Internal Medicine

Study: Vitamin D Not Linked to Fracture Risk

31 Aug, 2018 | 02:43h | UTC

Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study – The BMJ (free)

Commentaries: Vitamin D: a pseudo-vitamin for a pseudo-disease – The Conversatio n (free) AND Fracture risk not linked to low vitamin D or calcium levels – OnMedica (free)

Related: Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It (free commentaries and NICE Guideline)

New CDC Analysis Shows Steep and Sustained Increases in STDs in Recent Years

31 Aug, 2018 | 02:37h | UTC

2018 STD Prevention Conference – Centers for Disease Control and Prevention (free)

Press Release: New CDC analysis shows steep and sustained increases in STDs in recent years (free)

Commentaries: 5 reasons why 3 STDs are roaring back in America – VOX (free) AND Rates of three STDs in US reach record high, CDC says – CNN (free) AND Record High Number Of STD Infections In U.S., As Prevention Funding Declines – NPR (free) AND STD cases in U.S. hit record highs as officials warn about resistant gonorrhea – STAT (free) AND US sees record STD cases, rising gonorrhea resistance – CIDRAP (free)

Guideline: Management of Hip and Knee Osteoarthritis

31 Aug, 2018 | 02:31h | UTC

Guideline for the management of hip and knee osteoarthritis – Royal Australian College of General Practitioners (free PDF)

News Release: Updated osteoarthritis guideline designed to reduce unnecessary imaging and surgery (free)

Commentary: Australia hopes to reduce unnecessary imaging, surgery with updated osteoarthritis guidelines – Health Imaging (free)

““The Guideline for the management of knee and hip osteoarthritis,” offer up exercise and weight loss as a first line defense, and warn against costly treatments using glucosamine, opioids and arthroscopic surgery, said David Hunter, co-chair of the RACGP group responsible for the update.” (from Health Imaging)

Randomized Trial: Early vs. Standard Care Invasive Examination and Treatment of Patients with NSTE-ACS

31 Aug, 2018 | 02:29h | UTC

Early Versus Standard Care Invasive Examination and Treatment of Patients with Non-ST-Segment Elevation Acute Coronary Syndrome: The VERDICT (Very EaRly vs Deferred Invasive evaluation using Computerized Tomography) – Randomized Controlled Trial – Circulation (free PDF)

Editorial: Timing of Intervention in Non ST Elevation Acute Coronary Syndromes: And the VERDICT is? (free PDF)

Commentaries: VERDICT: Very Early Invasive Coronary Angiography vs. Standard Care in NSTE-ACS Patients- American College of Cardiology (free) AND ESC: Early Invasive Strategy in NSTEMI Does Not Improve Outcomes – MedPage Today (free registration required) AND VERDICT: Very Early Invasive Angiography No Help Overall for NSTE ACS – TCTMD (free)

Randomized Trial: One-Year Outcomes after PCI Strategies in Cardiogenic Shock

31 Aug, 2018 | 02:05h | UTC

One-Year Outcomes after PCI Strategies in Cardiogenic Shock – New England Journal of Medicine (free for a limited period)

Commentaries: Less Is Still More in Patients with Acute Myocardial Infarction and Cardiogenic Shock – NEJM Journal Watch (free for a limited period) AND 1-year outcomes still support culprit-only PCI for cardiogenic shock – Cardiovascular Business (free) CULPRIT-SHOCK: 1-Year Results Continue to Support Culprit-Only PCI for Shock Patients – TCTMD (free)

Zackary Berger’s journal reviews, 28 August 2018

31 Aug, 2018 | 02:02h | UTC

Zackary Berger’s journal reviews, 28 August 2018 – The BMJ Opinion (free)

Randomized Trial: Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients

31 Aug, 2018 | 01:58h | UTC

Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients – New England Journal of Medicine (free for a limited period)

Editorial: Lorcaserin — Elixir or Liability? (free for a limited period)

Commentaries: CAMELLIA-TIMI 61: Weight Loss Drug Lorcaserin Did Not Increase CV Events – American College of Cardiology (free) AND Weight-Loss Drug Lorcaserin Clears Cardiovascular Safety Hurdle: CAMELLIA-TIMI 61 – TCTMD (free) AND Weight loss drug lorcaserin found safe in large study – Reuters (free)

Guiding Principles for the Care of People with or at Risk for Diabetes

31 Aug, 2018 | 02:00h | UTC

Guiding Principles for the Care of People With or at Risk for Diabetes – National Institute of Diabetes and Digestive and Kidney Diseases (free PDF)

Commentaries: NIDDK Updates ‘Guiding Principles’ for Diabetes, Prediabetes – Medscape (free registration required) AND NDEP revises principles for managing diabetes, prediabetes – Cardiovascular Business (free)

Related Book: Diabetes in America, 3rd Edition – National Institutes of Health (free reference book, just released)

Randomized Trial: Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness

31 Aug, 2018 | 01:57h | UTC

Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness – New England Journal of Medicine (free for a limited period)

Commentaries: VTE risk unchanged by rivaroxaban after discharge – The Hospitalist (free) AND MARINER: Rivaroxaban vs. Placebo Post-Discharge in Patients at High Risk For VTE – American College of Cardiology (free) AND MARINER: No Reduction in Death, VTE With Rivaroxaban After Discharge in Medically Ill Patients – Medscape (free registration required)

