Internal Medicine
Meta-Analysis: Efficacy and Safety of Statin Therapy in Older People
3 Feb, 2019 | 15:43h | UTCCommentaries: Never too old for statin treatment? – The Lancet (free) AND Efficacy and safety of statin therapy in older people – expert comment – London School of Hygiene & Tropical Medicine (free) AND Expert reaction to meta-analysis looking at statins and cardiovascular events in all ages – Science Media Centre (free) AND Statin therapy reduces cardiovascular disease risk in older people – University of Oxford (free) AND Statins Lower Risk for CV Events in Elders, But Benefits for Primary Prevention Still in Question – NEJM Journal Watch (free)
“However, when stratified by history of vascular disease, a significant benefit among those aged 71 and older was limited to those with prior vascular disease.” (from NEJM Journal Watch)
Guideline: Management of Depression with Specific Comorbid Psychiatric Conditions
3 Feb, 2019 | 13:08h | UTCRelated Guideline: Depression in adults: recognition and management – National Institute for Health and Care Excellence (free)
Review: Benefits of Non‐invasive Ventilation in Acute Hypercapnic Respiratory Failure
3 Feb, 2019 | 11:30h | UTCBenefits of non‐invasive ventilation in acute hypercapnic respiratory failure – Respirology (free)
Related Guidelines: BTS/ICS guideline for the ventilatory management of acute hypercapnic respiratory failure in adults – Thorax (free) AND The Japanese Respiratory Society Noninvasive Positive Pressure Ventilation (NPPV) Guidelines – Respiratory Investigation (free) AND Management of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline – European Respiratory Journal (free)
Related Reviews: Non‐invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease – Cochrane Library (free) AND Noninvasive ventilation in acute respiratory failure: which recipe for success? – European Respiratory Review (free)
AACE/ACE Comprehensive Type 2 Diabetes Management Algorithm 2019
1 Feb, 2019 | 02:50h | UTCAACE/ACE Comprehensive Type 2 Diabetes Management Algorithm 2019 – Endocrine Practice (Free PDF and Slide Presentations)
Related Guidelines: ADA 2019 Standards of Medical Care in Diabetes (free supplement) AND Diabetes Canada 2018 clinical practice guidelines for the prevention and management of diabetes in Canada (free)
Systematic Review: Intermittent Iron Supplementation vs. Daily Supplementation for Preventing or Controlling Anemia
1 Feb, 2019 | 02:43h | UTCIntermittent iron supplementation for reducing anaemia and its associated impairments in adolescent and adult menstruating women – Cochrane Library (free)
Summary: Iron supplements taken one, two or three times a week for preventing anaemia, and its consequences in menstruating women – Cochrane Library (free)
“In comparison with daily supplementation, the provision of iron supplements intermittently is probably as effective in preventing or controlling anemia”
Review: Interstitial Lung Disease and Other Pulmonary Manifestations in Connective Tissue Diseases
1 Feb, 2019 | 02:40h | UTC
Systematic Review: General Health Checks for Reducing Illness and Mortality
1 Feb, 2019 | 02:41h | UTCGeneral health checks in adults for reducing morbidity and mortality from disease – Cochrane Library (free)
Summary: General health checks for reducing illness and mortality – Cochrane Library (free)
“General health checks are unlikely to be beneficial.”
The Alzheimer’s Disease Clinical Spectrum: Diagnosis and Management
1 Feb, 2019 | 02:38h | UTC
Randomized Trial: Oral versus Intravenous Antibiotics for Bone and Joint Infection
30 Jan, 2019 | 23:56h | UTCOral versus Intravenous Antibiotics for Bone and Joint Infection – New England Journal of Medicine (link to abstract – $ for full-text)
Related Trial: Partial Oral vs. Intravenous Antibiotic Treatment of Endocarditis (link to abstract and commentaries)
Commentary: Oral antibiotics may work for some ortho, heart infections – CIDRAP (free)
Related Commentary on Twitter
In this trial, 1054 participants with complex orthopedic infections were assigned to receive either oral or intravenous antibiotics for the first 6 weeks of treatment. At 1 year, oral therapy was noninferior to intravenous therapy.
