Internal Medicine
Perspective: What the Tests Don’t Show
11 Oct, 2018 | 20:11h | UTCWhat the tests don’t show – The Washington Post (a few articles per month are free)
“Many doctors are surprisingly bad at reading test results and/or fail to grasp how false positives work. This is putting patients at risk” (via @pash22 see Tweet)
Study: Outpatient Antibiotics Widely Prescribed Without an Infection Diagnosis
11 Oct, 2018 | 20:10h | UTCOutpatient antibiotics widely prescribed without an infection diagnosis – CIDRAP (free)
Related Commentary: Study Finds Almost Half of Antibiotic Prescriptions Written Without a Diagnosis – Pharmacy Times (free)
COPD Guidelines: A Review of the 2018 GOLD Report
11 Oct, 2018 | 20:07h | UTCCOPD Guidelines: A Review of the 2018 GOLD Report – Mayo Clinic Proceedings (free)
Related: Highlights from the New GOLD COPD Guidelines (free guideline and commentaries)
Review: The Diagnosis and Treatment of Anxiety Disorders
11 Oct, 2018 | 20:09h | UTCThe Diagnosis and Treatment of Anxiety Disorders – Deutsches Ärzteblatt international (free)
Review: Cardiovascular Disease and COPD
11 Oct, 2018 | 20:08h | UTCCardiovascular disease and COPD: dangerous liaisons? – European Respiratory Review (free)
Study: Incidence of Progression of Persistent Non-Dysplastic Barrett’s Esophagus to Malignancy
11 Oct, 2018 | 20:01h | UTCIncidence of Progression of Persistent Non-Dysplastic Barrett’s Esophagus to Malignancy – Clinical Gastroenterology and Hepatology (link to abstract – $ for full-text)
Commentary: Patients with stable Barrett’s esophagus may need less surveillance, study finds – ACP Gastroenterology (free)
Perspective: Given Their Potential for Harm, It’s Time to Focus on the Safety of Supplements
5 Oct, 2018 | 02:41h | UTCGiven Their Potential for Harm, It’s Time to Focus on the Safety of Supplements – JAMA (free for a limited period) (via @NUNESDOC)
“About 23 000 visits to emergency departments each year can be attributed to adverse events from dietary supplements.”
Meta-Analysis: Effects of Vitamin D Supplementation on Musculoskeletal Health
5 Oct, 2018 | 02:44h | UTCEffects of vitamin D supplementation on musculoskeletal health: a systematic review, meta-analysis, and trial sequential analysis – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentaries: The Lancet Diabetes & Endocrinology: Vitamin D supplementation in adults does not prevent fractures, falls or improve bone mineral density – The Lancet (free) AND Vitamin D supplements don’t help bone health, major study concludes – The Guardian (free) AND Millions of Americans take vitamin D. Most should just stop – VOX (free)
Related: Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It (free commentaries and NICE Guideline) AND Vitamin D Not Linked to Fracture Risk (free study and commentaries)
Study: Effect of Lorcaserin on Prevention and Remission of Type 2 Diabetes in Overweight and Obese Patients
5 Oct, 2018 | 02:38h | UTCEffect of lorcaserin on prevention and remission of type 2 diabetes in overweight and obese patients (CAMELLIA-TIMI 61): a randomised, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)
Commentaries: Weight loss drug shows positive effect on diabetes – Brigham and Women’s Hospital (free) AND Weight Loss Drug Helped Prevent Diabetes in Overweight People – MedPage Today (free registration required)
Related Article: Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients (link to abstract and commentaries)
Clinical Update: Immune Checkpoint Inhibitor Toxicity in 2018
5 Oct, 2018 | 02:42h | UTCImmune Checkpoint Inhibitor Toxicity in 2018 – JAMA (free for a limited period)
Related Guidelines: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)
Related Review: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)
Meta-Analysis: Prescribed Exercise with Compression vs Compression Alone in Treating Patients With Venous Leg Ulcers
5 Oct, 2018 | 02:36h | UTCPrescribed Exercise With Compression vs Compression Alone in Treating Patients With Venous Leg Ulcers: A Systematic Review and Meta-analysis – JAMA Dermatology (link to abstract – $ for full-text)
Commentaries: Adding Exercise to Compression Improves Outcomes in Venous Leg Ulcers – Physcian’s First Watch (free) AND Compressions May Remedy Venous Leg Ulcers – MedPage Today (free)