Review: Acute Clinical Care for Transgender Patients

31 Aug, 2018 | 01:59h | UTC

Acute Clinical Care for Transgender Patients – JAMA Internal Medicine (free for a limited period) (via @CarlosdelRio7)

Cohort Study: No Survival Benefit with Beta-Blockers Beyond 1 Year Post-MI in Stable CAD

31 Aug, 2018 | 01:55h | UTC

CLARIFY: No Survival Benefit With Beta-Blockers Beyond 1 Year Post-MI in Stable CAD – TCTMD (free)

“The problem, said Sorbets, is that there have never been large randomized trials to test the prognostic effects of beta-blockers in this patient group and instead, recommendations have been drawn from meta-analyses using data extracted from the acute MI setting or from observational studies.”

Study: Coronary CT Angiography and 5-Year Risk of Myocardial Infarction

31 Aug, 2018 | 01:55h | UTC

Coronary CT Angiography and 5-Year Risk of Myocardial Infarction – New England Journal of Medicine (free for a limited period)

Commentary: Five Reasons I Don’t Believe an Imaging Test Improves Outcomes – by Dr. John Mandrola, in Medscape (free registration required)

See also an interesting Tweetorial by @AnilMakam, also suggesting caution before adopting this study results in clinical practice.

Review: Treatment of Invasive Candidiasis

31 Aug, 2018 | 01:47h | UTC

Treatment of Invasive Candidiasis: A Narrative Review – Journal of Fungi (free)

Source: Hospital Medicine Virtual Journal Club

Cochrane Review: Xpert® MTB/RIF Test for Diagnosing Extrapulmonary TB

31 Aug, 2018 | 01:48h | UTC

Xpert^® MTB/RIF assay for extrapulmonary tuberculosis and rifampicin resistance – Cochrane Library (free for a limited period)

Summary: Xpert® MTB/RIF test for diagnosing extrapulmonary tuberculosis and rifampicin resistance – Cochrane Library (free)

Commentary: Cochrane review looks at the accuracy of Xpert® MTB/RIF for the diagnosis of extrapulmonary TB – Liverpool School of Tropical Medicine (free)

NICE Draft Guidance: Antibiotics Should Not Be Issued as First Line of Treatment for a Cough

23 Aug, 2018 | 23:52h | UTC

Antibiotics should not be issued as first line of treatment for a cough, says NICE and PHE – NICE News and Features (free)

Commentaries: Promote honey rather than antibiotics for coughs, doctors told – The Guardian (free) AND Use honey first for a cough, new guidelines say – BBC (free)

Related: Honey for acute cough in children – Cochrane Library (free systematic review and commentary)

Study: Alcohol Use and Burden for 195 Countries and Territories

23 Aug, 2018 | 23:53h | UTC

Alcohol use and burden for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet (free)

Commentaries: No level of alcohol consumption improves health – The Lancet (free) AND No amount of alcohol is good for your overall health, global study says – CNN (free) AND New scientific study: no safe level of alcohol – Institute for Health Metrics and Evaluation (free)

“Alcohol was responsible for nearly 3 million deaths in 2016, the study says. It was the leading risk factor for disease and premature death in men and women between the ages of 15 and 49 worldwide in 2016, accounting for nearly one in 10 deaths.” (from @cnni see Tweet)

Podcast: Things We Do For No Reason

23 Aug, 2018 | 23:44h | UTC

#109: Things We Do For No Reason: A High Value Episode – The Curbsiders (free audio and summary)

Related Series: Choosing Wisely: Things We Do For No Reason – Journal of Hospital Medicine (some free articles)

Study: Asthma and COPD Overlap in Women

23 Aug, 2018 | 23:42h | UTC

Asthma and COPD Overlap in Women: Incidence and Risk Factors – Annals of the American Thoracic Society (link to abstract – $ for full-text)

Commentaries: More than 40 percent of women with asthma may develop COPD, but risk may be reduced – Annals of Thoracic Society (free) AND Four in 10 women with asthma may develop COPD – Reuters (free) AND Four in 10 women with asthma may develop COPD – OnMedica (free)

Systematic Review: Phosphate Binders to Prevent Complications of Chronic Kidney Disease

23 Aug, 2018 | 23:40h | UTC

Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) – Cochrane Library (free for a limited period)

Summary: Phosphate binders to prevent complications of chronic kidney disease – Cochrane Library (free)

Extended Antibiotic Infusions Could Save Lives: Here’s How to Do It

23 Aug, 2018 | 23:40h | UTC

Extended antibiotic infusions could save lives: Here’s how to do it – PulmCCM (free)

“The simplest (and cheapest) technique is simply to reduce the time between doses.”

Study: Seven Days of Antibiotics Were as Good as 14 for Gram-Negative Bacteremia

23 Aug, 2018 | 23:39h | UTC

Seven days of antibiotics were as good as 14 for gram-negative bacteremia – PulmCCM (free)

“It’s important to note that source control was believed to be achieved in all enrolled patients. If source control cannot be achieved (e.g., an abscess, or an infected heart valve or indwelling catheter that cannot safely be removed), prolonged antibiotic courses are often advisable.”