Internal Medicine
Review: Side Effects of Long‐Term Proton Pump Inhibitor Use
2 Nov, 2018 | 03:40h | UTC
Systematic Review: Prophylactic Antibiotic Therapy for COPD
2 Nov, 2018 | 03:36h | UTCProphylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD) – Cochrane Library (free)
Summary: Preventative antibiotic therapy for people with COPD – Cochrane Library (free)
“Use of continuous and intermittent prophylactic antibiotics results in a clinically significant benefit in reducing exacerbations in COPD patients.”
Cohort Study: BMI of 21-25kg/m2 Linked to Lowest Risk of Dying
2 Nov, 2018 | 03:38h | UTCCommentaries: The association between BMI and mortality: implications for obesity prevention – The Lancet Diabetes & Endocrinology (free) AND BMI of 21-25kg/m2 linked to lowest risk of dying from cancer and heart disease – London School of Hygiene & Tropical Medicine (free) AND Being too fat or too thin ‘can cost four years of life’ – BBC (free)
Review: Management of Cancer-Therapy-Induced LV Dysfunction
2 Nov, 2018 | 03:34h | UTCManagement of Cancer-Therapy-Induced LV Dysfunction: Can the Guidelines Help? – American College of Cardiology (free) (via @md_arianemacedo)
Related: Cardio-Onco-Hematology in Clinical Practice (series of reviews and guidelines on the subject)
Meta-Analysis: Cannabinoids for the Treatment of Chronic Noncancer Pain Conditions
2 Nov, 2018 | 03:29h | UTC“It seems unlikely that cannabinoids are highly effective medicines for chronic noncancer pain conditions.”
Modernized Classification of Cardiac Antiarrhythmic Drugs
2 Nov, 2018 | 02:55h | UTCModernized Classification of Cardiac Antiarrhythmic Drugs – Circulation (free)
Systematic Review: Interventions for Preventing Thromboembolic Events in Patients With Atrial Fibrillation
2 Nov, 2018 | 03:18h | UTCCommentary: DOACs in AF: Observational and Randomized Studies Don’t Always Agree – Medscape (free registration required)
Alex Nowbar’s research reviews – 29 October 2018
2 Nov, 2018 | 02:52h | UTCAlex Nowbar’s research reviews, 29 October 2018 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
Cohort Study: Comparative Effectiveness and Safety of Bariatric Procedures for Weight Loss
2 Nov, 2018 | 02:56h | UTCCommentaries: Effectiveness and Safety of Bariatric Procedures for Weight Loss – Annals of Internal Medicine (free) AND Gastric bypass surgery associated with greater weight loss in adults – Kaiser Permanente (free)
Systematic Review: Drug-Induced Interstitial Lung Disease
2 Nov, 2018 | 02:54h | UTCDrug-Induced Interstitial Lung Disease: A Systematic Review – Journal of Clinical Medicine (free)
Commentary: Drugs’ side effects in lungs ‘more widespread than thought’ – The University of Manchester (free)
Cohort Study: Benefits and Harms of Antihypertensive Treatment in Low-Risk Patients With Mild Hypertension
2 Nov, 2018 | 02:44h | UTCBenefits and Harms of Antihypertensive Treatment in Low-Risk Patients With Mild Hypertension – JAMA Internal Medicine (free for a limited period)
Commentaries: Treatment for moderately high blood pressure may be best saved for those at high risk – University of Cambridge (free) AND Study Questions Whether Treating Mild Hypertension Benefits Patients – NEJM Journal Watch (free)
Podcast: Headaches Advanced Class
2 Nov, 2018 | 02:49h | UTC#122 Headaches Advanced Class: Migraines, medication overuse, and more! – Curbsiders Internal Medicine Podcast (free audio and summary)
Cohort Study: A Healthy Lifestyle Cuts Stroke Risk, Irrespective of Genetic Risk
2 Nov, 2018 | 02:41h | UTCCommentary: A healthy lifestyle cuts stroke risk, irrespective of genetic risk – University of Cambridge (free)
Systematic Review: Early Enteral Nutrition in Lower Gastrointestinal Surgery
2 Nov, 2018 | 02:26h | UTCEarly enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of hospital stay and postoperative complications – Cochrane Library (free)
This review suggests that early enteral feeding is associated with a shorter length of hospital stay. For all other outcomes (postoperative complications, mortality, adverse events, and QoL) the findings are inconclusive.
