Internal Medicine
Severe SARS-CoV-2 Infections: Practical Considerations and Management Strategy for Intensivists
27 Feb, 2020 | 08:36h | UTCRelated: Intensive care during the coronavirus epidemic – Intensive Care Medicine (free) AND How to face the novel coronavirus infection during the 2019–2020 epidemic: the experience of Sichuan Provincial People’s Hospital – Intensive Care Medicine (free) AND Critical care management of adults with community-acquired severe respiratory viral infection – Intensive Care Medicine (free) AND Coronavirus epidemic: preparing for extracorporeal organ support in intensive care – The Lancet Respiratory medicine (free) AND Preparing for the Most Critically Ill Patients With COVID-19: The Potential Role of Extracorporeal Membrane Oxygenation – JAMA (free)
Related Commentary on Twitter
Severe SARS-CoV-2 infections: practical considerations and management strategy for intensivists@yourICM #FOAMed https://t.co/E35YQ7wsyW pic.twitter.com/UWGokAFVJf
— Adrian Wong (@avkwong) February 26, 2020
COVID-19: Chest CT May be the Best Screening Tool for Diagnosis in Epidemic Areas
27 Feb, 2020 | 08:38h | UTCCommentary: CT provides best diagnosis for COVID-19 – Radiological Society of North America (free)
Related Articles: Sensitivity of Chest CT for COVID-19: Comparison to RT-PCR – Radiology (free) AND Coronavirus Outbreak: What the Department of Radiology Should Know – Journal of the American College of Radiology (free) AND Coronavirus Disease 2019 (COVID-19): A Perspective from China – Radiology (free) AND Chest CT Findings in Coronavirus Disease-19 (COVID-19): Relationship to Duration of Infection – Radiology (free) AND Outbreak of novel coronavirus (COVID-19): What is the role of radiologists? – European Radiology (free) AND Chest CT for Typical 2019-nCoV Pneumonia: Relationship to Negative RT-PCR Testing – Radiology (free) AND Pre- and Posttreatment Chest CT Findings: 2019 Novel Coronavirus (2019-nCoV) Pneumonia – Radiology (free)
Framingham Cohort Study: Sugar‐Sweetened Beverage Consumption and Lipid Profile
27 Feb, 2020 | 08:32h | UTCEditorial: Sugar‐Sweetened Beverage Consumption and Lipid Profile: More Evidence for Interventions (free)
Commentaries: Sugary drinks a sour choice for adults trying to maintain normal cholesterol levels – Tufts University (free) AND Drinks with added sugars linked to lipid imbalance, which increases CVD risk – American Heart Association (free)
[Abstract Only] Randomized Trial: Metformin May Reduce Metabolic Complications and Inflammation in Patients on Systemic Glucocorticoid Therapy
27 Feb, 2020 | 08:34h | UTCMetformin to reduce metabolic complications and inflammation in patients on systemic glucocorticoid therapy: a randomised, double-blind, placebo-controlled, proof-of-concept, phase 2 trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentaries: Metformin could mitigate glucocorticoid-related complications – Medicine Matters (free) AND Metabolic effects of glucocorticoids reversed with metformin – Healio (free registration required) AND Diabetes Drug May Benefit Long-Term Steroid Users – MedPage Today (free registration required)
Perspective: The Low-FODMAP Diet Helps IBS Symptoms, but Questions Remain
27 Feb, 2020 | 08:33h | UTCThe Low-FODMAP Diet Helps IBS Symptoms, but Questions Remain – JAMA (free for a limited period)
Related: Low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet improves symptoms in adults suffering from irritable bowel syndrome (IBS) compared to standard IBS diet: A meta-analysis of clinical studies – PLOS One (free) AND The Low FODMAP Diet: Recent Advances in Understanding Its Mechanisms and Efficacy in IBS – Gut (free PDF)
USPSTF Statement: Insufficient Evidence to Screen for Mild Cognitive Impairment in Older Adults
26 Feb, 2020 | 07:12h | UTCEvidence Report: Screening for Cognitive Impairment in Older Adults – US Preventive Services Task Force/JAMA (free)
