Internal Medicine
New Protocol for HIV Prevention Drug Reduces The Number Of Pills Required
31 Jul, 2019 | 02:08h | UTCNew Protocol For HIV Prevention Drug Reduces The Number Of Pills Required – Kaiser Health News (free)
Related: British Guidelines on the Use of HIV Pre–exposure Prophylaxis (PrEP) (several guidelines on the subject) AND USPSTF Statement: Preexposure Prophylaxis for the Prevention of HIV Infection (free guideline and commentaries)
“both organizations now endorse a strategy that requires taking just four pills timed to a specific sexual encounter — two within two to 24 hours before sex and one on each of the two following days… The new strategy, called “2-1-1” or “on-demand” PrEP, is becoming popular overseas but has gotten little traction in the United States thus far.”
Randomized Sham-Controlled Trial: Acupuncture as Adjunctive Therapy for Chronic Stable Angina
31 Jul, 2019 | 02:04h | UTCCommentary: Expert reaction to study looking at acupuncture as an added treatment for angina – Science Media Centre (free)
Meta-Analysis: Liberal vs. Restrictive Red Blood Cell Transfusion Strategy in Sepsis or Septic Shock
31 Jul, 2019 | 01:44h | UTCRelated Systematic Review: Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion – Cochrane Library (free)
Related Guideline: Guidelines on the management of anaemia and red cell transfusion in adult critically ill patients – British Committee for Standards in Haematology (free)
Meta-Analysis: Infection Rate Among Nutritional Therapies for Acute Pancreatitis
31 Jul, 2019 | 01:15h | UTCRelated Meta-Analysis: Efficacy comparisons of enteral nutrition and parenteral nutrition in patients with severe acute pancreatitis: a meta-analysis from randomized controlled trials – Bioscience Reports (free) AND Enteral nutrition provided within 48 hours after admission in severe acute pancreatitis: A systematic review and meta-analysis – Medicine (free)
Related Guidelines: 2019 WSES guidelines for the management of severe acute pancreatitis – World Journal of Emergency Surgery (free) AND American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis (free) AND Pancreatitis – National Institute for Health and Care Excellence (free) AND American College of Gastroenterology Guideline: Management of Acute Pancreatitis (free)
Simulation Study: Uniform CT Imaging for Patients with Hematuria May Result in Increased Costs and Harms of Secondary Cancers
30 Jul, 2019 | 01:37h | UTCComparison of the Harms, Advantages, and Costs Associated With Alternative Guidelines for the Evaluation of Hematuria – JAMA Internal Medicine (free for a limited period)
Commentaries: Hematuria Practice Guidelines That Explicitly Consider Harms and Costs – JAMA Internal Medicine (free for a limited period) AND Evaluating Hematuria: Uniform Use of CT Seen as Risky and Expensive – NEJM Journal Watch (free)
Related Commentary on Twitter (Thread – Click for More)
Excited to have our work examining tradeoffs of alternative approaches to hematuria evaluation out in @JAMAInternalMed today. Sharing here origin story, highlights from the paper and related thoughts (THREAD)
1/nhttps://t.co/f47L2BZOW7— Matt Nielsen, MD (@m_e_nielsen) July 29, 2019
Cohort Study: Among Patients Undergoing Noncardiac Surgery, Most Deaths Occurred After the Procedure
31 Jul, 2019 | 01:22h | UTCCommentaries: In Noncardiac Surgery, the Post-Op Period Is Riskiest – NEJM Journal Watch (free) AND Most deaths related to noncardiac surgery occur after surgery and after discharge from hospital – Canadian Medical Association Journal (free) AND Riskiest time for surgery patients is not in the operating room – Reuters (free)
“Among adults undergoing noncardiac surgery, 99.3% of deaths occurred after the procedure and 44.9% of deaths were associated with 3 complications: major bleeding, myocardial injury and sepsis.”
