Internal Medicine
Study: In intensively treated hypertensive patients, a diastolic blood pressure of less than 60 mm Hg was associated with increased risk of cardiovascular events
19 Feb, 2021 | 02:37h | UTCCommentary: Treated Diastolic Blood Pressure: How Low Is Too Low? – NEJM Journal Watch
Commentary on Twitter
Cohort study showed on-treatment diastolic BP <60 was associated with increased risk of adverse outcomes; on-treatment diastolic BP of 70-80 was associated with lowest adverse outcome risk in patients with on-treatment systolic BP <130 mmHg. @MayoClinic https://t.co/0wOfqpMcIH
— JAMA Network Open (@JAMANetworkOpen) February 17, 2021
Global guideline for the diagnosis and management of rare mold infections
19 Feb, 2021 | 02:18h | UTC
Commentary on Twitter
🔥🔥🔥 Global Guideline for Rare Moulds. Endorsed by 55 scientific societies in the field.
All you need to know about Diagnosis and Treatment of Rare Mould infections: from Fusarium to Purpureocillium. @eurconfmedmycol @ISHAM_Mycology @ASMicrobiology
https://t.co/YJ3BX58osW pic.twitter.com/nrAGZl5ox4— Martin Hoenigl🇺🇦🇦🇹 (@martinhoenigl) February 16, 2021
What does 95% COVID-19 vaccine efficacy really mean?
19 Feb, 2021 | 02:58h | UTCWhat does 95% COVID-19 vaccine efficacy really mean? – The Lancet Infectious Diseases
Related: Pfizer vaccine: what an ‘efficacy rate above 90%’ really means – The Conversation
COVID‐19 convalescent plasma: Interim recommendations from the AABB
19 Feb, 2021 | 02:56h | UTCCOVID‐19 convalescent plasma: interim recommendations from the AABB – Transfusion
News release: AABB panel issues interim recommendations for Covid-19 convalescent plasma use
Fauci: There’s evidence COVID-19 vaccines don’t just protect you — they may stop you from spreading the virus to others, too
19 Feb, 2021 | 02:46h | UTCRelated: [Preprint] Covid-19 vaccination associated with reduced viral load, may reduce transmission (study and commentary)
How many people get ‘long COVID’ – and who is most at risk?
19 Feb, 2021 | 02:54h | UTCHow many people get ‘long COVID’ – and who is most at risk? – The Conversation
SR: Integrating palliative care in ambulatory care of noncancer serious chronic illness
19 Feb, 2021 | 02:28h | UTCFull report: Integrating Palliative Care in Ambulatory Care of Noncancer Serious Chronic Illness
Evidence summary: Integrating Palliative Care in Ambulatory Care of Noncancer Serious Illness
A food allergy epidemic… or just another case of overdiagnosis?
19 Feb, 2021 | 02:13h | UTCA food allergy epidemic… or just another case of overdiagnosis? – The BMJ Opinion
Original study: Food anaphylaxis in the United Kingdom: analysis of national data, 1998-2018 – The BMJ
M-A: Not enough evidence there are individual differences in response to antidepressants
19 Feb, 2021 | 02:15h | UTCIndividual Differences in Response to Antidepressants: A Meta-analysis of Placebo-Controlled Randomized Clinical Trials – JAMA Psychiatry (free for a limited period)
Editorial: New Directions in Research on Heterogeneity of Treatment Effects for Major Depression (free for a limited period)
Commentary: Antidepressants for MDD: Time to Rethink Personalized Therapy? – Physician’s Weekly
Related studies: What are the chances for personalised treatment with antidepressants? Detection of patient-by-treatment interaction with a variance ratio meta-analysis – BMJ Open AND Individual response to antidepressants for depression in adults-a meta-analysis and simulation study – PLOS One
Commentary on Twitter (thread – click for more)
https://twitter.com/PloederlM/status/1362294365255852032
RCT: Levothyroxine does not reduce the risk of developing depressive symptoms in older adults with subclinical hypothyroidism
18 Feb, 2021 | 02:46h | UTCRelated Studies: Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism – JAMA AND Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism – New England Journal of Medicine AND L-Thyroxine Therapy for Older Adults With Subclinical Hypothyroidism and Hypothyroid Symptoms: Secondary Analysis of a Randomized Trial – Annals of Internal Medicine
Guidelines (conflicting viewpoints): BMJ Guideline: Treatment of Subclinical Hypothyroidism AND Society for Endocrinology & British Thyroid Association issue statement against new treatment recommendations for subclinical hypothyroidism
Commentary on Twitter
Ancillary study of the TRUST RCT of levothyroxine therapy finds it does not reduce depression risk among older adults with subclinical hypothyroidism and shouldn't be prescribed for this purpose. #VisualAbstract https://t.co/yu3EChdkm1
— JAMA Network Open (@JAMANetworkOpen) February 10, 2021
RCT: Vitamin D3 does not improve outcomes in hospitalized patients with moderate to severe COVID-19
18 Feb, 2021 | 03:20h | UTCEditorial: Vitamin D3 to Treat COVID-19: Different Disease, Same Answer
In this RCT a single high dose of #vitaminD3 (100K IU) raised mean serum 25OH D levels but had no effect on hospital LOS (primary outcome), in-hospital mortality, ICU admission, or need for mechanical ventilation (secondary outcomes) https://t.co/eozVaYnb25
— JAMA (@JAMA_current) February 17, 2021
M-A: The effect of convalescent plasma therapy on COVID-19 patient mortality
