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Internal Medicine

Guideline Synopsis: The Non-Surgical Management of Hip and Knee Osteoarthritis.

1 Oct, 2021 | 10:00h | UTC

Synopsis of the 2020 US Department of Veterans Affairs/US Department of Defense Clinical Practice Guideline: The Non-Surgical Management of Hip and Knee Osteoarthritis – Mayo Clinic Proceedings

 

Review: Membranous nephropathy.

1 Oct, 2021 | 10:01h | UTC

Membranous nephropathy – Nature Reviews Disease Primers (free for a limited period)

Infographic: Membranous nephropathy (free for a limited period)

 

Commentary on Twitter

 

RCT: REGEN-COV antibody combination reduces hospitalizations in outpatients with Covid-19.

30 Sep, 2021 | 10:33h | UTC

REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19 – New England Journal of Medicine

 

[Press release – Not published yet] Clover’s COVID-19 vaccine candidate demonstrates 79% efficacy against Delta.

30 Sep, 2021 | 10:30h | UTC

Clover’s COVID-19 Vaccine Candidate Demonstrates 79% Efficacy Against Delta in Global Phase 2/3 SPECTRA Trial Dominated by Variants of Concern and Interest – Clover Biopharmaceutical

Commentary: New Chinese vaccine could bolster global arsenal – Science

 

Randomized trial with over 30.000 patients showed AstraZeneca vaccine was safe and resulted in 74% efficacy against symptomatic SARS-CoV-2 infection.

30 Sep, 2021 | 10:32h | UTC

Phase 3 Safety and Efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 Vaccine – New England Journal of Medicine

 

Commentaries on Twitter

https://twitter.com/NEJM/status/1443331005050355715

https://twitter.com/EricTopol/status/1443336261897392133

 

RCT: Vasopressin + Methylprednisolone increase the likelihood of return of spontaneous circulation compared to placebo in patients with in-hospital cardiac arrest.

30 Sep, 2021 | 10:23h | UTC

Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Vasopressin and Steroids as Adjunctive Treatment for In-Hospital Cardiac Arrest (free for a limited period)

 

Commentary on Twitter

 

Over a third of COVID-19 patients diagnosed with at least one long-COVID symptom.

30 Sep, 2021 | 10:25h | UTC

News release: Over a third of COVID-19 patients diagnosed with at least one long-COVID symptom – University of Oxford

Original study: Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19 – PLOS Medicine

Commentaries:

Two studies tie long COVID-19 to severe initial illness – CIDRAP

Covid: 37% of people have symptoms six months after infection – The Guardian

Long Covid is a bigger problem than we thought – CNN

Expert reaction to study looking at incidence and co-occurrence of long COVID symptoms following COVID-19 infection and also after influenza – Science Media Centre

 

RCT: Maintenance vs. discontinuation of antidepressants in patients who felt well enough to discontinue antidepressant therapy.

30 Sep, 2021 | 10:22h | UTC

Maintenance or Discontinuation of Antidepressants in Primary Care – New England Journal of Medicine

Commentaries:

Many can stop anti-depressants without relapse – BBC

Study highlights difficulty of stopping antidepressants – Associated Press

 

RCT: A structured program of diet and exercise significantly reduced blood pressure and cardiovascular disease biomarkers in patients with resistant hypertension.

30 Sep, 2021 | 10:14h | UTC

Effects of Lifestyle Modification on Patients With Resistant Hypertension: Results of the TRIUMPH Randomized Clinical Trial – Circulation

News release: Healthy changes in diet, activity improved treatment-resistant high blood pressure – American Heart Association

 

Commentary on Twitter

 

Position Statement on Diagnosis and Treatment of Cardiac Amyloidosis – 2021

30 Sep, 2021 | 10:01h | UTC

Position Statement on Diagnosis and Treatment of Cardiac Amyloidosis – 2021 – Arquivos Brasileiros de Cardiologia

 

Supplement: Acute Respiratory Distress Syndrome.

30 Sep, 2021 | 10:03h | UTC

Homepage: Acute Respiratory Distress Syndrome – Critical Care Clinics

The Epidemiology of Acute Respiratory Distress Syndrome Before and After Coronavirus Disease 2019

Toward Optimal Acute Respiratory Distress Syndrome Outcomes

Pathophysiology of Acute Respiratory Distress Syndrome and COVID-19 Lung Injury

COVID-19–Associated Acute Respiratory Distress Syndrome

Pathophysiology of the Acute Respiratory Distress Syndrome

Acute Kidney Injury and Acute Respiratory Distress Syndrome

Acute Respiratory Distress Syndrome

Fluid Therapy and Acute Respiratory Distress Syndrome

Pharmacologic Treatments for Acute Respiratory Distress Syndrome

Long-Term Outcomes in Acute Respiratory Distress Syndrome

Related:

Position paper: Advancing precision medicine for acute respiratory distress syndrome.

Review: Personalized mechanical ventilation in acute respiratory distress syndrome.

Seminar | Acute respiratory distress syndrome.

M-A of randomized trials: In patients with acute respiratory distress syndrome, there was no difference in mortality between higher vs. lower positive end-expiratory pressure strategies.

