Internal Medicine
RCT: Among patients with ANCA-associated vasculitis without severe glomerulonephritis or alveolar hemorrhage treated with Rituximab, a reduced-dose glucocorticoids regimen (prednisolone 0.5 mg/kg/d) was noninferior to a high-dose glucocorticoid regimen (prednisolone 1 mg/kg/d) for the induction of disease remission.
4 Jun, 2021 | 10:25h | UTC
Countries hit hardest by COVID-19 – estimated mortality countries will have on September 1, 2021.
3 Jun, 2021 | 11:09h | UTCCountries Hit Hardest by COVID-19 – Think Global Health
Commentary on Twitter (thread – click for more)
❓🌎🌍🌏 Which countries will have the highest mortality from COVID-19 come September 1, 2021? IHME researchers ran the numbers for a new article in @ThinkGlobalHlth ⤵️🧵https://t.co/d2CFHVzCYX
— Institute for Health Metrics and Evaluation (IHME) (@IHME_UW) June 2, 2021
Diagnosis and management of diabetes insipidus for the internist: an update
4 Jun, 2021 | 10:22h | UTC
What We Know About the Dangerous COVID B.1.617.2 (Delta) Variant – “the Delta variant may soon become the most dominant COVID strain in the world and lead to rapid outbreaks in countries without high vaccination rates”.
3 Jun, 2021 | 11:05h | UTCWhat We Know About the Dangerous COVID B.1.617.2 (Delta) Variant – Intelligencer
Commentary on Twitter
Good summary of what's presently known about the B.1.617.2 (Delta) variant @NYMag. Important to emphasize 2-dose vaccination effectiveness is high.https://t.co/8cKvR5eBMM w/ @jburnmurdoch @zeynep @macroliter by @chasdanner
— Eric Topol (@EricTopol) June 1, 2021
RCT: Among patients with Type 2 diabetes treated with basal insulin with poor glycemic control (mean baseline HbA1c level = 9.1%), continuous glucose monitoring reduced HbA1c level by 0.4% compared to usual care (8.0% and 8.4%). Patient engagement (i.e., adherence, diet, physical activity in response to CGM readings) was the most likely source of improved glycemic control.
3 Jun, 2021 | 10:54h | UTCEditorial: Broadening Access to Continuous Glucose Monitoring for Patients With Type 2 Diabetes – JAMA
Commentary: Studies support wider CGM access in type 2 diabetes – medwire News
Commentary on Twitter
Continuous glucose monitoring resulted in better glycemic control compared with blood glucose meter monitoring in adults with poorly controlled type 2 diabetes treated with basal insulin without prandial insulin https://t.co/D0y7B8JsJE
— JAMA (@JAMA_current) June 2, 2021
Guideline: Diagnosis and management of acute lower gastrointestinal bleeding.
3 Jun, 2021 | 10:49h | UTC
AHA Statement: Physical Activity as a Critical Component of First-Line Treatment for Elevated Blood Pressure or Cholesterol: Who, What, and How?
3 Jun, 2021 | 10:52h | UTCNews Release: ‘Prescription’ to sit less, move more advised for mildly high blood pressure and cholesterol – American Heart Association
Commentary: AHA: Physical Activity Should First-line Therapy as BP, LDL Tick Upwards – TCTMD
Doctors tell how to make the most of your telehealth visits.
3 Jun, 2021 | 10:39h | UTCDoctors Tell How to Make the Most of Your Telehealth Visits – Kaiser Health News
Israel reports link between rare cases of heart inflammation and COVID-19 vaccination in young men.
2 Jun, 2021 | 08:37h | UTCIsrael reports link between rare cases of heart inflammation and COVID-19 vaccination in young men – Science (a few articles per month are free)
Commentary on Twitter
https://twitter.com/rfsquared/status/1399803644288061442
WHO validates Sinovac-CoronaVac COVID-19 vaccine for emergency use and issues interim policy recommendations.
2 Jun, 2021 | 08:42h | UTCCommentary: WHO grants emergency approval to 2nd Chinese COVID vaccine – MedicalXpress
Commentary on Twitter (thread – click for more)
WHO today validated the Sinovac-CoronaVac #COVID19 vaccine for emergency use, giving countries, funders, procuring agencies & communities the assurance that it meets international standards for safety, efficacy and manufacturing.
More ⬇️ https://t.co/Uy0xmGlAIT— World Health Organization (WHO) (@WHO) June 1, 2021
After COVID-19 successes, researchers push to develop mRNA vaccines for other infectious diseases and cancer.
2 Jun, 2021 | 08:34h | UTC
RCT: Among patient with recent ischemic stroke without known atrial fibrillation, implantable loop recorder monitoring for 12 months detects more occurrences of AF compared with conventional external loop recorder monitoring for 30 days (15.3% vs. 4.7%) – “further research is needed to compare clinical outcomes associated with these monitoring strategies”.
2 Jun, 2021 | 08:30h | UTCEffect of Implantable vs. Prolonged External Electrocardiographic Monitoring on Atrial Fibrillation Detection in Patients With Ischemic Stroke: The PER DIEM Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Detection of Subclinical Atrial Fibrillation After Stroke: Is There Enough Evidence to Treat? – JAMA (free for a limited period)
Commentary: Implantable device more effective at detecting atrial fibrillation than standard of care – News Medical
RCT: Insertable cardiac monitors used for 12 months detect more atrial fibrillation than usual care in patients with a recent ischemic stroke (12.1% vs. 1.8%) – “further research is needed to understand whether identifying AF in these patients is of clinical importance”.
