Internal Medicine
NICE Guideline: Management of Thyroid Disease
21 Nov, 2019 | 10:39h | UTCThyroid disease: assessment and management – National Institute for Health and Care Excellence (free)
Cohort Study: Association of Troponin Level and Age with Mortality in Acute Care Centers
21 Nov, 2019 | 08:41h | UTCCommentary: Small rise in heart attack protein linked to increased risk of early death – Imperial College London (free)
High-protein Diet is Bad for Kidney Health: Unleashing the Taboo
21 Nov, 2019 | 08:29h | UTCRelated: Dietary protein intake and kidney function decline after myocardial infarction: the Alpha Omega Cohort – Nephrology Dialysis Transplantation (free) AND High-protein diet with renal hyperfiltration is associated with rapid decline rate of renal function: a community-based prospective cohort study – Nephrology Dialysis Transplantation (link to abstract – $ for full-text) AND Dietary Protein Intake and Chronic Kidney Disease – Current Opinion in Clinical Nutrition & Metabolic Care (free)
Perspective: Cannabidiol Products Are Everywhere, but Should People Be Using Them?
21 Nov, 2019 | 08:16h | UTCCannabidiol Products Are Everywhere, but Should People Be Using Them? – JAMA (free for a limited period)
Related: NICE Guideline: Cannabis-Based Medicinal Products (free Guideline and other resources)
Systematic Review: Computed Tomography for Diagnosis of Acute Appendicitis in Adults
20 Nov, 2019 | 10:34h | UTCComputed tomography for diagnosis of acute appendicitis in adults – Cochrane Library (free)
Summary: How accurate is computed tomography for the diagnosis of acute appendicitis in adults? – Cochrane Library (free)
Study: Switching from Tobacco Cigarettes to Electronic Cigarettes May Improve Cardiovascular Health
20 Nov, 2019 | 10:31h | UTCCommentaries: Smokers who switch to vaping could soon ‘have healthier hearts’ – NHS Choices (free) AND Vaping less harmful than smoking for vascular health, major study finds – University of Dundee (free) AND Switching from cigarettes to vapes may be better for heart health, study says – CNN (free)
Review: Extra-cardiac Endovascular Infections in the Critically Ill
20 Nov, 2019 | 10:22h | UTCExtra-cardiac endovascular infections in the critically ill – Intensive Care Medicine (free)
Canadian Task Force Recommendation: Don’t Screen Asymptomatic Patients for Thyroid Dysfunction
19 Nov, 2019 | 10:17h | UTCNews Release: Screening for thyroid dysfunction in people without symptoms: Don’t routinely check that box – Canadian Medical Association Journal (free)
See also: Asymptomatic Thyroid Dysfunction (2019): Summary of recommendations for clinicians and policy-makers – Canadian Task Force on Preventive Health Care (free resources) AND Infographic (free PDF)
Related Commentary on Twitter
Should asymptomatic patients be screened for thyroid disease? The Canadian Task Force on Preventive Health Care says no: https://t.co/RLjRQwHsUX @cantaskforce #primarycare pic.twitter.com/CsBDvUQ2Po
— CMAJ (@CMAJ) November 18, 2019
Guideline: Treatment of Drug-Resistant Tuberculosis
19 Nov, 2019 | 10:32h | UTCNews Release: New clinical guideline for the treatment and prevention of drug-resistant tuberculosis – American Thoracic Society (free)
Related: WHO Consolidated Guidelines on Drug-resistant Tuberculosis Treatment (free guideline and commentary) AND Randomized Trial: 9-month Treatment for Multi-drug Resistant TB is as Effective as 24-month Treatment (free article and commentaries) AND The Lancet Commission: Management of Multidrug-resistant and Incurable Tuberculosis (free registration required)
This Week is World Antibiotic Awareness Week! – See Practical Resources
19 Nov, 2019 | 09:55h | UTC– Using Antibiotics Wisely in Primary Care – Choosing Wisely Canada (free)
– Using Antibiotics Wisely in Long-Term Care – Choosing Wisely Canada (free)
– Using Antibiotics Wisely in Hospitals – Choosing Wisely Canada (free)
