Internal Medicine
Study: Anticonvulsant and the Risk for Opioid-Related Death
23 Aug, 2018 | 23:21h | UTCPregabalin and the Risk for Opioid-Related Death: A Nested Case–Control Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Pregabalin may increase the risk of death when coprescribed with opioids – 2 Minute Medicine (free) AND Pregabalin Linked To Increased Risk for Opioid-Related Deaths – MedicalResearch.com (free) AND Anticonvulsant With Opioids Tied To Higher Mortality – MedPage Today (free registration required)
Cohort Study: Long-Term Association of LDL Cholesterol With Cardiovascular Mortality in Low-Risk Individuals
23 Aug, 2018 | 23:22h | UTCCommentaries: ‘Bad’ cholesterol can be deadly in otherwise healthy people – AHA News (free) AND LDL >160 Tied to Increased Mortality in Low-Risk Patients – Physician’s First Watch (free) AND Study: Elevated LDL, non-HDL increase CVD mortality risk in young, healthy individuals – Cardiovascular Business (free) AND Moderate ‘bad cholesterol’ levels tied to early death for healthy people – Reuters (free)
Meta-Analysis: Effect of Procalcitonin-Guided Antibiotic Treatment on Clinical Outcomes in ICU patients
23 Aug, 2018 | 23:21h | UTCCommentary: Procalcitonin guidance linked to improved sepsis survival – Univadis (free registration required)
WHO Rapid Communication: Key Changes to Treatment of Multidrug- and Rifampicin-Resistant Tuberculosis (MDR/RR-TB)
23 Aug, 2018 | 23:18h | UTCNews Release: WHO announces landmark changes in MDR-TB treatment regimens (free)
Commentary: WHO revises MDR-TB treatment with focus on oral drugs – CIDRAP (free)
Cohort Study: Assessment of the Safety of Discharging Select Patients Directly Home From the ICU
23 Aug, 2018 | 23:01h | UTCAssessment of the Safety of Discharging Select Patients Directly Home From the Intensive Care Unit: A Multicenter Population-Based Cohort Study – JAMA Internal Medicine (free for a limited period)
Invited Commentary: The Complexity and Challenges of Intensive Care Unit Admissions and Discharges: Similarities With All Hospitalized Patients – JAMA Internal Medicine (free for a limited period)
Randomized Trial: Treatment Strategies for Untreated Major Depressive Disorder
23 Aug, 2018 | 22:37h | UTC
Study: Clinical Chemistry Score to Identify Patients at Low or High Risk for Myocardial Infarction or Death
23 Aug, 2018 | 22:36h | UTCCommentaries: Simple score to diagnose heart attacks is safer, faster than current methods – McMaster University (free) AND Clinical Chemistry Score Helps Rule Out Diagnosis of Heart Attack – MedicalResearch.com (free)
Report: E-Cigarettes
23 Aug, 2018 | 22:33h | UTCReport: E-Cigarettes – House of Commons Science and Technology Committee (free PDF)
Commentaries: Stop treating e-cigs like conventional cigarettes, MPs tell NHS – OnMedica (free) AND E-cigarettes can be key weapon against smoking, say MPs – BBC (free)
See also: related guidelines, reports and commentaries on e-cigarettes (all free)
Study: Association Between Electronic Cigarette Use and Myocardial Infarction
23 Aug, 2018 | 22:35h | UTCAssociation Between Electronic Cigarette Use and Myocardial Infarction – American Journal of Preventive Medicine (free for a limited period)
Commentary: Risk of heart attacks is double for daily e-cigarette users – University of California – San Francisco, via ScienceDaily (free)
“New analysis shows five-fold risk for people who use both cigarettes and e-cigarettes daily” (from ScienceDaily)
Perspective: Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It
23 Aug, 2018 | 22:32h | UTCVitamin D, the Sunshine Supplement, Has Shadowy Money Behind It – The New York Times (10 articles per month are free) (via @CarlosdelRio7 see Tweet)
Related commentaries: Vitamin D Screening and Supplementation in Primary Care: Time to Curb Our Enthusiasm – American Family Physician (free) AND Your vitamin D tests and supplements are probably a waste of money – VOX (free) AND Why Are So Many People Popping Vitamin D? – The New York Times (10 articles per month are free)
Related Guideline: Vitamin D: supplement use in specific population groups – National Institute for Health and Care Excellence (free)
“Only test vitamin D status if someone has symptoms of deficiency or is at very high risk” (from NICE Guideline)
Meta-Analysis: Corticosteroids in Sepsis
23 Aug, 2018 | 22:32h | UTCCorticosteroids in Sepsis: An Updated Systematic Review and Meta-Analysis – Critical Care Medicine (free)
Related: Corticosteroid therapy for sepsis: a clinical practice guideline – The BMJ (free)
Review: Intravenous Fluid Therapy in Critically ill Adults
23 Aug, 2018 | 22:30h | UTCIntravenous fluid therapy in critically ill adults – Nature Reviews Nephrology (free for a limited period) (via @CritCareReviews)
Review: Airway and Ventilation Management During CPR and After Successful Resuscitation
23 Aug, 2018 | 22:27h | UTC
Study: Association of Body Mass Index With Blood Pressure
