Internal Medicine
Covid-19 vaccination prevents transmission from vaccinated to unvaccinated household members.
31 May, 2021 | 08:18h | UTCThe indirect effect of mRNA-based Covid-19 vaccination on unvaccinated household members – medRxiv
Commentary on Twitter
More on less transmission, yet another incentive:
"Our results suggest that mRNA-based vaccines do not only prevent #SARSCoV2 infections among vaccinated individuals but lead to a substantial reduction in infections among unvaccinated household members"https://t.co/sIqoOLiH3b pic.twitter.com/6rv2tojR2m— Eric Topol (@EricTopol) May 29, 2021
Vietnam finds new rapidly spreading SARS-CoV-2 variant, hybrid of B.1.617.2 and B.1.1.7 strains.
31 May, 2021 | 08:16h | UTCVietnam finds new virus variant, hybrid of India, UK strains – Associated Press
See also: Covid: Vietnam detects new UK-Indian variant, health officials say – BBC AND Vietnam says new Covid variant is hybrid of India and UK strains – The Guardian
[Not published yet] Observational study in Uruguay found CoronaVac reduced mortality by 97 percent – “In people who had received two doses, it reduced infection with the coronavirus by 57 percent and intensive care admissions by 95 percent”.
31 May, 2021 | 08:14h | UTCCoronaVac reduces mortality by 97 percent: Uruguay study – Associated Press
Guideline | Primary prophylaxis of bacterial infections and Pneumocystis jirovecii pneumonia in patients with hematologic malignancies and solid tumors.
31 May, 2021 | 08:09h | UTC
Providing more low-value care does not lead to higher patient experience ratings – “New study challenges the assumption that offering patients more tests and procedures will lead to higher patient experience ratings”.
31 May, 2021 | 08:11h | UTCOriginal Study: Association of Low-Value Care Exposure With Health Care Experience Ratings Among Patient Panels – JAMA Internal Medicine
Commentary on Twitter
New work led by @sanghavi_prachi w/ @A_Schwa & Alan Zaslavsky
We asked do PCPs w/ more wasteful practice patterns get better patient ratings?
Answer is no. No they don't
This should allay overblown concerns about pt experience measures leading us to satisfy patients to death https://t.co/cosXvLA6Ql
— Michael McWilliams (@JMichaelMcW) May 28, 2021
Observational study suggests ceftriaxone is similarly effective to benzylpenicillin for the treatment of neurosyphilis, potentially decreasing the length of hospital stay (mean 13.8 days vs. 8.9 days).
31 May, 2021 | 08:06h | UTCCeftriaxone compared with benzylpenicillin in the treatment of neurosyphilis in France: a retrospective multicentre study – The Lancet Infectious Diseases (link to abstract – $ for full-text)
Lab study found CoronaVac serum neutralization efficiency was significantly decreased against B.1.526, P.1, and B1.351 SARS-CoV-2 variants.
28 May, 2021 | 08:26h | UTC
COLCORONA RCT: Colchicine for community-treated patients with COVID-19 – findings suggest it may lower death and hospital admission rates, but further studies are required.
28 May, 2021 | 08:27h | UTCInvited Commentary: Exploiting an early immunological window of opportunity in COVID-19 – The Lancet Respiratory Medicine
The global burden of smoking tobacco and attributable disease in 204 countries and territories – “In the absence of intervention, the annual toll of 7.69 million deaths and 200 million disability-adjusted life-years attributable to smoking will increase over the coming decades”.
28 May, 2021 | 08:19h | UTCRelated studies: Spatial, temporal, and demographic patterns in prevalence of chewing tobacco use in 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Disease Study 2019 – The Lancet Public Health AND Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and initiation among young people in 204 countries and territories, 1990–2019 – The Lancet Public Health
RCT: Pfizer-BioNTech Covid-19 vaccine shows 100% efficacy in adolescents – mainly transient mild-to-moderate reactogenicity was frequently observed, such as injection-site pain (in 79 to 86% of participants), fatigue (in 60 to 66%), and headache (in 55 to 65%).
28 May, 2021 | 08:24h | UTC
Commentary on Twitter
The 12-15 year-olds mRNA vaccine randomized, placebo-controlled clinical trial is published @NEJM today [@BioNTech_Group/@Pfizer]https://t.co/7GlgC9xdd0
—100% efficacy (95% CI 75,100)
—1.8 X higher levels of neutralizing antibodies than 16-25 yr olds
—very good safety profile pic.twitter.com/hQzkpuA5Nu— Eric Topol (@EricTopol) May 27, 2021
Covid-19: Pfizer-BioNTech vaccine is “likely” responsible for deaths of some elderly patients, Norwegian review finds.
28 May, 2021 | 08:22h | UTC
Commentary on Twitter
The Pfizer-BioNTech covid-19 vaccine is “likely” to have been responsible for at least 10 deaths of frail elderly people in nursing homes in Norway, an expert review concluded, although it emphasised considerable uncertainty around its conclusionshttps://t.co/w32jH6MtRH
— The BMJ (@bmj_latest) May 27, 2021
Advance Care Planning for people with dementia: recognizing moral dilemmas faced by physicians.
28 May, 2021 | 08:14h | UTC
EULAR recommendations for intra-articular therapies.
28 May, 2021 | 08:16h | UTCEULAR recommendations for intra-articular therapies – Annals of Rheumatic Diseases
Management of patients after coronary artery bypass grafting surgery: a guide for primary care practitioners.
