Internal Medicine
RCT: Once weekly semaglutide 2.0 mg vs. 1.0 mg in patients with type 2 diabetes – Mean change in HbA1c from baseline was −2.2 percentage points with 2.0 mg vs. −1.9 percentage points with 1.0 mg; mean change in bodyweight from baseline was −6.9 kg with 2.0 mg vs. −6.0 kg with 1.0 mg.
20 Jul, 2021 | 10:09h | UTCEfficacy and safety of once-weekly semaglutide 2·0 mg versus 1·0 mg in patients with type 2 diabetes (SUSTAIN FORTE): a double-blind, randomised, phase 3B trial – The Lancet Endocrinology & Diabetes (link to abstract – $ for full-text)
Brief review: Management of coronary artery disease in high-risk occupations.
20 Jul, 2021 | 10:08h | UTCManagement of Coronary Artery Disease in High-Risk Occupations – American College of Cardiology
Commentary on Twitter
Cardiovascular events can be associated with sudden incapacitation, which in high-risk occupations, could result in catastrophic consequences for the driver or pilot, passengers and bystanders. Read the full story here: https://t.co/VhEa3ZSjMU @rblument1 #cvCAD #HeartDisease
— American College of Cardiology (@ACCinTouch) July 19, 2021
Expert opinion | Bioprosthetic valves and atrial fibrillation: Direct anticoagulants or warfarin – Until conclusive data are available for patients with rheumatic heart disease and those with mechanical valves, DOAC use is not indicated in these patients.
20 Jul, 2021 | 10:06h | UTC
Systematic review: In hospitalized non‐ICU patients, multicomponent non-pharmacological interventions are estimated to reduce the incidence of delirium by 43% compared to usual care.
20 Jul, 2021 | 10:07h | UTC
RCT: more data showing Azithromycin is not better than placebo in patients with Covid-19.
18 Jul, 2021 | 23:54h | UTCRelated: RCT: Another study shows Azithromycin does not improve outcomes in patients with Covid-19. (several articles on the subject)
Commentary on Twitter
Among outpatients with #SARSCoV2 infection, treatment with a single dose of oral #azithromycin compared with placebo did not result in a greater likelihood of being free of symptoms at day 14 https://t.co/dYDcSyGtwd #COVID19
— JAMA (@JAMA_current) July 16, 2021
Review: Symptoms, complications and management of long COVID.
18 Jul, 2021 | 23:46h | UTCCommentary: Long COVID: More likely in patients with 5+ symptoms in first week of infection – SAGE Publications
Commentary on Twitter
Pooled prevalence data in this review showed the 10 most prevalent reported symptoms of long covid were: fatigue, shortness of breath, muscle pain, joint pain, headache, cough, chest pain, altered smell, altered taste and diarrhoea.
https://t.co/ww5HM1s7vm— KK Cheng (@KKCheng4) July 16, 2021
Study: Coffee consumption not linked to increased incidence of tachyarrhythmias.
20 Jul, 2021 | 10:02h | UTCInvited commentary: Another Cup of Coffee Without an Arrhythmia, Please
Author interview: Coffee Consumption and Incident Tachyarrhythmias
Commentary on Twitter
Good news for coffee drinkers ☕️☕️
Debunking the dogma that coffee increases the risk of heart rhythm disturbances, from >386,000 people, 4.5 year follow-up, including putative genomic risk variants@JAMAInternalMed https://t.co/9bBihDfB3A @uk_biobank pic.twitter.com/V6yGeNg7Fp— Eric Topol (@EricTopol) July 19, 2021
Position Paper: Recommendations for the use of topical inhalant budesonide in COVID-19.
18 Jul, 2021 | 23:53h | UTCRecommendations for use of topical inhalant budesonide in COVID-19 – HNO
Related: RCT: Inhaled budesonide shortens recovery time in non-hospitalized patients with COVID-19 AND Phase 2 RCT: Inhaled budesonide shows promise for the treatment of early COVID-19
Studies elucidate poorly understood long COVID.
