Internal Medicine | Page 67 of 487 | Links Medicus Content Curation & Alerts in Medicine

Lipoprotein(a) is similar to LDL cholesterol but contains apolipoprotein(a). A trial tested the effects of an oligonucleotide drug targeting apo(a) mRNA on lipoprotein(a) concentrations in patients with CVD. #AHA22 https://t.co/eLgnrnTm5D pic.twitter.com/QmNUcxeJwX

— NEJM (@NEJM) November 6, 2022

RCT | Rapid up-titration of guideline-directed medical therapies for acute heart failure reduced readmissions and deaths.

8 Nov, 2022 | 12:24h | UTC

Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial – The Lancet (free registration required)

News Release: Maximizing heart failure meds within 2 weeks reduced risk of hospital readmission, death – American Heart Association

Commentary: STRONG-HF: Rapid Uptitration of GDMT After Acute HF Pays Dividends – TCTMD

Review | Management of heart failure with reduced ejection fraction.

8 Nov, 2022 | 12:17h | UTC

Management of heart failure with reduced ejection fraction – Heart

Review | Intravenous fluid therapy in patients with severe acute pancreatitis admitted to the intensive care unit.

8 Nov, 2022 | 12:15h | UTC

Intravenous fluid therapy in patients with severe acute pancreatitis admitted to the intensive care unit: a narrative review – Intensive Care Medicine

Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis – New England Journal of Medicine (link to abstract – $ for full-text)

Acute Pancreatitis: Diagnosis and Treatment – Drugs

Revised Clinical Practice Guidelines of the Korean Pancreatobiliary Association for Acute Pancreatitis – Gut and Liver

Guidelines for the management of patients with severe acute pancreatitis, 2021 – Anaesthesia Critical Care & Pain Medicine

Evidence-Based Disposition of Acute Pancreatitis – emDocs

2019 WSES guidelines for the management of severe acute pancreatitis – World Journal of Emergency Surgery

American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis

Pancreatitis – National Institute for Health and Care Excellence

RCT | Efficacy of a targeted-release formulation of budesonide for treating primary immunoglobulin A nephropathy.

8 Nov, 2022 | 12:14h | UTC

Results from part A of the multi-center, double-blind, randomized, placebo-controlled NefIgArd trial evaluated targeted-release formulation of budesonide for the treatment of primary immunoglobulin A nephropathy – Kidney International

Commentary: Oral Steroid Safely Treats IgA Nephropathy: Trial Published – Medscape (free registration required)

Commentary on Twitter (thread – click for more)

https://twitter.com/hswapnil/status/1582685958881021952

Review | Oral anticoagulant use in patients with atrial fibrillation and chronic kidney disease.

8 Nov, 2022 | 12:02h | UTC

Oral Anticoagulant Use in Patients With Atrial Fibrillation and Chronic Kidney Disease: A Review of the Evidence With Recommendations for Australian Clinical Practice – Heart Lung and Circulation

Cohort Study | Menstrual cycle regularity and length across the reproductive lifespan and risk of cardiovascular disease.

8 Nov, 2022 | 11:54h | UTC

Menstrual Cycle Regularity and Length Across the Reproductive Lifespan and Risk of Cardiovascular Disease – JAMA Network Open

Commentary: Irregular, Long Menstrual Cycles Up Risk for Cardiovascular Disease – HealthDay

Commentary on Twitter

Irregular and long menstrual cycles across a woman’s reproductive lifespan may identify women with a higher risk of cardiovascular disease, even after accounting for established CVD risk factors. #OAResearch #OAWeek https://t.co/BxNveNAqg5

— JAMA Network Open (@JAMANetworkOpen) October 29, 2022

CDC Clinical Practice Guideline for prescribing opioids for pain.

7 Nov, 2022 | 13:00h | UTC

CDC Clinical Practice Guideline for Prescribing Opioids for Pain — United States, 2022 – Morbidity and Mortality Weekly Report

Commentaries:

Prescribing Opioids for Pain — The New CDC Clinical Practice Guideline – New England Journal of Medicine

CDC issues new opioid prescribing guidance, giving doctors more leeway to treat pain – NPR

NICE Guideline | Self-harm: assessment, management and preventing recurrence.

7 Nov, 2022 | 12:58h | UTC

Self-harm: assessment, management and preventing recurrence – National Institute for Health and Care Excellence

RCT | In patients with CKD (eGFR 20-45 mL/min per 1.73 m2), Empagliflozin reduced the risk of progression of kidney disease.

