Internal Medicine
RCT: Bamlanivimab plus Etesevimab reduce mortality and hospitalization in ambulatory patients with early Covid-19 (within 3 days of a positive test) who are at risk for clinical deterioration (i.e., older people, obese, diabetics, immunocompromised, with CV disease).
15 Jul, 2021 | 09:26h | UTCBamlanivimab plus Etesevimab in Mild or Moderate Covid-19 – New England Journal of Medicine
COVID and the brain: researchers zero in on how damage occurs.
15 Jul, 2021 | 09:18h | UTCCOVID and the brain: researchers zero in on how damage occurs – Nature
Study shows the viral loads in the Delta infections are ~1000 times higher than those in the earlier strain infections on the day when viruses are firstly detected.
15 Jul, 2021 | 09:20h | UTCCommentary: The Delta Variant Isn’t Just Hyper-Contagious. It Also Grows More Rapidly Inside You – NPR
Related: WHO: Delta variant is ‘most transmissible’ identified so far. AND Increased transmissibility and global spread of SARS-CoV-2 variants of concern – “Estimated transmissibility increases of alpha 29% (95% CI: 24–33), beta 25% (95% CI: 20–30), gamma 38% (95% CI: 29–48) & delta 97% (95% CI: 76–117)”.
Commentary on Twitter
Part of the challenge that Delta presents may be tied to this finding
The variant's viral load ~1,000X higher than previous strains (reflected by low CTs), more infectious in the early stages of the illnesshttps://t.co/09CDQFwCSV pic.twitter.com/mjIfcNTYlO— Eric Topol (@EricTopol) July 9, 2021
[Preprint] Brain imaging before and after COVID-19 in UK Biobank.
15 Jul, 2021 | 09:17h | UTCBrain imaging before and after COVID-19 in UK Biobank – medRxiv
Commentaries: COVID linked to loss of brain tissue: but correlation doesn’t prove causation – The Conversation AND COVID-19 survivors may suffer from a loss of gray matter and other brain tissue over time, a long-term study suggests – Business Insider
Radiation therapy-associated toxicity: Etiology, management, and prevention.
15 Jul, 2021 | 09:13h | UTC
Tramadol: Where do we go from here? – “Tramadol’s unpredictability, unique potential harms, and lack of advantage over other opioids or NSAIDs are now well recognized”.
15 Jul, 2021 | 09:14h | UTC[131] Tramadol: Where do we go from here? – Therapeutic Initiative
Cohort study: Increased risk of long-term risk of anemia after bariatric surgery – Compared with the control group, the incidence of anemia was higher in the gastric bypass group (HR 5.05), the vertical-banded gastroplasty group (HR 2.67), and the gastric banding group (HR 2.76).
15 Jul, 2021 | 09:10h | UTCLong-term risk of anaemia after bariatric surgery: results from the Swedish Obese Subjects study – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Consensus Guidance: Budd-Chiari syndrome.
15 Jul, 2021 | 09:07h | UTC
A consensus integrated care pathway for patients with primary biliary cholangitis.
15 Jul, 2021 | 09:06h | UTC
Sarcoidosis: A clinical overview from symptoms to diagnosis.
15 Jul, 2021 | 08:58h | UTCSarcoidosis: A Clinical Overview from Symptoms to Diagnosis – Cells
Diagnosis and clinical management of hepatosplenic schistosomiasis: A scoping review of the literature.
15 Jul, 2021 | 09:02h | UTC
RCT: Lopinavir-ritonavir and hydroxychloroquine worsened outcomes in critically ill patients with COVID-19.
14 Jul, 2021 | 11:25h | UTC
Commentary on Twitter (thread – click for more)
Results of @remap_cap #Covid_19 #Antiviral Domain released Online First @yourICM: Among critically ill patients with COVID-19, #lopinavir-ritonavir, #HydroxyChloroquine, or combination therapy worsened outcomes compared to no antiviral therapy
— remap-cap (@remap_cap) July 13, 2021
Opinion | The case for mandating COVID-19 vaccines for health care workers.
14 Jul, 2021 | 11:22h | UTCThe Case for Mandating COVID-19 Vaccines for Health Care Workers – Annals of Internal Medicine
News release: Case is strong for mandating COVID-19 vaccination for health care workers – American College of Physicians
Commentary on Twitter
The Case for Mandating COVID-19 Vaccines for Health Care Workers https://t.co/pdaBRZdkfG via @AnnalsofIM "The case for mandating SARS-CoV-2 vaccines for health care workers is substantially stronger than the case was for mandating influenza vaccines." I fully agree.
— Kenny Lin, MD, MPH (@kennylinafp) July 12, 2021
RCT: Neither Remdesivir nor Hydroxychloroquine affect viral clearance in hospitalized patients with COVID-19.
