Internal Medicine
Randomized Trial: Intensive Blood Pressure Reduction Does Not Improve Outcomes in Patients with Acute Ischemic Stroke Treated with Thrombolytics
13 Feb, 2019 | 01:52h | UTCIntensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Commentaries: Intensive Blood Pressure Lowering With Intravenous Thrombectomy for Acute Ischemic Stroke Did Not Improve Functional Outcomes – Practical Neurology (free) AND Tighter BP Control No Better in Acute Stroke – MedPage Today (free registration required)
Australian Guideline for the Diagnosis and Management of Venous Thromboembolism
12 Feb, 2019 | 00:31h | UTCNews Release: New Guidelines for Venous Thromboembolism (free)
Related Guidelines: BTS Guideline: Outpatient Management of Pulmonary Embolism (free) AND ACEP Clinical Policy: Evaluation and Management of Suspected Acute Venous Thromboembolism (free) AND Evaluation of Patients With Suspected Acute Pulmonary Embolism: Best Practice Advice From the Clinical Guidelines Committee of the American College of Physicians (free) AND 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism: The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC) (free)
Related Commentary on Twitter
New guidelines from the Thrombosis and Haemostasis Society of Australia and New Zealand for diagnosis & management of venous thromboembolism … #freeaccess for 1 week … https://t.co/4TIweujdRd … #VTE #DVT #PE pic.twitter.com/UWmo9AnPgJ
— MJA (@theMJA) February 11, 2019
Review: Identifying and Managing Younger Women at High Risk of Cardiovascular Disease
12 Feb, 2019 | 00:21h | UTCIdentifying and managing younger women at high risk of cardiovascular disease – Canadian Medical Association Journal (free for 7 days)
Related Reviews: Knowledge, Attitudes, and Beliefs Regarding Cardiovascular Disease in Women: The Women’s Heart Alliance – Journal of the American College of Cardiology (free)
Related guidelines: Preventing and Experiencing Ischemic Heart Disease as a Woman: State of the Science: A Scientific Statement From the American Heart Association (free) AND Acute Myocardial Infarction in Women: A Scientific Statement From the American Heart Association (free) AND AHA/ACOG: Reduction of Cardiovascular Disease in Women Through Collaboration with Obstetricians and Gynecologists (free)
Observational Study: Antibiotics Provide No Benefit for Hospitalized Asthma Patients, Linked to Longer Hospital Stay
12 Feb, 2019 | 00:04h | UTCAssociation of Antibiotic Treatment With Outcomes in Patients Hospitalized for an Asthma Exacerbation Treated With Systemic Corticosteroids – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Should Hospitalized Asthma Patients Receive Antibiotics? – MedicalResearch.com (free) AND No benefit of antibiotic treatment for hospitalised asthma patients – medwire News (free) AND Antibiotic therapy for asthma exacerbation associated with longer hospital stay – 2 Minute Medicine (free) AND Antibiotics Provide No Added Benefit in Severe Asthma Flares – ACEPNow (free)
Related Commentary on Twitter
“…although guidelines do not recommend #antibiotics for patients hospitalized with an #asthma exacerbation (unless [there are] clear signs of infection) 41% of patients receive #abx on day 1 of hospitalization." #FOAMed
Full story here: https://t.co/cLvpFgcmMZ pic.twitter.com/1x01e2awIb
— ACEP – Members (@ACEPNow) February 8, 2019
Meta-Analysis: Effects of Dietary Improvement on Symptoms of Depression and Anxiety
11 Feb, 2019 | 23:43h | UTCCommentaries: Improved Diet Can Ease Depression Symptoms, Enhance Mood – PsychCentral (free) AND Many Different Diets Can Improve Mood And Reduce Depression Symptoms, Study Finds – Forbes (free) AND A diet rich in fiber and vegetables can relieve depression – Medical News Today (free)
Observational Study Suggests a Link Between Fruit and Vegetable Consumption and Mental Well-Being
11 Feb, 2019 | 23:41h | UTCCommentary: Hearts and minds: fruit and veg boost well-being – University of Leeds (free) AND Eating more fruit and veg ‘improves mental wellbeing’ – NHS Choices (free)
USPSTF Draft Recommendation Statement: Pancreatic Cancer Screening
11 Feb, 2019 | 21:06h | UTCDraft Recommendation Statement: Pancreatic Cancer Screening – U.S. Preventive Services Task Force (free)
Commentary: USPSTF Maintains Stance Against Routine Screening for Pancreatic Cancer – NEJM Journal Watch (free)
“The USPSTF recommends against screening for pancreatic cancer in asymptomatic adults.”
