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Internal Medicine

Review | Exertional heat stroke: pathophysiology and risk factors.

25 Nov, 2022 | 12:19h | UTC

Exertional heat stroke: pathophysiology and risk factors – BMJ Medicine

Related:

Classic and exertional heatstroke – Nature Reviews Disease Primers

Heat-Related Illness in Emergency and Critical Care: Recommendations for Recognition and Management with Medico-Legal Considerations – Biomedicines

Treatment and Prevention of Heat-Related Illness – New England Journal of Medicine

Wilderness Medical Society Clinical Practice Guidelines for the Prevention and Treatment of Heat Illness: 2019 Update

ACSM Expert Consensus Statement on Exertional Heat Illness: Recognition, Management, and Return to Activity

 

Commentary on Twitter

 

 


M-A | Risk of cardiovascular diseases associated with medications used in ADHD.

25 Nov, 2022 | 12:16h | UTC

Risk of Cardiovascular Diseases Associated With Medications Used in Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-analysis – JAMA Network Open

Commentaries: 

Paying Attention to Attention-Deficit/Hyperactivity Disorder Medications and Cardiovascular Risk – JAMA Network Open

Meta-Analysis Finds ADHD Drugs Not Linked To Risk Of Cardiovascular Disease – Reporter Health

 


RCT | Anticoagulation for 3 months reduces recurrence rates vs. treatment for 6 weeks in patients with isolated distal DVT.

24 Nov, 2022 | 13:34h | UTC

Rivaroxaban treatment for six weeks versus three months in patients with symptomatic isolated distal deep vein thrombosis: randomised controlled trial – The BMJ

News Release: Extending anti-clotting treatment after distal DVT reduces further clot risk – BMJ Newsroom

 


Review | Psychiatric issues among health professionals.

24 Nov, 2022 | 13:29h | UTC

Psychiatric Issues Among Health Professionals – Medical Clinics of North America

 


Review | Care of the seriously ill patient with SARS-CoV-2.

24 Nov, 2022 | 13:26h | UTC

Care of the Seriously Ill Patient with SARS-CoV-2 – Medical Clinics of North America

 


SR | Pharmacological interventions for preventing venous thromboembolism in people undergoing bariatric surgery.

24 Nov, 2022 | 13:21h | UTC

Pharmacological interventions for preventing venous thromboembolism in people undergoing bariatric surgery – Cochrane Library

 


RCT | Low-dose morphine did not significantly reduce the intensity of chronic breathlessness in patients with COPD.

23 Nov, 2022 | 14:09h | UTC

Effect of Regular, Low-Dose, Extended-release Morphine on Chronic Breathlessness in Chronic Obstructive Pulmonary Disease: The BEAMS Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Dyspnea—When a Sensation Becomes a Symptom – JAMA (free for a limited period)

See also: Visual Abstract

Commentary: Breathlessness in Patients with COPD isn’t Reduced with Daily Morphine – HCP Live

 


KDIGO 2022 Guideline for the prevention, diagnosis, evaluation, and treatment of Hepatitis C in chronic kidney disease.

23 Nov, 2022 | 14:11h | UTC

KDIGO 2022 Clinical Practice Guideline for the Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in Chronic Kidney Disease – Kidney International

Executive Summary: KDIGO 2022 Clinical Practice Guideline for the Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in Chronic Kidney Disease – Kidney International

News Release: KDIGO Announces Publication of 2022 Hepatitis C in Chronic Kidney Disease Guideline – Kidney Disease: Improving Global Outcomes (KDIGO)

 


Guideline Synopsis | Diagnosis and treatment of infertility in men.

23 Nov, 2022 | 14:08h | UTC

Diagnosis and Treatment of Infertility in Men – JAMA (free for a limited period)

Original Guideline: AUA/ASRM Guideline: Diagnosis and treatment of infertility in men

 


RCT | Treatment of early Lyme Disease with doxycycline for 7 days is noninferior to treatment for 14 days.

23 Nov, 2022 | 14:06h | UTC

Treatment of erythema migrans with doxycycline for 7 days versus 14 days in Slovenia: a randomised open-label non-inferiority trial – The Lancet Infectious Diseases (link to abstract – $ for full-text)

Commentary: Shorter Duration of Antibiotics Noninferior for Lyme Disease – JAMA (free for a limited period)

 

Commentary on Twitter

 


RCT | Impact of empagliflozin on decongestion in acute heart failure.

