Internal Medicine
Phase 2 RCT: Inhaled budesonide shows promise for the treatment of early COVID-19
12 Apr, 2021 | 01:24h | UTC
Commentary on Twitter
NEW Research— Early administration of inhaled budesonide reduced the likelihood of needing urgent medical care and reduced time to recovery after early #COVID19
RCT from Mona Bafadhel & colleagues https://t.co/6cJogJs7rp pic.twitter.com/C1dhmTcexP
— The Lancet Respiratory Medicine (@LancetRespirMed) April 10, 2021
NICE Guideline: Assessment and Management of Chronic Pain in Over 16s
8 Apr, 2021 | 08:54h | UTC
[Preprint] CoronaVac is 50% effective for reducing symptomatic SARS-CoV-2 infection after the first dose in the setting of high P.1 variant transmission in Brazil
9 Apr, 2021 | 03:36h | UTC
Commentary on Twitter (thread – click for more)
New 50% efficacy study of Brazil-predominant vaccine CoronaVac (by Sinovac) in Manaus ?? among healthcare workers when #P1 ~75% dominant. Not a trial, but the study found a 1st dose >=14-days efficacy of 50% on symptomatic #COVID19, ~32% if +asymptomatic. https://t.co/YMmZ3mmSDI pic.twitter.com/jwx5R627ys
— Eric Feigl-Ding (@DrEricDing) April 8, 2021
Commentary | Distinguishing the real from the hyperglycemia: does COVID-19 induce diabetes?
9 Apr, 2021 | 03:28h | UTC
The NIH COVID-19 Treatment Guidelines Panel’s Statement on the Emergency Use Authorization of Anti-SARS-CoV-2 Monoclonal Antibodies for the Treatment of COVID-19
9 Apr, 2021 | 03:35h | UTC
Large study finds 1 in 3 Covid-19 survivors have subsequent mental health and neurological conditions
8 Apr, 2021 | 09:14h | UTCCommentaries: 1 in 3 Covid-19 patients are diagnosed with a neuropsychiatric condition in the next six months, large study finds – STAT AND A longer look at COVID-19 and neuropsychiatric outcomes – The Lancet Psychiatry AND Largest study to date suggests link between COVID-19 infection and subsequent mental health and neurological conditions – The Lancet AND Covid-19: One in three has neurological or psychiatric condition diagnosed after covid infection, study finds – The BMJ AND One in three survivors of severe Covid diagnosed with mental health condition – The Guardian AND Covid-19 linked to depression and dementia, study suggests – BBC AND Expert reaction to observational study looking at neurological and psychiatric outcomes 6 months after COVID-19 – Science Media Centre AND 1 in 3 COVID Survivors Struggle With Mental Health Issues Months Later – HealthDay
Commentary on Twitter (thread – click for more)
?HUGE STUDY—One in 3 #COVID19 survivors received a neurological diagnosis within 6 months of infection—1 in 8 with first ever diagnosis, says study of 230,000 patient records. Also COVID patients had higher risk of dementia, anxiety, Parkinson’s vs flu.?https://t.co/BlhtUrOsvL pic.twitter.com/ZAcHZviGKR
— Eric Feigl-Ding (@DrEricDing) April 7, 2021
Cohort study: One in ten have long-term effects 8 months following mild COVID-19
8 Apr, 2021 | 09:12h | UTCOne in ten have long-term effects 8 months following mild COVID-19 – Karolinska Institutet
Original study: Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers – JAMA
Commentary on Twitter
#LongCovid in #Frontline: JAMA
Worrisome! N=323 COVID+ #Healthcare Workers vs. N=1072 w no COVID. At 8 mos, up to 4x risk of fxnl impairment in work, social & home life. REAL ongoing suffering in low-risk humans after #COVID.https://t.co/EwZWdW4ZtL#medtwitter #nurse pic.twitter.com/tofIx4p647— WesElyMD (@WesElyMD) April 7, 2021
Study: Outdoor transmission accounts for 0.1% of Covid-19 cases
8 Apr, 2021 | 09:11h | UTCOutdoor transmission accounts for 0.1% of State’s Covid-19 cases – The Irish Times
Meta-Analysis: Primary prevention of variceal bleeding in people with esophageal varices due to liver cirrhosis
8 Apr, 2021 | 08:45h | UTCRelated Cochrane Review: M-A: Secondary prevention of variceal bleeding in adults with previous esophageal variceal bleeding due to decompensated liver cirrhosis
Cancer Screening in the Coronavirus Pandemic Era: Adjusting to a New Situation
9 Apr, 2021 | 03:09h | UTCCancer Screening in the Coronavirus Pandemic Era: Adjusting to a New Situation – JCO Global Oncology
Perspective | Evidence isn’t Everything – Evidence-based medicine and statin decision-making
8 Apr, 2021 | 08:41h | UTCEvidence isn’t Everything – Evidence-based medicine and statin decision-making
Commentary on Twitter
My latest substack on using EBM for medical decisions.
Mike, a middle-aged active person, has been told to take a #statin
Should he?