18 Feb, 2021 | 03:07h | UTCRelated study (not published yet) with conflicting results: RECOVERY trial: No Benefit from convalescent plasma in hospitalized patients with Covid-19 (news release and commentary)
Patient characteristics and clinical outcomes of Type 1 vs. Type 2 myocardial infarction
18 Feb, 2021 | 02:54h | UTCPatient Characteristics and Clinical Outcomes of Type 1 Versus Type 2 Myocardial Infarction – Journal of the American Academy of Cardiology (link to abstract – $ for full-text)
Commentary on Twitter
What are the patient characteristics & clinical outcomes of type 1 vs type 2 #cvMI in the U.S.? Over 200K+ are analyzed. Find out in this week’s issue of #JACC: https://t.co/trgZtKgbOy @CianPMcCarthy @mvaduganathan @JJheart_doc #HFWeek2021 #HeartMonth #CardioTwitter pic.twitter.com/dCdinfeNwE
— JACC Journals (@JACCJournals) February 16, 2021
SR: Concomitant use of levothyroxine and proton pump inhibitors causes a significant increase in TSH concentration
18 Feb, 2021 | 02:48h | UTC
A small, randomized cross-over trial showed Ivabradine may be a useful medication for hyperadrenergic POTS (Postural orthostatic tachycardia syndrome)
18 Feb, 2021 | 02:56h | UTCRandomized Trial of Ivabradine in Patients With Hyperadrenergic Postural Orthostatic Tachycardia Syndrome – Journal of the American Academy of Cardiology (link to abstract – $ for full-text)
Commentaries: Existing heart failure drug may treat potential COVID-19 long-hauler symptom, study suggests – University of California – San Diego AND Randomized Trial of Ivabradine in Patients With Hyperadrenergic Postural Orthostatic Tachycardia Syndrome – Ivabradine in POTS – American College of Cardiology
Commentary on Twitter
Our study showing ivabradine's benefit for POTS patients is out @JACCJournals. Also has implications for post-COVID 19 POTS (part of long haulers syndrome). Congrats to my co-first author/mentee @AdenaZadourian and the rest of my research team. @Dysautonomia @NIH @UCSDHealth pic.twitter.com/KGtzFh9CnT
— Pam R. Taub, MD❤️💃🏻 (@PamTaubMD) February 15, 2021
M-A: Preventable medication harm across health care settings
18 Feb, 2021 | 02:43h | UTCCommentary: Preventable medication harm across health care settings: a systematic review and meta-analysis – PSNet
RCT: Avacopan for the treatment of ANCA-associated vasculitis
18 Feb, 2021 | 02:50h | UTCAvacopan for the Treatment of ANCA-Associated Vasculitis – New England Journal of Medicine (link to abstract – $ for full-text)
RCT: Among patients with knee osteoarthritis, high-intensity strength training was not associated with better outcomes compared with low-intensity strength training or an attention control
17 Feb, 2021 | 01:24h | UTCCommentary: No Benefit from High-Intensity Strength Training for Knee Osteoarthritis – NEJM Journal Watch
Commentary on Twitter
Hot from press: JAMA paper puts question mark on the effectiveness of both low- and high-intensity exercise for knee OA pain. Attention controls had similar improvement. Contextual effects and RTM phenomenon in OA may be powerful! https://t.co/EBrXZcvyXH@OARSInews @JAMA_current pic.twitter.com/880InW1Lag
— Martin Englund (@dr_englund) February 16, 2021
Effect of High-Intensity Strength Training on Knee Pain and Knee Joint Compressive Forces Among Adults With Knee OsteoarthritisThe START Randomized Clinical Trial
👀👀👇👇😳😳https://t.co/W6EQizkiAM pic.twitter.com/RViK36gjHv
— Physio Meets Science (@PhysioMeScience) February 16, 2021
WHO launches consolidated guidelines for malaria
17 Feb, 2021 | 01:27h | UTCWHO launches consolidated guidelines for malaria – World Health Organization
Online Platform: WHO Guidelines for malaria
Serology anno 2021 – fungal infections: from invasive to chronic
17 Feb, 2021 | 01:19h | UTC
Commentary on Twitter
🔥A masterpiece Review Article🔥 @CMIJournal
An updated 2021 inventory of fungal antigen and serology tests for diagnosing invasive and chronic fungal infections, focus was set on Aspergillus,Candida &
Cryptococcus species #IDTwitter #Fungtwitter https://t.co/vG27LagCw7 pic.twitter.com/66la84ixXN— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) February 16, 2021
Cohort study: Risk factors associated with transition from acute to chronic low back pain
17 Feb, 2021 | 01:21h | UTC
Commentary on Twitter
Risk Factors Associated With Transition From Acute to Chronic Low Back Pain in US Patients Seeking Primary Care
👀👀👇👇https://t.co/DzpfvWMzIV pic.twitter.com/qzvoJL2Mxf
— Physio Meets Science (@PhysioMeScience) February 16, 2021
The coronavirus is here to stay — here’s what that mean
17 Feb, 2021 | 01:44h | UTCThe coronavirus is here to stay — here’s what that means – Nature
COVID-19: A Hematologist’s Perspective
17 Feb, 2021 | 01:35h | UTCCoronavirus Disease 2019 (COVID-19): A Haematologist’s Perspective – Acta Haematologica
Editorial: A Haematologist’s Guide to Coronavirus Disease 2019: Encyclopaedia or Doorstop?
Incidence rate and clinical impacts of arrhythmia following COVID-19: a systematic review and meta-analysis of 17,435 patients
17 Feb, 2021 | 01:31h | UTC
Review: Diagnosis and treatment of hip and knee osteoarthritis
16 Feb, 2021 | 02:05h | UTCDiagnosis and Treatment of Hip and Knee Osteoarthritis: A Review – JAMA (free or a limited period)