Internal Medicine
Meta-Analysis: Comparison of Cardiovascular Events Among Users of Different Classes of Antihypertension Medications
23 Feb, 2020 | 22:10h | UTC
Community-acquired Pneumonia in Critically Ill Very Old Patients: A Growing Problem
23 Feb, 2020 | 22:06h | UTCEditorial: Natural enemy or friend? Pneumonia in the very elderly critically ill patient (free)
Review: How Can We Minimize the Use of Regular Oral Corticosteroids in Asthma?
23 Feb, 2020 | 21:15h | UTCHow can we minimise the use of regular oral corticosteroids in asthma? – European Respiratory Review (free)
Meta-Analysis: Individual Differences in Response to Antidepressants
21 Feb, 2020 | 07:33h | UTCIndividual Differences in Response to Antidepressants: A Meta-analysis of Placebo-Controlled Randomized Clinical Trials – JAMA Psychiatry (free for a limited period)
Editorial: Is This Where We Stand After Decades of Research to Develop More Personalized Treatments for Depression? (free for a limited period)
Commentary: How Variable are Patient Responses to Antidepressants? – MedPage Today (free registration required)
Perspective: How Common Mental Shortcuts Can Cause Major Physician Errors
21 Feb, 2020 | 07:30h | UTCHow Common Mental Shortcuts Can Cause Major Physician Errors – The New York Times (10 articles per month are free)
Related Study: Behavioral Heuristics in Coronary-Artery Bypass Graft Surgery – New England Journal of Medicine ($)
[Abstract Only] Cluster-Randomized Trial: Contact Isolation vs. Standard Precautions to Decrease Acquisition of Extended-spectrum β-lactamase-producing Enterobacterales in Non-critical Care Wards
21 Feb, 2020 | 07:26h | UTCContact isolation versus standard precautions to decrease acquisition of extended-spectrum β-lactamase-producing Enterobacterales in non-critical care wards: a cluster-randomised crossover trial – The Lancet Infectious Diseases (link to abstract – $ for full-text)
Related Commentary on Twitter
Just published: Contact isolation versus standard precautions to decrease acquisition of extended-spectrum β-lactamase-producing Enterobacterales in non-critical care wards: a cluster-randomised crossover trial https://t.co/ybK5EGb4cw #ESBL
— The Lancet Infectious Diseases (@TheLancetInfDis) February 20, 2020
Cohort Study: Macrolide Antibiotics in Early Pregnancy Linked to Increased Risk of Birth Defects
20 Feb, 2020 | 10:51h | UTCCommentaries: Warning over prescribing antibiotics during pregnancy – OnMedica (free) AND Some antibiotics prescribed during pregnancy linked with birth defects – BMJ (free) AND Expert reaction to study looking at macrolide antibiotics in pregnancy and birth defects – Science Media Centre (free) AND Macrolide Antibiotics Early in Pregnancy Tied to Birth Defects – The New York Times (10 articles per month are free)
Study: Vitamin E Acetate in Bronchoalveolar-Lavage Fluid Associated with EVALI (E-Cigarette, or Vaping, Product Use–Associated Lung Injury)
20 Feb, 2020 | 10:22h | UTCVideo Summary: Vitamin E Acetate Associated with EVALI (free)
Related Report: Syndromic Surveillance for E-Cigarette, or Vaping, Product Use–Associated Lung Injury – new England Journal of Medicine (free)
See also: The EVALI and Youth Vaping Epidemics — Implications for Public Health – New England Journal of Medicine (free) AND CDC: Vaping Lung Illness Probably Caused by Vitamin E Acetate (free resources)
Randomized Trial: Quality of Life and Patient Satisfaction at 7-Year Follow-up of Antibiotic Therapy vs. Appendectomy for Uncomplicated Acute Appendicitis
20 Feb, 2020 | 10:40h | UTCQuality of Life and Patient Satisfaction at 7-Year Follow-up of Antibiotic Therapy vs Appendectomy for Uncomplicated Acute Appendicitis: A Secondary Analysis of a Randomized Clinical Trial – JAMA Surgery (free for a limited period)
Author Interview: Quality of Life and Patient Satisfaction After Antibiotic Therapy vs Appendectomy (free audio)
Commentaries: Quality of Life—The Appendix – JAMA Surgery (free) AND Patient satisfaction and quality of life similar across all appendicitis treatments – News Medical (free)