Randomized Trial: Intravenous Iron in Patients Undergoing Maintenance Hemodialysis
2 Nov, 2018 | 02:30h | UTCIntravenous Iron in Patients Undergoing Maintenance Hemodialysis – New England Journal of Medicine (free)
“Proactive administration of high-dose iv iron did not adversely affect mortality or CV events, but enabled reduced erythropoiesis-stimulating agent dosing and transfusion rates.” (via @NatRevNeph see Tweet)
Perspective: Overdiagnosis of Penicillin Allergy Leads to Costly, Inappropriate Treatment
2 Nov, 2018 | 02:23h | UTCOverdiagnosis of Penicillin Allergy Leads to Costly, Inappropriate Treatment – JAMA (free for a limited period)
Related: NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk (free) AND Antibiotic Use After Removal of Penicillin Allergy Label (link to abstract and commentaries) AND Allergy Testing in Children With Low-Risk Penicillin Allergy Symptoms (link to abstract and commentaries)
Position Paper: Palliative Care in Chronic Lung Diseases
2 Nov, 2018 | 02:22h | UTC
Review: Medication Management of Patients with Cirrhosis
2 Nov, 2018 | 02:17h | UTCOptimizing medication management for patients with cirrhosis: Evidence‐based strategies and their outcomes – Liver International (free) (via @Abraham_RMI)
Randomized Trial: Long-Term Albumin Administration in Decompensated Cirrhosis
2 Nov, 2018 | 02:15h | UTCAlbumin administrations can prolong survival for some people with liver disease – NIHR Signal (free)
Original Article: Long-term albumin administration in decompensated cirrhosis (ANSWER): an open-label randomised trial – The Lancet (link to abstract – $ for full-text)
Guideline: Oxygen Therapy for Acutely Ill Medical Patients
26 Oct, 2018 | 02:59h | UTCOxygen therapy for acutely ill medical patients: a clinical practice guideline – The BMJ (free)
News Release: New guidance recommends minimal oxygen use for most people in hospital – The BMJ (free)
Guideline: Antiplatelet Therapy in Patients Undergoing Elective Invasive Procedures
26 Oct, 2018 | 02:58h | UTC
Review: Pacemaker‐Mediated Arrhythmias
26 Oct, 2018 | 02:49h | UTCPacemaker‐mediated arrhythmias – Journal of Arrythmia (free)
Randomized Trial: Low-Dose Imipramine for Refractory Functional Dyspepsia
26 Oct, 2018 | 02:47h | UTCLow-dose imipramine for refractory functional dyspepsia: a randomised, double-blind, placebo-controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)
Commentary: Refractory functional dyspepsia: low-dose imipramine safe, effective – Univadis (free registration required)
Randomized Trial: Proton-Pump Inhibitors Prophylaxis of Little Benefit in the ICU
26 Oct, 2018 | 02:41h | UTCPantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU – New England Journal of Medicine (free for a limited period)
Editorial: Proton-Pump Inhibitor Prophylaxis in the ICU — Benefits Worth the Risks? (free for a limited period)
“Proton pump inhibitors are minimally effective to reduce GI bleeding among the critically ill folks at high risk for stress ulcers. Takeaways: no role for routine PPI for any patients on the WARDS, and shouldn’t be considered ‘routine’ in the ICU” (via @AnilMakam see Tweet)
Cohort Study: Angiotensin Converting Enzyme Inhibitors and Risk of Lung Cancer
26 Oct, 2018 | 02:43h | UTCEditorial: Angiotensin converting enzyme inhibitors and lung cancer (free)
Commentaries: Blood pressure drug linked to possible small increased risk of lung cancer – NHS Choices (free) AND Expert reaction to study looking at blood pressure drugs and lung cancer risk – Science Media Centre (free)