– NICE Antimicrobial prescribing guidelines (resource covering many common conditions)
– NICE Summary of antimicrobial prescribing guidance – managing common infections (free PDF)
Cohort Study: Association of Premature Natural and Surgical Menopause with Incident Cardiovascular Disease
19 Nov, 2019 | 08:01h | UTCAssociation of Premature Natural and Surgical Menopause With Incident Cardiovascular Disease – JAMA (free for a limited period)
#AHA19 – [Abstract Only] Randomized Trial: After an Ischemic Stroke or TIE a Lower LDL Treatment Target Reduces Cardiovascular Events
19 Nov, 2019 | 09:51h | UTCA Comparison of Two LDL Cholesterol Targets after Ischemic Stroke – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Treat Stroke to Target Finds Lower Risk of CV Events With Lower LDL-C Levels – American College of Cardiology (free) AND Treat Stroke to Target – Treat Stroke to Target – American College of Cardiology (free) AND Lower Cholesterol Cuts CV Events: Treat Stroke to Target Trial – TCTMD (free)
#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting
Related Commentary on Twitter
In patients with stroke and atherosclerosis randomly assigned to LDL targets of 70 mg/dl or 100 mg/dL, a composite CV endpoint was 12% lower over a median of 3.5 years in the lower LDL target group. #AHA19 https://t.co/l8vZ1M7XF6
— NEJM (@NEJM) November 18, 2019
Review: Preoperative Evaluation Before Noncardiac Surgery
19 Nov, 2019 | 07:56h | UTCPreoperative Evaluation Before Noncardiac Surgery – Mayo Clinic Proceedings (free)
Related: Guideline: Preoperative Evaluation of Adult Patients Before Elective, Noncardiothoracic Surgery (free guidelines on the subject)
Review: Coronary Microvascular Dysfunction Causing Cardiac Ischemia in Women
19 Nov, 2019 | 07:41h | UTCCoronary Microvascular Dysfunction Causing Cardiac Ischemia in Women – JAMA (free for a limited period)
Related: Prognosis and Predictors of Mortality in Patients Suffering Myocardial Infarction With Non‐Obstructive Coronary Arteries (study, guidelines, and reviews on the subject)
Related Commentary on Twitter
2/3 of women with symptoms and signs of ischemia have no evidence of obstructive coronary artery disease (#INOCA). Many have coronary microvascular dysfunction, diagnosed by finding reduced coronary flow reserve on pharmacologic stress testing https://t.co/yNIFDVwNOm #AHA19
— JAMA (@JAMA_current) November 19, 2019
Review: HIV Preexposure Prophylaxis—The Role of Primary Care Clinicians in Ending the HIV Epidemic
19 Nov, 2019 | 07:38h | UTCHIV Preexposure Prophylaxis—The Role of Primary Care Clinicians in Ending the HIV Epidemic – JAMA Internal Medicine (free for a limited period)
Related: USPSTF Statement: Preexposure Prophylaxis for the Prevention of HIV Infection (free) AND British Guidelines on the Use of HIV Pre–exposure Prophylaxis (PrEP) (several guidelines on the subject)
#AHA19 – [Not Published Yet] Landmark ISCHEMIA Trial: A Routine Invasive Strategy Does Not Reduce Cardiovascular Events in Patients with Stable Coronary Artery Disease
18 Nov, 2019 | 01:13h | UTCCommentaries: International Study of Comparative Health Effectiveness With Medical and Invasive Approaches – ISCHEMIA – American College of Cardiology (free) AND ISCHEMIA Trial Examines Invasive vs. Conservative Strategy in SIHD Patients – American College of Cardiology (free) AND ISCHEMIA: Invasive Strategy No Better Than Meds for CV Events – TCTMD (free) AND Surgery for Blocked Arteries Is Often Unwarranted, Researchers Find – The New York Times (free) AND ISCHEMIA Trial Finds No Evidence of Lower Cardiac Event Rates in Patients Treated with Heart Procedures, but Better Quality of Life – PR Newswire (free) AND Big study casts doubt on need for many heart procedures – Associated Press (free) AND Stents no better than drugs for many heart patients: U.S. study – Reuters (free) AND Stents, bypass surgery show no benefit in heart disease mortality rates among stable patients – Stanford Medicine (free)
