Internal Medicine
Cohort Study: Association of Physician Orders for Life-Sustaining Treatment with ICU Admission Among Patients Hospitalized Near the End of Life
16 Feb, 2020 | 21:01h | UTCAssociation of Physician Orders for Life-Sustaining Treatment with ICU Admission Among Patients Hospitalized Near the End of Life – JAMA (free for a limited period)
Editorial: Physician Orders for Life-Sustaining Treatment and Limiting Overtreatment at the End of Life (free for a limited period)
Immunization Strategies to Span the Spectrum of Immunocompromised Adults
16 Feb, 2020 | 20:43h | UTCImmunization Strategies to Span the Spectrum of Immunocompromised Adults – Mayo Clinic Proceedings (free)
German Recommendations for Physical Activity and Physical Activity Promotion in Adults with Noncommunicable Diseases
14 Feb, 2020 | 02:15h | UTCRelated: Physical Activity Guidelines for Americans (free resources)
Updated Nomenclature of Delirium and Acute Encephalopathy: Statement of Ten Societies
14 Feb, 2020 | 02:13h | UTC
CDC Guidelines for the Treatment of Latent Tuberculosis Infection
14 Feb, 2020 | 02:22h | UTCRelated: WHO Guideline: Latent TB Infection (free) AND Study: Rifampicin is Likely to be the Safest Latent Tuberculosis Infection Treatment Option (free)
Commentary: Guidelines Updated on Treating Latent TB – NEJM Journal Watch (free)
State of The Art Review: Management of Acute Ischemic Stroke
14 Feb, 2020 | 02:12h | UTCManagement of acute ischemic stroke – The BMJ (free for a limited period)
Clinical Updates: Management of Acute and Chronic Asthma in Adults in 2020
14 Feb, 2020 | 02:06h | UTCManagement of Acute Asthma in Adults in 2020 – JAMA (free for a limited period)
Related Article: Outpatient Management of Chronic Asthma in 2020 – JAMA (free for a limited period)
Editorial: New Therapeutic Strategies for Asthma – JAMA (free for a limited period)
Guidelines for the Management of Exercise-Associated Hyponatremia
13 Feb, 2020 | 08:05h | UTCSee also: Wilderness Medical Society Full List of Updated Clinical Practice Guidelines (free articles
Systematic Review: Water for Preventing Urinary Stones
13 Feb, 2020 | 07:58h | UTCWater for preventing urinary stones – Cochrane Library (free)
Summary: Increased water intake for preventing urinary stones – Cochrane Library (free)
Related: Fluid Intake and Dietary Factors and the Risk of Incident Kidney Stones in UK Biobank: A Population-based Prospective Cohort Study – European Urology Focus (free) AND Dietary and Pharmacologic Management to Prevent Recurrent Nephrolithiasis in Adults: A Clinical Practice Guideline From the American College of Physicians (free)
[Abstract Only] Randomized Trial: Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis
13 Feb, 2020 | 08:00h | UTCPlasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis – New England Journal of Medicine (link to abstract – $ for full-text)
Visual Abstract: Plasma Exchange and Glucocorticoids for ANCA-Associated Vasculitis (free)
Commentary: PEXIVAS: No benefit of plasma exchange in ANCA-associated vasculitis – Medicine Matters (free)
NICE Guideline: Antimicrobial Prescribing for Leg Ulcer Infection
12 Feb, 2020 | 07:35h | UTCLeg ulcer infection: antimicrobial prescribing – National Institute for Health and Care Excellence (free)
Related: NICE Antimicrobial prescribing guidelines (resource covering many common conditions) AND NICE Summary of antimicrobial prescribing guidance – managing common infections (free PDF)
Related Commentary on Twitter
Using antibiotics when they're not needed means they may not work as well in the future.
