Internal Medicine
Randomized Trial: Intensive Treatment of Hyperglycemia Does Not Improve Outcomes in Patients with Acute Ischemic Stroke
24 Jul, 2019 | 09:18h | UTCIntensive vs Standard Treatment of Hyperglycemia and Functional Outcome in Patients With Acute Ischemic Stroke: The SHINE Randomized Clinical Trial – JAMA (free for a limited period)
Commentaries: Researchers get a handle on how to control blood sugar after stroke – NIH News Releases (free) AND Study Doesn’t Support Intensive Glucose Control in Patients with Stroke and Hyperglycemia – NEJM Journal Watch (free)
Review: Aspiration Pneumonia in Older Adults
24 Jul, 2019 | 08:44h | UTCAspiration Pneumonia in Older Adults – Journal of Hospital Medicine (free PDF)
Review: Dietary and Pharmacological Treatment of Nonalcoholic Fatty Liver Disease
24 Jul, 2019 | 08:16h | UTCDietary and Pharmacological Treatment of Nonalcoholic Fatty Liver Disease – Medicina (free)
Related Guidelines: Non-Alcoholic Fatty Liver Disease: Assessment and Management – National Institute for Health and Care Excellence (NICE) (free) AND The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases (free) AND Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis – Japanese Society of Gastroenterology (free) AND Nonalcoholic Fatty Liver Disease Brazilian Society of Hepatology Consensus (free PDF) AND EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease (free)
[Abstract Only] Prevalence of Obstructive Sleep Apnea in Patients with Major Depressive Disorder
24 Jul, 2019 | 01:16h | UTCPrevalence of obstructive sleep apnea in suicidal patients with major depressive disorder – Journal of Psychiatric Research (link to abstract – $ for full-text)
Commentary: Obstructive sleep apnea may be one reason depression treatment doesn’t work – Medical College of Georgia at Augusta University (free)
[Abstract Only] Study Shows Widespread Use of Aspirin for Primary Prevention of CV Disease Despite Few Benefits
24 Jul, 2019 | 07:49h | UTCPrevalence of Aspirin Use for Primary Prevention of Cardiovascular Disease in the United States: Results From the 2017 National Health Interview Survey – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Widespread aspirin use despite few benefits, high risks – Beth Israel Deaconess Medical Center (free) AND Many Americans mistakenly use aspirin to prevent heart disease – Reuters (free) AND Older Adults Should Reevaluate Daily Aspirin – MedicalResearch.com (free) AND Millions still take aspirin for their heart without a doctor’s recommendation, research suggests – CNN (free)
Related Commentary on Twitter (Thread – Click for More)
New pub out today in @AnnalsofIM. Our main finding: aspirin use for primary prevention is widespread among groups at risk for harm. https://t.co/s9h9BhjYgz
— Colin W. O'Brien (@ColinWOBrien) July 22, 2019
Diagnosing the Onset of Menopause
23 Jul, 2019 | 01:47h | UTCDiagnosing the Onset of Menopause – JAMA (free for a limited period)
Clinical Review Audio: Diagnosing Menopause (free)
Meta-Analysis: Diagnostic Performance of PET or PET/CT Using 18F-FDG Labeled White Blood Cells in Infectious Diseases
23 Jul, 2019 | 01:22h | UTC
Cancer and Heart Disease: Associations and Relations
21 Jul, 2019 | 21:55h | UTCCancer and heart disease: associations and relations – European Journal of Heart Failure (free)
Cochrane Review: Buffered Solutions Do Not Improve Mortality in Critically Ill Adults and Children Compared to 0,9% Saline
20 Jul, 2019 | 18:35h | UTCBuffered solutions versus 0.9% saline for resuscitation in critically ill adults and children – Cochrane Library (free)
Summary: Buffered solutions versus 0.9% saline for resuscitation in critically ill adults and children – Cochrane Library (free)
Related Meta-Analysis: Choice of Intravenous Crystalloid Fluid and Mortality in Critically Ill Adult Patients – Southern Medical Journal (link to abstract – $ for full-text)
Related Randomized Trials: Balanced Crystalloids vs Saline in Hospitalized Patients (free studies and commentary)
“The three ongoing studies once published and assessed may alter the conclusions of the review.”
