prescribing in Older Adults – JAMA Network Open

The MedSafer Study—Electronic Decision Support for Deprescribing in Hospitalized Older Adults: A Cluster Randomized Clinical Trial – JAMA Internal Medicine

Quantifying Anticholinergic Burden and Sedative Load in Older Adults with Polypharmacy: A Systematic Review of Risk Scales and Models – Drugs & Aging

Deprescribing in palliative patients with cancer: a concise review of tools and guidelines – Supportive Care in Cancer

Prescribing practices, patterns, and potential harms in patients receiving palliative care: A systematic scoping review – Exploratory Research in Clinical and Social Pharmacy

A narrative review of evidence to guide deprescribing among older adults – Journal of General and Family Medicine

Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens – The Lancet Health Longevity

Polypharmacy Management in Older Patients – Mayo Clinic Proceedings

Psychopharmacological Treatment in Older People: Avoiding Drug Interactions and Polypharmacy – Deutsches Ärzteblatt international

Eliminating Medication Overload: A National Action Plan – Lown Institute

International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): Position Statement and 10 Recommendations for Action – Drugs & Aging

Common ED Medication Errors: Polypharmacy – emDocs

Current and future perspectives on the management of polypharmacy – BMC Family Practice

Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety

Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international

Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety

RCT | Self-administered intranasal etripamil superior to placebo for acute supraventricular tachycardia conversion

12 Jul, 2023 | 13:54h | UTC

Self-administered intranasal etripamil using a symptom-prompted, repeat-dose regimen for atrioventricular-nodal-dependent supraventricular tachycardia (RAPID): a multicentre, randomised trial – The Lancet

M-A | The effect of blood pressure lowering medications on the prevention of episodic migraine

12 Jul, 2023 | 13:50h | UTC

The effect of blood pressure lowering medications on the prevention of episodic migraine: A systematic review and meta-analysis – Cephalalgia

News Release: New study shows common blood pressure meds underused for migraine – George Institute for Global Health

Myocarditis: a primer for intensivists

12 Jul, 2023 | 13:42h | UTC

Myocarditis: a primer for intensivists – Intensive Care Medicine

Commentary on Twitter

Fulminant myocarditis in #ICU
?short/long‑term prognosis
?clinical suspicion, initial recognition, differential diagnoses
?initial management & temporary #MCS: IABP #ECMO #Impella
?endomyocardial biopsy
?immunomodulatory therapies
?#FOAMcc @yourICM
?️https://t.co/JIGm4p0tv5 pic.twitter.com/o4RctuurEL

— Intensive Care Medicine (@yourICM) July 11, 2023

Retrospective Analysis | 18% of ICU patients develop sepsis-associated AKI, mostly stage 1, diagnosed by low urine output

12 Jul, 2023 | 13:39h | UTC

Sepsis-associated acute kidney injury in the intensive care unit: incidence, patient characteristics, timing, trajectory, treatment, and associated outcomes. A multicenter, observational study – Intensive Care Medicine

Commentary on Twitter

Fulminant myocarditis in #ICU
?short/long‑term prognosis
?clinical suspicion, initial recognition, differential diagnoses
?initial management & temporary #MCS: IABP #ECMO #Impella
?endomyocardial biopsy
?immunomodulatory therapies
?#FOAMcc @yourICM
?️https://t.co/JIGm4p0tv5 pic.twitter.com/o4RctuurEL

— Intensive Care Medicine (@yourICM) July 11, 2023

Intervention Study | Pharmacist review may reduce antibiotic overuse at discharge

12 Jul, 2023 | 13:37h | UTC

Improving antibiotic utilization through an outpatient stewardship initiative – Antimicrobial Stewardship & Healthcare Epidemiology

Commentary: Pharmacist review identifies improper antibiotic prescriptions – CIDRAP

M-A | Cognitive rehabilitation may improve everyday activities in mild to moderate dementia

12 Jul, 2023 | 13:34h | UTC

Cognitive rehabilitation for people with mild to moderate dementia – Cochrane Library

USPSTF | Routine depression screening recommended for adults including pregnant and postpartum women

11 Jul, 2023 | 14:09h | UTC

Screening for Depression and Suicide Risk in Adults: US Preventive Services Task Force Recommendation Statement – JAMA

Evidence Report: Depression and Suicide Risk Screening: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

Patient Page: Screening for Depression and Suicide Risk in Adults – JAMA

Editorials:

Reframing the Key Questions Regarding Screening for Suicide Risk – JAMA

Suicidality Screening Guidelines Highlight the Need for Intervention Studies – JAMA Network Open

USPSTF Statement | Screening for anxiety is recommended in children and adolescents aged 8 to 18 years.

USPSTF Statement | Screening for depression and suicide risk is recommended in children and adolescents aged 12 to 18 years.

M-A | P2Y12 inhibitors show superior efficacy over aspirin for secondary prevention in CAD

11 Jul, 2023 | 14:06h | UTC

P2Y12 Inhibitor or Aspirin Monotherapy for Secondary Prevention of Coronary Events – Journal of the American College of Cardiology (link to abstract – $ for full-text)

RCT | Clopidogrel is better than Aspirin for chronic maintenance monotherapy after percutaneous coronary intervention.

Meta-analysis of randomized trials: Clopidogrel is better than aspirin for the secondary prevention of cardiovascular events.

#ACC21 – RCT: Clopidogrel better than aspirin for chronic maintenance monotherapy after percutaneous coronary intervention.

Commentary on Twitter

Given superior efficacy & similar overall safety, #P2Y12 inhibitor monotherapy might be preferred over #aspirin monotherapy for long-term secondary prevention in pts w/ established #cvCAD. https://t.co/EehIEuWqOt #JACC #P2Y12i #CardioTwitter @FeliceGragnano @vlgmrc @Drroxmehran pic.twitter.com/betLycXGs5

— JACC Journals (@JACCJournals) July 5, 2023