Consensus Paper: Management of Severe Bleeding in Patients Treated with Oral Anticoagulants
30 Jul, 2019 | 01:39h | UTCRelated: 2017 ACC Expert Consensus Decision Pathway on Management of Bleeding in Patients on Oral Anticoagulants (free guideline and summary)
The Management of Diverticulitis: A Review of the Guidelines
30 Jul, 2019 | 01:32h | UTCThe management of diverticulitis: a review of the guidelines – Medical Journal of Australia (free for a limited period)
Related Guidelines: American Gastroenterological Association Institute Guideline on the Management of Acute Diverticulitis (free) AND EAES and SAGES 2018 consensus conference on acute diverticulitis management: evidence-based recommendations for clinical practice (free) AND Guidelines for Colonic Diverticular Bleeding and Colonic Diverticulitis: Japan Gastroenterological Association (free) AND Colorectal surgeon consensus with diverticulitis clinical practice guidelines (free) AND WSES Guidelines for the management of acute left sided colonic diverticulitis in the emergency setting (free) AND The Mexican Consensus on the Diagnosis and Treatment of Diverticular Disease of the Colon (free)
Hepatic Abscess: Pearls for Emergency Medicine Clinicians
29 Jul, 2019 | 20:00h | UTCHepatic Abscess: Pearls for Emergency Medicine Clinicians – emDocs (free)
Related: Therapy of Liver Abscesses – Visceral Medicine (free) AND The Evolving Nature of Hepatic Abscess: A Review – Journal of Clinical and Translational Hepatology (free)
[Abstract Only] Randomized Trial: Early TIPS vs. Standard Treatment for Acute Variceal Bleeding in Patients with Advanced Cirrhosis
29 Jul, 2019 | 19:56h | UTCEarly TIPS with covered stents versus standard treatment for acute variceal bleeding in patients with advanced cirrhosis: a randomised controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)
Related Commentary on Twitter
New online – early TIPS with covered stents versus standard treatment for acute variceal bleeding in patients with advanced cirrhosis: a randomised controlled trial – https://t.co/evc2BQZ9Lc #varices #TIPS #variceal #bleeding #cirrhosis pic.twitter.com/BjUeRjE5fa
— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) May 30, 2019
Study: A Cardiovascular Risk-based Strategy for the Treatment of Hypertensive Patients Could Prevent More Cardiovascular Disease Events
28 Jul, 2019 | 23:08h | UTCCommentaries: Strategies to identify patients for antihypertensive treatment – The Lancet (free) AND Using cardiovascular risk to identify patients eligible for blood pressure treatment could prevent significantly more heart attacks and strokes – London School of Hygiene & Tropical Medicine (free) AND Expert reaction to paper on identifying those eligible for blood pressure treatment and subsequent burden of cardiovascular disease – Science Media Centre (free)
Related Commentary on Twitter
NEW online: A #cardiovascular risk-based strategy could prevent over a third more cardiovascular disease events than the 2011 #NICE guideline and a fifth more than the 2019 #NICE guideline https://t.co/ZmfLpyN3iN @LSHTM
— The Lancet (@TheLancet) July 26, 2019
NICE Guideline: Generalized Anxiety Disorder and Panic Disorder in Adults
28 Jul, 2019 | 23:12h | UTCRelated Guideline: Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the treatment of panic disorder, social anxiety disorder and generalised anxiety disorder (free)
Updated CDC Recommendations for Measles in Healthcare Settings
28 Jul, 2019 | 23:04h | UTCCommentary: CDC Updates Measles Prevention Guidelines for Healthcare Workers – NEJM Journal Watch (free)
Alex Nowbar’s journal reviews—25 July 2019
28 Jul, 2019 | 22:50h | UTCAlex Nowbar’s journal reviews, 25 July 2019 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
[Abstract Only] Fluoroquinolones Linked to Serious Arrhythmias and Sudden Death in Large Observational Study
28 Jul, 2019 | 22:47h | UTCFluoroquinolone use and serious arrhythmias: A nationwide case-crossover study – Resuscitation (link to abstract – $ for full-text)
Commentary: Fluoroquinolones and Sudden Death – JournalFeed (free)
Related: Committee Recommends New Restrictions on the use of Fluoroquinolones (free report and commentaries) AND FDA Safety Alert: Warnings for Fluoroquinolones on Risks of Mental Health and Low Blood Sugar Adverse Reactions (free statement and commentaries) AND FDA Warns About Increased Risk of Aortic Dissection and Ruptures of Aortic Aneurism with Fluoroquinolones (free report and commentaries)