Mentions in the post — @AndrewFoy82 @LuisCLCorreia @ProfDFrancis @DrJHoward @RogueRad @ProfHayward https://t.co/XJ6eBQ7Zj7
— John Mandrola, MD (@drjohnm) April 7, 2021
Podcast: Evaluation and Management of Chronic Diarrhea
8 Apr, 2021 | 08:38h | UTC#267 Diarrhea Disemboweled Part 2: Chronic Diarrhea with Dr. Iris Wang – The Curbsiders
See also: #266 Diarrhea Disemboweled Part 1: Acute Diarrhea with Dr. Iris Wang – The Curbsiders
RCT: Among patients with peripheral artery disease, low-intensity exercise was significantly less effective than high-intensity exercise for improving 6-minute walk distance
7 Apr, 2021 | 01:31h | UTCEffect of Low-Intensity vs High-Intensity Home-Based Walking Exercise on Walk Distance in Patients With Peripheral Artery Disease: The LITE Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
In this RCT of patients with PAD, low-intensity home-based exercise was less effective than high-intensity home-based exercise, and similar to the nonexercise control, for improving 6-min walk distance https://t.co/dVWCDx5hLM @NUFeinbergMed @StanfordMed @UChicagoMed @wakehealth
— JAMA (@JAMA_current) April 6, 2021
Short review | Assessment and management of dysphagia and achalasia
7 Apr, 2021 | 01:13h | UTCAssessment and management of dysphagia and achalasia – Clinical Medicine Journal
Commentary on Twitter
Diagnostic approach to dysphagia and achalasia
? in this month’s @Clin_Med https://t.co/LDe7lI1Ruc pic.twitter.com/nnK09HBy8Z
— Keith Siau (@drkeithsiau) March 27, 2021
UK regulator confirms that people should continue to receive the COVID-19 vaccine AstraZeneca
8 Apr, 2021 | 09:05h | UTC
Commentary on Twitter
Following suspensions by some countries of the COVID-19 Vaccine AstraZeneca over suspected blood clots, the MHRA confirms that the benefits of the vaccine in preventing COVID-19 far outweigh the risks. People should still go and get their COVID-19 vaccine https://t.co/zse5RUIct1
— Antibiotic Steward??Bassam Ghanem (@ABsteward) April 7, 2021
WHO Interim statement: A causal relationship between the AstraZeneca COVID-19 vaccine and the occurrence of blood clots with low platelets is considered plausible but is not confirmed
8 Apr, 2021 | 09:09h | UTC
Commentary on Twitter (thread – click for more)
? Interim statement of the #COVID19 subcommittee of the WHO Global Advisory Committee on Vaccine Safety on the AstraZeneca vaccine https://t.co/p8XMMAiUne pic.twitter.com/7DMRNFxQsX
— World Health Organization (WHO) (@WHO) April 7, 2021
AstraZeneca’s COVID-19 vaccine: EMA finds possible link to very rare cases of unusual blood clots with low blood platelets. The benefits of the vaccine continue to outweigh the risks for people who receive it.
8 Apr, 2021 | 09:07h | UTCCommentaries: In rare instances, AstraZeneca’s Covid-19 vaccine linked to blood clots, regulators say – STAT AND Expert reaction to statements from MHRA and EMA in relation to the AstraZeneca vaccine and rare blood clots and low blood platelets – Science Media Centre
JCVI statement on use of the AstraZeneca COVID-19 vaccine: “JCVI currently advises that it is preferable for adults aged <30 years to be offered an alternative COVID-19 vaccine, if available.”
8 Apr, 2021 | 09:02h | UTCJCVI statement on use of the AstraZeneca COVID-19 vaccine: 7 April 2021 – GOV.UK
Commentaries: Covid: Under-30s offered alternative to Oxford-AstraZeneca jab – BBC AND Expert reaction to statements from MHRA and EMA in relation to the AstraZeneca vaccine and rare blood clots and low blood platelets – Science Media Centre
Consensus Document: Management of the complications of long term indwelling catheters
7 Apr, 2021 | 01:20h | UTC
Video: Coronavirus Variants and Vaccines
8 Apr, 2021 | 09:00h | UTCCoronavirus Variants and Vaccines – JAMA
Study finds low risk of venous thromboembolism in outpatients with Covid-19 – researchers advise against the use of anticoagulants outside clinical trials
8 Apr, 2021 | 08:59h | UTCCommentaries: VTE Related to SARS-CoV-2 Infection Less Of a Problem in Outpatients – TCTMD AND No Increase Seen in Outpatient VTE for SARS-CoV-2-Positive Patients – Physician’s Weekly
Commentary on Twitter (thread – Click for more)
Interesting report on VTE incidence in COVID-19 patients, starting with counting outside of the hospital. See https://t.co/XJvbrfHm6d … 1/n
— Geert-Jan Geersing (@gjgeersing) April 7, 2021
CDC Updated Guidance: “It is possible for people to be infected through contact with contaminated surfaces or objects, but the risk is generally considered to be low”
7 Apr, 2021 | 02:00h | UTCRelated: Catching COVID from surfaces is very unlikely. So perhaps we can ease up on the disinfecting – The Conversation AND Coronavirus is in the air — there’s too much focus on surfaces – Nature AND COVID-19 rarely spreads through surfaces. So why are we still deep cleaning? – Nature
Identifying and managing functional cardiac symptoms
7 Apr, 2021 | 01:15h | UTCIdentifying and managing functional cardiac symptoms – Clinical Medicine Journal
Practical Guide: Perioperative Pain Management and Opioid Stewardship
7 Apr, 2021 | 01:17h | UTCPerioperative Pain Management and Opioid Stewardship: A Practical Guide – Healthcare
ACP Guidance: Appropriate Use of Short-Course Antibiotics in Common Infections
6 Apr, 2021 | 01:12h | UTCSummary for Patients: Appropriate Use of Short-Course Antibiotics in Common Infections: Best Practice Advice From the American College of Physicians