Related: Meta-Analysis: Antibiotic Treatment vs. Appendectomy for Uncomplicated Acute Appendicitis in Adults and Children (several studies on the subject) AND Nonoperative treatment for nonperforated appendicitis in children: a systematic review and meta-analysis – Pediatric Surgery International (free)
[Abstract Only] Meta-Analysis: Clinical Pre‐test Probability Adjusted vs. Age‐adjusted D‐dimer Interpretation Strategy for DVT Diagnosis
20 Feb, 2020 | 08:36h | UTCClinical pre‐test probability adjusted versus age‐adjusted D‐dimer interpretation strategy for DVT diagnosis: A diagnostic individual patient data meta‐analysis – Journal of Thrombosis and Haemostasis (link to abstract – $ for full-text)
Commentary: Clinical Pre-test Prob vs. Age-adjusted D-dimer for DVT – The Meta Analysis – JournalFeed (free)
Related Studies: Diagnosis of Pulmonary Embolism with d-Dimer Adjusted to Clinical Probability – New England Journal of Medicine (link to abstract and commentary) AND Age-Adjusted D-Dimer Cutoff Levels to Rule Out Pulmonary Embolism: The ADJUST-PE Study – JAMA (free)
Alex Nowbar’s journal reviews—20 February 2020
20 Feb, 2020 | 10:11h | UTCAlex Nowbar’s journal reviews, 20 February 2020 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
Meta-Analysis: Effects of Percutaneous Coronary Intervention on Death and Myocardial Infarction Stratified by Stable and Unstable Coronary Artery Disease
19 Feb, 2020 | 10:21h | UTCEditorial: The ISCHEMIA Trial Meets the Rashomon Effect: Lessons for Clinical Practice (free for a limited period)
Related Commentary on Twitter
🔺meta-analysis on effects of percutaneous coronary intervention in stable & unstable CAD;includes ISCHEMIA trial
🔺PCI prevents death, cardiac death,&MI in pts w unstable CAD
🔺For pts w stable CAD,PCI shows🚫evidence of an effect on any of these outcomes https://t.co/zsEWWuVPmL pic.twitter.com/y0WLwIIVef— Circ: CQO (@CircOutcomes) February 18, 2020
China Releases Largest Study on COVID-19 Outbreak with Over 44.000 Patients – Elderly and Sick are Most at Risk
19 Feb, 2020 | 10:23h | UTCThe Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) – China, 2020 – China CDC Weekly (free PDF – link via Forbes)
Commentaries: Coronavirus: Largest study suggests elderly and sick are most at risk – BBC (free) AND New Chinese Study Finds That The Elderly Are Most At Risk From The Coronavirus [Infographic] – Forbes (free) AND Expert reaction to WHO Director General’s statement on new paper from China detailing over 44,000 of their cases – Science Media Centre (free)
Guideline Synopsis: Management of Chronic Insomnia Disorder and Obstructive Sleep Apnea
18 Feb, 2020 | 08:25h | UTCCommentary: New VA/DoD guidelines address sleep-related issues in military personnel, veterans – University of Texas Health Science Center at San Antonio (free)
Randomized Trial: Sodium Bicarbonate Prehydration Prior to Contrast-Enhanced Computed Tomography Does Not Prevent Postcontrast Acute Kidney Injury in Adults with Chronic Kidney Disease
18 Feb, 2020 | 08:18h | UTCRelated: ACR/NKF Consensus Statement: “The Risk of Acute Kidney Injury Developing in Patients with Reduced Kidney Function Following Exposure to Intravenous Iodinated Contrast Media has Been Overstated” (free statement and commentary) AND Another Study Questions the Association of Contrast Use and Acute Kidney Injury (studies on the subject)
Cluster Randomized Trial: Effect of Salt Substitution on Community-wide Blood Pressure and Hypertension Incidence
18 Feb, 2020 | 08:24h | UTCEffect of salt substitution on community-wide blood pressure and hypertension incidence – Nature Medicine (free for a limited period)
Commentaries Before Publication at #ESCCongress: Community-based salt substitution programme lowers blood pressure – European Society of Cardiology (free) AND Community-Level Salt-Swapping Strategy Pays Dividends in Peru – TCTMD (free)
Related Commentary on Twitter
What happens when you replace salt with 25% KCl (+75% NaCl) in many villages in Peru?https://t.co/hL053MXjHq