23 Nov, 2022 | 14:04h | UTC

Impact of empagliflozin on decongestion in acute heart failure: the EMPULSE trial – European Heart Journal

Commentary: Empagliflozin in Patients Hospitalized for Acute Heart Failure – EMPULSE – American College of Cardiology

 

Commentary on Twitter

 

Under a https://creativecommons.org/licenses/by-nc/4.0/ license

 


Cohort Study | Race-dependent association of HDL-C levels with incident coronary artery disease.

23 Nov, 2022 | 14:02h | UTC

Race-Dependent Association of High-Density Lipoprotein Cholesterol Levels With Incident Coronary Artery Disease – Journal of the American College of Cardiology

Editorial: HDL-C in Black Adults for ASCVD Risk Calculation: Benefit or Barrier to Achieving Health Equity? – Journal of the American College of Cardiology

News Release: Study challenges “good” cholesterol’s role in universally predicting heart disease risk – National Institutes of Health

Commentary: Study suggests that HDL or ‘good’ cholesterol is less beneficial than previously thought, especially for Black adults – CNN

 


Right heart failure in the ED: approach to diagnosis and management.

23 Nov, 2022 | 13:54h | UTC

Right Heart Failure in the ED: Approach to Diagnosis and Management – emDocs

 


SR | Blood pressure targets for the treatment of people with hypertension and cardiovascular disease.

22 Nov, 2022 | 13:39h | UTC

Blood pressure targets for the treatment of people with hypertension and cardiovascular disease – Cochrane Library 

Summary: Blood pressure targets in people with cardiovascular disease – Cochrane Library 

 

Commentary on Twitter 

https://twitter.com/CochraneUK/status/1594059435202289666

 


M-A | Use of CT of the head in patients with acute atraumatic altered mental status.

22 Nov, 2022 | 13:38h | UTC

Use of Computed Tomography of the Head in Patients With Acute Atraumatic Altered Mental Status: A Systematic Review and Meta-analysis – JAMA Network Open 

 

Commentary on Twitter 

 


Guardianship | A medicolegal review for clinicians.

22 Nov, 2022 | 13:33h | UTC

Guardianship: A medicolegal review for clinicians – Journal of the American Geriatrics Society 

 


M-A | Cardiac and kidney adverse effects of HIF Prolyl-Hydroxylase inhibitors for anemia in patients with CKD not receiving dialysis.

22 Nov, 2022 | 13:22h | UTC

Cardiac and Kidney Adverse Effects of HIF Prolyl-Hydroxylase Inhibitors for Anemia in Patients With CKD Not Receiving Dialysis: A Systematic Review and Meta-analysis – American Journal of Kidney Diseases 

 


M-A | Burden of respiratory syncytial virus infection in older and high-risk adults in developed countries.

22 Nov, 2022 | 13:05h | UTC

Burden of respiratory syncytial virus infection in older and high-risk adults: a systematic review and meta-analysis of the evidence from developed countries – European Respiratory Review 

 


RCT | New drug can improve constipation in patients with Parkinson Disease.

22 Nov, 2022 | 13:00h | UTC

Oral ENT-01 Targets Enteric Neurons to Treat Constipation in Parkinson Disease: A Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text) 

Commentaries:  

New Drug Could Ease Parkinson’s-Related Constipation – HealthDay 

Oral ENT-01 safe, significantly improves constipation in persons with Parkinson disease – American College of Physicians 

 

Commentary on Twitter 

 


RCT | Intermittently scanned continuous glucose monitoring vs. fingerstick testing for Type 1 DM.

21 Nov, 2022 | 14:45h | UTC

RCT | Intermittently scanned continuous glucose monitoring vs. fingerstick testing for Type 1 DM. 

Intermittently Scanned Continuous Glucose Monitoring for Type 1 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text) 

Commentary: Continuous Monitoring Outperforms Fingerstick Testing in Patients With T1D, High Glycated Hemoglobin – AJMC 

 

Commentary on Twitter 

 


RCT | The effects of modifying amount and type of dietary carbohydrate on esophageal reflux symptoms.