14 Jul, 2021 | 11:23h | UTCNews release: Neither remdesivir nor HCQ affect viral clearance in hospitalized patients with COVID-19 – American College of Physicians
Original Study: Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 – Annals of Internal Medicine
Commentary on Twitter
Newly published research in Annals concludes neither remdesivir nor #hydroxychloroquine affected viral clearance in hospitalized patients with #COVID19 https://t.co/K3qWLUW8uY. pic.twitter.com/ugbjJJ3qI5
— Annals of Int Med (@AnnalsofIM) July 12, 2021
Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.
14 Jul, 2021 | 11:20h | UTCBetween BNT162b2 Vaccination and Incidence of SARS-CoV-2 Infection in Pregnant Women – JAMA
Commentary: Pfizer COVID vaccine shows 78% efficacy in pregnancy – CIDRAP
Real-World Evidence: The low validity of temperature screening for COVID-19 triage.
14 Jul, 2021 | 11:11h | UTC
Commentary on Twitter
Temperature screening with infrared thermometers has a sensitivity of 9.43% for PCR+ COVID. https://t.co/GjaKpkUqwU
— Carlos del Rio (@CarlosdelRio7) July 7, 2021
One COVID vaccine dose yields good protection in elderly, 2 studies find.
14 Jul, 2021 | 11:15h | UTCOne COVID vaccine dose yields good protection in elderly, 2 studies find – CIDRAP
Commentary on Twitter (thread – click for more)
2 research Articles on #COVID19 vaccine effectiveness in older people:
1) Effectiveness of BNT162b2 and ChAdOx1 nCoV-19 COVID-19 vaccination at preventing hospitalisations in people aged at least 80 years: a test-negative, case-control study https://t.co/ELvMCPwSHF— The Lancet Infectious Diseases (@TheLancetInfDis) June 24, 2021
WHO: New study highlights unacceptably high global prevalence of syphilis among men who have sex with men.
14 Jul, 2021 | 11:04h | UTCOriginal Study: Prevalence of syphilis among men who have sex with men: a global systematic review and meta-analysis from 2000–20 – The Lancet Global Health
Commentary: Syphilis in men who have sex with men: advancing research and human rights – The Lancet Global Health
Global burden of cancer attributable to alcohol consumption – “Globally, an estimated 741.300, or 4·1% of all new cases of cancer in 2020 were attributable to alcohol consumption”.
14 Jul, 2021 | 11:07h | UTCNews release: Alcohol consumption linked to more than 740,000 new cancer cases in 2020 – The Lancet
Commentaries: Alcohol caused 740,000 cancer cases globally last year – study – The Guardian AND Expert reaction to study of alcohol and cancer – Science Media Centre
Review: Diagnosis and treatment of alcohol-associated liver disease.
14 Jul, 2021 | 11:02h | UTCDiagnosis and Treatment of Alcohol-Associated Liver Disease: A Review – JAMA (free for a limited period)
Audio Clinical Review: Diagnosis and Treatment of Alcohol-Associated Liver Disease – JAMA
Summary: SGLT2 inhibitors and GLP-1 receptor agonists established and emerging indications.
14 Jul, 2021 | 10:56h | UTCSGLT2 Inhibitors and GLP-1 Receptor Agonists: Indications – American College of Cardiology
Original review: SGLT2 inhibitors and GLP-1 receptor agonists: established and emerging indications – The Lancet (link to abstract – $ for full-text)
FDA Safety Alert: hydroxyethyl starch products should not be used unless adequate alternative treatment is unavailable.
14 Jul, 2021 | 10:48h | UTCCommentary: FDA Piles on New Warnings for Blood Volume Expanders – MedPage Today (free registration required)
Related: Hydroxyethyl-starch Solutions (HES) Should no Longer be Used – European Medicines Agency AND Randomized Trial: Hydroxyethyl Starch vs. Saline for Volume Replacement Therapy in High-Risk Patients Undergoing Major Abdominal Surgery AND Systematic Review: Colloids vs Crystalloids for Fluid Resuscitation in Critically Ill People
German national treatment guidance for hospitalized COVID-19 patients.
13 Jul, 2021 | 10:02h | UTC
Long Covid: 39% of patients report persistent symptoms more than seven months after diagnosis of COVID-19 in an outpatient setting.
13 Jul, 2021 | 09:57h | UTCCommentaries: Long COVID symptoms in a third of people with COVID-19 – American College of Physicians AND Covid-19: 1-in-3 Patients Reported Long-Hauler Symptoms – Physician’s Weekly
Commentary on Twitter
A new prospective cohort study of >400 people with mild to moderate (outpatient) covid at 7-9 months: nearly 1 of 3 had persistent symptoms #LongCovid @AnnalsofIM
https://t.co/ix1Hhsm0iZ
by @mayssamnehme and colleagues pic.twitter.com/Uc4UEclDvA— Eric Topol (@EricTopol) July 5, 2021
[Preprint] Long Covid: Persistent symptoms following SARS-CoV-2 infection in a random community sample of 508,707 people.
13 Jul, 2021 | 09:55h | UTCCommentary: Study explores the prevalence of long COVID in England – News Medical