Editorials: Issues and Questions Surrounding Screening for Cognitive Impairment in Older Patients – JAMA (free for a limited period) AND Evidence Still Lacking for Recommendation of Screening for Cognitive Impairment in Older Adults – JAMA Internal Medicine (free for a limited period)
Author Interview: USPSTF Recommendation: Screening for Cognitive Impairment (free audio)
JAMA Patient Page: Screening for Cognitive Impairment in Older Adults (free)
Commentary: U.S. Medical Panel Thinks Twice About Pushing Cognitive Screening For Dementia – Kaiser Health News (free)
Consensus Recommendations: Follow-Up After Colonoscopy and Polypectomy
26 Feb, 2020 | 07:14h | UTCRecommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer – Gastroenterology (free link via Google Scholar)
Summary: Updated Polypectomy Surveillance Recommendations – NEJM Journal Watch (free)
Related: British Society of Gastroenterology/Association of Coloproctology of Great Britain and Ireland/Public Health England post-polypectomy and post-colorectal cancer resection surveillance guidelines – Gut (free guidelines and studies on the subject)
Former CDC Director: A Coronavirus Pandemic is Inevitable. What Now?
26 Feb, 2020 | 07:06h | UTCFormer CDC director: A coronavirus pandemic is inevitable. What now? – CNN (free)
Related: Opinion on COVID-19 Outbreak – “Past Time to Tell the Public: “It Will Probably Go Pandemic, and We Should All Prepare Now”” (related opinions on the subject)
See also: Novel Coronavirus Disease (COVID-19) Latest Articles, Guidelines, News & Perspectives / 26 February 2020 Edition (free resources on the subject – updated daily)
Related Commentary on Twitter
#COVID19 will become a pandemic. We don’t know if it will be mild, moderate or severe, or how many countries it will reach. As we shift from the initiation phase of the pandemic to the acceleration stage, I’ve highlighted 8 things we must do for @CNN https://t.co/XAZx0jErbs
— Dr. Tom Frieden (@DrTomFrieden) February 25, 2020
Review: Preoperative Cardiac Risk Assessment
26 Feb, 2020 | 07:03h | UTCPreoperative Cardiac Risk Assessment – Mayo Clinic Proceedings (free)
Related guidelines: Preoperative evaluation of adult patients before elective, noncardiothoracic surgery – Der Anaesthesist (free) AND 2014 ACC/AHA Guideline on Perioperative Cardiovascular Evaluation and Management of Patients Undergoing Noncardiac Surgery (free) AND 2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management (free) AND Routine preoperative tests for elective surgery – NICE Guideline (free) AND Canadian Cardiovascular Society Guidelines on Perioperative Cardiac Risk Assessment and Management for Patients Who Undergo Noncardiac Surgery (free) AND 3rd Guideline for Perioperative Cardiovascular Evaluation of the Brazilian Society of Cardiology (free)
[Abstract Only] Meta-Analysis of Observational Studies Suggests No Benefit from Oral Anticoagulation in Patients With Atrial Fibrillation on Long-Term Dialysis
26 Feb, 2020 | 07:00h | UTCOral Anticoagulation for Patients With Atrial Fibrillation on Long-Term Dialysis – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentary: Anticoagulation for Dialysis Patients with Atrial Fibrillation: No Benefit Seen – NEJM Journal Watch (free for a limited period)
Perspective: “Milk and Juice Are Not as Needed as You Might Think”
26 Feb, 2020 | 06:56h | UTCMilk and Juice Are Not as Needed as You Might Think – The New York Times (10 articles per month are free)
[Abstract Only] Large Observational Study Suggests No Benefit from Adult Booster Vaccinations Against Tetanus or Diphtheria
26 Feb, 2020 | 06:59h | UTCIncidence of Tetanus and Diphtheria in Relation to Adult Vaccination Schedules – Clinical Infectious Diseases (link to abstract – $ for full-text)