23 Aug, 2018 | 22:26h | UTCCommentary: As body mass index increases, blood pressure may as well – Yale University (free)
AHA/ACC Guideline: Management of Adults with Congenital Heart Disease
17 Aug, 2018 | 02:37h | UTC2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease (free PDF)
News Release: Societies Release Updated Guideline for Treating Adult Congenital Heart Disease Patients (free)
Key Points to Remember: 2018 AHA/ACC Guideline for Adults With Congenital Heart Disease – American College of Cardiology (free)
Cohort Studies: Smoking Cessation, Weight Change, Type 2 Diabetes, and Mortality
17 Aug, 2018 | 02:35h | UTCSmoking Cessation, Weight Change, Type 2 Diabetes, and Mortality – The New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Weight gain after smoking cessation linked with increased short-term diabetes risk – Harvard T.H. Chan School of Public Health (free) AND Weight gain temporarily hikes diabetes risk when smokers quit – Reuters (free) AND Smokers Are Better Off After They Quit Even if They Gain Weight – Physician’s First Watch (free)
Guideline: Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in the ICU
17 Aug, 2018 | 02:32h | UTCClinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU – Critical Care Medicine (free) (via @Abraham_RMI)
Cohort Study: Risk Factors, Mortality, and Cardiovascular Outcomes in Patients with Type 2 Diabetes
17 Aug, 2018 | 02:26h | UTCRisk Factors, Mortality, and Cardiovascular Outcomes in Patients with Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: In Type 2 Diabetes, Five Risk Factor Targets Keep MI, Stroke, and Death in Check – TCTMD (free) AND How People With Type 2 Diabetes Can Lower Their Risk of Health Problems – TIME (free) AND T2D, Without Other Risks, Not Tied to Excess Mortality – MedPage Today (free registration required)
Meta-Analysis: Absolute Risk and Predictors of the Growth of Acute Spontaneous Intracerebral Hemorrhage
17 Aug, 2018 | 02:25h | UTCCommentary: Brain scan checklist set to boost care for stroke survivors – University of Edinburgh, via EurekAlert (free)
Study: Trends in Use of Daily Chest Radiographs Among Patients Receiving Mechanical Ventilation
17 Aug, 2018 | 02:23h | UTCCommentaries: Daily Chest X-Rays Still Overused in Mechanically Ventilated Patients – MedicalResearch.com (free) AND Routine daily CXRs for ventilated patients: de-adoption is lagging – Univadis (free registration required) AND Chest x-rays overused on ventilation patients despite ACR guideline – HealthImaging (free)
International Registry: Long-Term Prognosis of Patients With Takotsubo Syndrome
17 Aug, 2018 | 02:19h | UTCLong-Term Prognosis of Patients With Takotsubo Syndrome – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Long-Term Prognosis of Takotsubo Syndrome – American College of Cardiology (free) AND How deadly is Takotsubo syndrome? It depends on the trigger – Cardiovascular Business (free)
Related: International Expert Consensus Document on Takotsubo Syndrome (free)
Study: Polygenic Scores for Common Diseases Identify Individuals with Risk Equivalent to Monogenic Mutations
17 Aug, 2018 | 02:09h | UTCGenome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations – Nature Genetics (link to abstract – $ for full-text)
Commentaries: Researchers predict risk for common deadly diseases from millions of genetic variants – Broad Institute of MIT and Harvard, ScienceDaily (free) AND Clues to Your Health Are Hidden at 6.6 Million Spots in Your DNA – The New York Times (10 articles per month are free) AND Multi-gene test may find risk for heart disease and more – Associated Press (free) AND A Harvard Scientist Thinks He Has a Gene Test for Heart Attack Risk. He Wants to Give It Away Free – Forbes (free)
Review: Overdiagnosis in Primary Care
17 Aug, 2018 | 02:10h | UTCState of the Art Review: Overdiagnosis in primary care: framing the problem and finding solutions – The BMJ (free for two weeks)
Randomized Trial: Low-Dose Triple Combination Antihypertensive Medication vs Usual Care for Blood Pressure Control
17 Aug, 2018 | 02:06h | UTCFixed Low-Dose Triple Combination Antihypertensive Medication vs Usual Care for Blood Pressure Control in Patients With Mild to Moderate Hypertension in Sri Lanka: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Video Summary: Fixed-Dose Combination Pill for Hypertension Treatment in Sri Lanka (free)
Commentaries: Three-in-one pill lowers blood pressure significantly, study says – UPI (free) AND Innovative triple pill significantly lowers blood pressure, study finds – George Institute for Global Health, via EurekAlert (free)
Perspective: The Polypill and the Long Journey to Major Impact
17 Aug, 2018 | 02:05h | UTCRichard Smith: The polypill and the long journey to major impact – The BMJ Opinion (free)
Related Reviews: Strengths and Limitations of Using the Polypill in Cardiovascular Prevention – Current Cardiology Reports (free) AND The polypill approach – An innovative strategy to improve cardiovascular health in Europe – BMC Pharmacology and Toxicology (free)