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Internal Medicine

Perspective: What the Tests Don’t Show

11 Oct, 2018 | 20:11h | UTC

What the tests don’t show – The Washington Post (a few articles per month are free)

“Many doctors are surprisingly bad at reading test results and/or fail to grasp how false positives work. This is putting patients at risk” (via @pash22 see Tweet)

 


Study: Outpatient Antibiotics Widely Prescribed Without an Infection Diagnosis

11 Oct, 2018 | 20:10h | UTC

Outpatient antibiotics widely prescribed without an infection diagnosis – CIDRAP (free)

Related Commentary: Study Finds Almost Half of Antibiotic Prescriptions Written Without a Diagnosis – Pharmacy Times (free)

 


COPD Guidelines: A Review of the 2018 GOLD Report

11 Oct, 2018 | 20:07h | UTC

COPD Guidelines: A Review of the 2018 GOLD Report – Mayo Clinic Proceedings (free)

Related: Highlights from the New GOLD COPD Guidelines (free guideline and commentaries)

 


Review: The Diagnosis and Treatment of Anxiety Disorders

11 Oct, 2018 | 20:09h | UTC

The Diagnosis and Treatment of Anxiety Disorders – Deutsches Ärzteblatt international (free)

 


Review: Cardiovascular Disease and COPD

11 Oct, 2018 | 20:08h | UTC

Cardiovascular disease and COPD: dangerous liaisons? – European Respiratory Review (free)

 


Study: Incidence of Progression of Persistent Non-Dysplastic Barrett’s Esophagus to Malignancy

11 Oct, 2018 | 20:01h | UTC

Incidence of Progression of Persistent Non-Dysplastic Barrett’s Esophagus to Malignancy – Clinical Gastroenterology and Hepatology (link to abstract – $ for full-text)

Commentary: Patients with stable Barrett’s esophagus may need less surveillance, study finds – ACP Gastroenterology (free)

 


Perspective: Given Their Potential for Harm, It’s Time to Focus on the Safety of Supplements

5 Oct, 2018 | 02:41h | UTC

Given Their Potential for Harm, It’s Time to Focus on the Safety of Supplements – JAMA (free for a limited period) (via @NUNESDOC)

“About 23 000 visits to emergency departments each year can be attributed to adverse events from dietary supplements.”

 


Meta-Analysis: Effects of Vitamin D Supplementation on Musculoskeletal Health

5 Oct, 2018 | 02:44h | UTC

Effects of vitamin D supplementation on musculoskeletal health: a systematic review, meta-analysis, and trial sequential analysis – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentaries: The Lancet Diabetes & Endocrinology: Vitamin D supplementation in adults does not prevent fractures, falls or improve bone mineral density – The Lancet (free) AND Vitamin D supplements don’t help bone health, major study concludes – The Guardian (free) AND Millions of Americans take vitamin D. Most should just stop – VOX (free)

Related: Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It (free commentaries and NICE Guideline) AND Vitamin D Not Linked to Fracture Risk (free study and commentaries)

 


Study: Effect of Lorcaserin on Prevention and Remission of Type 2 Diabetes in Overweight and Obese Patients

5 Oct, 2018 | 02:38h | UTC

Effect of lorcaserin on prevention and remission of type 2 diabetes in overweight and obese patients (CAMELLIA-TIMI 61): a randomised, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Weight loss drug shows positive effect on diabetes – Brigham and Women’s Hospital (free) AND Weight Loss Drug Helped Prevent Diabetes in Overweight People – MedPage Today (free registration required)

Related Article: Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients (link to abstract and commentaries)

 


Clinical Update: Immune Checkpoint Inhibitor Toxicity in 2018

5 Oct, 2018 | 02:42h | UTC

Immune Checkpoint Inhibitor Toxicity in 2018 – JAMA (free for a limited period)

Related Guidelines: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)

Related Review: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)

 


Meta-Analysis: Prescribed Exercise with Compression vs Compression Alone in Treating Patients With Venous Leg Ulcers

5 Oct, 2018 | 02:36h | UTC

Prescribed Exercise With Compression vs Compression Alone in Treating Patients With Venous Leg Ulcers: A Systematic Review and Meta-analysis – JAMA Dermatology (link to abstract – $ for full-text)

Commentaries: Adding Exercise to Compression Improves Outcomes in Venous Leg Ulcers – Physcian’s First Watch (free) AND Compressions May Remedy Venous Leg Ulcers – MedPage Today (free)

 


NICE Guideline: Renal Replacement Therapy

5 Oct, 2018 | 02:31h | UTC

Renal replacement therapy and conservative management – National Institute for Health and Care Excellence (free)

 


Enhanced Recovery After Surgery Guidelines for Perioperative Care in Esophagectomy

5 Oct, 2018 | 02:29h | UTC

Guidelines for Perioperative Care in Esophagectomy: Enhanced Recovery After Surgery (ERAS®) Society Recommendations – World Journal of Surgery (free for a limited period)

 


