Internal Medicine
WHO Launches SAFER Alcohol Control Initiative
5 Oct, 2018 | 01:36h | UTCSee also: SAFER High Impact Strategies (free)
Related: WHO Global Status Report on Alcohol and Health 2018 (free report and commentaries)
Study: CT Screening for Early Lung Cancer Reduces Lung Cancer Mortality
5 Oct, 2018 | 01:31h | UTCWCLC 2018: NELSON Study: CT Screening for Early Lung Cancer Reduces Lung Cancer Mortality – The ASCO Post (free)
Related: NELSON lung cancer study encourages widespread screening, Medicare reimbursement – Health Imaging (free) AND Second Large Study Shows That Lung Cancer Screening Works – Medscape (free registration required)
Video: KHN Conversation on Overtreatment
5 Oct, 2018 | 01:33h | UTCKHN Conversation on Overtreatment – Kaiser Health News (free)
Commentary: Changing Healthcare’s Culture of Overtreatment a Challenge – MedPage Today (free registration required)
Related KHN Series: Treatment Overkill (free articles)
Podcast: Geriatric Psychiatry
5 Oct, 2018 | 01:29h | UTCRelated Podcast: #115 Geriatric Depression – The Curbsiders Internal Medicine Podcast (free)
Meta-Analysis: Effects of Coenzyme Q10 on Statin‐Induced Myopathy
5 Oct, 2018 | 01:27h | UTCCommentary: Coenzyme Q10 reduces statin-induced myopathy symptoms – Univadis (free registration required)
Guideline Summary: 2018 IDSA Guidelines for Clostridium Difficile Infection
5 Oct, 2018 | 01:24h | UTCRelated Guidelines: Clinical Practice Guidelines for Clostridium difficileInfection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) – Clinical Infectious Diseases (free) AND The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines – GUT (free)
Randomized Trial: Total Diet Replacement Programme to Treat Obesity
28 Sep, 2018 | 01:14h | UTCCommentaries: Susan Jebb: Interventions to treat obesity work—so why am I not celebrating? – The BMJ Opinion (free) AND Expert reaction to study looking at total diet replacement programmes and obesity – Science Media Centre (free) AND Crash diets are highly effective – new evidence – The Conversation (free)
Deprescribing Recommendations: An Essential Consideration for Clinical Guideline Developers
28 Sep, 2018 | 01:11h | UTCRelated: Position Statement: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject)
““Clinical guidelines often do not accommodate frailty or patients with multiple comorbid conditions. This can give rise to complex medication regimens and risk of medication harm.” Paper discusses the need to include deprescribing in clinical guidelines” (via @Deprescribing see Tweet)
Study: Ethanol Locks in Catheters for Dialysis May Prevent Sepsis
28 Sep, 2018 | 01:08h | UTCEthanol lock is effective on reducing the incidence of tunneled catheter-related bloodstream infections in hemodialysis patients: a systematic review and meta-analysis – International Urology and Nephrology (link to abstract – $ for full-text)
Commentary: Ethanol locks in catheters for dialysis may prevent sepsis – NIHR Signal (free)
Randomized Trial: Insomnia Symptoms Iimprove with Online Insomnia Program
28 Sep, 2018 | 00:59h | UTCEffect of Digital Cognitive Behavioral Therapy for Insomnia on Health, Psychological Well-being, and Sleep-Related Quality of Life: A Randomized Clinical Trial – JAMA Psychiatry (free for a limited period) (via @EricTopol)
Commentary: Insomnia symptoms, overall health improve with online insomnia program – Northwestern University (free)
Systematic Review: Modifying the Consistency of Food and Fluids for Swallowing Difficulties in Dementia
28 Sep, 2018 | 00:57h | UTCModifying the consistency of food and fluids for swallowing difficulties in dementia – Cochrane Library (free for a limited period)
Summary: Modifying the consistency of food and fluids for swallowing difficulties in dementia (free)
“We are uncertain about the immediate and long-term effects of modifying the consistency of fluid for swallowing difficulties in dementia”
Randomized Trial: Antibiotic Therapy Alone Seems Reasonable for Uncomplicated Appendicitis
28 Sep, 2018 | 00:55h | UTCFive-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Podcast: Treating Appendicitis Without Surgery – 5-Year Follow-up from a Randomized Clinical Trial of Antibiotic Treatment (free)
Video Summary: Five-Year Follow-up of Patients Given Antibiotic Therapy for Uncomplicated Acute Appendicitis (free)
Commentaries: Pills for appendicitis? Surgery often not needed, study says – STAT (free) AND Antibiotics Alone Seem Reasonable for Uncomplicated Appendicitis in Adults – Physician’s First Watch (free) AND Appendicitis? Antibiotics May Be All You Need – The New York Times (10 articles per month are free)