7 Nov, 2022 | 12:56h | UTC

Empagliflozin in Patients with Chronic Kidney Disease – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: EMPA-KIDNEY supports SGLT2 inhibition for chronic kidney disease – medwire News

Video Summary: EMPA-KIDNEY results: Empagliflozin reduces kidney disease progression and cardiovascular deaths

Commentary on Twitter

In this trial involving patients with chronic kidney disease, empagliflozin resulted in a lower risk of disease progression or death from cardiovascular causes than placebo. #KidneyWk https://t.co/HFgzPgrRFx pic.twitter.com/EPU6Rl14F1

— NEJM (@NEJM) November 4, 2022

RCT | Triglyceride lowering with Pemafibrate fails to reduce CVD risk in patients with Type 2 DM and hypertriglyceridemia.

7 Nov, 2022 | 12:54h | UTC

Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk – New England Journal of Medicine (link to abstract – $ for full-text)

News Releases:

New medicine reduces triglyceride by 25%, no change in CVD risk in people with Type 2 diabetes – American Heart Association

Triglyceride-lowering trial neutral for cardiovascular event reduction – Brigham and Women’s Hospital

Commentaries:

Pemafibrate Fails to Lower CVD Risk in Patients With High Triglycerides: PROMINENT – TCTMD

PROMINENT: Pemafibrate Effective in Lowering Tryglycerides, But Not Reducing Risk of CV Events – American College of Cardiology

Commentary on Twitter

In a randomized trial, the incidence of cardiovascular events was not lower in patients with diabetes, HTG, and low HDL cholesterol levels who received pemafibrate, although TG, VLDL cholesterol, remnant cholesterol, and Apo C-III levels decreased. #AHA22 https://t.co/bNtIAwWTX0 pic.twitter.com/yWaTWarlsv

— NEJM (@NEJM) November 5, 2022

RCT | Chlortalidone and Hydrochlorothiazide resulted in similar reductions of CVD in older patients with hypertension.

7 Nov, 2022 | 12:50h | UTC

News Release (not published yet): No difference in heart outcomes found in use of two diuretics to treat blood pressure – American Heart Association

Commentaries:

In High BP, Chlorthalidone and Hydrochlorothiazide Have Similar Impact on MACE – TCTMD

Diuretic Comparison Project – DCP – American College of Cardiology

RCT | Intravenous iron did not significantly reduce hospital admissions in patients with heart failure and iron deficiency.

7 Nov, 2022 | 12:48h | UTC

Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial – The Lancet

Commentaries:

Effectiveness of Intravenous Iron Treatment Versus Standard Care in Patients With Heart Failure and Iron Deficiency – IRONMAN – American College of Cardiology

IRONMAN Misses but Lends Support to IV Iron Repletion in HF – TCTMD

Cohort Study | Preoperative hemodialysis timing and postoperative mortality in patients with end-stage kidney disease.

7 Nov, 2022 | 12:46h | UTC

Association Between Preoperative Hemodialysis Timing and Postoperative Mortality in Patients With End-stage Kidney Disease – JAMA (free for a limited period)

Editorial: Optimal Timing of Hemodialysis Before Surgery – JAMA (free for a limited period)

Commentary from the author on Twitter (thread – click for more)

1/
In @JAMA_current, we asked: Is the timing of hemodialysis before surgery associated with postoperative mortality?

The answer: YES

Here’s what we found:https://t.co/ZQl0SHZpAn

— Vikram Fielding-Singh, MD, JD (@vikramfs) November 3, 2022

Guidelines for empirical antibacterial therapy of sepsis in adults.

7 Nov, 2022 | 12:40h | UTC

The 2021 Dutch Working Party on Antibiotic Policy (SWAB) guidelines for empirical antibacterial therapy of sepsis in adults – BMC Infectious Diseases

Updated systematic review on cannabis and other plant-based treatments for chronic pain.

7 Nov, 2022 | 12:39h | UTC

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain – Agency for Healthcare Research and Quality

Systematic Review: Cannabis-based products for chronic pain.

Podcast: #338 LIVE! Medical Cannabis: Is it still dope? – The Curbsiders

Medicinal Cannabis for Chronic Pain: The Bermuda Triangle of Low Quality Studies, Countless Meta-analyses and Conflicting Recommendations – European Journal of Pain

RCT: Effect of medical marijuana card ownership on pain, insomnia, and affective disorder symptoms in adults.

Cohort Study: Long-term cannabis use is associated with cognitive deficits and smaller hippocampal volume in midlife.

AHA Scientific Statement | How does cannabis use affect brain health? Caution advised, more research needed.

M-A: Birth outcomes of neonates exposed to marijuana in utero.