Observational Study: Rhythm Control in Older Patients with Atrial Fibrillation Linked to Increased Risk of Fall‐Related Injuries and Syncope
28 Jul, 2019 | 22:49h | UTCEditorial: Antiarrhythmic Drugs in Atrial Fibrillation: Is There Still a Role for Rhythm Control? (free)
Commentary: Medications used to treat atrial fibrillation may raise risk of falls – American Geriatrics Society (free)
Related Commentary on Twitter
We investigated if rate or rhythm therapy in older AF patients was associated with falls and syncope. The results might surprise you @gunngis @MRuwald @Jannik @AGSJournal https://t.co/7g28Vh7Uoh
— Frederik Dalgaard (@F_dalgaard) July 24, 2019
Management of Chronic Respiratory Failure in Interstitial Lung Diseases: Overview and Clinical Insights
27 Jul, 2019 | 20:04h | UTCRelated Review: Management of acute respiratory failure in interstitial lung diseases: overview and clinical insights – BMC Pulmonary Medicine (free)
ACG Clinical Guideline: Hereditary Hemochromatosis
26 Jul, 2019 | 01:13h | UTCACG Clinical Guideline: Hereditary Hemochromatosis – The American Journal of Gastroenterology (free PDF)
Related Guidelines: Diagnosis and management of hemochromatosis: 2011 Practice Guideline by the American Association for the Study of Liver Diseases (free) AND Therapeutic recommendations in HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype – Hepatology International (free)
Clinical Guide and Update on Porphyrias
26 Jul, 2019 | 01:11h | UTCClinical Guide and Update on Porphyrias – Gastroenterology (free)
Related Reviews: Update review of the acute porphyrias – British Journal of Haematology (free) AND Acute Hepatic Porphyrias: Review and Recent Progress – Hepatology Communications (free) AND Acute hepatic porphyrias: Recommendations for evaluation and long‐term management – Hepatology (free) AND An overview of the cutaneous porphyrias – F1000 Research (free)
Viewpoint: Realizing Shared Decision-making in Practice
26 Jul, 2019 | 01:01h | UTCRealizing Shared Decision-making in Practice – JAMA (free for a limited period)
Related Viewpoint: Shared Decision Making and the Importance of Time – JAMA (free)
Meta-Analysis: Risk of Recurrent Thromboembolism after Discontinuation of Anticoagulant Treatment for First Unprovoked Venous Thromboembolism Event
26 Jul, 2019 | 01:06h | UTCCommentary: Long-Term Risk for Recurrent VTE Significant After Stopping Anticoagulation – NEJM Journal Watch (free)
“the risk of recurrent VTE was 10% in the first year after treatment, 16% at two years, 25% at five years, and 36% at 10 years, with 4% of recurrent VTE events resulting in death.”
Related Commentary on Twitter
Excited to share my first study published today in @bmj_latest on recurrence risk after stopping #anticoagulation for unprovoked #VTE. Big thanks to the MARVELOUS collaborators, @CIHR_IRSC for funding/support & @RodgerMarc for continued mentorship https://t.co/jnT86dRzHK#phdlife pic.twitter.com/SSVTYwkXth
— Faizan Khan, PhD (@FaizanK91) July 25, 2019
Randomized Trial: Proton Pump Inhibitor Not Effective for Prevention of Gastroduodenal Events in Patients Receiving Low-dose Anticoagulation and/or Aspirin
26 Jul, 2019 | 00:44h | UTC
Pleural Effusion in Adults—Etiology, Diagnosis, and Treatment
25 Jul, 2019 | 01:49h | UTCPleural Effusion in Adults—Etiology, Diagnosis, and Treatment – Deutsches Ärzteblatt international (free)
Related Guideline: Investigation of a unilateral pleural effusion in adults: British Thoracic Society pleural disease guideline (free)
Related Reviews: Evaluation of the patient with pleural effusion – Canadian Medical Association Journal (free) AND Recommendations of Diagnosis and Treatment of Pleural Effusion. Update – Achivos de Broncopneumologia (free) AND State-of-the-art: Radiological investigation of pleural disease – Respiratory Medicine (free)
Source: Critical Care Reviews Newsletter
Multifaceted Intervention Associated with Reduced Ordering of Unnecessary Laboratory Tests Among Caregivers in Internal Medicine Departments
25 Jul, 2019 | 01:48h | UTC
Opinion: Antidepressants an Ace in the Hole for Urticaria
25 Jul, 2019 | 01:23h | UTCWhat to D.O. Antidepressants an Ace in the Hole for Urticaria – Emergency Medicine News (free)