Commentaries: Adults don’t need tetanus, diphtheria boosters if fully vaccinated as children – Oregon Health & Science University (free) AND Most adults don’t need booster vaccinations for tetanus and diphtheria, new study concludes – STAT (free)
Study: Evaluation of a Common Prescribing Cascade of Calcium Channel Blockers and Diuretics in Older Adults with Hypertension
25 Feb, 2020 | 06:42h | UTCEvaluation of a Common Prescribing Cascade of Calcium Channel Blockers and Diuretics in Older Adults With Hypertension – JAMA Internal Medicine (free for a limited period)
Commentary: Antihypertensive Prescribing Cascades as High-Priority Targets for Deprescribing – JAMA Internal Medicine (free for a limited period)
Related Commentary on Twitter
Prescribing cascades occur when a second medicine is prescribed to counteract the effects of the first medicine. This @JAMAInternalMed article is the strongest empiric evidence I have seen that these cascades are very real #geriatrics https://t.co/KmJ2nhLlXM
— Ken Covinsky (@geri_doc) February 24, 2020
Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases from the Chinese Center for Disease Control and Prevention
25 Feb, 2020 | 06:46h | UTCCommentary: Study of 72,000 COVID-19 patients finds 2.3% death rate – CIDRAP (free)
Related Commentary on Twitter
The Chinese CDC today published the largest case series to date of #COVID19 in mainland China (72 314 cases through 2/11/20). Here are some of the data:
Case-fatality rate
• 2.3% Overall
• 14.8% age >= 80
• 8.0% age 70-79
• 49.0% in critical caseshttps://t.co/ZFR6pScCpa— JAMA (@JAMA_current) February 24, 2020
Meta-Analysis: Evaluation of the Association Between Gastric Acid Suppression and Risk of Intestinal Colonization with Multidrug-Resistant Microorganisms
25 Feb, 2020 | 06:39h | UTCAuthor Interview: Evaluation of Association Between Gastric Acid Suppression and Risk of Intestinal Colonization With MDROs – JAMA (free)
Commentary: Deprescribing Proton Pump Inhibitors: Overcoming Resistance – JAMA Internal Medicine (free for a limited period)
Related: Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Deprescribing Proton Pump Inhibitors – Therapeutics Initiative (free)
Related Commentary on Twitter
NEW 🔥⚡systematic review& meta-analysis @JAMAInternalMed
The use of acid suppressants (mainly PPIs or H2RAs) associated w 75% ⬆️ odds of intestinal MDRO colonization,chiefly resistant Enterobacterales&VRE in the community&health care setting #IDTwitterhttps://t.co/ZKFtIYztqX pic.twitter.com/mLIuzM8V3p— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) February 24, 2020
Clinical Diagnosis of Benign Paroxysmal Positional Vertigo and Vestibular Neuritis
25 Feb, 2020 | 06:44h | UTC
Related Commentary on Twitter
How to diagnose and treat patients with vertigo? Two cases with links to demonstration videos show how to apply and interpret the Dix-Hallpike test and the HINTS plus exam: https://t.co/eK7hGVAHgj @PeterJohns84 @OttawaHospital @emergmedottawa #BPPV #FOAMed pic.twitter.com/R4AvYj6beV
— CMAJ (@CMAJ) February 24, 2020
[Abstract Only] Meta-Analysis: Pharmacologic Therapies in Patients with Exacerbation of Chronic Obstructive Pulmonary Disease
25 Feb, 2020 | 06:36h | UTCPharmacologic Therapies in Patients With Exacerbation of Chronic Obstructive Pulmonary Disease: A Systematic Review With Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Meta-Analysis: Systemic Corticosteroids, Antibiotics Effective for COPD Exacerbations – NEJM Journal Watch (free)
[Abstract Only] Study: Breast Cancer Screening Past Age 75 Years Does Not Seem to Reduce Breast Cancer Mortality
25 Feb, 2020 | 06:37h | UTCContinuation of Annual Screening Mammography and Breast Cancer Mortality in Women Older Than 70 Years – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Mammography may not benefit healthy women older than age 75 – ACP Internist (free) AND Mammography in Women Older Than 75 Does Not Confer an Additional Survival Benefit – AJMC (free)
