Internal Medicine
[Abstract Only] Meta-Analysis: Antibiotic Treatment vs. Appendectomy for Uncomplicated Acute Appendicitis in Adults and Children
14 Nov, 2019 | 10:22h | UTCAntibiotic Treatment and Appendectomy for Uncomplicated Acute Appendicitis in Adults and Children: A Systematic Review and Meta-analysis – Annals of Surgery (link to abstract – $ for full-text)
Related Meta-Analysis: Antibiotic therapy for acute uncomplicated appendicitis: a systematic review and meta-analysis – International Journal of Colorectal Disease (free) AND Antibiotics Versus Surgical Therapy for Uncomplicated Appendicitis (link to abstract and commentaries) AND Antibiotic Therapy versus Appendectomy for Acute Uncomplicated Appendicitis (free study and commentaries)
Related Randomized Trials: Antibiotic Therapy Alone Seems Reasonable for Uncomplicated Appendicitis (free study and commentaries) AND Randomized clinical trial of antibiotic therapy for uncomplicated appendicitis (link to abstract and commentaries)
Related Cohort Study: Study: Nonoperative Management of Uncomplicated Appendicitis (free study and commentary)
Guideline on the use of Iodinated Contrast Media in Patients with Kidney Disease
14 Nov, 2019 | 10:28h | UTC
Cohort Study: Even Minor Surgical Procedures Are Associated with High Risk for Patients with Frailty
14 Nov, 2019 | 10:19h | UTCAssociation of Preoperative Patient Frailty and Operative Stress With Postoperative Mortality – JAMA Surgery (free for a limited period)
Commentaries: Looking Beyond Mortality Among Older Adults Who Are Frail and Considering Surgical Intervention – JAMA Surgery (free for a limited period) AND No such thing as a low-risk surgery for frail patients – Vanderbilt University Medical Center (free) AND Even low-stress surgery can be fatal for frail patients, study finds – University of Texas Health Center at San Antonio (free)
Clinical Policy: Critical Issues in the Evaluation and Management of Adult Patients Presenting to the Emergency Department With Acute Headache
13 Nov, 2019 | 10:47h | UTC
STI Update: Testing, Treatment, and Emerging Threats
13 Nov, 2019 | 10:42h | UTCSTI update: Testing, treatment, and emerging threats – Cleveland Clinic Journal of Medicine (free)
Appropriate Laboratory Testing in Lyme Disease
13 Nov, 2019 | 10:41h | UTCAppropriate laboratory testing in Lyme disease – Cleveland Clinic Journal of Medicine (free)
Guideline Summary: Drugs for Atrial Fibrillation
13 Nov, 2019 | 10:36h | UTCDrugs for Atrial Fibrillation – JAMA (free for a limited period)
Podcast: Review of Atrial Fibrillation Treatment – JAMA (free audio)
Original Guideline: 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation (free)
NICE Guideline: Cannabis-Based Medicinal Products
12 Nov, 2019 | 11:27h | UTCCannabis-based medicinal products – National Institute for Health and Care Excellence (free)
Commentaries: Drug experts on the new guidance for medicinal cannabis – The Conversation (free) AND Ian Hamilton: New guidelines for prescribing medicinal cannabis—another dashed hope for patients – The BMJ Opinion (free)
Related: Guideline for Prescribing Medical Cannabinoids in Primary Care – Canadian Family Physician (free) AND Cannabinoids for Chronic Pain – Therapeutics Initiative AND (free) Meta-Analysis: Insufficient Evidence for The Use of Cannabinoids for Treating Mental Disorders – The Lancet Psychiatry (link to abstract and commentaries) AND The Effects of Cannabis Among Adults With Chronic Pain – Annals of Internal Medicine (link to abstract and commentaries)
“In short, NICE has concluded that more research is needed before it can recommend the use of cannabis-based products for medicinal use.” (from The Conversation)
#ACR19 – Randomized Trial: Low-Dose Corticosteroids for Short Periods Effective and Safe for Hand Osteoarthritis
12 Nov, 2019 | 11:23h | UTCResults of a 6-week treatment with 10 mg prednisolone in patients with hand osteoarthritis (HOPE): a double-blind, randomised, placebo-controlled trial – The Lancet (free registration required)
Commentaries: Low-Dose Oral Prednisolone Substantially Improves Pain and Function in Hand Osteoarthritis – American College of Rheumatology (free) AND Short-term prednisolone offers HOPE for painful hand osteoarthritis – Medicine Matters (free) AND Short Course of Low-Dose Prednisolone for Painful Hand Osteoarthritis – MedicalResearch.com (free)
