Internal Medicine
Study: Fournier Gangrene Associated with SGLT2 Inhibitors
7 May, 2019 | 01:13h | UTCFournier Gangrene Associated With Sodium–Glucose Cotransporter-2 Inhibitors: A Review of Spontaneous Postmarketing Cases – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: SGLT2 inhibitors associated with rare, life-threatening necrotizing genital infections – ACP Internist (free) AND Potentiall fatal infection of genitals identified as rare side effect of SGLT2 Inhibitors – American College of Physicians (free) AND Postmarketing data support Fournier gangrene link with SGLT2 inhibitors – Medicine Matters (free)
Related: SGLT2 inhibitors: reports of Fournier’s gangrene (necrotising fasciitis of the genitalia or perineum) – GOV.UK (free)
Meta-Analysis: Early Initiation of Renal Replacement Therapy in Critically Ill Patients
7 May, 2019 | 01:14h | UTCRelated: Updates in Management and Timing of Dialysis in Acute Kidney Injury (free) AND Randomized Trial: Early vs. Delayed Dialysis in Acute Kidney Injury (free study and commentaries)
Aspirin for Primary Prevention: Is This the End of the Road?
6 May, 2019 | 22:43h | UTCAspirin for primary prevention: Is this the end of the Road? – Indian Heart Journal (free)
Related Randomized Trials: Randomized Trial: Aspirin for Primary Prevention of Cardiovascular Disease (link to abstract and commentaries) AND Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes (free) AND Randomized Trial: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly (free)
Related Meta-Analysis: Meta-Analysis: Association of Aspirin Use for Primary Prevention with Cardiovascular Events and Bleeding Events (link to abstract and commentaries) AND Meta-Analysis: Efficacy and Safety of Aspirin for Primary Prevention of Cardiovascular Events (free)
Meta-analysis: Comparison of the Effects of GLP1 Receptor Agonists and SGLT2 Inhibitors for Prevention of Cardiovascular and Renal Outcomes in Type 2 Diabetes
6 May, 2019 | 22:27h | UTC
Study: Effects of Intensive Blood Pressure Therapy for Type 2 Diabetes
6 May, 2019 | 22:23h | UTCEffects of Blood Pressure Lowering on Clinical Outcomes According to Baseline Blood Pressure and Cardiovascular Risk in Patients With Type 2 Diabetes Mellitus: The ADVANCE Trial – Hypertension (link to abstract – $ for full-text)
Commentaries: Intensive blood pressure therapy for type 2 diabetes reduces cardiovascular risk – UPI (free) AND ADVANCE analysis fuels debate on BP targets in type 2 diabetes – Medwire News (free) AND Analysis Supports Aiming for Lower BP in Patients With Diabetes, Hypertension – TCTMD (free)
Current and Future Pharmacological Therapies for Managing Cirrhosis and its Complications
6 May, 2019 | 22:20h | UTCRelated Guidelines: Evidence-based clinical practice guidelines for liver cirrhosis 2015 – Journal of Gastroenterology (free) AND Chinese guidelines on the management of ascites and its related complications in cirrhosis – Hepatology International (free) AND Management of Adult Patients with Ascites Due to Cirrhosis: Update 2012 – American Association for the Study of Liver Diseases (free PDF) EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis (free) AND KASL clinical practice guidelines for liver cirrhosis: Ascites and related complications – Clinical and Molecular Hepatology (free) AND Cirrhosis in Over 16s: Assessment and Management – National Institute for Health and Care Excellence (free)
NICE Guideline: Management of Ulcerative Colitis
5 May, 2019 | 22:12h | UTCUlcerative colitis: management – National Institute for Health and Care Excellence (free)
Related Guidelines: ACG Clinical Guideline: Ulcerative Colitis in Adults – American Journal of Gastroenterology (free) AND AGA Clinical Practice Guidelines on the Management of Mild-to-Moderate Ulcerative Colitis – Gastroenterology (free) AND Updated S3-Guideline Ulcerative Colitis. German Society for Digestive and Metabolic Diseases (DGVS) – Zeitschrift für Gastroenterologie (free) AND Management of Paediatric Ulcerative Colitis (free)
NICE Guideline: Management of Crohn’s disease
5 May, 2019 | 22:10h | UTCCrohn’s disease: management – National Institute for Health and Care Excellence (free)
Related: ACG Clinical Guideline: Management of Crohn’s Disease in Adults – The American Journal of Gastroenterology (free)
Should Adults Get a Measles Booster Shot?