M-A: High versus low PEEP levels for mechanically ventilated adult patients with acute lung injury and ARDS

M-A: Decreased mortality in acute respiratory distress syndrome patients treated with corticosteroids

ARDS: Contemporary management and novel approaches during COVID-19

Systematic review: Evidence-based practices for acute respiratory failure and Acute Respiratory Distress Syndrome

Current and evolving standards of care for patients with acute respiratory distress syndrome (ARDS). Definition, ventilatory support, fluid management, use of corticosteroids, indications of prone positioning and ECMO, and more.

 

EM Cases: Liver Emergencies – Acute liver failure, hepatic encephalopathy, hepatorenal syndrome, liver test interpretation & drugs to avoid.

30 Sep, 2021 | 10:04h | UTC

EM Cases: Liver Emergencies – Acute Liver Failure, Hepatic Encephalopathy, Hepatorenal Syndrome, Liver Test Interpretation & Drugs to Avoid – emDocs

 

M-A: Efficacy and secondary infection risk of tocilizumab, sarilumab and anakinra in COVID-19 patients.

29 Sep, 2021 | 10:24h | UTC

Efficacy and secondary infection risk of tocilizumab, sarilumab and anakinra in COVID-19 patients: A systematic review and meta-analysis – Reviews in Medical Virology

 

Never Waste a Pandemic: Strategies to Increase Advance Care Planning Now.

29 Sep, 2021 | 10:22h | UTC

Never Waste a Pandemic: Strategies to Increase Advance Care Planning Now – Mayo Clinic Proceedings

 

Characterizing long COVID: a living systematic review.

29 Sep, 2021 | 10:29h | UTC

Characterising long COVID: a living systematic review – BMJ Global Health

Related:

Long Covid – The illness narratives.

New guidelines to help doctors manage long COVID patients published.

M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

 

Commentary on Twitter

https://twitter.com/CharitiniSt/status/1442528255718748164

 

Guideline for Perioperative Care for People Living with Frailty Undergoing Elective and Emergency Surgery.

29 Sep, 2021 | 10:10h | UTC

News release and infographic: Perioperative Care of People Living with Frailty – Centre for Perioperative Care

Guideline: Perioperative Care for People Living with Frailty Undergoing Elective and Emergency Surgery – British Geriatrics Society

 

Commentary on Twitter

 

AGA Clinical Practice Guideline on the Management of Coagulation Disorders in Patients With Cirrhosis.

29 Sep, 2021 | 10:07h | UTC

AGA Clinical Practice Guideline on the Management of Coagulation Disorders in Patients With Cirrhosis – Gastroenterology

See also: AGA Technical Review on Coagulation in Cirrhosis – Gastroenterology

 

WHO and partners call for urgent action on meningitis – New meningitis strategy aims to save more than 200,000 lives annually.

29 Sep, 2021 | 10:06h | UTC

News release: WHO and partners call for urgent action on meningitis – New meningitis strategy aims to save more than 200,000 lives annually – World Health Organization

See guidance: Defeating meningitis by 2030: a global road map – World Health Organization

Commentaries:

WHO Launches First Global Strategy to Eliminate Bacterial Meningitis by 2030 – Health Policy Watch

LSHTM joins WHO to call for urgent action on meningitis – London School of Hygiene & Tropical Medicine

 

Commentary on Twitter (thread – click for more)

 

Review: Sensory Dysfunction in Old Age.

29 Sep, 2021 | 09:57h | UTC

Sensory Dysfunction in Old Age – Deutsches Ärzteblatt International

 

Review: Implementing an early rule-out pathway for acute myocardial infarction in clinical practice.

29 Sep, 2021 | 10:00h | UTC

Implementing an early rule-out pathway for acute myocardial infarction in clinical practice – Heart

 

Review: Monitoring of Treatment for Arterial Hypertension.

29 Sep, 2021 | 09:59h | UTC

Monitoring of Treatment for Arterial Hypertension – Deutsches Ärzteblatt International

 

COVID-19 testing moves out of the clinic and into the home.

28 Sep, 2021 | 09:46h | UTC

COVID-19 Testing Moves Out of the Clinic and Into the Home – JAMA

 

Evidence shows that, yes, masks prevent COVID-19 – and surgical masks are the way to go.

28 Sep, 2021 | 09:45h | UTC

Evidence shows that, yes, masks prevent COVID-19 – and surgical masks are the way to go – The Conversation

Related: [Preprint] Largest study of masks yet details their importance in fighting Covid-19.

 

RCT: Methylphenidate may improve apathy in patients with Alzheimer Disease.

28 Sep, 2021 | 09:06h | UTC

Effect of Methylphenidate on Apathy in Patients With Alzheimer Disease: The ADMET 2 Randomized Clinical Trial – JAMA Neurology (free for a limited period)

Editorial: Methylphenidate for Apathy in Alzheimer Disease—Why Should We Care? (free for a limited period)

 

Commentary on Twitter

 

New analysis shows use and predictors of low-value care in health systems – “Patients at health systems with smaller shares of primary care physicians and without teaching hospitals were more likely to receive low-value services”.

28 Sep, 2021 | 09:08h | UTC

News release: New analysis shows use and predictors of low-value care in health systems nationwide – Brigham and Women’s Hospital

Original study: Low-Value Care at the Actionable Level of Individual Health Systems – JAMA Internal Medicine

Author interview: Low-Value Care at the Actionable Level of Individual Health Systems

 

Commentary on Twitter

 

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