#ACR19 – Just Presented at the 2019 American College of Rheumatology Annual Meeting
Study: Testosterone Therapy Linked to Increased Risk of Venous Thromboembolism Among Men with and Without Hypogonadism
12 Nov, 2019 | 11:22h | UTCAssociation of Testosterone Therapy With Risk of Venous Thromboembolism Among Men With and Without Hypogonadism – JAMA Internal Medicine (free for a limited period)
Related Commentary on Twitter
Using testosterone therapy in 6-month case period associated with doubling of VTE risk for men both with and without clinical hypogonadism. https://t.co/rosKWgWgBS
— JAMA Internal Medicine (@JAMAInternalMed) November 11, 2019
Meta-Analysis: Aspirin for Primary Prevention of Cardiovascular Disease with a Particular Focus on Subgroups
12 Nov, 2019 | 11:19h | UTCRelated: Acetylsalicylic acid for primary prevention of cardiovascular events – Canadian Family Physician (free) AND Evidence evolving on aspirin as prevention – ACP Internist (free) AND Benefits and Harms of Aspirin for Primary Prevention of Cardiovascular Disease – Annals of Internal Medicine (link to abstract and commentaries) AND Aspirin for Primary Prevention: Is This the End of the Road? (selection of resources on the subject)
Randomized Trial: 0/1-hour High-sensitivity Cardiac Troponin T Protocol Enables Faster Discharge of Patients with Suspected Acute Coronary Syndrome
12 Nov, 2019 | 11:20h | UTCA Randomized Trial of a 1-Hour Troponin T Protocol in Suspected Acute Coronary Syndromes – Circulation (free for a limited period)
Commentaries: World-First Trial Cuts ED Wait Times and Admissions – Flinders University (free) AND Ruling Out MI Safe With 0/1-Hour High-Sensitivity Troponin: RAPID-TNT – TCTMD (free)
Related Studies/Commentaries Highlighting Problems with High-sensitivity Cardiac Troponin: Myths in Emergency Medicine: Is hs-cTnT Worth the Downstream Testing? – Emergency Medicine News (free) AND Randomized Trial: High-Sensitivity Troponin in the Evaluation of Suspected Acute Coronary Syndrome – The Lancet (free study and commentaries) AND Cohort Study: The Introduction of High-sensitive Troponins Had No Impact on Survival – Journal of the American College of Cardiology (free) AND Cohort Study: High Sensitivity Cardiac Troponin May Result in Misdiagnosis of Acute Myocardial Infarction – The BMJ (free)
Review: Sleep-Related Disorders in Neurology and Psychiatry
12 Nov, 2019 | 11:16h | UTCSleep-Related Disorders in Neurology and Psychiatry – Deutsches Ärzteblatt international (free)
#ACR19 – [Not Published Yet] Meta-Analysis: For People with Osteoarthritis, Opioids Offer Minor Pain Relief and Function Benefits, but No Quality of Life Benefit
12 Nov, 2019 | 10:48h | UTCAbstract: Is There Any Role for Opioids in the Management of OA? (free)
#ACR19 – Just Presented at the 2019 American College of Rheumatology Annual Meeting
#KidneyWk – Randomized Trial: Vitamin D and Omega-3 Fatty Acids Do Not Preserve Kidney Function in Patients with Type 2 Diabetes
10 Nov, 2019 | 14:36h | UTCEffect of Vitamin D and Omega-3 Fatty Acid Supplementation on Kidney Function in Patients With Type 2 Diabetes: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Vitamin D and Health Outcomes: Then Came the Randomized Clinical Trials – JAMA (free for a limited period)
Commentary: Supplements don’t preserve kidney health in Type 2 diabetes – University of Washington School of Medicine (free)
#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019
Related Commentary on Twitter
Study findings do not support the use of #vitaminD or #omega3 fatty acid supplementation for preserving kidney function in adults with #type2diabetes https://t.co/ppUnvwMXRR #KidneyWk
— JAMA (@JAMA_current) November 9, 2019
#KidneyWk – Study: Development of a Risk Prediction Calculator for Incident Chronic Kidney Disease
10 Nov, 2019 | 14:39h | UTCDevelopment of Risk Prediction Equations for Incident Chronic Kidney Disease – JAMA (free for a limited period)
See Calculator: Risk of Developing Reduced Kidney Function (free tool)
Editorial: Predicting Risk of Kidney Disease: Is Risk-Based Kidney Care on the Horizon? – JAMA (free for a limited period)
Commentaries: New Tool Predicts Five-Year Risk of Chronic Kidney Disease With High Accuracy – Johns Hopkins Bloomberg School of Public Health (free) AND Researchers Develop Tool to Identify Those at Risk of Future CKD – AJMC (free)