2 Jun, 2021 | 08:29h | UTCEffect of Long-term Continuous Cardiac Monitoring vs Usual Care on Detection of Atrial Fibrillation in Patients With Stroke Attributed to Large- or Small-Vessel Disease: The STROKE-AF Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Detection of Subclinical Atrial Fibrillation After Stroke: Is There Enough Evidence to Treat? – JAMA (free for a limited period)
[Press release – not published yet] The city of Serrana in Brazil has seen a 95% drop in Covid-19 deaths after almost all adults were vaccinated with Chinese CoronaVac – The findings suggest the pandemic can be controlled after 75% of people are fully vaccinated.
2 Jun, 2021 | 08:39h | UTCCommentaries: Study in Brazilian town shows 95% efficacy of Sinovac’s vaccine in reducing death by COVID-19 – Global Times AND Brazil Covid: Deaths plunge after town’s adults vaccinated – BBC AND Sinovac vaccine restores a Brazilian city to near normal – Associated Press
M-A: After an acute coronary syndrome treated with coronary stenting, dual antiplatelet therapy (DAPT) for 1 to 3 months followed by P2Y12 inhibitor monotherapy is associated with improved outcomes compared with traditional DAPT for 12 months.
2 Jun, 2021 | 08:26h | UTCMeta-Analysis of Duration of Dual Antiplatelet Therapy in Acute Coronary Syndrome Treated With Coronary Stenting – American Journal of Medicine (link to abstract – $ for full-text)
Systematic review: Driving performance under treatment of most frequently prescribed drugs for mental disorders – 31% of schizophrenic or schizoaffective patients under antipsychotics, and 18% of unipolar and bipolar patients under antidepressants showed severe impairment in skills relevant for driving.
2 Jun, 2021 | 08:24h | UTC
WHO renames COVID-19 variants with the Greek alphabet (i.e., Alpha, Beta, Gamma, etc), making them simple, easy to say and remember. The naming system aims to prevent calling COVID-19 variants by the places where they are detected, which is stigmatizing & discriminatory.
1 Jun, 2021 | 08:26h | UTCTracking SARS-CoV-2 variants – World Health Organization
Commentaries: The name game for coronavirus variants just got a little easier – STAT AND Covid: WHO renames UK and other variants with Greek letters – BBC
Study shows low risk of SARS-CoV-2 reinfection 1 year after primary infection.
1 Jun, 2021 | 08:23h | UTCEditorial: Protection Because of Prior SARS-CoV-2 Infection
Commentary on Twitter
Lombardy, Italy was one of the worst-hit places in the world in the 1st wave of the pandemic. Now, a year later, how many had reinfections?
0.3%
And 13-15 X infections for those who did not have covidhttps://t.co/ewpMRcPIMB @JAMAInternalMed pic.twitter.com/I7z2L04Evp— Eric Topol (@EricTopol) May 28, 2021
Perspective | Can I get AstraZeneca now and Pfizer later? Why mixing and matching COVID vaccines could help solve many rollout problems.
1 Jun, 2021 | 08:20h | UTC
M-A: Triple vs. dual inhaler therapy in patients with moderate to severe asthma – fewer severe asthma exacerbations, but without significant differences in quality of life or mortality.
1 Jun, 2021 | 08:12h | UTCTriple vs Dual Inhaler Therapy and Asthma Outcomes in Moderate to Severe Asthma: A Systematic Review and Meta-analysis – JAMA (free for a limited period)
Commentary on Twitter
Among patients with moderate to severe asthma, triple therapy compared with dual therapy was significantly associated with fewer severe asthma exacerbations and modest improvements in asthma control but no significant difference in quality of life https://t.co/icKsWu0Md9 #ATS2021
— JAMA (@JAMA_current) May 19, 2021
Podcast | Osteoporosis in Primary Care.
1 Jun, 2021 | 08:06h | UTC#277 Bone Up on Osteoporosis in Primary Care with Dr. Carolyn Crandall – The Curbsiders
AGA Clinical Practice Guidelines on the Medical Management of Moderate to Severe Luminal and Perianal Fistulizing Crohn’s Disease.
1 Jun, 2021 | 08:07h | UTCTechnical Review: AGA Technical Review on the Medical Management of Moderate to Severe Luminal and Perianal Fistulizing Crohn’s Disease
Clinical Decision Support Tool / Algorithm: Medical Management of Adult Outpatients With Moderate to Severe Lunminal Crohn’s Disease
Commentary on Twitter
Here are the @AmerGastroAssn guidelines on the management of moderate-severe Crohn disease. #GITwitter #GI #gut #IBD https://t.co/VlT4xTUE8t pic.twitter.com/ayYlpVkkod
— John Damianos, M.D. (@john_damianosMD) May 28, 2021
Opinion | 7 reasons why we should not need boosters for COVID-19.
31 May, 2021 | 08:21h | UTC7 Reasons Why We Should Not Need Boosters for COVID-19 – by Monica Ghandi, MD
No COVID-19 cases found after a well-controlled indoor concert.
31 May, 2021 | 08:24h | UTCNo COVID-19 cases found after well-controlled indoor concert – CIDRAP
Invited Commentary: Innovations in COVID-19 testing: the road from pandemic response to control – The Lancet Infectious Diseases
Commentary on Twitter (thread – click for more)
Report of the Barcelona music event out here. These are difficult studies to do – and you need to carefully review them.
Same-day SARS-CoV-2 antigen test screening in an indoor mass-gathering live music event: a randomised controlled trial https://t.co/KDMtsGD23v
— Jon Deeks FMedSci (@deeksj) May 28, 2021
New IDSA Guidelines on antigen testing for the diagnosis of COVID-19.
31 May, 2021 | 08:25h | UTC