A small reduction in blood pressure and 51% reduced risk of developing hypertension@NatureMedicine by @jjaimemiranda @cronicasperu
@CayetanoHeredia and colleagues pic.twitter.com/gqBtbJN47k— Eric Topol (@EricTopol) February 17, 2020
Large Observational Study Suggests Hydrochlorothiazide may be as Effective as Chlortalidone with Less Adverse Effects
18 Feb, 2020 | 08:17h | UTCComparison of Cardiovascular and Safety Outcomes of Chlorthalidone vs Hydrochlorothiazide to Treat Hypertension – JAMA Internal Medicine (free for a limited period)
Commentary: Hypertension Treatments with Chlorthalidone vs HCTZ: Cardiac and Safety Outcomes – MedicalResearch.com (free)
Podcast – Things we Do for No Reason Episode 3: Potassium, Oxygen, and Antipsychotics
18 Feb, 2020 | 08:20h | UTC#195 TWDFNR 3: Potassium, Oxygen, and Antipsychotics – The Curbsiders Internal Medicine Podcast (free)
Related Podcasts: #109: Things We Do For No Reason: A High Value Episode (free) AND #165 Things We Do For No Reason™ Part 2 (free)
See also: Choosing Wisely: Things We Do For No Reason – Journal of Hospital Medicine (free articles)
Observational Study: Empirical Anti-MRSA Antibiotic Therapy Does Not Improve Outcomes in Patients Hospitalized for Pneumonia
18 Feb, 2020 | 08:15h | UTCEmpirical Anti-MRSA vs Standard Antibiotic Therapy and Risk of 30-Day Mortality in Patients Hospitalized for Pneumonia – JAMA Internal Medicine (free for a limited period)
Editorial: Overuse of Broad-Spectrum Antibiotics for Pneumonia (free for a limited period)
Related Commentary on Twitter
NEW 🔥⚡Retrospective multicenter cohort study @JAMA_current
Empirical Anti-MRSA vs Standard Antibiotic Therapy and Risk of 30-Day Mortality in Patients Hospitalized for Pneumonia. #IDTwitter #medtwitter https://t.co/X0jWhMaUMT pic.twitter.com/FwNadOZrjx— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) February 17, 2020
Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU
16 Feb, 2020 | 21:42h | UTCNews Release: New guidelines for hepatic failure in the intensive care unit – Wolters Kluwer Health (free)
See also: Executive Summary (free)
[Abstract Only] Randomized Trial: Ceftriaxone and Doxycycline, with or Without Metronidazole, for the Treatment of Acute Pelvic Inflammatory Disease
16 Feb, 2020 | 21:39h | UTCA Randomized Controlled Trial of Ceftriaxone and Doxycycline, with or Without Metronidazole, for the Treatment of Acute Pelvic Inflammatory Disease – Clinical Infectious Diseases (link to abstract – $ for full-text)
Related Commentary on Twitter
NEW ⚡🔥#CID
Randomized Controlled Trial of Ceftriaxone and Doxycycline, with or Without Metronidazole, for the Treatment of Acute Pelvic Inflammatory Disease. #IDTwitter @PittHealthSci @PittsburghPG https://t.co/L4IWzRJRhi pic.twitter.com/GJeJxqxOq4— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) February 13, 2020
Alex Nowbar’s weekly journal review—14 February 2020
16 Feb, 2020 | 21:34h | UTCAlex Nowbar’s weekly journal review, 14 February 2020 – The BMJ Opinion (free)
“Alex Nowbar reviews the latest research from the top medical journals.”
FDA Requests the Withdrawal of the Weight-loss Drug Lorcaserin from the Market – Potential Risk of Cancer Outweighs the Benefits
16 Feb, 2020 | 21:33h | UTCSource: Lorcaserin (Belviq ) Withdrawn From US Market Due to Cancer Risk – Medscape (free registration required)
Related: FDA Safety Communication: Possible Increased Risk of Cancer with Weight-loss Medicine Lorcaserin (free)
[Abstract Only] Meta-Analysis: Fecal Occult Blood Testing Should Not be Used as a Diagnostic Tool for Clinical Indications
16 Feb, 2020 | 21:31h | UTCUse of Fecal Occult Blood Testing as a Diagnostic Tool for Clinical Indications: A Systematic Review and Meta-Analysis – The American Journal of Gastroenterology (link to abstract – $ for full-text)
Commentary: Fecal Occult Blood Tests Should Not Be Used for Diagnostic Indications – NEJM Journal Watch (free for a limited period)
Bloodstream Infections in Critically Ill Patients: An Expert Statement
16 Feb, 2020 | 21:03h | UTCBloodstream infections in critically ill patients: an expert statement – Intensive Care Medicine (free)