#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019
Related Commentary on Twitter
Equations for predicting risk of incident #CKD were developed from more than 5 million individuals from 34 multinational cohorts and demonstrated high discrimination and variable calibration in diverse populations https://t.co/7uNRpv4m3Y #KidneyWk
— JAMA (@JAMA_current) November 8, 2019
#KidneyWk – Study: Baclofen Associated with Increased Risk of Encephalopathy in Patients with Chronic Kidney Disease
10 Nov, 2019 | 14:35h | UTCAssociation of Baclofen with Encephalopathy in Patients With Chronic Kidney Disease – JAMA (free for a limited period)
Commentary: Common muscle relaxant causes severe confusion in patients with kidney disease – University of Western Ontario (free)
#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019
Updated Cardiovascular Prevention Guideline of the Brazilian Society of Cardiology – 2019
10 Nov, 2019 | 13:59h | UTCRelated Guidelines: 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease (free guideline and resources) AND Cardiovascular disease: risk assessment and reduction, including lipid modification – National Institute for Health and Care Excellence (free) AND Canadian Cardiovascular Harmonized National Guidelines Endeavour (C-CHANGE) guideline for the prevention and management of cardiovascular disease in primary care: 2018 update – Canadian Medical Association Journal (free)
Podcast: Management of Multimorbidity
10 Nov, 2019 | 13:55h | UTC#181 The Multimorbidity Games with Josh Uy MD – The Curbsiders Internal Medicine Podcast (free text and audio)
See also: Episode List
Related: Multimorbidity: clinical assessment and management – NICE Guideline (free) AND Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology (free) AND Effectiveness of interventions for managing multiple high-burden chronic diseases in older adults: a systematic review and meta-analysis – Canadian Medical Association Journal (free) AND Multimorbidity: a priority for global health research – The Academy of Medical Sciences (free)
FDA Safety Communication: Biotin Supplements May Result in Falsely Low Troponin Results
10 Nov, 2019 | 13:43h | UTCCommentary: FDA Updates Warning on Biotin Interfering with Lab Results – NEJM Journal Watch (free)
“…the FDA is particularly concerned about biotin interference causing a falsely low result for troponin, a clinically important biomarker to aid in the diagnosis of heart attacks, which may lead to a missed diagnosis and potentially serious clinical implications. The FDA continues to receive adverse events reports indicating biotin interference caused falsely low troponin results.”
Study Commentary: Can C-reactive Protein Improve Treatment for COPD Exacerbations?
10 Nov, 2019 | 13:25h | UTCCan C-reactive protein improve treatment for COPD exacerbations? – PulmCCM (free)
Original Study: Randomized Trial: C-Reactive Protein Can Guide Antibiotics for COPD Exacerbations (link to abstract and commentaries)
Guideline Summary: Obesity Hypoventilation Syndrome
10 Nov, 2019 | 13:11h | UTCNew guidelines on obesity hypoventilation syndrome released – PulmCCM (free)
Original Article: ATS Guideline: Evaluation and Management of Obesity Hypoventilation Syndrome (free article and news release)
Cardiovascular Risk of Electronic Cigarettes: A Review of Preclinical and Clinical Studies
8 Nov, 2019 | 08:22h | UTCCommentaries: Vaping not worth potential heart risk, researchers say – Ohio State University (free) AND Vaping risks significant, says new review – News Medical (free) AND E-cigs may damage the heart, study says – MedicalXpress (free)
[Abstract Only] Randomized Trial Suggests Possible Harm from Perioperative Probiotics Among Patients Undergoing Major Abdominal Operation
8 Nov, 2019 | 07:49h | UTCRandomized Trial of Perioperative Probiotics Among Patients Undergoing Major Abdominal Operation – Journal of the American College of Surgeons (link to abstract – $ for full-text)
Source: EvidenceAlerts
“A significantly higher readmission rate was observed among those exposed to probiotics. Additional studies remain warranted.”
Systematic Review: Strategies to Reduce Non-ventilator-associated Hospital-acquired Pneumonia
8 Nov, 2019 | 08:14h | UTC