18 Jul, 2021 | 23:42h | UTCStudies elucidate poorly understood long COVID – CIDRAP
Long Covid: fatigue, post-exertional malaise, and cognitive dysfunction are the most common symptoms, according to an international survey.
18 Jul, 2021 | 23:44h | UTCCommentaries: Identification of over 200 long COVID symptoms prompts call for UK screening programme – University College London AND A survey of long-haulers found 66 symptoms that lasted more than 6 months. Tiredness and brain fog were most common. – Insider AND Long Covid has more than 200 symptoms, study finds – The Guardian
CDC warns Covid-19 vaccines might not protect people who are immunocompromised – “CDC is looking into ongoing research exploring the possibility that immunocompromised could benefit from an additional dose”.
18 Jul, 2021 | 23:38h | UTCCDC warns Covid-19 vaccines might not protect people who are immunocompromised – CNN
WHO publishes new Consolidated HIV guidelines for prevention, treatment, service delivery & monitoring.
18 Jul, 2021 | 23:22h | UTC
Review: Acute kidney injury.
18 Jul, 2021 | 23:18h | UTCAcute kidney injury – Nature Reviews Disease Primers (free for a limited period)
Commentary on Twitter
Get Primed on #AcuteKidneyInjury with our NEW PrimeView, FREE to download this week https://t.co/4RAOOaB8ep pic.twitter.com/d5iHCcqJwY
— Nature Reviews Disease Primers (@DiseasePrimers) July 15, 2021
Review: Parkinson disease-associated cognitive impairment.
18 Jul, 2021 | 23:17h | UTCParkinson disease-associated cognitive impairment – Nature Reviews Disease Primers (free for a limited period)
Infographic: Parkinson disease-associated cognitive impairment
Review: Glucocorticoid induced adrenal insufficiency.
18 Jul, 2021 | 23:15h | UTCGlucocorticoid induced adrenal insufficiency – The BMJ
Commentary on Twitter
◾ What factors affect the risk of Glucocorticoid induced adrenal insufficiency?
◾ What regimen can be used for glucocorticoid taper?
◾ How can adrenal function recovery be best assessed?Read our latest clinical review to find out: https://t.co/m814c1rgIs
— The BMJ (@bmj_latest) July 13, 2021
Study: Pooled saliva analysis is a low-cost and effective strategy for surveillance of Covid-19 in schools and universities and allows to rapidly assess transmission and adjust prevention protocols.
18 Jul, 2021 | 23:37h | UTCRelated: Pooling of Samples for Testing for SARS-CoV-2 in Asymptomatic People AND Implementation of a Pooled Surveillance Testing Program for Asymptomatic SARS-CoV-2 Infections on a College Campus — Duke University, Durham, North Carolina, August 2–October 11, 2020 – CDC Morbidity and Mortality Weekly Report
AHA/ASA Scientific Statement: Primary Care of Adult Patients After Stroke.
18 Jul, 2021 | 23:20h | UTCNews release: Comprehensive primary care is vital to holistic care and optimal recovery after a stroke – American Heart Association
Commentary on Twitter
Primary Care of Adult Patients After Stroke: A Scientific Statement From the American Heart Association/American Stroke Association https://t.co/moIZ1W2cXL @American_Heart @American_Stroke pic.twitter.com/jWOK8Fz0vM
— Stroke AHA/ASA (@StrokeAHA_ASA) July 15, 2021
M-A: benefit-to-harm balance of statins in primary prevention of cardiovascular disease generally favorable.
18 Jul, 2021 | 23:16h | UTCNews release: New study suggests benefit-to-harm balance of statins for healthy adults ‘generally favorable’ – BMJ
Commentary on Twitter
Statins are associated with a small increased risk of side effects in patients without a history of heart disease, but these effects are mild compared with the potential benefits of treatment in preventing major cardiovascular events, say researchers https://t.co/Yvn7Ojtx2F
— The BMJ (@bmj_latest) July 17, 2021
Why was a major study on ivermectin for covid-19 just retracted?
