Internal Medicine
Systematic review: macrolide antibiotics for bronchiectasis
3 Apr, 2018 | 17:32h | UTCMacrolide antibiotics for bronchiectasis – Cochrane Library (link to abstract – $ for full-text)
Summary: Macrolide antibiotics for bronchiectasis – Cochrane Library (free)
“Long-term macrolide therapy may reduce the frequency of exacerbations and improve quality of life, although supporting evidence is derived mainly from studies of azithromycin, rather than other macrolides, and predominantly among adults rather than children. However, macrolides should be used with caution, as limited data indicate an associated increase in microbial resistance”.
Systematic review: non-invasive diagnostic tests for Helicobacter pylori infection
3 Apr, 2018 | 16:05h | UTCNon-invasive diagnostic tests for Helicobacter pylori infection – Cochrane Library (link to abstract – $ for full-text)
Perspective: paying hospitals to keep people out of hospitals?
3 Apr, 2018 | 15:42h | UTCPaying Hospitals To Keep People Out Of Hospitals? It Works In Maryland – Kaiser Health News (free)
The Assessment of Pain in Older People: UK National Guidelines
30 Mar, 2018 | 04:43h | UTCThe Assessment of Pain in Older People: UK National Guidelines – Age and Ageing (free)
The human microbiome: why our microbes could be key to our health
30 Mar, 2018 | 04:40h | UTCThe human microbiome: why our microbes could be key to our health – The Guardian (free) (via @trished see Tweet)
Myocarditis in Patients Treated With Immune Checkpoint Inhibitors
30 Mar, 2018 | 04:37h | UTCMyocarditis in Patients Treated With Immune Checkpoint Inhibitors – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Myocarditis a Risk with Checkpoint Inhibitors – CRTOnline.org (free) AND Myocarditis in Patients Treated With Immune Checkpoint Inhibitors – American College of Cardiology, Latest in Cardiology (free)
Related Guidelines and Reviews: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free) AND New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)
Meta-Analysis: A Comparison of the Quick-SOFA and Systemic Inflammatory Response Syndrome Criteria in Sepsis
30 Mar, 2018 | 04:29h | UTCRelated meta-analysis and commentaries: Prognostic Accuracy of the Quick Sequential Organ Failure Assessment for Mortality in Patients With Suspected Infection: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text) AND For mortality prediction, qSOFA has poor sensitivity, moderate specificity, review finds – ACP Hospitalist (free) AND Systemic inflammatory response syndrome criteria may be more sensitive than quick sequential organ failure assessment for predicting mortality in patients with suspected infection – 2 Minute Medicine (free)
“The SIRS was significantly superior to the qSOFA for sepsis diagnosis, and the qSOFA was slightly better than the SIRS in predicting hospital mortality. The association of both criteria could provide a better model to initiate or escalate therapy in patients with sepsis”.