Two Antiplatelet Drugs may Prevent Further Strokes but Increase Major Bleeds

5 Oct, 2018 | 02:24h | UTC

Two antiplatelet drugs may prevent further strokes but increase major bleeds – NIHR Signal (free)

Original Article: Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA – New England Journal of Medicine (link to abstract – $ for full-text)

 


Ten Principles for More Conservative, Care-Full Diagnosis

5 Oct, 2018 | 02:22h | UTC

Ten Principles for More Conservative, Care-Full Diagnosis – Annals of Internal Medicine (free) (via @EricTopol)

 


Guideline: Management of Malignant Pleural Effusions

5 Oct, 2018 | 02:21h | UTC

Management of Malignant Pleural Effusions. An Official ATS/STS/STR Clinical Practice Guideline – American Journal of Respiratory and Critical Care Medicine (free)

Related Guideline: ERS/EACTS statement on the management of malignant pleural effusions – European Respiratory Journal (free)

 


Sytematic Review: Antidepressant Withdrawal Effects

5 Oct, 2018 | 02:06h | UTC

A systematic review into the incidence, severity and duration of antidepressant withdrawal effects: Are guidelines evidence-based? – Addictive Behaviours (free PDF)

Commentaries: Antidepressant withdrawal ‘hits millions’ – BBC (free) AND Antidepressant withdrawal symptoms severe, says new report – The Guardian (free)

Related: Antidepressant Withdrawal Syndrome (free review and NYT article)

 


Meta-Analysis: Treating Subclinical Hypothyroidism is Not Associated with Quality of Life and Thyroid-Related Symptoms

5 Oct, 2018 | 02:18h | UTC

Association of Thyroid Hormone Therapy With Quality of Life and Thyroid-Related Symptoms in Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)

Commentaries: Most Patients With Subclinical Hypothyroidism May Not Require Thyroid Medication – MedicalResearch.com (free) AND Hormone Tx May Not Benefit Subclinical Hypothyroidism – MedPage Today (free registration required) AND Treating Subclinical Hypothyroidism Is of Little Benefit – Medscape (free registration required)

 


Randomized Trial: Low-Dose Amitriptyline for Chronic Low Back Pain

5 Oct, 2018 | 02:00h | UTC

Efficacy of Low-Dose Amitriptyline for Chronic Low Back Pain: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Low-dose antidepressants ease back pain – Australian Hospital + Healthcare Bulletin (free) AND Antidepressant Amitriptyline Might Help Ease Low Back Pain – Physician’s First Watch (free)

 


Clinical Guide: Neuro-Ophthalmology at the Bedside

5 Oct, 2018 | 02:02h | UTC

Neuro-Ophthalmology at the bedside: A clinical guide – Journal of Neurosciences in Rural Practice (free)

 


Randomized Trial: Six months versus 12 months dual antiplatelet therapy after drug-eluting stent implantation in ST-elevation myocardial infarction

5 Oct, 2018 | 01:59h | UTC

Six months versus 12 months dual antiplatelet therapy after drug-eluting stent implantation in ST-elevation myocardial infarction (DAPT-STEMI): randomised, multicentre, non-inferiority trial – The BMJ (free)

Related Research: 6-month versus 12-month or longer dual antiplatelet therapy after percutaneous coronary intervention in patients with acute coronary syndrome (link to abstract and commentaries)

In this study, DAPT for 6 months was non-inferior to DAPT for 12 months after drug-eluting stent implantation in ST-elevation myocardial infarction.

 


Randomized Trial: Drinking More Water Prevents Recurrent Cystitis

5 Oct, 2018 | 01:48h | UTC

Effect of Increased Daily Water Intake in Premenopausal Women With Recurrent Urinary Tract Infections: A Randomized Clinical Trial – JAMA Internal Medicine (free)

Editorial: Drinking More Water for Prevention of Recurrent Cystitis (free)

Commentaries: Drinking more water reduces bladder infections in women – UT Southwestern Medical Center (free) AND Drinking more water linked to fewer bladder infections in women – UPI (free)

 


Supplement: Practical Guide for Allergy and Immunology in Canada 2018

5 Oct, 2018 | 01:46h | UTC

Practical guide for allergy and immunology in Canada 2018 – Allergy, Asthma & Clinical Immunology (free reviews)

Homepage

Introduction from the Editors

An introduction to immunology and immunopathology

Asthma

Allergic rhinitis

Atopic dermatitis

Allergen-specific immunotherapy

Anaphylaxis

IgE-mediated food allergy

Non-IgE-mediated food hypersensitivity

Early introduction of foods to prevent food allergy

Eosinophilic esophagitis

Urticaria and angioedema

Drug allergy

Primary immunodeficiency

 


Zackary Berger’s Journal Reviews, 1 October 2018

5 Oct, 2018 | 01:43h | UTC

Zackary Berger’s journal reviews, 1 October 2018 – The BMJ Opinion (free)

 


Review: Pulmonary Vasculitis

5 Oct, 2018 | 01:41h | UTC

Pulmonary vasculitis – Journal of Thoracic Disease (free)

 


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