Study: Only a Minority of Adults and Youth with T1D Achieve ADA goals for HbA1c
11 Feb, 2019 | 21:03h | UTCCommentary: Minority of patients with type 1 diabetes achieve ADA goals for glycemic control, study finds – ACP Diabetes (free)
Perspective: The Path to Diagnostic Excellence Includes Feedback to Calibrate How Clinicians Think
11 Feb, 2019 | 20:55h | UTCThe Path to Diagnostic Excellence Includes Feedback to Calibrate How Clinicians Think – JAMA (free for a limited period)
NICE Guideline: Antimicrobial Prescribing for Acute Cough
11 Feb, 2019 | 00:20h | UTCCough (acute): antimicrobial prescribing – National Institute for Health and Care Excellence (free)
Infographic: 2-page visual summary of the recommendations (free PDF)
See also: NICE Antimicrobial prescribing guidelines (resource covering many common conditions) AND NICE Summary of antimicrobial prescribing guidance – managing common infections (free PDF)
Randomized Trial: Intense IV Blood Sugar Control Doesn’t Improve Stroke Outcomes
11 Feb, 2019 | 00:15h | UTCCommentaries: NIH study provides answer to long-held debate on blood sugar control after stroke – National Institute of Health (free) AND Stroke: Intensive Blood Sugar Control Did Not Improve Outcomes – MedicalResearch.com (free) AND Live from the ISC: Standard treatment of hyperglycaemia in acute ischaemic stroke outperforms an intensive approach – NeuroNews (free)
Related Cochrane Review: Insulin for glycaemic control in acute ischaemic stroke (free) AND Summary: Controlling high blood sugar levels with insulin in people who have had an acute ischaemic stroke (free)
“Intensive glucose control (80–130mg/dL) does not improve 90-day functional outcome and increases the risk of severe hypoglycaemia.” (from NeuroNews)
Five Warning Signs of Overdiagnosis
11 Feb, 2019 | 00:05h | UTCFive warning signs of overdiagnosis – The Conversation (free)
Related: Overdiagnosis: Causes and Consequences in Primary Health Care (free) AND Screening: How Overdiagnosis and Other Harms can Undermine the Benefits (free) AND WONCA Position Paper on Overdiagnosis and Action to be Taken (free) AND Overdiagnosis: what it is and what it isn’t (free) AND Review: Overdiagnosis Across Medical Disciplines (free) AND Too much medical care: bad for you, bad for health care systems (free)
Systematic Review: Managing Antidepressant Discontinuation
11 Feb, 2019 | 00:00h | UTCManaging Antidepressant Discontinuation: A Systematic Review – Annals of Family Medicine (free)
Commentary: Psychotherapy Ups Odds of Tapering Off Antidepressants – Medscape (free registration required)
Potential Excessive Testing at Scale: Biomarkers, Genomics, and Machine Learning
11 Feb, 2019 | 00:02h | UTCViewpoint: Potential Excessive Testing at Scale: Biomarkers, Genomics, and Machine Learning – JAMA (free for a limited period)
Related Commentary on Twitter
Excessive medical testing in the era of big data and precision medicine can lead to potential harms and unnecessary healthcare costs. @mandl & @arjunmanrai write an insightful @JAMA_current viewpoint on how to deal with this threat. https://t.co/uu1Cjwqy8n pic.twitter.com/L67aJhetCf
— Dr Muin J. Khoury (@MuinJKhoury) February 8, 2019
Systematic Review Supports Lengthening of the Screening Interval of Patients with Type 2 Diabetes Without Retinopathy at Last Screening Session
10 Feb, 2019 | 23:58h | UTCCommentary: How often should patients with T2D be screened for retinopathy? – Univadis (free registration required)
Related: Evidence‐based Guidelines for Screening of Diabetic Retinopathy (free)
“This review supports lengthening of the screening interval of patients with Type 2 diabetes without retinopathy at last screening session”
Review: Cardiovascular Manifestations of Inflammatory Bowel Disease
10 Feb, 2019 | 15:41h | UTC
Cohort Study: Effect of Gastric Bypass Surgery on Diabetes Remission and Complications
10 Feb, 2019 | 15:44h | UTCEffect of Roux-en-Y gastric bypass surgery on diabetes remission and complications in individuals with type 2 diabetes: a Danish population-based matched cohort study – Diabetologia (free for a limited period)