JAMA Patient Page: Aspirin for Prevention of Cardiovascular Disease
25 Feb, 2020 | 06:07h | UTCAspirin for Prevention of Cardiovascular Disease – JAMA (free)
Related: Aspirin for primary prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups – BMC Medicine (free) AND Acetylsalicylic acid for primary prevention of cardiovascular events – Canadian Family Physician (free) AND Evidence evolving on aspirin as prevention – ACP Internist (free) AND Benefits and Harms of Aspirin for Primary Prevention of Cardiovascular Disease – Annals of Internal Medicine (link to abstract and commentaries) AND Aspirin for Primary Prevention: Is This the End of the Road? (selection of resources on the subject)
Cohort Study: The Associations of Major Foods and Fiber with Risks of Ischemic and Hemorrhagic Stroke
25 Feb, 2020 | 06:34h | UTCThe associations of major foods and fibre with risks of ischaemic and haemorrhagic stroke: a prospective study of 418 329 participants in the EPIC cohort across nine European countries – European Heart Journal (free for a limited period)
Commentaries: Study of 418,000 Europeans finds different foods linked to different types of stroke – European Society of Cardiology (free) AND Expert reaction to study looking at foods and stroke risk – Science Media Centre (free)
Related Commentary on Twitter
Associations in #diet and stroke in >418,000 Europeans from 9 countries w/ ~13 year follow up https://t.co/8WqqzoPO22 @escardio @tammy_tong @Oxford_NDPH @MRC_Epid et al
(usual caveats) but note risk w/ eggs, red meat; poss benefit of dairy products, fiber, fruit & vegetables pic.twitter.com/3ubKmkxzvX— Eric Topol (@EricTopol) February 24, 2020
[Abstract Only] Meta-Analysis: Lower vs. Standard INR Targets in Atrial Fibrillation
25 Feb, 2020 | 06:04h | UTCLower versus Standard INR Targets in Atrial Fibrillation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials – Thrombosis and Haemostasis (link to abstract – $ for full-text)
Source: EvidenceAlerts
A Review of Primary Vasculitis Mimickers Based on the Chapel Hill Consensus Classification
25 Feb, 2020 | 06:03h | UTC
Cohort Study: Maternal and Fetal Outcomes Following Exposure to Duloxetine in Pregnancy
25 Feb, 2020 | 05:59h | UTCMaternal and fetal outcomes following exposure to duloxetine in pregnancy: cohort study – The BMJ (free)
Opinion on COVID-19 Outbreak – “Past Time to Tell the Public: “It Will Probably Go Pandemic, and We Should All Prepare Now””
23 Feb, 2020 | 22:13h | UTCRelated commentaries: Covid-19 now a pandemic, say global experts – RTHK (free) AND Covid-19 is now a pandemic, says Leuven specialist – The Brussels Times (free) AND “We are at a turning point”: The coronavirus outbreak is looking more like a pandemic – Vox (free) AND Understanding pandemics: What they mean, don’t mean, and what comes next with the coronavirus – STAT (free)
Note: As with every article on this website, this is not necessarily an endorsement.
Related Commentary on Twitter
https://twitter.com/MackayIM/status/1231384813900140544
Clinical Update – Preventing Surgical Site Infections: Looking Beyond the Current Guidelines
23 Feb, 2020 | 22:21h | UTCPreventing Surgical Site Infections: Looking Beyond the Current Guidelines – JAMA (free for a limited period)
Related Guidelines: Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017 – JAMA Surgery (free) AND Global guidelines on the prevention of surgical site infection – World Health Organization (free) AND Surgical site infections: prevention and treatment – National Institute for Health and Care Excellence (free) AND APSIC guidelines for the prevention of surgical site infections – Antimicrobial Resistance & Infection Control (free) AND Intraoperative surgical site infection control and prevention: a position paper and future addendum to WSES intra-abdominal infections guidelines – World Journal of Emergency Surgery (free)