Canadian Guidelines for the Management of Luminal Crohn’s Disease
19 Jul, 2019 | 09:53h | UTCRelated Guidelines: Crohn’s disease: management – National Institute for Health and Care Excellence (free) AND ACG Clinical Guideline: Management of Crohn’s Disease in Adults – The American Journal of Gastroenterology (free)
[Abstract Only] Effect of Systolic and Diastolic Blood Pressure on Cardiovascular Outcomes
19 Jul, 2019 | 09:48h | UTCEffect of Systolic and Diastolic Blood Pressure on Cardiovascular Outcomes – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Hypertension From Top to Bottom: Don’t Ignore Diastolic BP – TCTMD (free) AND Both Systolic and Diastolic BP Affect CV Outcomes – NEJM Journal Watch (free)
Alex Nowbar’s journal reviews—18 July 2019
19 Jul, 2019 | 09:40h | UTCAlex Nowbar’s journal reviews, 18 July 2019 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
Review: Anticoagulation in the Cirrhotic Patient
19 Jul, 2019 | 09:38h | UTCAnticoagulation in the cirrhotic patient – JHEP Reports (free)
Related: The Complex Role of Anticoagulation in Cirrhosis: An Updated Review of Where We Are and Where We Are Going – Digestion (free) AND Direct Oral Anticoagulants in Cirrhotic Patients: Current Evidence and Clinical Observations – Canadian Journal of Gastroenterology and Hepatology (free) AND Anticoagulation in cirrhosis: a new paradigm? – Clinical and Molecular Hepatology (free)
[Abstract Only] Observational Study Points to Increased Cardiovascular and Cerebrovascular Risk with Testosterone Replacement Therapy (TRT) in Aging Men
19 Jul, 2019 | 09:37h | UTCCardiovascular and Cerebrovascular Safety of Testosterone Replacement Therapy Among Aging Men with Low Testosterone Levels: A Cohort Study – American Journal of Medicine (link to abstract – $ for full-text)
Commentary: Testosterone replacement therapy (TRT) can increase men’s risk of stroke and heart attack – Elsevier (free)
Meta-Analysis: Preventable Patient Harm Across Medical Care Settings
18 Jul, 2019 | 10:54h | UTCEditorial: Preventable harm: getting the measure right (free)
Commentaries: One in 20 patients exposed to preventable harm in medical care – OnMedica (free) AND Half of All Patient Harms ‘Preventable’ – Medscape (free registration required)
Related Commentary on Twitter
Around one in 20 patients are affected by preventable harm in medical care, of which around 12% causes permanent disability or death, finds a study published by @bmj_latest today – take a look at the research https://t.co/oHxTBlh4s1 and linked editorial https://t.co/MBW6moT3pE pic.twitter.com/gxoL4V435w
— BMJ Group (@bmj_company) July 18, 2019
International Registry: 16.6% of Patients with Takotsubo Syndrome Have Underlying Malignancy
18 Jul, 2019 | 10:15h | UTCEditorial: Is Transient Takotsubo Syndrome Associated With Cancer? Why, and With What Implications for Oncocardiology? (free)
Commentary: Cancer Rates High in Patients with Takotsubo Syndrome – NEJM Journal Watch (free)
New Blood Test Seems Promising for the Diagnosis of Alzheimer’s Disease
18 Jul, 2019 | 09:49h | UTCAssociation of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging – JAMA Neurology (free for a limited period)
Commentaries: Scientists close in on blood test for Alzheimer’s – STAT (free) AND Predicting Alzheimer’s – Blood markers close in on helping determine who will develop Alzheimer’s disease – MedPage Today (free registration required)
“What good will that do without a cure?” (from STAT)
Meta-Analysis: Antiplatelet Therapy After Noncardioembolic Stroke
17 Jul, 2019 | 10:47h | UTCSource: EvidenceAlerts
“Results favor clopidogrel and aspirin/dipyridamole combination for long-term secondary prevention after noncardioembolic stroke or transient ischemic attack”.