— NEJM (@NEJM) January 30, 2019
10 Myths About Frusemide
30 Jan, 2019 | 23:31h | UTC10 myths about frusemide – Intensive Care Medicine (free)
Note: if the above link is paywalled, try this one
Randomized Trial: E-Cigarettes vs. Nicotine-Replacement Therapy
30 Jan, 2019 | 23:35h | UTCA Randomized Trial of E-Cigarettes versus Nicotine-Replacement Therapy – New England Journal of Medicine (link to abstract – $ for full-text)
Editorial: The Dangerous Flavors of E-Cigarettes (free)
Commentaries: E-cigarettes more effective than nicotine replacement therapies, finds major trial – Queen Mary University of London (free) AND UK study shows e-cigarettes help adult smokers quit, but US experts urge caution – CNN (free) AND E-Cigarettes Are Effective at Helping Smokers Quit, a Study Says – The New York times (10 articles per month are free) AND E-cigarettes ‘much better for quitting smoking’ – BBC (free) AND Study Found Vaping Beat Traditional Smoking-Cessation Options – NPR (free)
Related Commentary on Twitter
Trial finds e-cigarettes more effective than nicotine-replacement therapy with respect to the 1-year abstinence rate (18% vs. 10%). Throat or mouth irritation was more common with e-cigarettes, and nausea was more common with nicotine-replacement. https://t.co/cyEnDP630v pic.twitter.com/1je5vN87ru
— NEJM (@NEJM) January 30, 2019
Perspective: Are Probiotics Money Down the Toilet? Or Worse?
30 Jan, 2019 | 23:34h | UTCAre Probiotics Money Down the Toilet? Or Worse? – JAMA (free for a limited period)
Related: Randomized Trials: Probiotics Ineffective Against Gastroenteritis (link to abstract and commentaries) AND Perspective: The Problem with Probiotics (free commentaries) AND Probiotics: Does the Evidence Match the Hype? (link to abstract and commentaries) AND Systematic Review: Harms Reporting in Trials with Probiotics (link to abstract and commentaries)
Perspective: Debates in Sepsis
30 Jan, 2019 | 23:20h | UTCDebates in sepsis – ACP Hospitalist (free)
Related: Point and Counterpoint: Should the Surviving Sepsis Campaign Guidelines Be Retired? (free commentaries) AND The 2018 Surviving Sepsis Campaign’s Treatment Bundle: When Guidelines Outpace the Evidence Supporting Their Use (free commentaries)
ESC Position Statement: Depression and Coronary Heart Disease
30 Jan, 2019 | 23:30h | UTC
Observational Study: β-Blocker Therapy Reduces the Risk for COPD Hospitalization
30 Jan, 2019 | 01:22h | UTCCommentary: Beta-Blocker Use Linked to Lower Risk for COPD Hospitalization – NEJM Journal Watch (free)
Related review and meta-analysis: Beta-blockers in patients with chronic obstructive disease and coexistent cardiac illnesses – COPD Research and Practice (free) AND Beta-blocker use and COPD mortality: a systematic review and meta-analysis – BMC Pulmonary Medicine (free)
Related observational studies: β-Blockers in COPD: A Cohort Study From the TONADO Research Program – CHEST (free) AND Effect of β blockers in treatment of chronic obstructive pulmonary disease: a retrospective cohort study – The BMJ (free)
Study: Patients with Type 2 Diabetes Safely Switched from Analog to Less Costly Human Insulin
30 Jan, 2019 | 01:13h | UTCImplementation of a Health Plan Program for Switching From Analogue to Human Insulin and Glycemic Control Among Medicare Beneficiaries With Type 2 Diabetes – JAMA (link to abstract – $ for full-text)
Commentary: Medicare Patients with Type 2 Diabetes Safely Switched From Analog to Human Insulin, JAMA Study Finds – AJMC (free)
Related: Meta-Analysis: Comparative Benefits and Harms of Basal Insulin Analogues for Type 2 Diabetes (link to abstract and commentaries) AND Retrospective Observational Study: Basal Insulin Analogs vs NPH Insulin for Type 2 Diabetes (link to abstract and commentaries)
“Patients with type 2 diabetes (T2D) enrolled in a CareMore Health Medicare Part D plan switched from analog to human insulin without significant loss of glycemic control while saving millions for themselves and for the health plan.: (from AJMC)
Ann Robinson’s Research Reviews, 29 January 2019
30 Jan, 2019 | 01:05h | UTCAnn Robinson’s research reviews, 29 January 2019 – The BMJ Opinion (free)
Ann Robinson reviews the latest research from the top medical journals.