Commentary: Gastric Bypass Surgery Linked to Diabetes Remission – MedicalResearch.com (free)
Study: Lifestyle Changes May be More Important than Drugs for Mild Hypertension
10 Feb, 2019 | 15:37h | UTCLifestyle changes may be more important than drugs for mild hypertension – NIHR Signal (free)
Original Study: Cohort Study: Benefits and Harms of Antihypertensive Treatment in Low-Risk Patients With Mild Hypertension (link to abstract and commentaries)
Clinical Practice Guidelines for Diagnosis and Management of Cough
10 Feb, 2019 | 14:35h | UTCRelated Guideline: KAAACI Evidence-Based Clinical Practice Guidelines for Chronic Cough in Adults and Children in Korea – Allergy, Asthma & Immunology Research (free)
See also recently published CHEST guidelines on the management of cough in specific populations: Classification of Cough as a Symptom in Adults and Management Algorithms (free) AND Adult Outpatients With Acute Cough Due to Suspected Pneumonia or Influenza – CHEST Guideline and Expert Panel Report (free) AND Clinically Diagnosing Pertussis-associated Cough in Adults and Children (free) AND Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold (free) AND Cough Due to TB and Other Chronic Infections (free) AND Chronic Cough Due to Gastroesophageal Reflux in Adults (free) AND Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer (free) AND Cough in the athlete (free) AND Occupational and Environmental Contributions to Chronic Cough in Adults (free) AND Treatment of Unexplained Chronic Cough (free) AND Use of Management Pathways or Algorithms in Children With Chronic Cough (free) AND Management of Children With Chronic Wet Cough and Protracted Bacterial Bronchitis (free)
Expert Consensus on Diagnosis and Management of Severe Asthma
10 Feb, 2019 | 14:34h | UTCChinese expert consensus on diagnosis and management of severe asthma – Journal of Thoracic Disease (free)
Related Guidelines: Recognition and management of severe asthma: A Canadian Thoracic Society position statement (free) AND International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma (free) AND Guidelines for Severe Uncontrolled Asthma – Spanish Society of Pulmonology and Thoracic Surgery (free) AND Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults (free)
Study: Cardiovascular Risk Factors Associated With Venous Thromboembolism
10 Feb, 2019 | 13:48h | UTCCardiovascular Risk Factors Associated with Venous Thromboembolism – JAMA Cardiology (free)
“Older age, smoking, and adiposity were consistently associated with higher VTE risk.”
Expert Panel Recommendations: Fluid Administration for Acute Circulatory Dysfunction Using Basic Monitoring
7 Feb, 2019 | 23:26h | UTCFluid administration for acute circulatory dysfunction using basic monitoring: narrative review and expert panel recommendations from an ESICM task force – Intensive Care Medicine (free for a limited period)
Note: if the above link is paywalled, try this one
Related Commentary on Twitter
Fluid administration for acute circulatory failure: go back to the basics, thanks to the expert panel recommendations from an ESICM task force!
Read the full text article for free at https://t.co/VPtl6cD0aN @Dr_Cit @ESICM @ClinMedJournals pic.twitter.com/pBoJiKHihT— Intens Care Med (@yourICM) February 1, 2019
Review: Diagnosis and Treatment of Primary Headache Disorders in Older Adults
7 Feb, 2019 | 22:50h | UTCSource: Medscape
Study: Patterns in Outpatient Benzodiazepine Prescribing
7 Feb, 2019 | 15:13h | UTCPatterns in Outpatient Benzodiazepine Prescribing in the United States – JAMA Network Open (free)
Commentary: Steep Climb In Benzodiazepine Prescribing By Primary Care Doctors – NPR (free)
Related: A Quiet Drug Problem Among the Elderly – The New York Times (10 articles per month are free) AND Benzodiazepines: our other prescription drug epidemic – STAT (free)
Consensus: Diagnosis of Peripheral Bone Infection in Adults
7 Feb, 2019 | 15:05h | UTC