NICE Guideline: Renal Replacement Therapy
5 Oct, 2018 | 02:31h | UTC
Enhanced Recovery After Surgery Guidelines for Perioperative Care in Esophagectomy
5 Oct, 2018 | 02:29h | UTCGuidelines for Perioperative Care in Esophagectomy: Enhanced Recovery After Surgery (ERAS®) Society Recommendations – World Journal of Surgery (free for a limited period)
Two Antiplatelet Drugs may Prevent Further Strokes but Increase Major Bleeds
5 Oct, 2018 | 02:24h | UTCTwo antiplatelet drugs may prevent further strokes but increase major bleeds – NIHR Signal (free)
Original Article: Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA – New England Journal of Medicine (link to abstract – $ for full-text)
Ten Principles for More Conservative, Care-Full Diagnosis
5 Oct, 2018 | 02:22h | UTCTen Principles for More Conservative, Care-Full Diagnosis – Annals of Internal Medicine (free) (via @EricTopol)
Guideline: Management of Malignant Pleural Effusions
5 Oct, 2018 | 02:21h | UTCRelated Guideline: ERS/EACTS statement on the management of malignant pleural effusions – European Respiratory Journal (free)
Sytematic Review: Antidepressant Withdrawal Effects
5 Oct, 2018 | 02:06h | UTCA systematic review into the incidence, severity and duration of antidepressant withdrawal effects: Are guidelines evidence-based? – Addictive Behaviours (free PDF)
Commentaries: Antidepressant withdrawal ‘hits millions’ – BBC (free) AND Antidepressant withdrawal symptoms severe, says new report – The Guardian (free)
Related: Antidepressant Withdrawal Syndrome (free review and NYT article)
Meta-Analysis: Treating Subclinical Hypothyroidism is Not Associated with Quality of Life and Thyroid-Related Symptoms
5 Oct, 2018 | 02:18h | UTCAssociation of Thyroid Hormone Therapy With Quality of Life and Thyroid-Related Symptoms in Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)
Commentaries: Most Patients With Subclinical Hypothyroidism May Not Require Thyroid Medication – MedicalResearch.com (free) AND Hormone Tx May Not Benefit Subclinical Hypothyroidism – MedPage Today (free registration required) AND Treating Subclinical Hypothyroidism Is of Little Benefit – Medscape (free registration required)
Randomized Trial: Low-Dose Amitriptyline for Chronic Low Back Pain
5 Oct, 2018 | 02:00h | UTCEfficacy of Low-Dose Amitriptyline for Chronic Low Back Pain: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Low-dose antidepressants ease back pain – Australian Hospital + Healthcare Bulletin (free) AND Antidepressant Amitriptyline Might Help Ease Low Back Pain – Physician’s First Watch (free)
Clinical Guide: Neuro-Ophthalmology at the Bedside
5 Oct, 2018 | 02:02h | UTCNeuro-Ophthalmology at the bedside: A clinical guide – Journal of Neurosciences in Rural Practice (free)
Randomized Trial: Six months versus 12 months dual antiplatelet therapy after drug-eluting stent implantation in ST-elevation myocardial infarction
5 Oct, 2018 | 01:59h | UTCRelated Research: 6-month versus 12-month or longer dual antiplatelet therapy after percutaneous coronary intervention in patients with acute coronary syndrome (link to abstract and commentaries)
In this study, DAPT for 6 months was non-inferior to DAPT for 12 months after drug-eluting stent implantation in ST-elevation myocardial infarction.
Randomized Trial: Drinking More Water Prevents Recurrent Cystitis
5 Oct, 2018 | 01:48h | UTCEditorial: Drinking More Water for Prevention of Recurrent Cystitis (free)
Commentaries: Drinking more water reduces bladder infections in women – UT Southwestern Medical Center (free) AND Drinking more water linked to fewer bladder infections in women – UPI (free)
Supplement: Practical Guide for Allergy and Immunology in Canada 2018
5 Oct, 2018 | 01:46h | UTCPractical guide for allergy and immunology in Canada 2018 – Allergy, Asthma & Clinical Immunology (free reviews)
An introduction to immunology and immunopathology
Allergen-specific immunotherapy
Non-IgE-mediated food hypersensitivity
Early introduction of foods to prevent food allergy
Zackary Berger’s Journal Reviews, 1 October 2018
5 Oct, 2018 | 01:43h | UTCZackary Berger’s journal reviews, 1 October 2018 – The BMJ Opinion (free)
Review: Pulmonary Vasculitis
5 Oct, 2018 | 01:41h | UTCPulmonary vasculitis – Journal of Thoracic Disease (free)