Smoking and smoking cessation in relation to risk of diabetes
30 Mar, 2018 | 04:28h | UTCCommentaries: Combating diabetes in China: a long-term perspective is needed – The Lancet Public Health (free) AND Smoking linked with higher risk of type 2 diabetes – University of Oxford (free)
“Among Chinese adults, smoking associated with 18-33% increased risk of diabetes” (via @kamleshkhunti see Tweet)
Meta-Analysis: Patent foramen ovale closure vs. medical therapy for cryptogenic stroke
30 Mar, 2018 | 04:27h | UTC“5-study EHJ meta analysis confirms value of PFO closure after cryptogenic stroke. “Number Needed to Close”: 178 pts to prevent one stroke over 1 year. Size matters (no effect for small shunts, “NNC” 96 for large shunts)” (via @Steph_Achenbach see Tweet)
High red and processed meat consumption is associated with non-alcoholic fatty liver disease and insulin resistance
30 Mar, 2018 | 04:08h | UTCHigh red and processed meat consumption is associated with non-alcoholic fatty liver disease and insulin resistance – Journal of Hepatology (link to abstract – $ for full-text) (via @kamleshkhunti see Tweet)
Commentaries: High Consumption Of Red And Processed Meat Linked to Non-Alcoholic Fatty Liver Disease And Insulin Resistance – EASL (free) AND More People Can Afford Meat Now, And Hepatologists Claim That Is Causing Liver Disease – Science 2.0 (free)
Guideline – Otitis media (acute): antimicrobial prescribing
30 Mar, 2018 | 04:10h | UTCGuideline: Otitis media (acute): antimicrobial prescribing – National Institute for Health and Care Excellence (NICE) (free)
Commentaries: Most common ear infections should not be treated with antibiotics, says NICE (free) AND Common ear infections don’t need antibiotics, health watchdog says – The Guardian (free) AND Antibiotics not recommended for acute otitis, says NICE – OnMedica (free)
Related guideline: Clinical Practice Guideline: Otitis Media with Effusion (Update) – Otolaryngol Head Neck Surg (free) AND Executive Summary – Otolaryngol Head Neck Surg (free)
The Effect of Door-to-Diuretic Time on Clinical Outcomes in Patients With Acute Heart Failure
30 Mar, 2018 | 04:09h | UTCCommentaries: Quicker Diuretics Not Associated With Better Outcomes in Acute Heart Failure – TCTMD (free) AND Door-to-Diuretic Time in Acute Heart Failure – American College of Cardiology, Latest in Cardiology (free) AND Door-to-diuretic time didn’t affect mortality from heart failure in Korean registry – ACP Hospitalist (free)
“Overall, there isn’t strong evidence of benefit from early use of diuretics and “the overriding consideration should remain ‘get it right’ rather than ‘do it fast,’” the editorial concluded”. (from ACP)
Review: Venous Thromboembolism Prevention in Emergency General Surgery
30 Mar, 2018 | 04:06h | UTCVenous Thromboembolism Prevention in Emergency General Surgery: A Review – JAMA Surgery (free for a limited period)
Commentary: VTE Risk Up in Most Emergency General Surgery Patients – Physician’s Weekly (free)
Long-term Thromboembolic Risk in Patients With Postoperative Atrial Fibrillation After Coronary Artery Bypass Graft Surgery and Patients With Nonvalvular Atrial Fibrillation
30 Mar, 2018 | 04:05h | UTCLong-term Thromboembolic Risk in Patients With Postoperative Atrial Fibrillation After Coronary Artery Bypass Graft Surgery and Patients With Nonvalvular Atrial Fibrillation – JAMA Cardiology (free for a limited period)
Commentaries: Postoperative A-fib Not as Bad as Nonsurgical A-fib for Thromboembolism – TCTMD (free) AND Fib after CABG linked to minimal long-term stroke risk – Cardiovascular Business (free)
Antibiotic Therapy Duration in US Adults With Sinusitis
30 Mar, 2018 | 03:52h | UTCAntibiotic Therapy Duration in US Adults With Sinusitis – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Sinus Infections: Majority of Antibiotics Prescriptions Longer Than Recommended – MedicalResearch.com (free) AND CDC Study Says Sinus Infections Are Treated With Antibiotics Longer Than Necessary – AJMC (free) AND Most Courses of Antibiotics for Sinusitis Are Too Long – NEJM Physician’s First Watch (free)
Related Guideline: IDSA Clinical Practice Guideline for Acute Bacterial Rhinosinusitis in Children and Adults – Clinical Infectious Diseases (free)
The World Health Organization standards for tuberculosis care and management
30 Mar, 2018 | 03:51h | UTC#WorldTBDay (March 24, 2018) – The World Health Organization standards for tuberculosis care and management – European Respiratory Journal (free)
Original Guideline: Compendium of WHO guidelines and associated standards: ensuring optimum delivery of the cascade of care for patients with tuberculosis (free PDF)
“My dream of placing all recent and still valid older WHO TB guidelines into a short compendium, to facilitate life of users, is now accomplished. With this booklet, one can access immediately all WHO standards of TB care”. (via @M_Raviglione see Tweet)
Richard Lehman’s journal reviews – 26 March 2018
30 Mar, 2018 | 03:47h | UTCRichard Lehman’s journal reviews, 26 March 2018 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals.
