Internal Medicine
Review: Pulmonary arterial hypertension
16 Mar, 2018 | 02:38h | UTCState of The Art Review: Pulmonary arterial hypertension: pathogenesis and clinical management – The BMJ (free for a limited period)
Related Guidelines: Pharmacologic Therapy for Pulmonary Arterial Hypertension in Adults – CHEST Guideline and Expert Panel Report (free) AND 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension (free)
Guideline: Evaluation and Treatment of Hirsutism in Premenopausal Women
16 Mar, 2018 | 02:28h | UTCKey Points: Evaluation and Treatment of Hirsutism in Premenopausal Women – JAMA Clinical Guidelines Synopsis (free for a limited period)
Meta-Analysis: Digital Rectal Examination for Prostate Cancer Screening in Primary Care
16 Mar, 2018 | 02:26h | UTCCommentaries: New analysis recommends against using digital rectal exam in primary care – American Academy of Family Physicians, vie EurekAlert (free) AND Little Evidence Supports Use of Digital Rectal Exam – Medscape (free registration required) AND Digital Rectal Exams for Routine Prostate Screening Discouraged – NEJM Physician’s First Watch (free)
Research: Endovascular treatment for acute ischaemic stroke in routine clinical practice
16 Mar, 2018 | 02:25h | UTCRelated guideline: 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association / American Stroke Association (free PDF) AND Summary for ED-relevant care: 2018 AHA/ASA Ischemic Stroke Updates – emDocs (free)
“In routine clinical practice, endovascular treatment for patients with acute ischemic stroke is at least as effective and safe as in the setting of a randomized controlled trial”.
Research: Sustained Physical Activity, Not Weight Loss, Associated With Improved Survival in Coronary Heart Disease
16 Mar, 2018 | 02:24h | UTCSustained Physical Activity, Not Weight Loss, Associated With Improved Survival in Coronary Heart Disease – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentary: For CHD Patients, Physical Activity More Meaningful Than Weight Changes Over Time – TCTMD (free)
Research: Colonoscopy and Colorectal Cancer Mortality
16 Mar, 2018 | 02:23h | UTCColonoscopy and Colorectal Cancer Mortality in the Veterans Affairs Health Care System: A Case–Control Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Colonoscopy significantly reduces mortality from colorectal cancer in Veterans Affairs study – 2 Minute Medicine (free) AND Colonoscopy Significantly Reduces CRC Deaths – Medscape (free registration required)
Research: BNP in the emergency department
16 Mar, 2018 | 02:22h | UTCN-Terminal Pro–B-Type Natriuretic Peptide in the Emergency Department – Journal of the Americana College of Cardiology (link to abstract – $ for full-text)
Commentary: NT-proBNP cutpoints validated for diagnosing and ruling out heart failure in the ED – ACP Hospitalist (free)
Related review: BNP in the emergency department: The evidence – First10EM (free)
“In acutely dyspneic patients seen in the ED setting, age-stratified NT-proBNP cutpoints may aid in the diagnosis of acute HF. An NT-proBNP <300 pg/ml strongly excludes the presence of acute HF”.
Research: Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout
16 Mar, 2018 | 02:14h | UTCCommentaries: Gout Drug Febuxostat Linked to More CV Deaths Without Uptick in CV Events: CARES Trial – TCTMD (free) AND CARES: Increased Risk of Death With Febuxostat in Patients With Gout and CV Disease – American College of Cardiology (free) AND
More Deaths, Strokes Seen with Perioperative Beta Blocker
16 Mar, 2018 | 02:13h | UTCRelated (just published) systematic review: Perioperative beta-blockers for preventing surgery-related mortality and morbidity – Cochrane Library (free)
Research: Calcium and vitamin D supplementation and increased risk of serrated polyps
16 Mar, 2018 | 02:10h | UTCCalcium and vitamin D supplementation and increased risk of serrated polyps: results from a randomised clinical trial – Gut (link to abstract – $ for full-text)
Commentaries: Calcium and vitamin D supplements may raise risk of polyps – MedicalNewsToday (free) AND Calcium Supplements Up Risk for Precancerous Serrated Polyps – Medscape (free registration required)
See related meta-analysis of RCT showing calcium and vitamin D don’t prevent bone fractures
Statement: ADA Deeply Concerned About New Guidance from ACP Regarding Blood Glucose Targets
16 Mar, 2018 | 02:10h | UTCSee original guideline and commentary: ACP Guideline: Hemoglobin A1c Targets for Glycemic Control in Type 2 Diabetes
Wearable technology to screen for atrial fibrillation: does it raise more questions than it answers?