Related: Randomized clinical trial of antibiotic therapy for uncomplicated appendicitis (link to abstract and commentaries) AND Antibiotics Versus Surgical Therapy for Uncomplicated Appendicitis (link to abstract and commentaries) AND Antibiotic Therapy versus Appendectomy for Acute Uncomplicated Appendicitis (free study and commentaries) AND New appendicitis guideline incorporates the possibility of non-operative treatment for uncomplicated disease (free guideline)
ADA Guideline: Type 1 Diabetes in Children and Adolescents
28 Sep, 2018 | 00:54h | UTC
Study: Drug–herb and Drug–supplement Interactions in Older Adults
27 Sep, 2018 | 23:05h | UTCCommentaries: New study finds concurrent use of prescription drugs and dietary supplements could pose health risks – University of Hertfordshire (free) AND Concerns raised about older adults mixing prescription drugs and herbal remedies – NHS Choices (free)
Review: Pharmacokinetics–Pharmacodynamics Issues Relevant for the Clinical use of Beta-lactams in Critically Ill Patients
27 Sep, 2018 | 23:02h | UTCRelated: Extended Antibiotic Infusions Could Save Lives: Here’s How to Do It (free commentary) AND Mortality lower with prolonged vs. short-term IV infusion of antipseudomonal beta-lactams (link to abstract and free commentary)
Study: Adverse Outcomes After Arthroscopic Partial Meniscectomy
27 Sep, 2018 | 22:59h | UTCInvited Commentary: Potential harms of isolated arthroscopic partial meniscectomy (free)
Related: Needless procedures: knee arthroscopy is one of the most common but least effective surgeries – The Conversation (free) AND Arthroscopic surgery for degenerative knee arthritis and meniscal tears: a clinical practice guideline (free guideline and commentary)
Randomized Trial: Transcatheter Mitral-Valve Repair in Patients with Heart Failure
27 Sep, 2018 | 22:56h | UTCTranscatheter Mitral-Valve Repair in Patients with Heart Failure – New England Journal of Medicine (free)
Commentary: COAPT: MitraClip Reduces Repeat Hospitalizations, Mortality in Functional MR Patients With Severe HF – TCTMD (free)
Related MITRA-FR trial: Percutaneous Repair or Medical Treatment for Secondary Mitral Regurgitation – New England Journal of Medicine (free)
“Physicians responded with shock and excitement to findings, but struggled to reconcile the results with the MITRA-FR trial.” (from TCTMD)
Review: Streptococcal Toxic Shock Syndrome in the Intensive Care Unit
27 Sep, 2018 | 22:46h | UTCStreptococcal toxic shock syndrome in the intensive care unit – Annals of Intensive Care (free)
Source: Critical Care Reviews Newsletter
Study: Benefit of Anticoagulation for Stroke Prevention May Vary in Patients with Atrial Fibrillation
27 Sep, 2018 | 22:56h | UTCEffect of Variation in Published Stroke Rates on the Net Clinical Benefit of Anticoagulation for Atrial Fibrillation – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Benefit of anticoagulation for stroke prevention may vary in patients with afib, study finds – ACP Internist (free)
Ann Robinson’s research reviews – 24 September 2018
27 Sep, 2018 | 22:43h | UTCAnn Robinson’s research reviews, 24 September 2018 – The BMJ Opinion (free)
Ann Robinson reviews the latest research from the top medical journals.
Podcast: Geriatric Depression
27 Sep, 2018 | 22:45h | UTC#115 Geriatric Depression – The Curbsiders Internal Medicine Podcast (free)
Summary: #115 Geriatric Depression: Diagnosis, Antidepressants, and More (free)
Free Online Course: Antibiotic Stewardship
27 Sep, 2018 | 22:42h | UTCFree Online Course: Antibiotic Stewardship – Stanford University and Coursera (via @classcentral)
NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk
27 Sep, 2018 | 22:41h | UTCRelated Study: Risk of Meticillin Resistant Staphylococcus Aureus and Clostridium Difficile in Patients with a Documented Penicillin Allergy (free article and commentaries)
Clinical Update: Management of Chronic Wounds
27 Sep, 2018 | 22:36h | UTCManagement of Chronic Wounds—2018 – JAMA (free for a limited period)
Study: Immediate Compression Could Help Prevent Complications after DVT
27 Sep, 2018 | 22:39h | UTCCommentary: Immediate compression could help prevent complications after deep-vein thrombosis – American Society of Hematology (free)
“Study supports use of this simple, low-cost intervention even for patients without symptoms” (from American Society of Hematology)