28 May, 2021 | 08:12h | UTC
Count the cost of disability caused by COVID-19 – “Focusing only on cases and deaths hides the pandemic’s lasting health burden on people, societies and economies”.
27 May, 2021 | 08:35h | UTCCount the cost of disability caused by COVID-19 – Nature
RCT: 2 inactivated SARS-CoV-2 vaccines show efficacy of 72.8% and 78.1% on symptomatic COVID-19 infection in adults.
27 May, 2021 | 08:38h | UTCCommentary: China’s Sinopharm Publishes Awaited Covid Vaccine Study Details – Bloomberg
Commentary on Twitter (thread – click for more)
https://twitter.com/hildabast/status/1397678056270012419
Systematic review of 45 studies including 9751 participants, most of which were hospitalized, found 73% had at least 1 persistent symptom for weeks after Covid-19.
27 May, 2021 | 08:37h | UTCCommentary: Seven out of ten hospitalized COVID-19 patients will have long-haul symptoms – MedicalXpress
Can people vaccinated against COVID-19 still spread the coronavirus? – “Preliminary evidence seems to suggest the COVID-19 vaccines make it less likely someone who’s vaccinated will transmit the coronavirus”.
27 May, 2021 | 08:27h | UTCCan people vaccinated against COVID-19 still spread the coronavirus? – The Conversation
Related: Indirect Protection by Reducing Transmission: Ending the Pandemic with SARS-CoV-2 Vaccination – “Tell the hesitant: the vaccines protect both you and protect others — a lot!”
[Preprint] More data showing a single-dose SARS-CoV-2 mRNA vaccine may be enough in individuals with previous COVID-19.
27 May, 2021 | 08:31h | UTCSingle-dose SARS-CoV-2 vaccine in a prospective cohort of COVID-19 patients – medRxiv
See also: SARS-CoV-2 vaccines for all but a single dose for COVID-19 survivors – EClinicalMedicine
Related: Another study shows a single dose of mRNA vaccine may be enough for patients with previous Covid-19
Commentaries on Twitter
If you had prior covid and you're wondering about getting vaccinated, here's a new prospective study showing single dose -> marked neutralizing antibody protection to the major variants AND again more than without prior covid and 2 mRNA doses https://t.co/k9v5gEDn2M pic.twitter.com/Z8nT3pL04v
— Eric Topol (@EricTopol) May 26, 2021
One dose of vaccine for prior covid.
Change the policy. Avoid unnecessary side effects and instead of wasting vaccine doses get them to the people around the world in needhttps://t.co/ODhx5kgAnq @EBioMedicine @MattFrieman @VivianaSimonLab @florian_krammer pic.twitter.com/oAeju9AASm— Eric Topol (@EricTopol) May 26, 2021
COVID Morbidity – The emerging burden of long COVID is significant, and needs to be considered when evaluating the risk vs. benefit of pandemic measures.
27 May, 2021 | 08:34h | UTCCOVID Morbidity – Science-Based Medicine
RCT: Among patients with prosthetic joint infection, antibiotic therapy for 6 weeks was NOT shown to be noninferior to antibiotic therapy for 12 weeks and resulted in a higher percentage of patients with unfavorable outcomes.
27 May, 2021 | 08:20h | UTCAntibiotic Therapy for 6 or 12 Weeks for Prosthetic Joint Infection – New England Journal of Medicine (link to abstract – $ for full-text)
Global cardiovascular organizations release joint opinion on achieving the ‘tobacco endgame’.
27 May, 2021 | 08:22h | UTCNews release: Global cardiovascular organizations release joint opinion on achieving the ‘tobacco endgame’ – American College of Cardiology
Commentary: The Tobacco Endgame—Eradicating a Worsening Epidemic – American College of Cardiology
[Preprint] Meta-analysis of RCT: Ivermectin for the treatment of COVID-19 – no effect on all-cause mortality, length of stay, or viral clearance
26 May, 2021 | 08:41h | UTC
Commentary on Twitter
🆕💥💥Preprint
Ivermectin for the treatment of #COVID19 : A systematic review & meta-analysis of RCTs
10 RCTs
1173 patients
8 RCTs➡️ Mild
1 RCT ➡️ Moderate
1 RCT➡️ Mild& mod
Ivermectin did not reduce all-cause mortality,length of stay or viral clearance https://t.co/QMx0wlfS8f pic.twitter.com/6yddqwqPF6— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) May 25, 2021
Study shows acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection.
26 May, 2021 | 08:37h | UTCRelated: Distinguishing the real from the hyperglycaemia: does COVID-19 induce diabetes? – The Lancet Diabetes & Endocrinology AND SARS-CoV-2 infects human pancreatic β-cells and elicits β-cell impairment – Cell Metabolism
Commentary on Twitter
For at least 2 months after COVID-19 in people without #diabetes, glucose regulation can be abnormal, along with insulin resistance and abnormal cytokineshttps://t.co/P1xa0lx2c4 @NatMetabolism @PAOLOFIORINA @FiorinaLab pic.twitter.com/Lu7GDMjzdy
— Eric Topol (@EricTopol) May 25, 2021
Methotrexate reduces immune response to mRNA COVID-19 vaccine in patients with immune-mediated inflammatory disease.
26 May, 2021 | 08:38h | UTCCommentary: Methotrexate users have a reduced immune response to mRNA COVID-19 vaccine – BMJ