Review: Cannabis-based medicines and medical cannabis for chronic neuropathic pain.

Cannabinoid metabolites as inhibitors of major hepatic CYP450 enzymes, with implications for cannabis-drug interactions.

The International Cannabis Toolkit (iCannToolkit): a multidisciplinary expert consensus on minimum standards for measuring cannabis use.

Cannabis products are being sold as sleep remedies – here’s the evidence about their effectiveness.

Guideline: Medical cannabis or cannabinoids for chronic pain.

Cannabis and Cannabinoid Analgesia position statement – “Due to the lack of high-quality clinical evidence, the IASP does not currently endorse general use of cannabis and cannabinoids for pain relief.”

NICE Guideline: Cannabis-Based Medicinal Products

Consensus recommendations for perioperative management of cannabis and cannabinoid-based medicine users

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain – Agency for Healthcare Research and Quality

Short Review: Drug Interactions with Cannabinoids

Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain

Review: Considerations for cannabinoids in perioperative care by anesthesiologists.

Review: Cannabis-based Medicines and the Perioperative Physician

Study: Cannabis Use Disorder May Increase the Risk of Cardiovascular Events in Major Elective Surgeries

Perspective: If You Smoke Pot, Your Anesthesiologist Needs To Know

Perioperative Care of Cannabis Users: A Comprehensive Review of Pharmacological and Anesthetic Considerations

RCT | Efficacy of a digital behavioral therapeutic application to improve glycemic control in adults with Type 2 DM.

7 Nov, 2022 | 12:33h | UTC

Randomized, Controlled Trial of a Digital Behavioral Therapeutic Application to Improve Glycemic Control in Adults With Type 2 Diabetes – Diabetes Care

Commentary: Smartphone-delivered CBT improves glycemic control in people with type 2 diabetes – medwire News

RCT | Efficacy of prune juice containing sorbitol, pectin, and polyphenol in chronic constipation.

7 Nov, 2022 | 12:34h | UTC

Prune Juice Containing Sorbitol, Pectin, and Polyphenol Ameliorates Subjective Complaints and Hard Feces While Normalizing Stool in Chronic Constipation: A Randomized Placebo-Controlled Trial – American Journal of Gastroenterology (free for a limited period)

Commentary on Twitter

In the 📕#RedJournal — Prune Juice Containing Sorbitol, Pectin, and Polyphenol Ameliorates Subjective Complaints and Hard Feces While Normalizing Stool in Chronic Constipation: A Randomized Placebo-Controlled Trial
Koyama, et al.

👉 https://t.co/IFnZTfnw8I @AmCollegeGastro pic.twitter.com/C244dAWNIa

— AJG – The American Journal of Gastroenterology (@AmJGastro) October 19, 2022

Crossover RCT | Efficacy of low-dose Empagliflozin as an adjunct to hybrid closed-loop insulin therapy in adults with Type 1 DM.

7 Nov, 2022 | 12:24h | UTC

Low-Dose Empagliflozin as Adjunct to Hybrid Closed-Loop Insulin Therapy in Adults With Suboptimally Controlled Type 1 Diabetes: A Randomized Crossover Controlled Trial – Diabetes Care (link to abstract – $ for full-text)

Review | Early appropriate diagnostics and treatment of MDR Gram-negative infections.

7 Nov, 2022 | 12:19h | UTC

Early appropriate diagnostics and treatment of MDR Gram-negative infections – JAC-Antimicrobial Resistance

The threat of multidrug-resistant/extensively drug-resistant Gram-negative respiratory infections: another pandemic – European Respiratory Review

A position paper for the diagnosis and management of infections caused by multidrug-resistant bacteria: Endorsed by the Italian Society of Infection and Tropical Diseases (SIMIT), the Italian Society of Anti-Infective Therapy (SITA), the Italian Group for Antimicrobial Stewardship (GISA), the Italian Association of Clinical Microbiologists (AMCLI), and the Italian Society of Microbiology (SIM) – International Journal of Antimicrobial Agents

IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections: Version 2.0 – Infectious Diseases Society of America

IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections: Version 1.0 – Infectious Diseases Society of America

Commentary on Twitter

This is a ⚡fantastic article⚡
by super 🌟s Dr. Bassetti & @davidvanduin @jac_amr
We really need more adoption to RDTs coupled with stewardship programs
Early appropriate diagnostics and treatment of MDR Gram-negative infections #IDTwitter #MedEd https://t.co/h6eOvK2iH8 pic.twitter.com/WBjogJ6IYu

— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) September 14, 2022

Under a https://creativecommons.org/licenses/by/4.0/ license