#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting
#AHA19 – [Abstract Only] Practice Changing? – Randomized Trial: Low-Dose Colchicine Improves Outcomes after Myocardial Infarction
18 Nov, 2019 | 01:11h | UTCEfficacy and Safety of Low-Dose Colchicine after Myocardial Infarction – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Colchicine Cardiovascular Outcomes Trial – COLCOT – American College of Cardiology (free) AND COLCOT Renews Hope for Anti-inflammatory in Secondary Prevention: Colchicine – TCTMD (free)
#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting
Related Commentary on Twitter
In a randomized, placebo-controlled trial of 4745 patients with recent myocardial infarction, low-dose colchicine (0.5 mg once daily) prevented ischemic cardiovascular events. See the COLCOT trial. #AHA19 https://t.co/H2eubZ6HRD
— NEJM (@NEJM) November 16, 2019
AHA Updates on Advanced Cardiovascular Life Support (ACLS)
18 Nov, 2019 | 01:00h | UTC– 2019 American Heart Association and American Red Cross Focused Update for First Aid: Presyncope – Circulation (free PDF)
Summary of Recommendations: International Consensus on CPR and Emergency Cardiovascular Care for Children and Adults
18 Nov, 2019 | 00:52h | UTC
SEEDS for Success: Lifestyle Management in Migraine
18 Nov, 2019 | 00:25h | UTCSEEDS for success: Lifestyle management in migraine – Cleveland Clinic Journal of Medicine (free)
Meta-Analysis: Comparative Efficacy and Safety of New Surgical Treatments for Benign Prostatic Hyperplasia
15 Nov, 2019 | 10:36h | UTC
Meta-Analysis: Outcomes at Follow-up of Negative Colonoscopy in Average Risk Population
15 Nov, 2019 | 10:25h | UTCRelated Guidelines: ACP Guideline: Screening for Colorectal Cancer in Asymptomatic Average-Risk Adults (free) AND BMJ Guideline: Colorectal Cancer Screening with Fecal Immunochemical Testing, Sigmoidoscopy or Colonoscopy (new guideline suggesting a more selective approach to screening) AND Colorectal cancer screening for average‐risk adults: 2018 guideline update from the American Cancer Society (recent guideline with recommendation to start screening at 45 years, with links to guidelines from other organizations)
“Our findings suggest that 10 year intervals for colonoscopy screening after a negative colonoscopy, as currently recommended, may be adequate”
Review: Post-operative Abdominal Infections: Epidemiology, Operational Definitions, and Outcomes
15 Nov, 2019 | 10:14h | UTCRelated Guidelines: The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines – World Journal of Emergency Surgery (free) AND Management of intra-abdominal infections: recommendations by the WSES 2016 consensus conference – World Journal of Emergency Surgery (free) AND The Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal Infection – Surgical Infections (free) AND The 2018 Lebanese Society of Infectious Diseases and Clinical Microbiology Guidelines for the use of antimicrobial therapy in complicated intra-abdominal infections in the era of antimicrobial resistance – BMC Infectious Diseases (free)
Alex Nowbar’s weekly review—15 November 2019
15 Nov, 2019 | 10:11h | UTCAlex Nowbar’s weekly review, 15 November 2019 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
[Abstract Only] Large-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation
14 Nov, 2019 | 10:37h | UTCLarge-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: What Can We Learn From The Apple Heart Study? – Cardiobrief (free)
“…nearly half a million people were required to identify a few hundred people with AF. (It should further be noted that we have no idea whether the patients identified in this group will even benefit from their diagnosis, since they may differ in important ways from AF patients identified by traditional means.)” (from Cardiobrief)