Systematic Review: Point-of-Care Ultrasound in General Practice
30 Jan, 2019 | 00:58h | UTCPoint-of-Care Ultrasound in General Practice: A Systematic Review – Annals of Family Medicine (free)
British Guideline for the Management of Neisseria Gonorrhoeae
30 Jan, 2019 | 00:51h | UTCCommentary: UK Gonorrhea Guideline Guards Against Antibiotic Resistance – MD Magazine (free)
Related Guideline: WHO Guidelines for the Treatment of Neisseria gonorrhoeae – World Health Organization (free)
Atrial Fibrillation Guideline: 2019 AHA/ACC/HRS Focused Update
29 Jan, 2019 | 00:08h | UTCNews Release: Updated treatment guidelines for atrial fibrillation recommend a new class of blood thinners to help prevent stroke – American Heart Association (free)
Commentaries: Focused Update of the AHA/ACC/HRS Atrial Fibrillation Guideline – American College of Cardiology (free) AND
Randomized Trial: Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia
29 Jan, 2019 | 00:05h | UTCEffect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Prevention of Cognitive Impairment With Intensive Systolic Blood Pressure Control (free for a limited period)
Commentaries: Does intensive blood pressure control reduce dementia? – NIH News Releases (free) AND Intensive BP Control Helps Prevent Mild Cognitive Impairment – NEJM Journal Watch (free)
Related Commentary on Twitter
Among ambulatory adults with hypertension, treatment to
an SBP goal < 120 mm Hg did not reduce risk of #dementia compared with a goal < 140, but did reduce risk of mild cognitive impairment and risk of a composite of MCI or probable dementia. https://t.co/hJFckI5iAx #MCI pic.twitter.com/K0tdHspupy— JAMA (@JAMA_current) January 28, 2019
European Practical and Patient-Centred Guidelines for Adult Obesity Management in Primary Care
29 Jan, 2019 | 00:07h | UTC
Cohorty Study: Patient-reported Complications Related to Peripherally Inserted Central Catheters
28 Jan, 2019 | 23:55h | UTC
Related Commentary on Twitter
Three in four patients that receive a #PICC report a complication after discharge – yet very few are ever documented. Our new multicenter study in @BMJ_Qual_Saf exploring this issue is now out! #FOAMVa @AVATAR_grp @ISaveThatLine @ins1org #MAGIC https://t.co/sU3sL8aMGG
— Vineet Chopra (@vineet_chopra) January 26, 2019
Meta-Analysis: Aerobic Exercise for Adult Patients with Major Depressive Disorder
28 Jan, 2019 | 23:49h | UTCCommentary: Aerobic exercise is an effective treatment for depression – NIHR Signal (free)
Related Study: Assessment of Bidirectional Relationships Between Physical Activity and Depression Among Adults: A 2-Sample Mendelian Randomization Study – JAMA Psychiatry (link to abstract – $ for full-text) AND Commentary: Exercise can reduce risk for depression, research shows – UPI (free)
Interstitial Lung Disease and Pulmonary Fibrosis: A Practical Approach for General Medicine Physicians with Focus on the Medical History
28 Jan, 2019 | 23:38h | UTC