16 Mar, 2018 | 02:08h | UTCRelated: Get Ready For A Tsunami Of ECGs – Cardiobrief (free) AND: Thoughts on the Apple Watch and Mobile ECG, by Dr John Mandrola (free) AND Overdiagnosis Only a Matter of Time With ECG Watches – Medscape (free registration required)
Review: Sudden Unexplained Nocturnal Death Syndrome
16 Mar, 2018 | 02:05h | UTCReview: Sudden Unexplained Nocturnal Death Syndrome: The Hundred Years’ Enigma – Journal of the American Heart Association (free)
Management of eosinophilic esophagitis in daily clinical practice
16 Mar, 2018 | 02:03h | UTCManagement of eosinophilic esophagitis in daily clinical practice – Diseases of the Esophagus (free)
Related guidelines: Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults – United European Gastroenterology (free) Management Guidelines of Eosinophilic Esophagitis in Childhood – Journal of Pediatric Gastroenterology and Nutrition (free) AND ACG Clinical Guideline: Evidenced Based Approach to the Diagnosis and Management of Esophageal Eosinophilia and Eosinophilic Esophagitis (EoE) (free)
Research: Low-Calorie Vegetarian vs Mediterranean Diets
16 Mar, 2018 | 01:43h | UTCLow-Calorie Vegetarian Versus Mediterranean Diets for Reducing Body Weight and Improving Cardiovascular Risk Profile: CARDIVEG Study (Cardiovascular Prevention With Vegetarian Diet) – Circulation (free PDF for a limited period)
Commentaries: Low-Calorie Vegetarian vs. Mediterranean Diets – American College of Cardiology, Latest in Cardiology (free) AND Vegetarian and Mediterranean diet may be equally effective in preventing heart disease – American Heart Association, via ScienceDaily (free)
Review: Advances in the diagnosis and treatment of Clostridium difficile infections
16 Mar, 2018 | 01:42h | UTCAdvances in the diagnosis and treatment of Clostridium difficile infections – Emerging Microbes and Infections (free)
Perspective: The importance and challenges of shared decision making in older people with multimorbidity
16 Mar, 2018 | 01:37h | UTCPerspective: The importance and challenges of shared decision making in older people with multimorbidity – PLOS Medicine (free)
Meta-Analysis: Relative efficacy and safety of topical non-steroidal anti-inflammatory drugs for osteoarthritis
16 Mar, 2018 | 01:32h | UTC
Management of acute aortic dissection and thoracic aortic rupture
16 Mar, 2018 | 01:08h | UTCManagement of acute aortic dissection and thoracic aortic rupture – Journal of Intensive Care (free)
Source: Critical Care Reviews Newsletter
Review: Management of patients with high-risk pulmonary embolism
16 Mar, 2018 | 01:05h | UTCSource: Critical Care Reviews Newsletter
Vasoplegia treatments: the past, the present, and the future
16 Mar, 2018 | 01:07h | UTCVasoplegia treatments: the past, the present, and the future – Critical Care (free)
Source: Critical Care Reviews Newsletter
Predicting acute kidney injury: current status and future challenges
16 Mar, 2018 | 01:04h | UTCPredicting acute kidney injury: current status and future challenges – Journal of Nephrology (free)
Source: Critical Care Reviews Newsletter
A Practical Review of the Emerging Direct Anticoagulants, Laboratory Monitoring, and Reversal Agents
16 Mar, 2018 | 01:01h | UTCSource: Critical Care Reviews Newsletter
Meta-analysis: carbohydrate restriction on glycemic control in adults with diabetes
16 Mar, 2018 | 00:54h | UTCEffect of dietary carbohydrate restriction on glycemic control in adults with diabetes: a systematic review and meta-analysis – Diabetes Research and Clinical Practice (link to abstract – $ for full-text)
“Carbohydrate-restricted diets, associated with reductions in HbA1c of around 0.4% in short term” (via @kamleshkhunti see Tweet)
ACP Guideline: Hemoglobin A1c Targets for Glycemic Control in Type 2 Diabetes
8 Mar, 2018 | 22:32h | UTCCommentary: Major Medical Associations Feud Over Diabetes Guidelines – NPR (free)
“Clinicians should aim to achieve an HbA1c level between 7% and 8% in most patients with type 2 diabetes”