Guideline: Stop smoking interventions and services
30 Mar, 2018 | 03:46h | UTCGuideline: Stop smoking interventions and services – National Institute for Health and Care Excellence (NICE) (free)
Commentaries: Help people make informed decisions when they want to quit smoking, says NICE and Public Health England – NICE News Release (free) AND Doctors should tell patients e-cigarettes ‘less harmful than smoking but not without risk’ – iNews (free)
Related guidelines and reports: E-cigarettes and heated tobacco products: evidence review – Public Health England (free PDF) AND Public Health Consequences of E-Cigarettes – National Academies of Sciences, Engineering, and Medicine (free PDF) AND E-cigarettes: balancing risks and opportunities – British Medical Association (free PDF) AND Nicotine without smoke: Tobacco harm reduction – Royal College of Physicians (free summary and PDF) AND RCGP Position Statement on the use of electronic nicotine vapour products (E-Cigarettes) – Royal College of General Practitioners (free PDF)
Clinical Updates: Palliative radiotherapy
30 Mar, 2018 | 03:49h | UTCClinical Updates: Palliative radiotherapy – The BMJ (free)
Clinical Update for non-specialists on the benefits, practicalities, and side effects of palliative radiotherapy
Vaccine waning and mumps re-emergence
30 Mar, 2018 | 03:44h | UTCVaccine waning and mumps re-emergence in the United States – Science Translational Medicine (link to abstract – $ for full-text)
Commentaries: Mumps resurgence likely due to waning vaccine-derived immunity – Harvard T.H. Chan School of Public Health (free) AND Mumps Vaccine Effectiveness Declines Over Time. But There’s A Solution – Forbes (free) AND Mumps Vaccine Protection Wanes Over Time, Study Finds – CommonHealth (free) AND Mumps Is On the Rise. A Waning Vaccine Response May Be Why – The New York Times (10 articles per month are free)
“a booster dose at age 18 should be a straight-forward solution to the problem based on models of how mumps spreads” (from Forbes)
Viewpoint: Individualizing Blood Pressure Targets for People With Diabetes and Hypertension
30 Mar, 2018 | 03:48h | UTCViewpoint: Individualizing Blood Pressure Targets for People With Diabetes and Hypertension: Comparing the ADA and the ACC/AHA Recommendations – JAMA (free for a limited period)
Facing the Shortage of IV Fluids — A Hospital-Based Oral Rehydration Strategy
30 Mar, 2018 | 03:43h | UTCCommentary: Boston Hospital May Have a Solution to IV Bag Shortage – Medscape (free registration required)
Systematic Review: Accuracy of different non-invasive methods for identifying Helicobacter pylori
30 Mar, 2018 | 03:31h | UTCAccuracy of different non-invasive methods for identifying Helicobacter pylori – Cochrane Library (free)
Research: Effect of Protein Intake on Lean Body Mass in Functionally Limited Older Men
30 Mar, 2018 | 03:33h | UTCEffect of Protein Intake on Lean Body Mass in Functionally Limited Older Men: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Does Protein Intake Beyond Recommended Dietary Allowance Increase Lean Body Mass? – NEJM Journal Watch (free for a limited period) AND More Protein No Benefit to Older Men – MedPage Today (free)
Guidelines on Chronic Obstructive Pulmonary Disease
30 Mar, 2018 | 03:32h | UTCMOH Clinical Practice Guidelines on Chronic Obstructive Pulmonary Disease – Singapore Ministry of Health (free PDF)
See also: Summary Card (free PDF)