21 Nov, 2022 | 14:42h | UTC

The Effects of Modifying Amount and Type of Dietary Carbohydrate on Esophageal Acid Exposure Time and Esophageal Reflux Symptoms: A Randomized Controlled Trial – The American Journal of Gastroenterology 

Commentary: Study finds that reducing intake of simple sugars improves GERD – Vanderbilt University 

 


M-A | Global monkeypox case hospitalization rates.

21 Nov, 2022 | 14:36h | UTC

Global monkeypox case hospitalisation rates: A rapid systematic review and meta-analysis – eClinicalMedicine 

Related: 

Human monkeypox virus infection in women and non-binary individuals during the 2022 outbreaks: a global case series – The Lancet 

Monkeypox — A Sobering Sentinel for Pandemic Preparedness and Sexual Health System Capacity – New England Journal of Medicine 

CDC study shows healthcare workers have a low risk of infection after exposure to patients with monkeypox. 

Monkeypox – New England Journal of Medicine 

Diagnosis and Management of Monkeypox: A Review for the Emergency Clinician – Annals of Emergency Medicine 

Monkeypox: disease epidemiology, host immunity and clinical interventions. 

Monkeypox: A clinical update for paediatricians – Journal of Pediatrics and Child Health 

Cohort Study | Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain. 

CDC Report | Epidemiologic and clinical characteristics of Monkeypox cases in the US. 

Update on the Monkeypox Outbreak – JAMA 

Antivirals with Activity Against Monkeypox: A Clinically Oriented Review – Clinical Infectious Diseases 

Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series – The BMJ 

WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch 

Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022 – New England Journal of Medicine 

Monkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases 

 


Human monkeypox virus infection in women and non-binary individuals during the 2022 outbreaks: a global case series.

21 Nov, 2022 | 14:35h | UTC

Human monkeypox virus infection in women and non-binary individuals during the 2022 outbreaks: a global case series – The Lancet 

Commentaries: 

First study of monkeypox infection in women provides new insights to inform public health response to ongoing outbreak – Queen Mary University of London 

Study describes monkeypox in women; CDC warns of Tpoxx resistance – CIDRAP 

Related: 

Global monkeypox case hospitalisation rates: A rapid systematic review and meta-analysis – eClinicalMedicine 

Monkeypox — A Sobering Sentinel for Pandemic Preparedness and Sexual Health System Capacity – New England Journal of Medicine 

CDC study shows healthcare workers have a low risk of infection after exposure to patients with monkeypox. 

Monkeypox – New England Journal of Medicine 

Diagnosis and Management of Monkeypox: A Review for the Emergency Clinician – Annals of Emergency Medicine 

Monkeypox: disease epidemiology, host immunity and clinical interventions. 

Monkeypox: A clinical update for paediatricians – Journal of Pediatrics and Child Health 

Cohort Study | Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain. 

CDC Report | Epidemiologic and clinical characteristics of Monkeypox cases in the US. 

Update on the Monkeypox Outbreak – JAMA 

Antivirals with Activity Against Monkeypox: A Clinically Oriented Review – Clinical Infectious Diseases 

Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series – The BMJ 

WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch 

Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022 – New England Journal of Medicine 

Monkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases 

 


Cohort Study | Association of antidepressant use during pregnancy with risk of neurodevelopmental disorders in children.

21 Nov, 2022 | 14:33h | UTC

Association of Antidepressant Use During Pregnancy With Risk of Neurodevelopmental Disorders in Children – JAMA Internal Medicine (link to abstract – $ for full-text) 

Commentaries: 

Antidepressant Use During Pregnancy Not Associated With Neurodevelopmental Risk in Children – Psychiatric News Alert 

Antidepressants in Pregnancy Do Not Affect Child Neurodevelopment – HealthDay 

 

Commentary on Twitter 

https://twitter.com/JAMAInternalMed/status/1593046260440776704 

 


SR | Exercise for acutely hospitalized older medical patients.

21 Nov, 2022 | 14:28h | UTC

Exercise for acutely hospitalised older medical patients – Cochrane Library 

Summary: Exercise for older patients during unplanned hospital stays – Cochrane Library 

 

Commentary on Twitter 

https://twitter.com/CochraneUK/status/1593169319881756672 

 


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