16 Jul, 2021 | 11:11h | UTCWhy Was a Major Study on Ivermectin for COVID-19 Just Retracted? – Grifter Analysis and Review
See also: Huge study supporting ivermectin as Covid treatment withdrawn over ethical concerns – The Guardian AND Some problems in the dataset of a large study of Ivermectin for the treatment of Covid-19 – Nick Brown’s Blog AND Is Ivermectin for Covid-19 Based on Fraudulent Research? – Gideon M-K; Health Nerd
Commentary on Twitter (thread – click for more)
So, one of the biggest studies to date on ivermectin for COVID-19 has issues significant enough that, if not fraud, are so serious that it invalidates the study without further explanation
I promised a thread
Here we go 1/n https://t.co/L9QOChmGtA
— Health Nerd (@GidMK) July 16, 2021
Heterologous Oxford–AstraZeneca and Moderna Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.
16 Jul, 2021 | 11:02h | UTCHeterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination – New England Journal of Medicine
Related: [Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”. AND Phase 2 RCT: Immunogenicity and reactogenicity of a Pfizer-BioNTech booster in patients that have received a single dose of AstraZeneca vaccine – “BNT162b2 (Pfizer) given as a second dose in individuals prime vaccinated with ChAdOx1-S (AstraZeneca) induced a robust immune response, with an acceptable and manageable reactogenicity profile”. AND RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
Commentary on Twitter
Health care workers who had received a dose of ChAdOx1 nCoV-19 were offered either ChAdOx1 nCoV-19 or mRNA-1273 9 to 12 weeks later. Levels of S-specific and RBD-specific IgG increased by a factor of 5 after ChAdOx1 nCoV-19 and by a factor of 115 to 125 after mRNA-1273.
— NEJM (@NEJM) July 14, 2021
Short review: The gut in COVID-19.
16 Jul, 2021 | 10:54h | UTCThe gut in COVID-19 – Intensive Care Medicine
Commentary on Twitter
Gut & #COVID19, main findings
➡️clinical GI features
➡️pathophysiology: cytotoxic enterocyte injury, microvascular injury/thromboinfammation, non‑specifc critical illness‑related dysfunction
➡️GI dysfunction in severe #SARSCoV2 vs other critical illnesseshttps://t.co/wzzTNldInN pic.twitter.com/DnHLMsSu6v— Intensive Care Medicine (@yourICM) July 9, 2021
Heterologous Oxford–AstraZeneca and BioNTech/Pfizer Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.
16 Jul, 2021 | 11:00h | UTCHeterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination – New England Journal of Medicine
Related: [Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”. AND Phase 2 RCT: Immunogenicity and reactogenicity of a Pfizer-BioNTech booster in patients that have received a single dose of AstraZeneca vaccine – “BNT162b2 (Pfizer) given as a second dose in individuals prime vaccinated with ChAdOx1-S (AstraZeneca) induced a robust immune response, with an acceptable and manageable reactogenicity profile”. AND RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
Commentary on Twitter
https://twitter.com/EricTopol/status/1415297187718696964
AAFP Guideline: Pharmacologic Management of COPD Exacerbations.
16 Jul, 2021 | 10:51h | UTC
Assessment and management of peripheral arterial disease: what every cardiologist should know.
16 Jul, 2021 | 10:33h | UTC
Commentary on Twitter
https://twitter.com/Heart_BMJ/status/1400364145980100609
Beyond coronavirus: the virus discoveries transforming biology – “SARS-CoV-2 is just one of nonillions of viruses on our planet, and scientists are rapidly identifying legions of new species”.
16 Jul, 2021 | 10:35h | UTCBeyond coronavirus: the virus discoveries transforming biology – Nature
Commentary on Twitter
.@Nature reports how over the past 10 years, the number of known and named viruses has exploded, owing to advances in the technology for finding them, plus a recent change to the rules for identifying new species. https://t.co/lGqrpOWBsB
— Nature Portfolio (@NaturePortfolio) July 3, 2021