Post‐intensive Care Syndrome: Its Pathophysiology, Prevention, and Future Directions
17 Jul, 2019 | 08:59h | UTCPost‐intensive care syndrome: its pathophysiology, prevention, and future directions – Acute Medicine & Surgery (free) (via @NydahlPeter)
Related Reviews: Post-intensive care outpatient clinic: is it feasible and effective? A literature review – Revista Brasileira de Medicina Intensiva (free) AND Post-intensive Care Syndrome: an Overview – Journal of Translational Internal Medicine (free) AND Optimizing Post-Intensive Care Unit Rehabilitation – Turkish Thoracic Journal (free)
“Not Initiating is Not the Same Thing as Discontinuing” – Update on Acetylsalicylic Acid for Primary Prevention of Cardiovascular Disease
17 Jul, 2019 | 08:40h | UTCSee also: Acetylsalicylic acid for primary prevention of cardiovascular events – Canadian Family Physician (free)
Related: A Practical Approach to Low-Dose Aspirin for Primary Prevention (free) AND Aspirin for Primary Prevention: Is This the End of the Road? (free) AND Evidence evolving on aspirin as prevention – ACP Internist (free)
Study: Health Lifestyle May Reduce the Incidence of Dementia Even in Patients with High Genetic Risk
16 Jul, 2019 | 09:42h | UTCAssociation of Lifestyle and Genetic Risk With Incidence of Dementia – JAMA (free for a limited period)
Commentaries: Healthy lifestyle reduces dementia risk even in those with genetic risk factors – NHS Choices (free) AND Healthy lifestyle may offset genetic risk of dementia – University of Exeter (free) AND Genes vs. lifestyle: Study ‘undermines fatalistic view of dementia’ – Medical News Today (free) AND Healthy living may help offset genetic risk of dementia: study – Reuters (free) AND Healthy lifestyle may cut risk of dementia regardless of genes – The Guardian (free)
[Abstract Only] Meta-Analysis: Benefits and Harms of Oral Anticoagulant Therapy in Chronic Kidney Disease
16 Jul, 2019 | 09:43h | UTCBenefits and Harms of Oral Anticoagulant Therapy in Chronic Kidney Disease: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Non-vitamin K oral anticoagulants appear superior to vitamin K antagonists in early-stage CKD – ACP Internist (free) AND Evidence Favors NOACs for Anticoagulation in Early Chronic Kidney Disease – NEJM Journal Watch (free)
Review: Diagnostic Evaluation of Bronchiectasis
16 Jul, 2019 | 09:19h | UTCDiagnostic evaluation of bronchiectasis – Respiratory Medicine (free)
Related Guidelines: British Thoracic Society Guideline for bronchiectasis in adults – Thorax (free) AND Bronchiectasis (non-cystic fibrosis), acute exacerbation: antimicrobial prescribing – National Institute for Health and Care Excellence (free) AND European Respiratory Society guidelines for the management of adult bronchiectasis (free)
Clinical Practice: Measles
14 Jul, 2019 | 20:05h | UTCMeasles – New England Journal of Medicine (free)
[Abstract Only] Randomized Trial: Calorie Restriction Reduces Heart and Metabolic Risk Factors
14 Jul, 2019 | 19:55h | UTC2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentaries: Moderate calorie restriction in young and middle-aged adults significantly reduces heart and metabolic risk factors independent of weight loss – NIH News Releases (free) AND Cutting calories improves health markers even in slim adults, study reports – Diabetes.co.uk (free) AND Cutting Just 300 Calories Per Day May Keep Your Heart Healthy – NPR (free) AND Cutting about 300 calories a day might benefit your heart, study finds – CNN (free)
Related Commentary on Twitter
Online now: 2 years of #calorie restriction and #cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial https://t.co/RpLfyuNVzN #metabolic syndrome #cardiovascular #hypertension #diabetes #obesity #diet #CVD pic.twitter.com/Ft8YsmQkXj
— The Lancet Diabetes & Endocrinology (@TheLancetEndo) July 12, 2019