5 May, 2019 | 22:03h | UTCShould Adults Get a Measles Booster Shot? – The New York Times (10 articles per month are free)
See also: Measles Shots Aren’t Just For Kids: Many Adults Could Use A Booster Too – NPR (free) AND HHS, CDC Address Ongoing Measles Outbreaks – AAFP (free) AND Measles, Mumps, and Rubella (MMR) Vaccination: What Everyone Should Know – CDC (free)
Treating Asymptomatic MRSA on Discharge from Hospital Reduces Risk of Later Infection
5 May, 2019 | 16:03h | UTCTreating asymptomatic MRSA on discharge from hospital reduces risk of later infection – NIHR Signal (free)
Related Randomized Trial: Decolonization to Reduce Postdischarge Infection Risk among MRSA Carriers (link to abstract and commentaries)
AUA/CUA/SUFU Guideline: Recurrent Uncomplicated Urinary Tract Infections in Women
3 May, 2019 | 07:43h | UTCRecurrent Uncomplicated Urinary Tract Infections in Women: AUA/CUA/SUFU Guideline (2019)
Commentary: Recommendations for the Evaluation, Management of Recurrent UTI in Women Released – MPR (free)
Guideline: Alcohol-related Liver Disease
3 May, 2019 | 07:41h | UTC
Undetectable = Untransmittable: Risk of HIV Transmission in Serodifferent Gay Couples
3 May, 2019 | 07:38h | UTCCommentary: Successful treatment of HIV eliminates sexual transmission – The Lancet (free)
Related: Systematic Review: Negligible Risk of Transmitting HIV During Sex When Viral Load is Suppressed (free study and commentaries) AND UNAIDS Explainer: UNDETECTABLE = UNTRANSMITTABLE (free)
Perspective: Why Your Doctor’s White Coat Can Be a Threat to Your Health
3 May, 2019 | 07:16h | UTCWhy Your Doctor’s White Coat Can Be a Threat to Your Health – The New York Times (10 articles per month are free)
Related: Long Sleeves on Doctors’ White Coats May Spread Germs (free commentaries)
Study: Diagnostic Performance of Creatinine-Based Equations for Estimating GFR in Adults 65 Years and Older
3 May, 2019 | 07:14h | UTCDiagnostic Performance of Creatinine-Based Equations for Estimating Glomerular Filtration Rate in Adults 65 Years and Older – JAMA Internal Medicine (free for a limited period)
Related Commentary on Twitter
In estimating glomerular filtration rate, no major performance advantage exists between CKD-EPI, LMR, FAS, and BIS 1 equation in people aged {greater than or equal to}65 years https://t.co/y5Of6Z3H7o
— JAMA Internal Medicine (@JAMAInternalMed) May 1, 2019
Study: Basal Insulin Doses >0.5 IU/kg/d Have Diminishing Additional Impact on Improving Glycemic Measures
2 May, 2019 | 12:53h | UTCCommentary: What’s the maximum effective basal insulin dose in T2D? – Univadis (free registration required)
NICE Guideline: Stroke and Transient Ischemic Attack
2 May, 2019 | 04:39h | UTCRelated Guidelines: Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the AHA/ASA (free) AND Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke – The BMJ (free) AND Canadian Stroke Best Practice Recommendations for Acute Stroke Management (free)
FDA Safety Alert: Serious Incidents Related to Certain Prescription Insomnia Medicines
2 May, 2019 | 04:34h | UTCFor Consumers: Taking Z-drugs for Insomnia? Know the Risks – U.S. Food & Drug Administration (free)
Commentaries: Drug Agency Calls for Strong Warning Labels on Popular Sleep Aids – The New York Times (10 articles per month are free) AND FDA Requires Stronger Warnings for Common Insomnia Medications – Psychiatric News Alert (free)
Key Points From the 2019 ACC/AHA Guidelines on the Primary Prevention of Cardiovascular Disease
2 May, 2019 | 04:37h | UTCOriginal Guideline: 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease (free guideline and resources)
Review: Chronic Constipation
2 May, 2019 | 04:31h | UTCChronic Constipation – Mayo Clinic Proceedings (free)
Related: Indian Consensus on Chronic Constipation in Adults (free guidelines and reviews on the subject)
Diagnostic and Therapeutic Approach to Infectious Diseases in Solid Organ Transplant Recipients
1 May, 2019 | 07:22h | UTCRelated: 10 Tips for Intensive Care Management of Transplanted Patients (free articles) AND Special Issue: Infections in Solid Organ Transplantation Guidelines (free articles)
Source: Critical Care Reviews Newsletter
Randomized Trial: Two Weeks vs. Four Weeks of Antibiotic Therapy for Native Joint Bacterial Arthritis
1 May, 2019 | 07:12h | UTCCommentary: Shorter Treatment Succeeds in Septic Arthritis – RheumNow (free)
Alex Nowbar’s research reviews – 30 April 2019
1 May, 2019 | 07:02h | UTCAlex Nowbar’s research reviews, 30 April 2019 – The BMJ Opinion (free)
KDIGO Controversies Conference: Heart Failure in Chronic Kidney Disease
30 Apr, 2019 | 02:44h | UTCHeart failure in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference – Kidney International (free) (via @paomorejon)
Study: Fluoroquinolones Associated with Peripheral Neuropathy
30 Apr, 2019 | 02:40h | UTCAssociation Between Peripheral Neuropathy and Exposure to Oral Fluoroquinolone or Amoxicillin-Clavulanate Therapy – JAMA Neurology (free for a limited period)
Editorial: On the Association Between Fluoroquinolones and Neuropathy (free)
Related: Committee Recommends New Restrictions on the use of Fluoroquinolones (free report and commentaries)