Today, we've published final guidance that sets out an antimicrobial prescribing strategy for adults with leg ulcer infection.https://t.co/4UIa6VcHr8 pic.twitter.com/Wk3V93Ycp7
— NICE (@NICEComms) February 11, 2020
Randomized Trial: Among Patients with MRSA Bacteremia, the Addition of an Antistaphylococcal β-lactam to Standard Therapy Does Not Improve Outcomes
12 Feb, 2020 | 07:29h | UTCEffect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal β-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Combination Therapy for Methicillin-Resistant Staphylococcus aureus Bacteremia: Not Ready for Prime Time (free for a limited period)
Commentaries: Trial pours cold water on combo treatment for MRSA bacteremia – CIDRAP (free) AND Trial shows using two drugs not better than one when treating MRSA blood infections – University of Melbourne (free)
Related Commentary on Twitter
Adding an antistaphylococcal β-lactam to standard #antibiotic therapy w vancomycin or daptomycin did not improve a primary composite outcome of mortality, persistent #bacteremia, relapse, or Tx failure in pts with #MRSA bacteremia https://t.co/UpyCz3Ss4F #VisualAbstract
— JAMA (@JAMA_current) February 12, 2020
Review: Diagnosis and Treatment of Parkinson Disease
12 Feb, 2020 | 07:20h | UTCDiagnosis and Treatment of Parkinson Disease: A Review – JAMA (free for a limited period)
Related Clinical Review Audio: Parkinson Disease (free)
Randomized Trial: Palliative Care Associated with Benefits Among Patients with Parkinson Disease
12 Feb, 2020 | 07:18h | UTCEditorial: Palliative Programs for Persons With Parkinsonism—The Next Frontier (free for a limited period)
Commentaries: Palliative Care Improves Quality of Life, Symptom Burden of Patients With Parkinson Disease – AJMC (free) AND Palliative care could benefit people with Parkinson’s – OnMedica (free)
Critical Care Management of Adults with Community-acquired Severe Respiratory Viral Infection
11 Feb, 2020 | 02:25h | UTC
Meta-analysis: Mortality Comparisons of Peritoneal vs. In-center Hemodialysis
11 Feb, 2020 | 02:18h | UTCCommentaries: Dialysis Modalities Found to Offer Similar Survival – Renal & Urology News (free) AND UL study reveals ‘identical’ survival for kidney dialysis patients using different treatments – University of Limerick (free)
Alex Nowbar’s weekly journal review—7 February 2020
11 Feb, 2020 | 02:16h | UTCAlex Nowbar’s weekly journal review, 7 February 2020 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
Podcast: Alcohol Use Disorder Treatment
11 Feb, 2020 | 02:13h | UTCSee also: Episode List
Podcast: Intermittent Fasting
11 Feb, 2020 | 02:11h | UTCIntermittent fasting – NEJM Journal Watch (free audio)
“Intermittent fasting has salutary effects. Listen how Dr. Mark P. Mattson, co-author of a recent NEJM review on the topic, assesses the practice — and how he’s managed to skip breakfast for the past 30 years or so.”
For those interested in the subject, we suggest the reading of the recent review by Dr. Mark P. Mattson: Effects of Intermittent Fasting on Health, Aging, and Disease – New England Journal of Medicine ($)
Review: Cardiovascular Safety Considerations in the Treatment of Neurogenic Orthostatic Hypotension
11 Feb, 2020 | 02:01h | UTC
[Abstract Only] Another Study Suggesting One Dose of HPV Vaccine may be Effective for Prevention of Cervical Cancer
11 Feb, 2020 | 01:52h | UTCComparison of the long‐term impact and clinical outcomes of fewer doses and standard doses of human papillomavirus vaccine in the United States: A database study – Cancer (link to abstract – $ for full-text)
Commentaries: Single HPV vaccine dose may be effective against cervical cancer – Wiley (free) AND Expert reaction to study on single dose of HPV vaccine – Science Media Centre (free)
Related: Another Observational Study Suggests One Dose of HPV Vaccine may be Enough (free studies)
[Abstract Only] Meta-Analysis: Increased Fluid Intake to Prevent Urinary Tract Infections
11 Feb, 2020 | 01:48h | UTCIncreased fluid intake to prevent urinary tract infections: systematic review and meta-analysis – British Journal of General Practice (link to abstract – $ for full-text)
Related Randomized Trial: Drinking More Water Prevents Recurrent Cystitis (free study and commentaries)
Clinical Update: Diagnosis and Management of Primary Hyperparathyroidism
9 Feb, 2020 | 20:45h | UTCDiagnosis and Management of Primary Hyperparathyroidism – JAMA (free for a limited period)
Related Commentary on Twitter
JAMA Insights: the presentation and diagnostic workup of primary #hyperparathyroidism, and indications for surgical vs surveillance management. https://t.co/kUg9WeCCsc
— JAMA (@JAMA_current) February 8, 2020
Study: Lower GI-bleeding in Anticoagulated Patients with Atrial Fibrillation Should Always Raise Suspicion of Colorectal Cancer
9 Feb, 2020 | 20:47h | UTCCommentary: GI Bleeding and Colorectal Cancer Risk in Anticoagulated AF Patients – American College of Cardiology (free) AND GI bleeding often mistaken as side effect of blood thinners when it could indicate cancer – Cardiovascular Business (free)
De-implementing Wisely: Developing the Evidence Base to Reduce Low-value Care
9 Feb, 2020 | 20:49h | UTCDe-implementing wisely: developing the evidence base to reduce low-value care – BMJ Quality & Safety (free) (via @brhospitalist)